Journals Clinical and Molecular Allergy...

Clinical and Molecular Allergy : CMA
Naghmeh Kian, Alireza Bagheri, Fardis Salmanpour, Afsaneh Soltani, Zahra Mohajer, Noosha Samieefar, Behzad Barekatain, Roya Kelishadi
Asthma is a chronic condition that affects children worldwide. Accumulating number of studies reported that the prevalence of pediatric obesity and asthma might be altered through breastfeeding. It has been proposed that Leptin, which exists in human milk, is oppositely associated with weight increase in newborns. It may also influence peripheral immune system by promoting TH1 responses and suppressing TH2 cytokines. Leptin influences body weight and immune responses through complex signaling pathways at molecular level...
October 3, 2023: Clinical and Molecular Allergy: CMA
Ahmad Piroozmand, Batool Zamani, Hamed Haddad Kashani, Javad Amini Mahabadi
BACKGROUND: Primary Systemic Sclerosis (PSS) is a connective tissue disorder characterized by excessive collagen deposition in the skin and internal organs. Interstitial lung disease (ILD) is a late demonstration of PSS and cytokines can contribute to the disease pathology. The purpose of the current study was to determine the association between serum interleukin-6 level and pulmonary involvement in progressive systemic sclerosis. METHODS AND MATERIALS: Demographic data and serum interleukin-6 levels were measured for 30 PSS patients with pulmonary involvement (case group) and 30 PSS patients without pulmonary involvement (control group) following informed consent...
September 5, 2023: Clinical and Molecular Allergy: CMA
Janitha Iddagoda, Peshala Gunasekara, Shiroma Handunnetti, Chandima Jeewandara, Chandima Karunatilake, Gathsaurie Neelika Malavige, Rajiva de Silva, Dhanushka Dasanayake
BACKGROUND: It is clinically important to identify allergens in Artocarpus heterophyllus (jackfruit), Moringa oleifera (moringa), Trianthema portulacastrum (horse purslane) and Syzygium samarangense (rose apple). This study included 7 patients who developed anaphylaxis to jackfruit (1), moringa (2), horse purslane (3) and rose apple (1). We sought to determine allergens in the edible ripening stages of jackfruit (tender, mature, and ripened jackfruit) and seeds, edible parts of moringa (seeds, seedpod, flesh inside seedpod, and leaves), horse purslane leaves and ripened rose apple fruit...
August 11, 2023: Clinical and Molecular Allergy: CMA
Dinastry Pramadita Zakiudin, Anne Dorthea Bjerkenes Rø, Vibeke Videm, Torbjørn Øien, Melanie Rae Simpson
BACKGROUND: Maternal probiotic supplementation has a promising effect on atopic dermatitis (AD) prevention in infancy. In the randomised controlled study, Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotics reduced the cumulative incidence of AD in their offspring by 40% at 2 years of age. However, our understanding on how probiotics prevented AD is still limited, and the role of inflammatory proteins in infants following maternal probiotic supplementation is unclear...
July 29, 2023: Clinical and Molecular Allergy: CMA
Matineh Nirouei, Mona Kouchekali, Homa Sadri, Mostafa Qorbani, Hadi Montazerlotfelahi, Narges Eslami, Marzieh Tavakol
BACKGROUND: Asthma is the most prevalent respiratory disease caused by chronic airway inflammation. Attention Deficit Hyperactivity Disorder (ADHD) is children's most common psychological and neurodevelopmental disorder. Increased risk for ADHD in patients with inflammatory and autoimmune diseases supports the role of inflammatory mechanisms in the occurrence of ADHD. However, the association between asthma and ADHD remains unclear. OBJECTIVE: This study was designed to evaluate the prevalence of ADHD in patients with asthma who were referred to the clinic of allergy and clinical immunology...
June 27, 2023: Clinical and Molecular Allergy: CMA
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Amelia Licari, Gian Luigi Marseglia, Antonio Di Sabatino
BACKGROUND: Non-specific lipid-transfer protein (nsLTP) is a pan-allergen in the plant world, and a cause of significant concern as food allergen in the Mediterranean area, due to its general heat- and acid-resistance and hence the risk of severe allergic reactions. Pru p 3, the peach nsLTP, is considered the primary sensitizer to this allergen family and this allergy is usually persistent. Allergen-free diet and acute treatment of manifestations are the main recognized management goals in food allergy...
May 31, 2023: Clinical and Molecular Allergy: CMA
Prapasri Kulalert, Padcha Pongcharoen, Paskorn Sritipsukho, Sukkrawan Intraakhao, Punnapat Piriyanon, Patcharapa Thaweekul, Sira Nanthapisal, Orapan Poachanukoon
BACKGROUND: The accuracy of an atopy patch test (APT) for fresh cow's milk allergy is controversial. Few studies have focused on commercial extract solutions. We aimed to evaluate the diagnostic performance of the APT in cow's milk allergic children using fresh cow's milk and commercial extracts of cow's milk and its components including casein, α-lactalbumin, and β-lactoglobulin. METHODS: A prospective study was carried out in children with a history of cow's milk allergy...
April 7, 2023: Clinical and Molecular Allergy: CMA
Serhii Yuriev, Victoria Rodinkova, Vitalii Mokin, Ilona Varchuk, Olena Sharikadze, Yuriy Marushko, Bohdan Halushko, Andrii Kurchenko
BACKGROUND: As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective. METHODS: The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used...
February 3, 2023: Clinical and Molecular Allergy: CMA
Zahra Alibolandi, Amirreza Ostadian, Saeed Sayyah, Hamed Haddad Kashani, Hassan Ehteram, Hamid Reza Banafshe, Mohammad Hajijafari, Mahdi Sepehrnejad, Narjes Riahi Kashani, Mohammd-Javad Azadchehr, Hossein Nikzad, Elahe Seyed Hosseini
OBJECTIVES: This study aimed to determine the levels of IgM and IgG antibody response to the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with different disease severity. METHODS: IgM and IgG antibody levels were evaluated via enzyme-linked immunosorbent assay (ELISA). In total, 100 patients with confirmed SARS-CoV-2 infection were enrolled in this study and viral RNA was detected by using Real-time PCR technique...
December 22, 2022: Clinical and Molecular Allergy: CMA
Janitha Iddagoda, Peshala Gunasekara, Shiroma Handunnetti, Chandima Jeewandara, Chandima Karunatilake, Gathsaurie Neelika Malavige, Rajiva de Silva, Dhanushka Dasanayake
BACKGROUND: Despite the low prevalence of IgE sensitivity to fresh or boiled coconut milk and coconut oil, those may contain allergens of which the clinical significance remains undetermined. This study aimed to identify and compare allergens in fresh coconut milk (FCM), boiled coconut milk (BCM), unrefined wet-processed coconut oil (WPCO), and dry-processed coconut oil (DPCO) using sera from patients with allergy to coconut milk. METHODS: The study included 18 patients with immediate hypersensitivity to coconut milk, including five who developed anaphylaxis...
December 20, 2022: Clinical and Molecular Allergy: CMA
Danilo Di Bona, Andrea Miniello, Eustachio Nettis
Systemic drug-related intertriginous and flexural exanthema (SDRIFE) is an adverse drug reaction which manifests as a symmetrical erythematous rash involving the skin folds after systemic drug exposure. A vast array of possible side effects associated with administration of different anti-SARS-CoV-2 vaccines have been reported in literature since the beginning of the COVID-19 pandemic, but only few times SDRIFE-like eruptions have been described in this context. We discuss here a case of SDRIFE-like eruption following the second dose of Oxford-Astrazeneca Vaxzevria vaccine...
December 12, 2022: Clinical and Molecular Allergy: CMA
Xiaowen Fan, Tory McKnight, Johnathan Neshiwat, Song Park, Danna Chung, Xiu-Min Li
BACKGROUND: Food allergy is becoming increasingly common among the pediatric population. Despite strict avoidance of food allergens, a subgroup of sensitive individuals still develops frequent, persistent, and difficult to treat hives (FPDTH) for which there is no curative therapy. Although these cases are rare, these patients are in most need of therapy. CASE PRESENTATIONS: This is a retrospective review of 3 pediatric patients with highly sensitive food allergies who initially presented with hives daily or every other day, or multiple times a day, but achieved marked remission after traditional Chinese medicine (TCM) therapies...
November 25, 2022: Clinical and Molecular Allergy: CMA
Peshala Gunasekara, S M Handunnetti, Sunil Premawansa, E W R A Witharana, Indra P Ratnayake, Pradeep Kaluarachchi, Chandima Karunatilake, R K S Dias, G A S Premakumara, W M D K Dasanayake, Suranjith L Seneviratne, Rajiva de Silva
BACKGROUND: Allergy to Apis dorsata (Giant Asian Honeybee) venom is the commonest insect allergy in Sri Lanka and South East Asia. However, laboratory diagnosis is difficult as the pure venom and diagnostic reagents are not commercially available. OBJECTIVE: This study assessed the use of four recombinant allergens of A. mellifera venom and the passive basophil activation test in the diagnosis of A. dorsata venom anaphylaxis. METHODS: Serum IgE levels to four recombinant allergens of A...
September 14, 2022: Clinical and Molecular Allergy: CMA
Laura J H Sonneveld, Joyce A M Emons, Nicolette J T Arends, Lonneke J Landzaat, Sharon Veenbergen, Marco W J Schreurs
ALEX multiplex array is a relatively new multiplex allergy test which analyses more than 120 allergen extracts and 170 molecular components. ISAC is the most used and studied multiplex array to date, offering 112 molecular components. In ten atopic children with multiple food allergies good agreement was observed between ALEX and ISAC sIgE results for nearly all shared food components. Presence of larger number of allergens in ALEX could help clinicians to improve personalized dietary advice. However more positive sensitizations with unknown clinical relevance were found by ALEX, potentially increasing clinical complexity...
August 27, 2022: Clinical and Molecular Allergy: CMA
Erminia Ridolo, Cristoforo Incorvaia, Francesco Pucciarini, Elena Makri, Giovanni Paoletti, Giorgio Walter Canonica
INTRODUCTION: Allergic rhinitis (AR) is very commonly caused by pollens. The symptoms of AR consist of sneezing, nasal congestion, rhinorrhea, nasal itching and airflow obstruction. The diagnosis has long been based on clinical history, skin prick tests and in vitro measurement of specific IgE, but the innovative approach of precision medicine has made diagnostic tools of much greater accuracy available. AREAS COVERED: This review covers the advances in the treatment of seasonal AR concerning the drugs to be used according to the grade of disease and the characteristics of the patients, and the role of allergen immunotherapy (AIT), which is the only treatment capable of acting, in addition to the symptoms, on the cause of AR and therefore to modify its natural history...
August 10, 2022: Clinical and Molecular Allergy: CMA
Carlo Maria Rossi, Marco Vincenzo Lenti, Giovanna Achilli, Stefania Merli, Aurelio Mauro, Andrea Anderloni, Antonio Di Sabatino
No abstract text is available yet for this article.
July 20, 2022: Clinical and Molecular Allergy: CMA
Ana Delgado-Prada, Julián Borrás, Roxana Farzanegan, María Cruz Torres Gorriz, Adrián Germán-Sánchez, Raquel Cervera Aznar, Isabela Raducan, Jose Vicente Castelló, Alfredo Sanchez-Hernandez, Ernesto Enrique
BACKGROUND: Ifosfamide is an alkylating agent used in the treatment of a wide range of tumours. Because of known side effects it is usually administered in combination with mesna, a thiol agent with uroprotective activity, to reduce them and increase the therapeutic dose. The most frequently administered regimens for ifosfamide are fractionated doses for 3 to 5 days, high-dose intravenous bolus, and continuous infusion over 24 to 72 h. Hypersensitivity reactions to ifosfamide plus mesna are not frequently described in the literature...
May 23, 2022: Clinical and Molecular Allergy: CMA
Eustachio Nettis, Luisa Brussino, Vincenzo Patella, Laura Bonzano, Aikaterini Detoraki, Elisabetta Di Leo, Maria Maddalena Sirufo, Cristiano Caruso, Fabio Lodi Rizzini, Mariaelisabetta Conte, Mona-Rita Yacoub, Massimo Triggiani, Erminia Ridolo, Luigi Macchia, Giovanni Rolla, Raffaele Brancaccio, Amato De Paulis, Giuseppe Spadaro, Danilo Di Bona, Angela Maria D'Uggento, Lia Ginaldi, Francesco Gaeta, Eleonora Nucera, Kliljeda Jaubashi, Danilo Villalta, Lorenzo Dagna, Domenico Ciotta, Francesco Pucciarini, Diego Bagnasco, Giorgio Celi, Fulvia Chieco Bianchi, Lorenzo Cosmi, Maria Teresa Costantino, Maria Angiola Crivellaro, Simona D'Alò, Pietro Del Biondo, Stefano Del Giacco, Mario Di Gioacchino, Linda Di Pietro, Elisabetta Favero, Sebastiano Gangemi, Gabriella Guarnieri, Enrico Heffler, Maria Stefania Leto Barone, Carla Lombardo, Francesca Losa, Andrea Matucci, Paola Lucia Minciullo, Paola Parronchi, Giovanni Passalacqua, Stefano Pucci, Oliviero Rossi, Lorenzo Salvati, Michele Schiappoli, Gianenrico Senna, Andrea Vianello, Alessandra Vultaggio, Yang Baoran, Cristoforo Incorvaia, Giorgio Walter Canonica
BACKGROUND: Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies...
May 19, 2022: Clinical and Molecular Allergy: CMA
Amin Moradi Hasan-Abad, Mohsen Mohammadi, Hamed Mirzaei, Mohsen Mehrabi, Hossein Motedayyen, Reza Arefnezhad
Type I hypersensitivity (allergic reaction) is an unsuitable or overreactive immune response to an allergen due to cross-link immunoglobulin E (IgE) antibodies bound to its high-affinity IgE receptors (FcεRIs) on effector cells. It is needless to say that at least two epitopes on allergens are required to the successful and effective cross-linking. There are some reports pointing to small proteins with only one IgE epitope could cross-link FcεRI-bound IgE through homo-oligomerization which provides two same IgE epitopes...
April 29, 2022: Clinical and Molecular Allergy: CMA
Antonia Glaeser, Christoph Müller, Sebastian Bode
BACKGROUND: Anaphylaxis occurs in up to 3.5% of hymenoptera stings and can be a life-threatening emergency. Venom immunotherapy (VIT) provides excellent protection from further episodes of anaphylaxis and is well tolerated. In this study the frequency of anaphylactic reactions in pediatric patients undergoing rush bee venom immunotherapy was assessed as well as possible risk factors and modified up-dosing schemes are reported. METHODS: 19 consecutive pediatric patients, who had previously experienced an anaphylactic reaction following a bee sting and showed IgE-mediated sensitization to bee venom, underwent inpatient rush immunotherapy with bee venom extract...
April 29, 2022: Clinical and Molecular Allergy: CMA
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