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Iranian Journal of Allergy, Asthma, and Immunology

Fatemeh Esna-Ashari, Farzaneh Sabahi, Mehrdad Ravanshad, Ashraf Mohammadi
Preparation of the indigenous varicella zoster vaccine could significantly reduce the disease burden of varicella zoster virus especially in immunosuppressed children. To achieve this goal, the varicella zoster virus was isolated from an 8 years boy infected with chicken pox. The virus was cultivated in sensitive cell line and determined varicella zoster. The adaptation and attenuation of virus was carried out after several passages in MRC-5 cell culture, Primary Guinea pig embryo fibroblast cell culture and again switching in MRC-5 cell culture...
December 31, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Farhad Abolnezhadian, Ali Saeedi-Boroujeni, Sara Iranparast
Major histocompatibility complex (MHC) class II deficiency is a rare primary immunodeficiency disorder (PID) with less than 200 cases worldwide. Here, we report an 8 month-old girl with MHC class II deficiency with a novel homozygous mutation in RFXANK gene (NM_001278728: exon 5: c.495G>A: p.Trp165*) and normal CD4+ T cell counts, diagnosed by whole exome sequencing (WES) and negative HLA-DR proteins on peripheral blood mononuclear cell (PBMC) in flow cytometry. She was referred with pneumonia, prolonged fever, resistance to antibiotics (ceftriaxone, clindamycin, and vancomycin), and low serum immunoglobulin (IG) levels, while natural killer (NK), B, and T cells were normal...
December 4, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Vajiheh Gharzi, Maziar Gangi, Arezou Sayad, Mehrdokht Mazdeh, Shahram Arsang-Jang, Mohammad Taheri
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS), in which axonal damage is a deteriorative factor. Brain-Derived Neurotrophic Factor (BDNF) is described as a neuronal-survival gene, also capable of exerting pleiotropic effects on the immune cells. Here, we aimed to investigate expression levels of BDNF and its antisense RNA, BDNF-AS, in Iranian MS patients. Our case-control study was based on collecting 50 whole blood samples of relapsing-remitting MS patients and 50 healthy controls...
December 4, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Negin Rostamzadeh, Ali Akbari Sari, Mohammad Gharagozlou
Asthma is one of the most common chronic diseases all over the world, which impacts socioeconomics of families and health care systems. We need to estimate the costs of asthma to set health policies and structural adjustments to control burden of asthma in societies. The aim of present study was to evaluate direct costs of asthma in children in Tehran-Iran. In a descriptive-analytical study, 100 children who were referred to Children's Medical Center of Tehran University of Medical sciences, from March 2014 to March 2015, were selected randomly and studied...
December 3, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Hamid Kazemian, Davoud Afshar, Ernesto Garcia, Mohammad Reza Pourmand, Mahmood Jeddi-Tehrani, Farzaneh Aminharati, Fazel Shokri, Mohammad Hossein Yazdi
Among many pneumococcal antigens, choline-binding proteins (CPBs) display a high immunogenicity in animal models. This study aims to determine the immunogenicity of CbpM, CbpG and CbpL proteins of Streptococcus pneumoniae in a mice model. The genes were cloned into pET21a expression vector and the recombinant proteins were produced. Mice were immunized with the purified recombinant proteins. Subsequently, the mice were challenged with S. pneumoniae ATCC 49619 (2×106 CFU) and their survival and bacterial clearances were followed 24 hours after infection...
December 3, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Mansour Arab, Maryam Razzaghy-Azar, Zahra Salehi, Maryam Keshavarz, Ensieh Nasli-Esfahani, Mahdi Shekarabi, Maryam Izad
 Type 1 diabetes (T1D) is an autoimmune disease resulting from the damage of pancreatic B-cells mediated by autoreactive CD4+ and CD8+ T cells. In recent years, follicular T helper (Tfh) cells have been recognized as a subpopulation of CD4+ T cells providing help for B cells differentiation and antibody production. In this study, we examined the frequency of circulating CD4+CXCR5+ and CD4+CXCR5+ICOS+ (representing Tfh) cells as well as serum levels of anti-glutamic acid decarboxylase 65 (GAD65) and islet cell autoantibodies (ICA) in children with type I diabetes...
December 3, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Tooba Momen, Hossein Saneian, Nilufar Amini
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease isolated to the esophagus Food allergy is thought to play an important role in the pathophysiology of EOE. The aim of this study is to evaluate demographic features and sensitivity of patients with reference to common food allergens. Children with documented EoE were enlisted for this study. Skin prick test and patch test were done for all participants. Each test contained common food allergens. Other tests, such as evaluation of total IgE and eosinophil count, were also done...
December 3, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Maryam Zare, Mehrnoosh Doroudchi, Behrouz Gharesi-Fard
Regulatory T cells are of utmost importance for tolerating the fetus. In some pregnancy complications such as pre-eclampsia, the frequency of CD4+CD25+Foxp3+ regulatory T cells is altered, but there is no consistency regarding the results. Besides, little is known about the frequency of CD8+CD25+Foxp3+ Treg cells in pregnancy complications. Therefore, we aimed to investigate the frequency of both CD4+ and CD8+ regulatory T cells in the peripheral blood of women afflicted by preeclampsia. Ten non-pregnant, ten healthy pregnant, and ten preeclamptic women participated in this study...
December 2, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Ali Mosayebian, Zohreh Koohini, Hadi Hossein-Nataj, Saeid Abediankenari, Siavash Abedi, Hossein Asgarian-Omran
Asthma is a chronic disorder of the airways characterized by reversible airflow obstruction, inflammation and bronchial hyperresponsiveness. Different immune cells and molecules have been attributed to involve in pathogenesis of asthma. In the current case-control study, the expression of T cell Ig and mucin domain-containing molecule-3 (Tim-3) and programmed death-1 (PD-1) was studied on CD4+ T cells of patients with asthma and normal controls. The frequency of Tim-3+/PD-1+/CD4+ T cells was determined by a three color flow cytometry method in 37 patients with asthma and 32 healthy controls...
December 2, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Mehdi Rasouli, Yaser Jafari-Khataylou, Javad Ashrafi-Helan
Type 1 diabetes (T1D), a spontaneous autoimmune disease, is associated with destruction of insulin-producing β-cells in the pancreas. Since some heat shock proteins (HSP), such as HSP70 exert a protective effect in both tissues and cells, the present study was conducted to elucidate the effects of carbenoxolone (CBX) as an HSP70 inducer on T1D. The disease was induced in male C57BL/6 mice using streptozotocin (STZ) and subjects were allocated to therapeutic 1 and therapeutic 2 groups, as well as negative and positive control groups...
December 1, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Ilghar Zeinaly, Naghmeh Vossoughi, Daniel Elieh Ali Komi, Tohid Kazemi, Zohreh Babaloo, Alireza Razavi, Mohammad Sajay-Asbaghi, Mahnaz Sadeghi-Shabestari
Orosomucoid 1-like 3 (ORMDL3) gene, located on chromosome 17q21, is an asthma candidate gene that encodes ORMDL3. This molecule has been reported to play a role in airway remodeling and bronchial hyper-responsiveness. In this study, we aimed to investigate the possible association of ORMDL3 single nucleotide polymorphism (SNP) (rs12603332) with susceptibility to allergic asthma in Iranian Northwestern Azeri population. 193 asthmatic patients and 185 normal individuals were included. Genomic DNA was extracted and genotyping was performed by standard restriction fragment length polymorphism-polymerase chain reaction RFLP-PCR method using BstUI restriction enzyme...
December 1, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Shikun Ma, Jian Guan
Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety...
December 1, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Elahe Izadi, Fateme Vafashoar, Paria Jorbozedar, Pendar Safari, Mohamad Ali Assarehzadegan, Hadi Poormoghim, Jalil Kuhpayezadeh, Nazanin Mojtabavi
Gender medicine is a new era of science which focuses on the impact of sex hormones and gender on normal physiology, pathobiology and clinical features of diseases. In this study we investigated the impact of pregnancy doses of progesterone hormone on the expression of a couple of matrix metalloproteinase (MMPs), which are known to be involved in tissue remodeling of lungs in health and disease, namely MMP7 and 13. Pregnancy maintenance dose of progesterone was administered to female BALB/c mice for 21 and 28 days, the control group received PBS for the same days...
October 20, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Hamed Mohammadi, Farhad Babaie, Maryam Hemmatzadeh, Gholamreza Azizi, Mehrzad Hajaliloo, Ali Asghar Ebrahimi, Tohid Kazemi, Mehdi Yousefi, Alireza Rezaiemanesh, Elham Safarzadeh, Elham Baghbani, Jafar Majidi, Behzad Baradaran
Ankylosing spondylitis (AS), an autoinflammatory disease, has been associated with impaired Endoplasmic reticulum aminopeptidase (ERAP) 1 activity, which is involved in priming antigenic peptides. The purpose of this study was to evaluate if the genetic variant of ERAP1 gene could impress the inflammation status of the AS patients. For genotyping, 140 AS cases and 140 healthy controls were enrolled. After isolation of peripheral blood mononuclear cells (PBMCs) and DNA extraction, all the subjects were genotyped for rs27044 polymorphism using SSP-PCR assay...
October 20, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Zeynab Golshani, Zohreh Hojati, Ali Sharifzadeh, Vahid Shaygannejad, Mojtaba Jafarinia
MicroRNAs (miRNAs), have been documented to perform a key role in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory and autoimmune disease. Recent studies have shown that single nucleotide polymorphism in the sequence of the miRNA may change their production and expression which can lead to miRNA dysfunction and pathogenicity. Some studies have reported the relationship between miRNA polymorphism and the increased risk of autoimmune disease. This study was conducted to investigate the association between mir155 rs767649, mir196a2 rs11614913 and mir23a rs3745453 polymorphism and the risk of multiple sclerosis in the Iranian MS patients in Isfahan...
October 14, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Behnaz Esmaeili, Parvin Mansouri, Alipasha Meysamie, Maryam Izad
Memory regulatory T cells (Tregs) has been demonstrated to produce IL-17 in Psoriasis. Forkhead box P3 (Foxp3) has been demonstrated not to be reliable marker to evaluate Treg cells. Effector CD4+T cells also express Foxp3 after activation. Human T helper-17 cells (Th-17) express high level of surface CD26, while regulatory T cells are CD26 negative or low and this phenotype is stable even after activation of Treg cells. In this study, we aimed to analyze IL-17 producing Treg cells using CD26. Memory T cells were isolated from 10 patients with psoriasis and 10 controls...
October 14, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Sogol Shahidi, Shahla Jamili, Pargol Ghavam Mostafavi, Sassan Rezaie, Mohammadreza Khorramizadeh
Marine novel natural products have been applied for cancer therapy. Enzyme-digested gelatin hydrolysates have proven to serve as promising sources of potent biologically active peptides. Potential anti-breast cancer properties of the extracted Ficin-digesterd gelatin hydrolysate from Indian squid (Uroteuthis duvauceli) was extensively characterized by cellular and animal models. Gelatin was extracted from squid skin, hydrolyzed by Ficin, and characterized by standard physico-chemical methods. Ficin-digested gelatin hydrolysate was used at various doses of 0-0...
October 14, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Da Rae Kang, Shah Ahmed Belal, Ho Sung Choe, Dae Keun Shin, Kwan Seob Shim
Kaempferol, a phytochemical found in many edible plants, is known to alleviate diseases such as cancer, allergy, and inflammation. The objective of this study was to investigate whether kaempferol could reduce omega-6 and ovalbumin-mediated allergic reactions at lung and trachea in BALB/c mice. Mice were allocated into five groups: 1) control group (CON); 2) positive control group with orally administration of omega-6 (POS); 3) bovine serum albumin (BSA) sensitization group (with BSA injection and ovalbumin inhalation); 4) BSA+K10 group: BSA injection, 10 μg/g of kaempferol administration and ovalbumin inhalation; and 5) BSA+K20 group: BSA injection, 20 μg/g of kaempferol administration and ovalbumin inhalation...
October 14, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Elham Harati, Maryam Bahrami, Alireza Razavi, Mohammad Kamalinejad, Maryam Mohammadian, Tayebeh Rastegar, Hamid Reza Sadeghipour
Asthma is a chronic inflammatory disease of the lungs driven by T cell activation. Viola tricolor L. as a traditional medical herb could suppress activated T lymphocytes and has been used empirically for asthma remedy. In the present study, we investigated the anti-inflammatory effect of Viola tricolor and its underlying mechanism on asthma characteristics induced by ovalbumin (OVA) in mice. BALB/c mice were randomly divided into six groups: normal control, Ovalbumin (OVA) control, OVA mice treated with Viola tricolor (50, 100 and 200 mg/kg) and dexamethasone (3 mg/kg)...
October 14, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Dimitri Poddighe, Elena Virginia Comi, Ilaria Brambilla, Amelia Licari, Paola Bruni, Gian Luigi Marseglia
Mycoplasma pneumoniae has been recognized to be involved in several extra-pulmonary diseases, but the underlying immunologic mechanisms are still largely unknown. Recently, we observed a significant elevation of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE levels in children affected with Mycoplasma pneumoniae-related extra-pulmonary diseases. We prospectively collected the data of 162 children admitted to the hospital (because of respiratory infections or extra-pulmonary diseases) who were evaluated for Mycoplasma pneumoniae serology and total serum IgE levels, concomitantly...
October 9, 2018: Iranian Journal of Allergy, Asthma, and Immunology
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