journal
Journals Assay and Drug Development Tec...

Assay and Drug Development Technologies

https://read.qxmd.com/read/38489509/a-perspective-on-various-facets-of-nanoemulsions-and-its-commercial-utilities
#1
JOURNAL ARTICLE
Isha Mishra, Raghav Mishra, Ashutosh Dubey, Prashant Kumar Dhakad
Nanotechnology is a captivating contemporary technology owing to its extensive range of potential applications. This study emphasizes nanomaterials, substances with a size <100 nm, offering better qualities than coarse particles. Nanoparticles have several advantages compared with conventional drug delivery methods, including enhanced bioavailability and a larger surface area because of their smaller particle size. These characteristics make the nanoparticles a viable clinical candidate. Controlled-release drug delivery systems and targeted drug delivery systems rely heavily on nanoparticles...
March 14, 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38437578/drug-repurposing-patent-applications-october-december-2023
#2
JOURNAL ARTICLE
Hermann A M Mucke
No abstract text is available yet for this article.
March 5, 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38407852/exosomes-key-players-for-treatment-of-cancer-and-their-future-perspectives
#3
JOURNAL ARTICLE
Reena Gupta, Jitendra Gupta, Suchismita Roy
Cancer is one of the leading causes of mortality worldwide. As the population increases, there is an enriched thrust for screening a newer delivery system for anticancer agents to treat cancer. Therefore, exosome-mediated cell communication is the hallmark of its participation in cancer metastasis and progression. Furthermore, the inward budding of endosomes is referred to as the multivesicular body. Exosome constitutes phospholipid bilayer-bound vesicles. It transfers bioactive compounds between various cells and the tumor microenvironment...
February 26, 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38193798/potential-of-nanocarrier-associated-approaches-for-better-therapeutic-intervention-in-the-management-of-glioblastoma
#4
JOURNAL ARTICLE
Vikram, Shobhit Kumar, Javed Ali, Sanjula Baboota
Glioblastoma, commonly known as glioblastoma multiforme (GBM), is one of the deadliest and most invasive types of brain cancer. Two factors account for the majority of the treatment limitations for GBM. First, the presence of the blood-brain barrier (BBB) renders malignancy treatment ineffective, leading to recurrence without full recovery. Second, several adverse effects are associated with the drugs used in conventional GBM treatment. Recent studies have developed nanocarrier systems, such as liposomes, polymeric micelles, dendrimers, nanosuspensions, nanoemulsions, nanostructured lipid carriers, solid lipid nanocarriers, metal particles, and silica nanoparticles, which allow drug-loaded formulations to penetrate the BBB more effectively...
January 9, 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38193797/nanoliposomes-embedded-nanocochleates-for-codelivery-of-artemether-and-lumefantrine-an-in-vitro-and-in-vivo-study
#5
JOURNAL ARTICLE
Dyandevi Mathure, Prashant Sonawane, Hemantkumar Ranpise, Rajendra Awasthi
Antimalarial drugs are being encapsulated in nanotechnology-based carriers because there are not enough new treatment options and people are becoming more resistant to the ones that are already available. This approach uses two or more biochemical targets of malarial parasites. The codelivery of artemether and lumefantrine (AL) combines the synergistic effect of artemether for an early onset of action followed by the prolonged effect of lumefantrine. The bioavailability of artemether and lumefantrine is low due to their low solubility...
January 9, 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38156818/quality-by-design-assisted-development-of-luliconazole-transethosomes-in-gel-for-the-management-of-candida-albicans-infection
#6
JOURNAL ARTICLE
Gurmeet Singh, Raj Kumar Narang
The objective of this study was to develop and evaluate a novel vesicular formulation of luliconazole (LUL) for the management of Candida albicans infection through a topical route. LUL-loaded transethosomes (LUL-TE) were prepared by the film hydration method and various independent and dependent variables were optimized using the Box-Behnken design. Selected critical material attributes were the content of phospholipids (X1), concentration of ethanol (X2), and amount of sodium cholate (X3). Formulated LUL-TE were characterized for percent entrapment efficiency, percent drug loading, vesicle size, and polydispersity index (PDI) and were incorporated into the carbomer gel base and further evaluated for gel characterizations...
December 29, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/38150563/development-and-characterization-of-novel-chitosan-coated-curcumin-nanophytosomes-for-treating-drug-resistant-malaria
#7
JOURNAL ARTICLE
Bhargav Eranti, Padmanabha Reddy Yiragamreddy, Koteshwara Kunnatur Balasundara
This study aimed at enhancing the efficacy of curcumin (CR) by formulating and coating it with chitosan. In silico molecular docking studies revealed that CR exhibited almost similar and low binding energies when compared to artemisinin, indicating high stability at the target site. It can be confirmed that CR is effective in treating and reducing Plasmodium falciparum parasites. Fourier transform infrared studies confirmed that there was a shift and disappearance of some drug peaks in the formulation which revealed complexation with phospholipids...
December 27, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/38150562/optimization-of-lurasidone-hcl-loaded-plga-nanoparticles-for-intramuscular-delivery-enhanced-bioavailability-reduced-dosing-frequency-pharmacokinetics-and-therapeutic-outcomes
#8
JOURNAL ARTICLE
Nikita Macwan, Hemil S Patel, Rakesh K Sharma, Nihali Jain, Hemal Tandel
This study aimed to develop a nanoparticle drug delivery system using poly (lactic-co-glycolic acid) (PLGA) for enhancing the therapeutic efficacy of lurasidone hydrochloride (LH) in treatment of schizophrenia through intramuscular injection. LH-loaded PLGA nanoparticles (LH-PNPs) were prepared using the nanoprecipitation technique and their physicochemical characteristics were assessed. Particle size (PS), zeta potential, morphology, % encapsulation efficiency, % drug loading, drug content, and solid-state properties were analyzed...
December 27, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/38150558/development-and-validation-of-reverse-phase-high-performance-liquid-chromatography-method-for-simultaneous-estimation-of-doxorubicin-and-clotrimazole
#9
JOURNAL ARTICLE
Priyanka Sharma, Bhupinder Kapoor, Md Sadique Hussain, Gurvinder Singh, Pooja Rani, Balraj Saini, Pankaj Wadhwa, Rajesh Kumar
A reverse-phase high-performance liquid chromatographic (RP-HPLC) method was developed to analyze the simultaneous estimation of doxorubicin and clotrimazole. The method was achieved by Nucleodur C18 column with dimension 250 × 4.6 mm (5 μm) using gradient elution. The mobile phase contained 0.2% formic acid (pH 3.2) and acetonitrile. The flow rate was kept at 1.0 mL/min and detection and quantitation of both drugs (doxorubicin and clotrimazole) were achieved using a photodiode array detector at 276 nm, which was the isosbestic point for both drugs...
December 27, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/38150225/implementation-of-quality-by-design-approaches-for-development-and-validation-of-reverse-phase-high-performance-liquid-chromatography-assay-method-for-determination-of-glycyrrhizin-in-nanoformulation
#10
JOURNAL ARTICLE
Jitu Halder, Ivy Saha, Tushar Kanti Rajwar, Biswakanth Kar, Goutam Ghosh, Goutam Rath
Glycyrrhizin (GL) is the principal constituent of Glycyrrhiza glabra , having antiallergic, anticancer, anti-inflammatory, and antimicrobial action. The reverse-phase high-performance liquid chromatography (RP-HPLC) analytical method was used to quantitatively estimate GL in a nanoformulation and validated as per International Conference on Harmonization Q2 (R1) standards. A stationary phase of the C18-HL reversed-phase column and a mobile phase of acetonitrile and water were used for effective elution. The chromatographic conditions of RP-HPLC were optimized utilizing a quality-by-design approach to accomplish the required chromatographic separation of GL from its nanoformulation with minimal experimental runs...
December 26, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/38232353/a-review-on-molecular-docking-as-an-interpretative-tool-for-molecular-targets-in-disease-management
#11
REVIEW
Divya Sahu, Lokendra Singh Rathor, Shradha Devi Dwivedi, Kamal Shah, Nagendra Singh Chauhan, Manju Rawat Singh, Deependra Singh
One of the most often utilized methods for drug discovery is molecular docking. With docking, one may discover new therapeutically relevant molecules by targeting the molecule and predicting the target-ligand interactions as well as different conformation of ligand at various positions. The prediction signifies the effectiveness of the molecule or the developed molecule having different affinity with target. Drug discovery plays an important role in the development of a new drug molecule of different moiety attached to it, which leads us in the management of several diseases...
January 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38010987/%C3%AE-tocopherol-polyethylene-glycol-1000-succinate-based-cationic-liposome-for-the-intracellular-delivery-of-doxorubicin-in-mda-mb-231-triple-negative-breast-cancer-cell-line
#12
JOURNAL ARTICLE
Pallavi Sandal, Preeti Patel, Dilpreet Singh, Ghanshyam Das Gupta, Balak Das Kurmi
Present research work reports the development of doxorubicin (DOX) loaded α-tocopherol polyethylene glycol 1000 succinate (TPGS)-coated cationic liposomes. The developed formulation was evaluated for its anticancer potential and intracellular uptake against the MDA-MB-231 breast cancer cell line. Moreover, hemocompatibility studies were also done on human blood red blood cells for the determination of blood compatibility. The prepared doxorubicin-loaded TPGS liposomes (DOX-LIPO-TPGS) and doxorubicin-loaded cationic liposomes (DOX-LIPO+ -TPGS) reveal vesicle size (177...
November 21, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/38010949/a-short-appraisal-of-biomimetic-hydrogels-to-improve-penetration-of-poorly-permeable-drugs
#13
JOURNAL ARTICLE
Dilpreet Singh, Sahil Arora, Vimal Arora
Effective drug delivery to target sites is critical for achieving desired therapeutic outcomes. However, the poor permeability of certain drugs poses significant challenges in achieving adequate drug concentrations at the desired locations. Biomimetic hydrogels have emerged as a promising approach to enhance the penetration of poorly permeable drugs. These hydrogels, designed to mimic natural biological systems, offer unique properties and functionalities that enable improved drug permeation. In this review, we provide a comprehensive appraisal of the role of biomimetic hydrogels in enhancing drug penetration...
November 21, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/37971781/-letter-to-the-editor-concerns-regarding-ethical-issues-in-reviewer-recommendations-for-citations
#14
JOURNAL ARTICLE
Rajendra Awasthi
No abstract text is available yet for this article.
November 15, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/37948550/drug-repurposing-patent-applications-july-september-2023
#15
JOURNAL ARTICLE
Hermann A M Mucke
No abstract text is available yet for this article.
November 10, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/37930848/-letter-to-the-editor-repurposing-tafenoquine-as-a-potential-inhibitor-against-severe-acute-respiratory-syndrome-coronavirus-2-main-protease-via-a-fluorescence-polarization-assay
#16
JOURNAL ARTICLE
Rui Zhang, Haohao Yan, Gangan Yan, Xiaoping Liu, Yunyu Chen
No abstract text is available yet for this article.
November 7, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/37801663/illuminating-insights-clinical-study-harnessing-pharmacoscintigraphy-for-permeation-study-of-radiolabeled-nimesulide-topical-formulation-in-healthy-human-volunteers
#17
JOURNAL ARTICLE
Nitin Sharma, Kushagra Khanna, Neeraj Kumar, Ritu Karwasra, Ashok Kumar Janakiraman, Mogana Sundari Rajagopal
An alternative to oral administration for the delivery of therapeutic substances is the topical route, which frequently has comparable efficacy but may have a better tolerability profile. Gamma scintigraphy is a noninvasive technique that involves the application of radioactive substances to conduct biodistribution studies of therapeutic substances delivered through various routes. Nimesulide (NSD) was radiolabeled with technetium pertechnetate (Technetium99m [99m Tc]) and this radiolabeled drug complex (99m Tc-NSD) was used to prepare a topical gel formulation...
October 6, 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/37831909/formulation-and-characterization-of-nanoparticulate-drug-carrier-system-for-lacidipine
#18
JOURNAL ARTICLE
Ashveta Anant Dessai, Mrunali Navin Kantak, Cleona Elizabeth Mary DCruz, Lalit Kumar, Prashant Jivaji Bhide, Rupesh Kalidas Shirodkar
Lacidipine, a calcium channel antagonist, is primarily used to treat hypertension. It is classified as a Biopharmaceutics Classification System Class II drug and exhibits an oral bioavailability of 10% due to its extensive hepatic first-pass metabolism. This research study focused on formulating lacidipine-loaded cubosomal nanovesicles developed into rapidly dissolving oral films as an alternative to overcome the downsides faced by conventional antihypertensive therapy. Lacidipine-loaded cubosomes were prepared utilizing a top-down technique using lipid and surfactant and were further developed into fast dissolving oral films...
October 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/37831908/quality-by-design-approach-for-optimization-of-microbial-and-ph-triggered-colon-targeted-tablet-formulation-using-carboxymethyl-tamarind-gum
#19
JOURNAL ARTICLE
Jaymin Patel, Kaushika Patel, Shreeraj Shah
ABSTRACT The purpose of this study was to apply the quality by design (QbD) approach in the development of a microbial and pH-triggered colon-targeted budesonide tablet. A retrospective research strategy was used to select various polysaccharide-based natural gums such as tamarind gum, gellan gum, karaya gum, gum ghutti, and khaya gum, which were then evaluated for their effectiveness in microbial degradation and targeting the colon. Viscosity profiles were generated in the presence of a prebiotic culture medium prepared by using the Velgut capsule that mimicked the impact of 4% rat cecal content and helpful in screening of natural polymer...
October 2023: Assay and Drug Development Technologies
https://read.qxmd.com/read/37831907/determination-of-the-toxicity-preferences-of-ocular-drug-delivery-system-by-comparing-two-different-toxicity-bioassays
#20
JOURNAL ARTICLE
Burcu Uner, Meltem Ezgi Durgun, Samet Ozdemir, Cetin Tas, Melike Uner, Yildiz Ozsoy
Ocular drug delivery methods are highly favored for boosting bioavailability, patient compliance, and lower adverse effects and dose frequency. In addition to preventing adverse effects from the active ingredient, the parts of drug delivery systems must be nontoxic and nonallergic as well. Mitochondrial toxicity test (MTT) and Hen's egg chorioallantois membrane (HET-CAM) assay are the most often utilized tests based on this dilemma. The toxicity of loteprednol etabonate loaded solid lipid nanoparticles, lipid nanostructured carriers, and nanoemulsion were compared...
October 2023: Assay and Drug Development Technologies
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