Journals Metabolic Syndrome and related...

Metabolic Syndrome and related Disorders
Cindy Piao, Elvis J Arteaga, Shuai Chen, Aili Guo, Scott T Macdonald, Souvik Sarkar
Background: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease with increasing rates globally. Patients with type 2 diabetes mellitus have higher risk of developing NAFLD. Patients with a higher degree of liver fibrosis in NAFLD are at an increased risk for liver-related mortality, but get missed easily during the referral process. This project aims to improve early detection and linkage-to-care of fibrotic NAFLD patients. Methods: We utilized a combination of automated electronic health record (EHR)-based fibrosis (FIB)-4 score and directed provider education...
September 27, 2023: Metabolic Syndrome and related Disorders
Marina L V Ferreira, Alex Castro, Silas G O Nunes, Marcus V M A Santos, Cláudia R Cavaglieri, Mara Patrícia T Chacon-Mikahil
Blood pressure (BP) responses to recommended aerobic training can vary widely between individuals. Although studies demonstrate the role of exercise training in regulating BP responsiveness, predictive models are still unknown. This study aimed to identify hemodynamic predictive markers for the diagnosis of BP responsiveness based on baseline characteristics and postexercise ambulatory blood pressure (ABP) before an aerobic training program in postmenopausal women. Sixty-five postmenopausal women with essential hypertension were randomly allocated into the continuous aerobic training (CAT, n  = 51) and nonexercising control (CON, n  = 14) groups...
September 6, 2023: Metabolic Syndrome and related Disorders
Aleksandra Klisic, Jelena Kotur-Stevuljevic, Dimitrios Patoulias, Ana Ninic
Aim: Studies that explored endocan (as a novel marker of endothelial dysfunction) in relation to metabolic syndrome (MetS) are scarce and show discordant results. Importantly, no study has yet examined serum endocan levels in exclusively postmenopausal women with MetS and free of diabetes. Oxidative stress and inflammation are the key features of MetS and consequently cardiovascular diseases. Hence, we aimed to explore the potential relationship between endocan, oxidative stress [ i.e., determined by total antioxidant status, total oxidant status, and pro-oxidant/antioxidant balance (PAB)], inflammation, and MetS in a cohort of postmenopausal women...
September 5, 2023: Metabolic Syndrome and related Disorders
Hye Lyn Lee, Su Jung Baik, Wan Je Cho, Da-Hye Son, Yong-Jae Lee
Background: Body mass index (BMI) and waist circumference (WC) are the most widely used anthropometric indices for identifying obesity. This study aimed to compare and clarify the usefulness of BMI, WC, and the combination of these two indicators in predicting nonalcoholic fatty liver disease (NAFLD). Methods: This cross-sectional study included 15,267 Korean adults. We defined four obesity categories using BMI and WC as follows: BMI nonobese and WC nonobese (BNWN); BMI obese and WC nonobese (BOWN); BMI nonobese and WC obese (BNWO); and BMI obese and WC obese (BOWO)...
September 5, 2023: Metabolic Syndrome and related Disorders
Rafael Garcia-Carretero, Oscar Vazquez-Gomez, Marta Lopez-Lomba, Ruth Gil-Prieto, Angel Gil-de-Miguel
Aim: Conditions linked to metabolic syndrome, such as obesity, hypertension, insulin resistance, and dyslipidemia, are common in patients with severe coronavirus disease 2019 (COVID-19). These conditions can act synergistically to contribute to negative outcomes. We describe and analyze the relationship between metabolic syndrome and COVID-19 severity in terms of risk of hospitalization. Methods: We designed a retrospective, cross-sectional study, including patients with confirmed COVID-19 diagnosis. Clinical and laboratory parameters regarding metabolic syndrome were collected...
September 5, 2023: Metabolic Syndrome and related Disorders
Moon Sook Hwang, Eunjeong Song, Jeonghee Ahn, Seungmi Park
Objective: Current evidence regarding the safety of abdominal subcutaneous injections in pregnant women is limited. In this study, we developed a predictive model for abdominal skin-subcutaneous fat thickness (S-ScFT) by gestational periods (GP) in pregnant women. Methods: A total of 354 cases were measured for S-ScFT. Three machine learning algorithms, namely deep learning, random forest, and support vector machine, were used for S-ScFT predictive modeling and factor analysis for each abdominal site. Data analysis was performed using SPSS and RapidMiner softwares...
September 5, 2023: Metabolic Syndrome and related Disorders
Qianyun Wang, Wah Yang, Yuan Chen, Junqing Liu, Chaofan Zhou, Zhiyong Dong, Cunchuan Wang, Jun Guo
Introduction: Obesity contributes to cardiac dysfunction and has an impact on atherosclerotic cardiovascular disease. Bariatric surgery (BS) is being considered a therapeutic option for patients with obesity and also can improve cardiac function. Very few studies considered the Chinese population. This study aimed to examine the effect of BS on cardiac function and structure in Chinese subjects with obesity. Methods: A single-center retrospective analysis of 143 patients with obesity was included. To observe and analyze the short-term, midterm, and long-term effects of BS on cardiovascular function and structure, the study population was divided into three groups according to the time of review...
September 2023: Metabolic Syndrome and related Disorders
Yushi Chen, Ling Xiang, Ling Luo, Haixia Qin, Shiwen Tong
Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is a global health problem, and dietary intervention is still considered one of the primary interventions. This study aimed to examine cross-sectional associations between dietary and serum levels of folate and NAFLD. Methods: We conducted a study of 7543 adults who participated in the National Health and Nutrition Examination Survey, 2009-2018. NAFLD status was determined by a fatty liver index (FLI) value ≥60. Multivariable logistic regression models were used to estimate associations between folate and NAFLD...
September 2023: Metabolic Syndrome and related Disorders
Muhammed Talha Bilgihan, Rafiye Ciftciler
A thorough examination of the available literature has revealed a well-established association of obesity and high body mass index (BMI) with an increased risk of various types of cancers, including hematologic malignancies. Specifically, the studies reviewed indicate a clear correlation between obesity and an increased risk of leukemias, lymphomas, multiple myeloma, myelodysplastic syndrome, and myeloproliferative diseases. Despite the established association of obesity and high BMI with hematologic malignancies, the underlying mechanisms remain largely undetermined...
September 2023: Metabolic Syndrome and related Disorders
Aleksandra Klisic, Jelena Kotur-Stevuljevic, Ana Ninic
Aim: Type 2 diabetes mellitus (T2D) patients have an increased risk for cardiovascular disease (CVD). Different algorithms are used for the CVD risk quantification and United Kingdom Prospective Diabetes Study (UKPDS) score was among the most validated. Endocan is a novel endothelial dysfunction marker. The aim was to explore the potential relationship between serum endocan level and UKPDS risk engine score [which enables calculation of the 10-year risk of nonfatal and fatal coronary heart disease (eCHD) and stroke] in T2D patients...
September 2023: Metabolic Syndrome and related Disorders
Maren S Fragala, Fumika Matsushita, Zhen Chen, Lance A Bare
Background: Public health measures necessary to mitigate the spread of coronavirus disease 2019 (COVID-19) impacted lifestyles and health practices. This multiyear cohort analysis of U.S. working-aged adults aims to evaluate the impact of the COVID-19 pandemic on metabolic syndrome and explores contributing factors. Methods: This longitudinal study ( n  = 19,543) evaluated year-to-year changes in metabolic syndrome and cardiometabolic risk factors through employer-sponsored annual health assessment before and during the COVID-19 pandemic using logistic mixed-effects model...
August 24, 2023: Metabolic Syndrome and related Disorders
Huixin Sun, Jing Zhao, Xinxin Hu, Rencheng Zhao, Maofu Wu, Youxia Qiu, Feifei Yao
Objectives: We aim to investigate the correlation between sleep and metabolic syndrome (MS) among a community population 45 years of age and older in China. Methods: A cross-sectional analysis of 9096 participants from China health and longitudinal study was carried out. MS was defined by consensus criteria. Sleep durations were assessed by self-reported questionnaire. Odds ratio (OR) and 95% confidence intervals (CIs) for MS were obtained using multivariable-adjusted regression analysis. Results: Long habitual daytime sleep had a positive influence on MS (OR = 1...
August 21, 2023: Metabolic Syndrome and related Disorders
Conghui Liu, Jing Tian, Matthew D Jose, Terence Dwyer, Alison J Venn
Background: Relationships between metabolic syndrome (MetS), inflammation, and chronic kidney disease (CKD) have been reported, but long-term follow-up studies are limited. This study aimed to investigate whether MetS and C-reactive protein (CRP) from young adulthood associated with the risk of subclinical kidney damage (SKD), a surrogate measure for CKD, in mid-adulthood. Materials and Methods: One thousand fifteen participants from the Childhood Determinants of Adult Health study aged 26-36 years at baseline (2004-2006) were followed up at age 36-49 (2014-2019)...
August 9, 2023: Metabolic Syndrome and related Disorders
Thelma Canto-Cetina, Diana Silva-Nicanor, Ramón Mauricio Coral-Vázquez, Luis Javier Cano-Martínez, Patricia Canto
Objective: To investigate the possible association between rs3480 and rs16835198 of the fibronectin type III domain containing 5 ( FNDC5 ) /Irisin and their haplotypes with the presence of type 2 diabetes mellitus (T2DM) in Maya-Mestizo women. Methods: We studied 547 postmenopausal women of Maya-Mestizo origin. The diagnosis of T2DM was based on the criteria of the American Diabetes Association. DNA was obtained from blood leukocytes. rs3480 and rs16835198 of FNDC5/Irisin were studied using real-time polymerase chain reaction allelic discrimination...
August 9, 2023: Metabolic Syndrome and related Disorders
Eleanna De Filippis
No abstract text is available yet for this article.
August 2023: Metabolic Syndrome and related Disorders
Xiaowei Liu, Chan Yang, Yuanyuan Dang, Zhenqi Chang, Juan Li, Yi Zhao, Yuhong Zhang
Objectives: Various diseases are associated with obesity and metabolism. We sought to investigate the risk of cardiovascular disease (CVD) in diverse metabolic obesity phenotypes. Methods and Results: A prospective observational study of 1517 participants ≥25 years of age without CVD at baseline was conducted. Participants were categorized into four groups based on the condition of central obesity and metabolic health status: metabolically healthy normal weight, metabolically healthy obesity (MHO), metabolically unhealthy normal weight, and metabolically unhealthy obese (MUO)...
August 2023: Metabolic Syndrome and related Disorders
Pelumi Samuel Akinola, Isabelle Tardif, Jacinthe Leclerc
Schizophrenia, a serious psychiatric disorder, is among the top 10 global causes of disability and affects nearly 1% of the world population. Antipsychotics constitute the best treatment for patients with schizophrenia, however, this treatment class carries a high risk of metabolic syndrome, including lipid abnormalities. Indeed, the risk of metabolic syndrome would be increased in the population with schizophrenia compared to the general population. The objective is to summarize the prevalence, the mechanisms, and the potential treatments of antipsychotic-induced metabolic syndrome...
August 2023: Metabolic Syndrome and related Disorders
Madhumati S Vaishnav, Namita Kumari, Sathyanarayana Srikanta, Patnam R Krishnaswamy, Padmanabhan Balaram, Navakanta Bhat
Background: Albumin, the most abundant and physiologically vital serum protein, accumulates a range of chemical modifications, as consequence of encounters with large number of reactive molecules whose concentrations increase in serum under pathological conditions. Methods: In a "proof of concept" study, mass spectrometric analysis was utilized to quantitate albumin post-translational modifications (glycation, oxidation, and truncation; individual isoforms and total) in four informative subject groups [type 1 diabetes (T1DM), type 2 diabetes (T2DM), prediabetes-obesity and healthy; all with estimated glomerular filtration rate ≥60 mL/(min·m2 )]...
July 20, 2023: Metabolic Syndrome and related Disorders
Suleyman Nahit Sendur, Kübra Isgin Atici, Busra Turan Demirci, Incilay Lay, Zehra Buyuktuncer, Tomris Erbas
Purpose: To evaluate the association between diverse surrogate markers of insulin resistance and adiponectin concentrations. Methods: Four hundred healthy participants were included. Two different cohorts were formed according to the body mass index (BMI) values. Group 1 ( n  = 200) consisted of individuals with normal BMI values (18.50-24.99 kg/m2 ), whereas in Group 2 ( n  = 200) there were overweight or obese individuals (BMI ≥25.00 kg/m2 ). Homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and triglycerides-glucose index (TyG) were calculated...
July 12, 2023: Metabolic Syndrome and related Disorders
Nereida Spahia, Merita Rroji, Myftar Barbullushi, Goce Spasovski
Thyroid hormone (TH) imbalances, particularly subclinical hypothyroidism (SCHT), are associated with chronic kidney disease (CKD) and end-stage kidney disease (ESKD). SCHT is more prevalent in CKD and ESKD patients than in the general population, and this condition increases the risk of cardiovascular disease (CVD) morbidity and mortality. The risk of CVD is higher in CKD and ESKD patients compared with the general population. Traditional and nontraditional risk factors, including TH abnormalities, contribute to the high CVD burden in CKD and ESKD patients...
July 11, 2023: Metabolic Syndrome and related Disorders
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