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Journals Iranian Journal of Allergy, As...

Iranian Journal of Allergy, Asthma, and Immunology

https://read.qxmd.com/read/37524668/association-of-interleukin-2-gene-polymorphism-with-henoch-sch%C3%A3-nlein-purpura-nephritis
#21
JOURNAL ARTICLE
Jiajia Cao, Junfeng Zhang, Hui Xu, Wei Li, Jianrong Shi, Qing Ye
Henoch-Schönlein purpura nephritis (HSPN) is a common vasculitis that mostly affects children, and previous studies have indicated that genetic factors may influence disease susceptibility. The aim of this study was to evaluate a possible association of three interleukin-2 (IL-2) gene polymorphisms (rs3136534, rs2069776, and rs2069762) with HSPN in the Chinese population. A total of 81 patients with HSPN and 200 healthy children were enrolled. The distribution of genotypes, allelic frequencies, and haplotype frequencies among the three IL-2 polymorphisms were analyzed using the Sequenom MassARRAY system by means of matrix-assisted laser desorption ionization-time of flight mass spectrometry method...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524666/il-25-impact-on-malignant-b-cells-survival-and-t-cells-activation-in-chronic-lymphocytic-leukemia
#22
JOURNAL ARTICLE
Mehrnoosh Pashei, Farahnaz Ghahremanfard, Ehsan Manouchehri Doulabi, Maral Hemmati, Fatemeh Pak, Parviz Kokhaei
T cell dysregulation and shift to T helper 2 responses, boosting tumor microenvironment support, contributes to the survival of leukemic B cells in Chronic Lymphocytic Leukemia. Interleukin (IL)-25 is involved in the initiation of T helper 2 cell responses. Signal transduction of IL-25 begins with the heterodimer receptor (IL-17RA/IL-17RB). The presence of IL-25 in the tumor microenvironment may affect the supportive effects of T cells in the surrounding tumor cell environment. The purpose of this study was to evaluate the role of IL-25 in the biology of CLL...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524665/clinical-characteristics-and-economic-burden-of-asthma-in-china-a-multicenter-retrospective-study
#23
JOURNAL ARTICLE
Bin Shang, Xiangguo Li, Yu Xu, Wenxin Ren, Junren Wang, Chunyan Xing, Shujuan Jiang, Jian Sun
Asthma is a common chronic airway inflammation that produces a healthcare burden on the economy. We aim to obtain a better understanding of the clinical status and disease burden of patients with asthma in China. A retrospective study was carried out based on the computerized medical records in the Jinan Health Medical Big Data Platform between 2011 and 2019 (available data from 38 hospitals). The asthma severity of each patient was assessed retrospectively and categorized as mild, moderate, or severe according to Global Initiative for Asthma 2020 (GINA 2020)...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524664/anti-inflammatory-effects-of-ziziphus-jujube-mill-on-lps-induced-acute-lung-injury-in-mice
#24
JOURNAL ARTICLE
Parastoo Shaban, Niloofar Honari, Nafiseh Erfanian, Mehran Hosseini, Hossein Safarpour, Saeed Nasseri
Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524663/formulation-and-evaluation-of-the-anti-inflammatory-anti-oxidative-and-anti-remodelling-effects-of-the-niosomal-myrtenol-on-the-lungs-of-asthmatic-rats
#25
JOURNAL ARTICLE
Mohammad Amin Rajizadeh, Mohammad Hadi Nematollahi, Elham Jafari, Mohammad Abbas Bejeshk, Mehrnaz Mehrabani, Farzaneh Rostamzadeh, Mitra Samareh Fekri, Hamid Najafipour
Asthma is a common chronic allergic disease that affects a significant percentage of the world's population. Niosomes are nanoparticles consisting of non-ionic surfactants that can be used for drug delivery. This research was designed to investigate the impacts of inhalation of simple and niosomal forms of myrtenol against adverse consequences of asthma in rats. Asthma induction was performed via injection of ovalbumin, followed by its inhalation. Niosomes were created by a heating protocol, and their physicochemical features were evaluated...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524662/effect-of-vitamin-d-on-the-hmgb1-rage-pathway-and-adipokines-levels-in-obese-asthmatic-mice
#26
JOURNAL ARTICLE
Yijia Fan, Junguo Chen, Xiaofeng Zhu
Compared to common asthma, obese asthma is difficult to control. Previous studies have shown that vitamin D (Vit D) has a therapeutic effect on asthma. Nevertheless, the action mechanism of Vit D for obese asthma are not well known. In this study, we, therefore, induced obesity and established an obese asthma mouse model using ovalbumin (OVA) stimulation and applied treatment with Vit D (100 ng/kg). Accordingly, thirty mice were randomly divided into 5 equal groups of normal control, asthma, obese asthma, asthma+Vit D, and obese asthma+ Vit D...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524661/health-status-and-inconveniences-of-asthmatic-children-during-the-first-year-of-the-covid-19-pandemic
#27
JOURNAL ARTICLE
Saber Gharagozlou, Negin Rostamzadeh, Mohammad Gharagozlou
The Coronavirus Disease 2019 (COVID-19) pandemic has been the most significant health concern in recent years, with respiratory symptoms being the most prominent. In children, asthma is the most prevalent chronic disease. Due to the similarities between the symptoms of these two conditions, we sought to assess the general health status of pediatric patients with asthma and their COVID-19-related difficulties during the first year of the pandemic in Iran. We collected data for this study by administering a questionnaire to the parents of 200 children with asthma who were registered in the database of the Asthma Clinic at a tertiary medical center in Tehran, Iran...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524660/exosomes-from-adipose-tissue-derived-mesenchymal-stem-cells-induce-regulatory-t-cells-in-covid-19-patients
#28
JOURNAL ARTICLE
Morteza Motallebnezhad, Ali Hazrati, Hadi Esmaeili Gouvarchin Ghaleh, Nematollah Jonaidi-Jafari, Sanaz Abbaspour-Aghdam, Kosar Malekpour, Mehdi Yousefi, Hossein Samadi Kafil, Farhad Jadidi-Niaragh, Leila Roshangar, Hamed Valizadeh, Morteza Izadi, Majid Ahmadi
An imbalance between regulatory T (Treg) and T-helper (Th)-17 cells has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) exert immunomodulatory properties through secreting exosomes. This study aimed to assess the effect of MSC-derived exosomes (MSC-Exo) on the differentiation of peripheral blood mononuclear cells (PBMCs) into  Tregs from patients with COVID-19. Exosomes were isolated from adipose tissue-derived MSCs. PBMCs were separated from the whole blood of COVID-19 patients (n=20)...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37524659/immune-profiling-of-sars-cov-2-what-we-know-and-what-we-don-t-know
#29
JOURNAL ARTICLE
Mahshid Zohouri, Atri Ghods, Mina Roshan Zamir, Fazel Shokri, Abbas Ghaderi
Coronavirus disease 2019 (COVID-19), described as World War 3, is the current worldwide health challenge and nearly all countries have so far faced this disaster. There is still no cure because of the complicated pathogenesis, however, there are several studies on track investigating different aspects of the immune response to the virus. In this review, we will provide an overview of recent investigations that have analyzed immune cells in patients with COVID-19. We will then discuss the differences in immune profiles between healthy controls and various clinical presentations, including asymptomatic, mild, moderate, and severe cases...
June 16, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496415/effects-of-dupilumab-for-asthma-chronic-obstructive-pulmonary-disease-overlap
#30
JOURNAL ARTICLE
Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Yuka Yamada, Hiroto Matsuse
No Abstract.
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496414/food-protein-induced-enterocolitis-syndrome-due-to-cuttlefish-in-a-child-with-anaphylaxis-to-crustaceans
#31
JOURNAL ARTICLE
Simona Barni, Marta Vazquez-Ortiz, Mattia Giovannini, Giulia Liccioli, Lucrezia Sarti, Giulia Lascialfari, Laura Pisano, Silvia Boscia, Francesca Mori
Shellfish is defined as any edible marine invertebrate and refers to crustaceans and mollusks. Crustaceans belong to the phylum Arthropods. Mollusks belong to the phylum Mollusca. This report illustrates a rare case of a 6-year-old girl with challenge-proven acute food protein-induced enterocolitis syndrome (FPIES) to cuttlefish (phylum Mollusca, class Cephalopoda), anaphylaxis to crustaceans (phylum Arthropoda), and tolerance to other mollusks, including clams and mussels (phylum Mollusca, class Bivalvia)...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496413/evaluation-of-inflammatory-markers-in-patients-with-depressed-episodes-in-major-depressive-disorder-and-bipolar-disorder-before-and-after-treatment
#32
JOURNAL ARTICLE
Laya Kafami, Sara Assadiasl, Sara Hashempour, Mohammad Hossein Niknam, Bahareh Mohebbi, Mohammad Amin Hashemnezhad, Bita Ansaripour, Arash Mirabzadeh, Banafsheh Mosharmovahed, Fateme Fazli, Mahshid Saleh, Nam I Mohammadian Khanssari, Ahmad Ali Noorbala
Depression is one of the current dilemmas in both developed and developing societies. Studies show that the severity of psychiatric symptoms is directly related to the degree of inflammation caused by cytokines secreted by the immune system. Hence, evaluating serum cytokine levels in patients with depression can help to understand the pathogenesis of the disease and make the best therapeutic decisions. The present study investigated the levels of inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) in patients with major depression or bipolar disorder during depressive episodes (BDDE) before and after a 6-month pharmaceutical intervention...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496412/insights-into-overlappings-of-fibrosis-and-cancer-exploring-the-tumor-related-cardinal-genes-in-idiopathic-pulmonary-fibrosis
#33
JOURNAL ARTICLE
Marjan Taherian, Paria Bayati, Mohammad-Ali Assarehzadegan, Mansoureh Soleimani, Hadi Poormoghim, Nazanin Mojtabavi
The pathogenesis of idiopathic pulmonary fibrosis (IPF) is quite similar to that of cancer pathogenesis, and several pathways appear to be involved in both disorders. The mammalian target of the rapamycin (mTOR) pathway harbors several established oncogenes and tumor suppressors. The same signaling molecules and growth factors, such as vascular endothelial growth factor (VEGF), contributing to cancer development and progression play a part in fibroblast proliferation, myofibroblast differentiation, and the production of extracellular matrix in IPF development as well...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496411/the-effects-of-mesenchymal-stem-cells-on-the-gene-expression-of-tgf-beta-and-ifn-gamma-in-patients-with-rheumatoid-arthritis
#34
JOURNAL ARTICLE
Maryam Rahimi Khorashad, Mohsen Ghoryani, Arezoo Gowhari Shabgah, Zhaleh Shariati-Sarabi, Jalil Tavakkol Afshari, Mojgan Mohammadi
The therapeutic and immunomodulatory potential of mesenchymal stem cells (MSCs) in rheumatoid arthritis (RA) has attracted considerable scientific attention in recent decades. This study aimed to evaluate the expression of genes encoding interleukin (IL)4 and IL10, as well as interferon-gamma (IFNG) and transforming growth factor beta (TGFB1) in refractory RA patients following intravenous injection of autologous bone marrow-derived MSCs (BM-MSCs). This study was registered in Iranian Registry of Clinical Trials (IRCT) (2015102824760N1) and ClinicalTrials...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496410/astragalus-polysaccharide-mediates-immunomodulatory-effects-on-crosstalk-between-human-peripheral-blood-mononuclear-cells-and-ovarian-cancer-cell-line
#35
JOURNAL ARTICLE
Elham Shokati, Morteza Motallebnezhad, Elaheh Safari
Astragalus polysaccharide (APS) is a functional component of Astragalus membranaceus with antitumor and immunomodulatory properties. This study evaluated the effect of APS on the peripheral blood mononuclear cell (PBMC) proliferation, cytokine secretion, and regulatory T cell (Treg) induction in an in vitro coculture model of human PBMCs and A2780 human ovarian cancer cells. PBMC proliferation and Treg frequency were measured by flow cytometry. Cytokine levels were assessed by enzyme-linked immunosorbent assay...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496409/evaluation-of-molecular-level-changes-of-programmed-cell-death-ligand-1-after-radiation-therapy-in-a-balb-c-ct26-colorectal-mouse-tumor-model
#36
JOURNAL ARTICLE
Fateme Khani Chamani, Mahdi Shabani, Afshin Moradi, Maedeh Alinejad, Seyed Amir Jalali
The effects of radiation therapy (RT) for cancer can be systemic and partially mediated by the immune system. However, radiation alone is unlikely to transform an immunosuppressive environment into an immunostimulatory one. Therefore, an effective combination of RT and immunotherapy may provide a new, more efficient treatment approach. Here, we investigated how the expression of programmed cell death-ligand 1 (PD-L1) in the tumor microenvironment varied in different RT regimens with the same biologically effective dose...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496408/serum-level-of-antibodies-against-novel-acinetobacter-baumannii-ompa-selected-peptides-in-icu-staff-promise-for-the-future-of-vaccine-development
#37
JOURNAL ARTICLE
Shadi Paydarfar, Mohammad Amin Abbasi, Ali Hashemi, Sodabe Taheri, Mojgan Bandehpour, Nariman Mosaffa
Extensively drug-resistant Acinetobacter baumannii is considered one of the most dangerous threats to global health, requiring novel therapeutic interventions. The outer membrane protein A (OmpA) is an immunogenic agent that triggers immune responses. The current study evaluated serum antibody levels against previously determined immunogenic OmpA peptides from A baumannii in ICU staff. Serum samples were collected from 62 ICU staff members (representing the exposed group), healthy controls (representing the nonexposed group), and patients with systemic lupus erythematosus (SLE) (as controls for nonspecific antibody reactions)...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496407/the-alleviating-impacts-of-quercetin-on-inflammation-and-oxidant-antioxidant-imbalance-in-rats-with-allergic-asthma
#38
JOURNAL ARTICLE
Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Amir Hossein Doustimotlagh, Hamid Najafipour, Maryam Eftekhari, Merat Mahmoodi, Mahdokht Azizi, Fahimeh Rostamabadi, Hossein Pourghadamyari
Asthma is an inflammatory disease of the airways. We assessed the anti-inflammatory and antioxidative impacts of quercetin, a plant derivative, on inflammatory and oxidative indices in lung tissue and serum of rats with asthma.Asth ma was induced by ovalbumin. Rats were divided into 4 groups: control, asthma+vehicle (Receieved normal saline), asthma+dexamethasone, and asthma+quercetin. After asthma induction, quercetin (50 mg/kg) and dexamethasone (2.5 mg/kg) were injected intraperitoneally once daily for 1 week...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37496406/the-effectiveness-of-probiotics-in-treating-food-and-cow-s-milk-allergies-among-pediatric-age-group-a-meta-analysis-of-randomized-controlled-trials
#39
JOURNAL ARTICLE
Hua Feng, Yongning Wu
The global prevalence of allergies is on the rise. Food allergies are of special concern among children under 5 years of age, leading to morbidity and mortality. Though the standard management is avoidance, probiotics are being used widely to prevent and treat food allergies. We aimed to determine the effect of probiotics as a therapeutic option for controlling food and cow's milk allergy among children under 5 years of age. A systematic search of electronic medical literature databases was conducted. We included all eligible randomized controlled trials available from inception until May 2021...
April 30, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/37002635/changes-in-pd-1-and-ctla-4-bearing-blood-lymphocytes-in-icu-covid-19-patients-treated-with-favipiravir-kaletra-or-dexamethasone-remdesivir-a-pilot-study
#40
JOURNAL ARTICLE
Esmaeil Mortaz, Hamidreza Jamaati, Neda K Dezfuli, Hakime Sheikhzade, Seyed MohammadReza Hashemian, Neda Dalil Roofchayee, Frazaneh Dastan, Payam Tabarsi, Gert Folkerts, Johan Garssen, Sharon Mumby, Ian M Adcock
COVID-19, caused by SARS-CoV-2, requires new approaches to control the disease. Programmed cell death protein (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) play important roles in T-cell exhaustion in severe COVID-19. This study evaluated the frequency of whole blood lymphocytes expressing PD-1 and CTLA-4 in COVID-19 patients upon admission to the intensive care unit (ICU) (i.e., severe) or infection ward (i.e., moderate) and after 7 days of antiviral therapy. COVID-19 patients were treated with either favipiravir or Kaletra (FK group, 11 severe and 11 moderate) or dexamethasone plus remdesivir (DR group, 7 severe and 10 moderate) for 7 days in a pilot study...
February 20, 2023: Iranian Journal of Allergy, Asthma, and Immunology
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