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Metabolic Syndrome and related Disorders

Yue Su, Yan-Ling Zhang, Meng Zhao, Hai-Qing Zhang, Xu Zhang, Qing-Bo Guan, Chun-Xiao Yu, Shan-Shan Shao, Jin Xu
BACKGROUND: Given its high incidence, thyroid nodule (TN) warrants public attention. Thyroid volume (TV) has also been associated with multiple factors, such as iodine deficiency and supply and body mass index. It is well known that metabolic syndrome (MetS) comprises many metabolic disturbances, with insulin resistance being its major component. MATERIALS AND METHODS: The aim of this study was to investigate the relationship between TN and TV and MetS and its components in an iodine-adequate area in Asia...
February 11, 2019: Metabolic Syndrome and related Disorders
Kayoung Lee
BACKGROUND: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control and Prevention (US-CDC), and World Health Organization (WHO) charts for their ability to detect MetS in Korean children and examine their associations with the severity of MetS. METHODS: Among 3094 children (1653 boys, age: 10-16 years) from the Korean National Health and Examination Survey 2011-2016, age and sex-specific BMI percentiles using the three charts (Korean, US-CDC, and WHO charts) were determined...
February 11, 2019: Metabolic Syndrome and related Disorders
Zhaohui Cui, Jianwen Cai, Cora E Lewis, June Stevens
BACKGROUND: It is well known that total and intentional weight loss (IWL) are associated with reductions in cardiovascular disease (CVD) risk factors, however, associations with unintentional weight loss (UWL) have not been studied. METHODS: We examined annual changes in blood pressure and lipids associated with UWL versus IWL in 576 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study who had lost weight over one of two time intervals (i...
February 7, 2019: Metabolic Syndrome and related Disorders
Kelly Villegas, Joy L Meier, Maureen Long, Julio Lopez, Arthur Swislocki
BACKGROUND: Type 2 diabetes patients have decreased pancreatic beta cell mass with a decline in beta cell function. Gastrin has increased beta cell proliferation in vitro and in animal studies. High gastric acid levels inhibit gastrin secretion. Proton pump inhibitors (PPIs) lower gastric acid, subsequently increasing gastrin levels. This may stimulate beta cell proliferation and function, and improve glycemic control. Studies with small numbers of type 2 diabetes patients have shown a slightly lower A1C in those taking PPI versus non-PPI users...
February 7, 2019: Metabolic Syndrome and related Disorders
Marzieh Salehi, Jonathan Q Purnell
Energy homeostasis is coordinated by bidirectional communication pathways between the brain and peripheral organs, including adipose tissue, muscle, the pancreas, liver, and gut. Disruption of the integrated chemical, hormonal, and neuronal signals that constitute the gut-brain axis significantly contributes to disorders of metabolism and body weight. Initial studies of glucagon-like peptide-1 (GLP-1), a gut hormone released in response to the ingestion of nutrients, focused on its incretin actions to improve postprandial glucose homeostasis by enhancing meal-induced insulin secretion...
February 5, 2019: Metabolic Syndrome and related Disorders
Ting-Ting Wu, Ying-Ying Zheng, Yi-Ning Yang, Xiao-Mei Li, Yi-Tong Ma, Xiang Xie
AIM: To understand age- and gender-related differences and secular trends in coronary artery disease (CAD) lipid profiles and the characteristic of dyslipidemia in western China. METHODS: An age-matched case-control study, including 2400 patients and 1200 controls was performed. All blood lipid tests evaluated from January 2012 to January 2015 at First Affiliated Hospital of Xinjiang Medical University were analyzed. Details of the gender and age of the patients were available...
February 5, 2019: Metabolic Syndrome and related Disorders
Sinem Kiyici, Metin Guclu, Ferah Budak, Deniz Sigirli, Ercan Tuncel
BACKGROUND: We investigated the effect of short-term telmisartan usage in addition to lifestyle changes such as diet and exercise on insulin resistance, lipid metabolism, and serum adiponectin and tumor necrosis factor-alpha (TNF-α) levels in hypertensive patients with metabolic syndrome (MetS). METHODS: A total of 36 hypertensive patients with MetS were randomized to telmisartan and control groups in an open-labeled prospective study. RESULTS: There were significant decreases in anthropometric variables of patients according to baseline measurements in both groups at the end of the study...
January 28, 2019: Metabolic Syndrome and related Disorders
Şahbender Koç, Sadettin Selçuk Baysal
BACKGROUND: Salt is important in the pathogenesis of hypertension (HT). Salt-sensitive hypertension (SSH) accounts for about half of all HT cases. In SSH, sodium/potassium adenosine triphosphatase (Na+ /K+ -ATPase) activity is impaired. Impaired Na+ /K+ -ATPase activity in the lens epithelium results in cortical opacities in the peripheral equator of the lens. We investigated the sensitivity of cortical lens opacities in detecting SSH. METHODS: The study included 191 SSH and 159 non-SSH, salt-resistant HT (SRH) patients (350 HT patients total), aged 40-80 years...
January 22, 2019: Metabolic Syndrome and related Disorders
Kayoung Lee
BACKGROUND: Compared to studies evaluating the effect of environmental factors on weight and health, relationships between housing types and health conditions are understudied. This study aimed to assess the relationship between housing types and metabolic and weight phenotypes using data from the 2014 to 2015 Korea National Health and Nutrition Examination Survey. METHODS: A total of 9586 Korean adults (4128 men and 5458 women; mean age, 50.7 ± 16.5 years) were considered for this study...
January 22, 2019: Metabolic Syndrome and related Disorders
Dorte Worm, Sten Madsbad, Dorte L Hansen
BACKGROUND: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described. AIM: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery. METHODS: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45.6 (range: 35-72.6) kg/m2 and mean age of 42.9 (range: 18-72) years were included...
January 16, 2019: Metabolic Syndrome and related Disorders
Hossein Khosravi-Boroujeni, Nizal Sarrafzadegan, Masoumeh Sadeghi, Hamidreza Roohafza, Shu-Kay Ng, Faruk Ahmed
BACKGROUND: The prevalence of metabolic syndrome (MetS) and its components have been increasing globally; therefore, there is a need for better understanding of MetS components and their risk factors, as well as their development and changes over time. This study was designed to identify the determinants of the changes in the components of MetS in a cohort of Iranian adults from 2001 to 2013. METHODS: A total of 6504 adults, ≥35 years of age, were recruited from central Iran in 2001and were followed up in an ongoing longitudinal population-based study for 12 years...
January 8, 2019: Metabolic Syndrome and related Disorders
Ali Reza Khoshdel, Radina Eshtiaghi
BACKGROUND: Assessment of subclinical atherosclerosis in metabolic syndrome is one of the global health targets' priorities. This study aimed to evaluate the subclinical atherosclerosis in metabolic syndrome related to insulin resistance in healthy and physically active men. METHODS: A consecutive group of 68 healthy men, 30-55 years of age, was studied. Anthropometric parameters, proinflammatory factors, and insulin level were measured, and pulse wave analysis (PWA) was performed by applanation tonometry and then processed with dedicated software (SphygmoCor® )...
January 8, 2019: Metabolic Syndrome and related Disorders
Do Kyung Kim, Won Hah Park
BACKGROUND: Abdominal obesity increases rapidly after middle age in Korean men, and there is an associated trend toward increasing levels of cardiovascular disease (CVD). The purpose of this study was to examine the effect of cardiorespiratory fitness (CRF) on arterial stiffness in men with abdominal obesity. METHODS: A total of 387 middle-aged men (ages 42-59 years) with abdominal obesity participated in this cross-sectional study. Abdominal obesity was defined as a waist circumference ≥90 cm...
January 8, 2019: Metabolic Syndrome and related Disorders
Afruz Mammadova, Selen Yilmaz Isikhan, Aylin Acikgoz, Bulent Okan Yildiz
BACKGROUND: Metabolic syndrome (MetS) is an important public health concern associated with an increased risk for cardiovascular disease and type 2 diabetes. Despite its global significance, the prevalence of MetS in Azerbaijan is unknown. The purpose of this study was to examine the prevalence of MetS and its relation to physical activity (PA) and nutrition in a representative sample of Azerbaijani adults. METHODS: The study included 288 adults (159 women and 129 men), 20 years of age and older, from Guba, Azerbaijan recruited between January and April 2016 by random sampling in line with gender and age distribution...
January 8, 2019: Metabolic Syndrome and related Disorders
Hüseyin Kurku, Müge Atar, Özgür Pirgon, Muammer Büyükinan, Said Sami Erdem, İsa Deniz, Yavuz Turgut Gederet
BACKGROUND: In adult studies, obese subjects with nonalcoholic fatty liver disease (NAFLD) have been shown to have poor sperm quality, and lower testosterone and luteinizing hormone levels. The aim of this study was to investigate the pubertal status and gonadal functions in obese boys with NAFLD. MATERIALS AND METHODS: The study included 119 obese and 78 nonobese age-matched adolescents. The obese boys were separated into two groups based on the presence (NAFLD group) or absence of liver steatosis with high transaminases (non-NAFLD group)...
January 7, 2019: Metabolic Syndrome and related Disorders
Ryuichi Kawamoto, Daisuke Ninomiya, Taichi Akase, Asuka Kikuchi, Yoshihisa Kasai, Tomo Kusunoki, Nobuyuki Ohtsuka, Teru Kumagi
BACKGROUND: Metabolic syndrome (MetS) is related to the increased risk of major cardiovascular disease. The link between high serum uric acid (SUA) and creatinine (Cr) levels is causally related to MetS and its components. However, whether renal function-normalized SUA [i.e., SUA to Cr ratio (SUA/Cr)] predicts incident MetS and its components remains inconclusive. MATERIALS AND METHODS: We conducted a prospective cohort study designed as part of the Nomura study...
January 7, 2019: Metabolic Syndrome and related Disorders
Yeon-Yong Kim, Eunjung Seo, Jiyeon Baek, Seongjun Ha, Hyung-Soo Kang
BACKGROUND: The Korean Obesity Index, which contains standard reference data (SRD) of obesity, was established in 2016 and revised in 2017 based on national health screening data to provide the distribution of the body mass index (BMI) of the whole population of Korea as a reference. This study aimed to investigate the effect of the SRD of obesity on the incidence of hypertension (HTN) and diabetes mellitus (DM). METHODS: The percentile of BMI was calculated for each of the 864 subgroups by defined by gender, region, and age group according to the groupings in the SRD...
December 13, 2018: Metabolic Syndrome and related Disorders
Joana Araújo, Jianwen Cai, June Stevens
BACKGROUND: Several guidelines for cardiometabolic risk factor identification and management have been released in recent years, but there are no estimates of current prevalence of metabolic health among adults in the United States. We estimated the proportion of American adults with optimal cardiometabolic health, using different guidelines. METHODS: Data from the National Health and Nutrition Examination Survey 2009-2016 were analyzed (n = 8721). Using the most recent guidelines, metabolic health was defined as having optimal levels of waist circumference (WC <102/88 cm for men/women), glucose (fasting glucose <100 mg/dL and hemoglobin A1c <5...
November 27, 2018: Metabolic Syndrome and related Disorders
Rodrigo Fonseca-Portilla, Janina Krell-Roesch, Gabriel Q Shaibi, Richard J Caselli, Lawrence J Mandarino, Nan Zhang, Joseph G Hentz, Dawn K Coletta, Elena Anna de Filippis, Sara Dawit, Yonas E Geda
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is associated with body weight and other health conditions but remains understudied in the Latino population. The aim of this study was to examine the associations of BDNF serum levels with body mass index (BMI), physical activity, and the rs6265 nonconservative polymorphism among 349 Latinos aged ≥18 years enrolled in the Arizona Insulin Resistance Registry. MATERIALS AND METHODS: Data on physical activity were acquired using a self-reported questionnaire...
November 10, 2018: Metabolic Syndrome and related Disorders
Young Sammy Choi, John S Klaric, Thomas H Beltran
BACKGROUND: Adolescent obesity is an important risk factor for cardiovascular disease in part due to its relationship to type 2 diabetes. Therefore, screening for type 2 diabetes is recommended. However, since insulin resistance (IR) is an early precursor of diabetes, it would be beneficial if IR predictors from routine assessments could identify those at greatest metabolic risk before diabetes has developed. METHODS: Adolescents aged 14-18 years with normal fasting plasma glucose (n = 252) were selected from the National Health and Nutrition Examination Survey 2013-2014...
November 3, 2018: Metabolic Syndrome and related Disorders
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