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Lipids in Health and Disease

Hsiu-Chi Ting, Li-Tzu Chen, Jo-Yu Chen, Yi-Li Huang, Rui-Cheng Xin, Jui-Fen Chan, Yuan-Hao Howard Hsu
BACKGROUND: Supplemented fatty acids can incorporate into cardiolipin (CL) and affect its remodeling. The change in CL species may alter the mitochondrial membrane composition, potentially disturbing the mitochondrial structure and function during inflammation. METHOD: To investigate the effect of the unsaturation of fatty acids on CL, we supplemented macrophage-like RAW264.7 cells with 18-carbon unsaturated fatty acids including oleic acid (OA, 18:1), linoleic acid (LA, 18:2), α-linolenic acid (ALA, 18:3), γ-linolenic acid (GLA, 18:3), and stearidonic acid (SDA, 18:4)...
February 14, 2019: Lipids in Health and Disease
Yan Cui, Na Feng, Xiaoming Gu, Feng Fu, Jun Li, Haitao Guo, Yali Liu, Shumiao Zhang, Juan Li, Yuanbo Wang, Min Jia, Lu Yang, Fuyang Zhang, Yuemin Wang, Rong Fan, Jianming Pei
BACKGROUND: This study was designed to test the hypothesis that κ-opioid receptor (κ-OR) stimulation reduces palmitate-induced HUVECs apoptosis and to investigate its mechanisms. METHODS: HUVECs were subjected to sodium palmitate, apoptosis and cell viability were determined, HUVECs were treated with specific inhibitors to PI3K, Akt, eNOS and siRNAs targeting κ-OR and Akt. Groups were divided as follows: the control group, the sodium palmitate group, the sodium palmitate+U50,488H (a selective κ-OR agonist) group and the sodium palmitate+U50,488H + nor-BNI (a selective κ-OR antagonist) group...
February 14, 2019: Lipids in Health and Disease
Yingyun Tan, Bing Yan, Lili Xue, Yi Li, Xianyang Luo, Ping Ji
February 13, 2019: Lipids in Health and Disease
Yanna Zhu, Baoting He, Yunjun Xiao, Yajun Chen
BACKGROUND: Information on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association between iron metabolism and dyslipidaemia risk. METHOD: In total, 1866 children and adolescents aged 7-18 were enrolled in this study, including 912 boys and 954 girls. In this cross-sectional study, parameters for anthropometry, lipids and iron metabolism including transferrin, soluble transferrin receptor (sTfR), ferritin and serum iron (SF) were evaluated...
February 12, 2019: Lipids in Health and Disease
Yongliang Zhang, Jian Yang, Jun Ye, Qiao Guo, Weimin Wang, Yining Sun, Qiang Zeng
BACKGROUND: This study evaluated the separate and combined associations of physical activity and obesity with blood lipids in Chinese adults with and without diabetes. METHODS: Data of 17,535 participants aged 18 to 78 years old were collected. Physical activity was categorized as inactive (low) or active (moderate or high) according to the International Physical Activity Questionnaire. Linear and logistic regression analyses were performed to investigate the associations of physical activity and obesity with lipid-related indices...
February 12, 2019: Lipids in Health and Disease
Chloé Saadé, Ghassan Sleilaty, Marie-Hélène Gannagé-Yared
BACKGROUND: Few studies looked at the prevalence of dyslipidemia in pediatric Middle-Eastern countries. In addition, worldwide longitudinal changes of lipid profile is not well documented. The purpose of this study is to look at the longitudinal changes of lipid parameters in Lebanese school-age children. MATERIALS AND METHODS: A total of 97 subjects (41 girls and 56 boys) aged between 11 and 21 years were included in this study. The subjects were selected among 339 school-age children with a previous abnormal lipid profile who were recruited from 10 schools of varying socio-economic levels (SEL)...
February 11, 2019: Lipids in Health and Disease
Xiao Yu Ren, Dian Shi, Jiao Ding, Zhi Yuan Cheng, Hai Yan Li, Juan Sheng Li, Hong Quan Pu, Ai Min Yang, Cai Li He, Jian Ping Zhang, Yu Bao Ma, Ya Wei Zhang, Tong Zhang Zheng, Ya Na Bai, Ning Cheng
BACKGROUND: Some studies found out that TC/HDL-C ratio is a predictor of Cardiovascular disease (CVD) and Nonalcoholic fatty liver (NAFLD) is related to CVD. And some researches have already studied that Apolipoprotein B to Apolipoprotein A1 ratio (ApoB/ApoA1) and Triglyceride to High-density lipoprotein cholesterol ratio (TG/HDL-C) were both related with CVD and NAFLD, but few studied the association between TC/HDL-C ratio and NAFLD. So, we suspected the ratio was also related to NAFLD...
February 11, 2019: Lipids in Health and Disease
Li-Zhen Chen, Hong-Yun Ding, Shou-Sheng Liu, Qun Liu, Xiang-Jun Jiang, Yong-Ning Xin, Shi-Ying Xuan
BACKGROUND: PNPLA3 I148M variant and TM6SF2 E167K variant are recognized as the major genetic modifiers of nonalcoholic fatty liver disease (NAFLD). The present study sought to evaluate the potential additive effect of the two variants on the risk of NAFLD in Qingdao Han Population, China. METHODS: We genotyped PNPLA3 I148M variant and TM6SF2 E167K variant in a cohort of 512 unrelated NAFLD patients and 451 healthy controls by sequencing and polymerase chain reaction analysis...
February 9, 2019: Lipids in Health and Disease
Jian Song, Yujie Wang, Xiaoqin Fan, Hanwei Wu, Jinghong Han, Ming Yang, Lu Lu, Guohui Nie
BACKGROUND: Intake of trans fatty acids (TFAs) from partially hydrogenated vegetable oil is associated with a variety of adverse outcomes, but little is known about the health effects of ruminant trans fats. Trans-vaccenic acid (TVA) is a naturally occurring TFA found in the fat of ruminants and in human dairy products. The present study was conducted to investigate the anticancer activity and underlying mechanisms of TVA on human nasopharyngeal carcinoma (NPC) 5-8F and CNE-2 cells. METHODS: A CCK8 assay was used to determine the effect of TVA and the Mcl-1 inhibitor S63845 on the proliferation of NPC cells...
February 9, 2019: Lipids in Health and Disease
Fábio da Silva Pimenta, Hadnan Tose, Élio Waichert Jr, Márcia Regina Holanda da Cunha, Fabiana Vasconcelos Campos, Elisardo Corral Vasquez, Hélder Mauad
BACKGROUND: Mobility of fat deposited in adipocytes among different fatty territories can play a crucial role in the pathogenesis of obesity-related diseases. Our goal was to investigate which of the remaining fat pads assume the role of accumulating lipids after surgical removal of parietal WAT (lipectomy; LIPEC) in rats of both sexes displaying MSG-induced obesity. METHODS: The animals entered the study straight after birth, being separated according to gender and randomly divided into CON (control, saline-treated) and MSG (monosodium glutamate-treated) groups...
February 9, 2019: Lipids in Health and Disease
Gustavo Tomás Díaz-Gerevini, Alejandro Daín, María Eugenia Pasqualini, Cristina B López, Aldo R Eynard, Gastón Repossi
BACKGROUND: Diabetic encephalopathy is a chronic complications of diabetes mellitus that affects the central nervous system. We evaluated the effect of ω3 and ω6 polyunsaturated fatty acids (PUFAs) supplementation plus the antioxidant agent nordihydroguaiaretic acid (NDGA) on the etiopathology of diabetic encephalopathy in eSS rats, a spontaneous model of type 2 diabetes. METHODS: One hundred twenty spontaneous diabetic eSS male rats and 38 non-diabetic Wistar, used as healthy control, received monthly by intraperitoneal route, ω3 or ω6 PUFA (6...
February 8, 2019: Lipids in Health and Disease
Robinson Ramírez-Vélez, Paula Andrea Hernández-Quiñones, Alejandra Tordecilla-Sanders, Cristian Álvarez, Rodrigo Ramírez-Campillo, Mikel Izquierdo, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Ronald G Garcia
BACKGROUND: Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases, such as cardiovascular disease (CVD), metabolic syndrome, and breast and colon cancers, and shortens life expectancy. We aimed to determine the effects of moderate (MCT)- versus high-intensity interval training (HIT) on vascular function parameters in physically inactive adults. We hypothesized that individualized HIT prescription would improve the vascular function parameters more than the MCT in a greater proportion of individuals...
February 4, 2019: Lipids in Health and Disease
Imran Taj Khan, Muhammad Nadeem, Muhammad Imran, Rahman Ullah, Muhammad Ajmal, Muhammad Hayat Jaspal
Milk and dairy products are integral part of human nutrition and they are considered as the carriers of higher biological value proteins, calcium, essential fatty acids, amino acids, fat, water soluble vitamins and several bioactive compounds that are highly significant for several biochemical and physiological functions. In recent years, foods containing natural antioxidants are becoming popular all over the world as antioxidants can neutralize and scavenge the free radicals and their harmful effects, which are continuously produced in the biological body...
February 4, 2019: Lipids in Health and Disease
Nengguang Fan, Liang Peng, Zhenhua Xia, Lijuan Zhang, Zhiyi Song, Yufan Wang, Yongde Peng
BACKGROUND: Triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) has been recommended as a surrogate marker for insulin resistance. In the present study, we aimed to investigate the relationship between TG/HDL-C and NAFLD in an apparently healthy population. METHODS: A total of 18,061 subjects who participated in a health checkup program were included. NAFLD was diagnosed by ultrasonography. RESULTS: The prevalence rate of NAFLD was 24...
February 2, 2019: Lipids in Health and Disease
Zhixiong Zhong, Jingyuan Hou, Qifeng Zhang, Wei Zhong, Bin Li, Cunren Li, Zhidong Liu, Min Yang, Pingsen Zhao
BACKGROUND: Despite significant advances in the management of acute coronary syndromes (ACS), there are still plenty of patients undergoing percutaneous coronary intervention (PCI) and stent implantation suffered poor prognosis and high treatment expenditure. Evidence increasingly suggests that the ratio of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio might be a novel marker for the risk of atherosclerotic cardiovascular disease, but the impact of LDL-C/HDL-C ratio on 1-year prognosis of drug-eluting stent (DES) implantation patients after PCI is still not reported...
February 2, 2019: Lipids in Health and Disease
Pierre Zalloua, Hanane Kadar, Essa Hariri, Layal Abi Farraj, Francois Brial, Lyamine Hedjazi, Aurelie Le Lay, Alexandre Colleu, Justine Dubus, David Touboul, Fumihiko Matsuda, Mark Lathrop, Jeremy K Nicholson, Marc-Emmanuel Dumas, Dominique Gauguier
BACKGROUND: Lipoproteins are major players in the development and progression of atherosclerotic plaques leading to coronary stenosis and myocardial infarction. Epidemiological, genetic and experimental observations have implicated the association of sphingolipids and intermediates of sphingolipid synthesis in atherosclerosis. We aimed to investigate relationships between quantitative changes in serum sphingolipids, the regulation of the metabolism of lipoproteins (LDL, HDL), and endophenotypes of coronary artery disease (CAD)...
February 2, 2019: Lipids in Health and Disease
Jingjie Ju, Zhaojun Zheng, Yong-Jiang Xu, Peirang Cao, Jingwei Li, Qiu Li, Yuanfa Liu
BACKGROUND: Recently, the harmful effects of frying oil on health have been gradually realized. However, as main components of frying oils, biochemical effects of total polar compounds (TPC) on a cellular level were underestimated. METHODS: The effects of total polar compounds (TPC) in the frying oil on the lipid metabolism, oxidative stress and cytotoxicity of HepG2 cells were investigated through a series of biochemical methods, such as oil red staining, real-time polymerase chain reaction (RT-PCR), cell apoptosis and cell arrest...
February 1, 2019: Lipids in Health and Disease
Ziyu Yan, Yaguang Fan, Zhaowei Meng, Chao Huang, Ming Liu, Qing Zhang, Kun Song, Qiyu Jia
OBJECTIVE: Metabolic syndrome (MS) is a group of risk factors which includes hypertension, hyperglycemia, abnormal cholesterol levels, and obesity. Red blood cell distribution width (RDW) is a parameter that reflects the heterogeneity of erythrocyte volume. But the relationship between MS and RDW is intricate and remains poorly understood. We hypothesized that high RDW was associated with MS via inflammation. Our study aimed to investigate the association between RDW and MS in Chinese elderly large cohort...
January 31, 2019: Lipids in Health and Disease
Shuhei Nakanishi, Hidenori Hirukawa, Masashi Shimoda, Fuminori Tatsumi, Kenji Kohara, Atsushi Obata, Seizo Okauchi, Tomoe Kinoshita, Junpei Sanada, Yoshiro Fushimi, Momoyo Nishioka, Yuki Kan, Akiko Tomita, Akiko Mashiko, Megumi Horiya, Yuichiro Iwamoto, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
BACKGROUND: The study aimed to examine the relationship between levels of serum eicosapentaenoic acid (EPA), arachidonic acid (AA), as well as EPA/AA ratio and weight loss during hospitalization in participants considered to be overweight, with type 2 diabetes. METHODS: The study participants included 142 patients who were hospitalized for treatment of type 2 diabetes. We divided the participants into two groups depending on the achievenemt in reduction of bodyweight 3% or more during hospitalization and examined the relationship between serum levels of EPA and AA, as well as ratio of EPA/AA on admission and effectiveness of weight loss under strict dietary therapy during hospitalization, using Cox proportional hazard models...
January 31, 2019: Lipids in Health and Disease
Muhammad Ali, Muhammad Imran, Muhammad Nadeem, Muhammad Kamran Khan, Muhammad Sohaib, Hafiz Ansar Rasul Suleria, Reeja Bashir
BACKGROUND: Fish meat and its products are usually accepted as good source of biological high value food components and especially for polyunsaturated fatty acids. The quality of fish meat products is considered to be decreased by the lipid peroxidation which leads to reduction in nutritional quality, financial loss and severe health problems. Many tactics are present to reserve their quality and safety. In the present investigation, the extraction and supplementation of optimal total polyphenol extracts (TPC) from vegetable and fruit by- products was explored for lipids oxidative stability and sensoric acceptability of functional fish product samples...
January 31, 2019: Lipids in Health and Disease
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