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Journals Iranian Journal of Allergy, As...

Iranian Journal of Allergy, Asthma, and Immunology

https://read.qxmd.com/read/38822517/the-effect-of-priming-new-plastic-spacers-with-20-puffs-salbutamol-on-bronchodilator-response-in-asthmatic-children
#1
JOURNAL ARTICLE
Homa Sadri, Mohammad Reza Fazlollahi
The static charge on the plastic body of spacers attracts drug aerosols, reducing the drug available for inhalation from plastic spacers. Some instructions exist to decrease the electric charge on plastic spacers, such as priming them with salbutamol (20 puffs) before use. This study investigates whether priming plastic spacer devices with this method can improve the bronchodilator test result. This study included children with stable mild to moderate asthma. All subjects underwent two pulmonary function tests to evaluate their bronchodilator response on separate days at 24-48 hours intervals...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822516/the-evaluation-of-the-n-cadherin-promoter-s-ability-to-block-emt-by-specific-expression-of-diphtheria-toxin-in-emt-induced-a549-cell-lines
#2
JOURNAL ARTICLE
Zohreh Mehmandoostli, Mahmood Dehghani Ashkezari, Seyed Morteza Seifati, Vida Sadeghi, Reza Falak, Gholam Ali Kardar
During epithelial to mesenchymal transition, the ability of cancer cells to transform and metastasize is primarily determined by N-cadherin-mediated migration and invasion. This study aimed to evaluate whether the N-cadherin promoter can induce diphtheria toxin expression as a suicide gene in epithelial to mesenchymal transition (EMT)-induced cancer cells and whether this can be used as potential gene therapy. To investigate the expression of diphtheria toxin under the N-cadherin promoter, the promoter was synthesized, and was cloned upstream of diphtheria toxin in a pGL3-Basic vector...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822515/alkbh5-modulates-asthma-progression-by-downregulating-n6-methyladenosine-methylation
#3
JOURNAL ARTICLE
Xiang Fan, Chen Wei, Yongguang Han
Asthma is a chronic respiratory disease that is characterized by airway inflammation, excessive mucus production, and airway remodeling. Prevention and treatment for asthma is an urgent issue in clinical studies. In recent years, N6-methyladenosine methylation (m6A) has emerged as a promising regulatory approach involved in multiple diseases. ALKBH5 (alkB homolog 5) is a demethylase widely studied in disease pathologies. This work aimed to explore the regulatory mechanisms underlying the ALKBH5-regulated asthma...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822514/interferon-%C3%AE-induces-interleukin-6-production-and-alpha-smooth-muscle-actin-expression-in-systemic-sclerosis-fibroblasts
#4
JOURNAL ARTICLE
Mohsen Rokni, Elham Farhadi, Hoda Kavosi, Maryam Akhtari, Elham Madreseh, Samaneh Enayati, Mina Sadeghi Shaker, Shayan Mostafaei, Farhad Gharibdoost, Mahdi Mahmoudi, Mohammad Vodjgani
Systemic sclerosis (SSc) is an autoimmune systemic disease that is characterized by immune dysregulation, inflammation, vasculopathy, and fibrosis. Tissue fibrosis plays an important role in SSc and can affect several organs such as the dermis, lungs, and heart. Dysregulation of interferon (IFN) signaling contributes to the SSc pathogenesis and interferon regulatory factor 1 (IRF1) has been indicated as the main regulator of type I IFN. This study aimed to clarify the effect of IFN-gamma (-γ) and dexamethasone (DEX) on the IRF1, extracellular signal-regulated kinase 1/2 (ERK1/2), and the expression of alpha-smooth muscle actin (α-SMA) in myofibroblasts and genes involved in the inflammation and fibrosis processes in early diffuse cutaneous systemic sclerosis (dcSSc)...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822513/altered-expression-of-b-cell-receptor-signaling-pathway-genes-in-peripheral-blood-of-patients-with-multiple-sclerosis
#5
JOURNAL ARTICLE
Shirin Jalili, Hadi Shirzad, Seyed Amin Mousavi Nezhad
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease and has adverse implications. The exact mechanism of its pathogenesis is not fully understood and remains to be elucidated. In the current study we aimed to identify key genes that can serve as potential biomarkers and therapeutic targets for MS and shed light on pathogenesis mechanisms involved in MS. We analyzed a gene expression dataset (GES21942) and found 266 differentially expressed genes (DEGs) including 183 upregulated and 83 downregulated genes in MS patients compared to controls...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822512/trial-of-cardiovascular-risk-factor-assessment-and-transthoracic-echocardiography-results-in-patients-with-primary-antibody-deficiency
#6
JOURNAL ARTICLE
Katarzyna Napiórkowska-Baran, Grzegorz Grześk, Jan Błażejewski, Marcin Ziętkiewicz, Ewa Więsik-Szewczyk, Aleksandra Matyja-Bednarczyk, Marta Tykwińska, Elżbieta Grześk, Jakub Lubański, Oskar Schmidt, Bartłomiej Szymczak, Robert Zacniewski, Ewa Szynkiewicz, Michał Owsiany, Zbigniew Bartuzi
The life expectancy and the risk of developing cardiovascular diseases in patients with inborn errors of immunity are systematically increasing. The aim of the study was to assess cardiovascular risk factors and to evaluate the heart in echocardiography in patients with primary antibody deficiency (PAD). Cardiac echography and selected cardiovascular risk factors, including body mass index, sedentary lifestyle, nicotine, glucose, C-reactive protein, lipid profile, uric acid level, certain chronic diseases, and glucocorticoid use, were analyzed in 94 patients >18 years of age with PAD...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822511/antibody-response-before-and-after-the-booster-dose-of-inactivated-corona-vaccine-in-antibody-deficient-patients
#7
JOURNAL ARTICLE
Mahshid Movahedi, Masoud Movahedi, Nima Parvaneh, Hassan Abolhassani, Mohadese Mahdavi, Mohadese Sadat Mosavikhorshidi, Fatemeh Alizadeh, Mehdi Shokri, Arash Kalantari
Patients with inborn errors of immunity (IEI) are among the high-risk groups regarding COVID-19. Receiving booster doses (third and fourth) in addition to the standard doses is recommended in these patients. This study investigated the antibody response before and after a booster dose of Sinopharm vaccine in IEI patients.  Thirty patients (>12 years) with antibody deficiencies, referred to Imam Khomeini Hospital and Children's Medical Center in Tehran, were enrolled in this prospective cross-sectional study...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822510/fluctuation-of-disease-severity-and-quality-of-life-applying-intralymphatic-immunotherapy-for-patients-with-seasonal-allergic-rhinitis
#8
JOURNAL ARTICLE
Maryam Khoshkhui, Farahzad Jabbari, Fateme Shafiee Zargar, Nasrin Motavalli Haghi, Nazila Ariaee
Allergen-specific immunotherapy is the only disease-modifying treatment for IgE-mediated allergic disorders. Intra lymphatic immunotherapy (ILIT) is an efficacious and time-saving alternative to subcutaneous immunotherapy (SCIT). This study aimed to evaluate the effects and safety of ILIT in patients with moderate to severe allergic rhinitis.  In this clinical trial, patients between 18 and 65 years old with moderate to severe allergic rhinitis were enrolled. They received monthly intra-lymphatic inguinal injections of an active allergen (1000 SQ-U Salsola kali pollen)...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822509/antiepileptic-medication-induced-severe-cutaneous-adverse-reactions-in-hospitalized-children-a-retrospective-study
#9
JOURNAL ARTICLE
Bahareh Abtahi-Naeini, Reza Makhmali, Niloufar Amini, Mohammad Reza Maracy, Nikta Nouri, Tooba Momen
BACKGROUND: There are limited data on severe cutaneous adverse reactions (SCARs) associated with antiepileptic medications. The current study aims to investigate the clinical and epidemiological characteristics of antiepileptic medication-induced SCARs in hospitalized children. MATERIALS AND METHODS: The current five-year retrospective study was conducted at Isfahan University of Medical Sciences, Iran. This study included all children with a definite diagnosis of SCARs secondary to the use of antiepileptic medications based on the world health organization (WHO) definition...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38822508/prevalence-and-severity-of-covid-19-among-pediatric-patients-with-atopy-a-cross-sectional-study-in-kerman-southeast-iran
#10
JOURNAL ARTICLE
Fakhry Shafiee, Afshin Sarafinejad, Nasrin Bazargan Harandi, Ali Hossininasab, Sareh Saadat Ebrahimi
The tragic COVID-19 pandemic affected many children worldwide. Among the factors that may influence the course of viral infections including COVID-19, it is still uncertain whether atopy has a protective or predisposing role. The study aims to address the knowledge gap by investigating the prevalence and severity of COVID-19 among atopic children in Kerman, in 2022. A descriptive-analytical cross-sectional study on children with a history of atopy was performed in Kerman Medical University. Demographic information, type of atopy (including allergic rhinitis, Hyper-Reactive Airway Disease (HRAD) or asthma, eczema, urticaria, anaphylaxis, and food allergy), history of COVID-19 infection, and disease severity were recorded...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485913/exosomes-derived-from-heat-shocked-tumor-cells-promote-in-vitro-maturation-of-bone-marrow-derived-dendritic-cells
#11
JOURNAL ARTICLE
Neda Heidari, Hajar Abbasi-Kenarsari, Bahare Niknam, Ali Asadirad, Davar Amani, Zahra Mirsanei, Seyed Mahmood Hashemi
Dendritic cells (DCs), professional antigen-presenting cells that process and deliver antigens using MHC II/I molecules, can be enhanced in numerous ways.  Exosomes derived from heat-shocked tumor cells (HS-TEXs) contain high amounts of heat-shock proteins (HSPs). HSPs, as chaperons, can induce DC maturation. This study aimed to investigate whether HS-TEXs can promote DC maturation. To generate DC, bone marrow-derived cells were treated with Interleukin-4 and GM-CSF. Exosomes were isolated from heat-treated CT-26 cells...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485912/tocilizumab-failed-to-reduce-mortality-in-severe-covid-19-patients-results-from-a-randomized-controlled-clinical-trial
#12
JOURNAL ARTICLE
Mona Talaschian, Maryam Akhtari, Mahdi Mahmoudi, Shayan Mostafaei, Mohamadreza Jafary, Seyyed Mostafa Jalali, Kourosh Sadeghi, Keivan Gohari Moghadam, Hengameh Ansari Tadi, Ahmadreza Jamshidi
The severe coronavirus disease 2019 (COVID-19) is associated with increased levels of blood interleukin (IL)-6. Therefore, it is hypothesized that modulating the levels or effects of IL-6  could diminish airway inflammation and alter the course of COVID-19. We conducted a controlled, randomized, double-blind clinical trial on hospitalized patients with severe COVID-19 in Iran. The patients were randomly distributed by block randomization to take either standard-of-care (SOC) plus 1 or 2 doses of tocilizumab 8 mg/kg or SOC alone...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485911/different-gene-expression-patterns-of-il-1-family-members-in-parkinson-s-disease-results-from-bayesian-regression-model
#13
JOURNAL ARTICLE
Negin Jafariaghdam, Majid Khoshmirsafa, Alireza Zamani, Elahe Talebi-Ghane, Shadi Moradi, Faezeh Shahba, Mehrdokht Mazdeh, Mohammad Mahdi Eftekharian
Parkinson's disease, the second most prevalent neurodegenerative disorder lacking a recognized etiology, is influenced by oxidative stress and alterations in inflammatory cytokine levels. This study aimed to investigate the expression levels of Interleukin(IL)1 receptor accessory protein (IL-1RAcP), IL1β, IL1α, IL33, and IL36 genes in blood cells and serum IL-1β levels in Parkinson's disease patients compared to healthy controls (HCs).I n this case-control study, 44 Parkinson's disease patients and 44 age- and sex-matched HCs were included...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485910/a-quality-of-life-study-in-patients-with-anaphylaxis-to-hymenoptera-venom-in-iran
#14
JOURNAL ARTICLE
Mohammad Hasan Bemaniyan, Maryam Heidari, Marzieh Tavakol, Mohammad Nabavi, Fatemeh Ramezani Kashal, Maryam Gholami, Bita Bemaniyan
Little is known about the quality of life of patients with anaphylaxis to Hymenoptera venom. The Vespid Allergy Quality of Life Questionnaire (VQLQ) is commonly used to assess the psychological burden of this condition. This study aimed to evaluate the validity and reliability of the Persian version of VQLQ. In this cross-sectional study, VQLQ was translated into Persian according to expert recommendations.  The final translated version of VQLQ was then administered to 115 patients with Hymenoptera venom allergy at an asthma and allergy clinic in Iran...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485909/baseline-severity-and-disease-duration-can-predict-the-response-to-allergen-specific-immunotherapy-in-allergic-rhinitis
#15
JOURNAL ARTICLE
Yan Li, Haiqing Xiao, Yinhui Zeng, Yiquan Tang, Lifeng Zhou, Wenlong Liu
Allergen-specific immunotherapy (AIT) has confirmed its efficacy in improving the symptoms of allergic rhinitis. However, no reliable biomarkers have been identified to predict the efficacy of AIT were found. We aimed to find clinical and immunological markers to predict efficacy in children after 2 years of sublingual immunotherapy (SLIT). A total of 285 children diagnosed with allergic rhinitis were recruited. The clinical efficacy was evaluated by comparing endpoint and baseline symptom and medication scores (SMS)...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485908/iranian-journal-of-allergy-asthma-and-immunology-a-bibliometric-and-altmetric-analysis-from-2005-to-2022
#16
JOURNAL ARTICLE
Mojgan Zareivenovel, Leila Nemati-Anaraki, Ali Ouchi, Maryam Nourizadeh, Motahareh Aghashahi
This study aimed to present a bibliometric and altmetric Analyses of the Iranian Journal of Allergy, Asthma, and Immunology (IJAAI). The citation performance and altmetric data were extracted from Scopus and Altmetric Explorer, respectively. Analyses were done using SPSS 26, Microsoft Excel, VOSviewer, and CiteSpace. The results of the bibliometric analysis revealed that IJAAI had experienced respectable growth. Among the total citations, 4746 citations belong to the first decade (2005-2014) and 3,035 citations belong to the second (2015-2022)...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485907/description-of-a-novel-pathogenic-variant-in-the-arpc1b-and-a-severe-allergy-in-two-infants
#17
JOURNAL ARTICLE
Oscar Zaveleta Martínez, Ana Eunice Fregoso-Zuñiga, Cielo Razo Requena, Sara Espinosa Padilla, Lzbeth Blancas Galicia
Actinrelated protein 2/3 complex subunit 1B (ARPC1B) deficiency is an inborn error of immunity (IEI) characterized by a combination of immunodeficiency and immune dysregulation and classified as an IEI with allergic manifestations. Here, we describe two patients with pathogenic variants in the ARPC1B gene. The first patient presented with eczema and bronchospasm at six months of age. The second patient presented with eczema and milk protein allergy at five months of age. The c.899_944 (p.Glu300Glyfs*7) pathogenic variant was previously described, whereas the c...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485906/measurement-of-the-neutrophils-count-and-oxidative-burst-in-neutrophils-of-patients-with-sanjad-sakati-syndrome
#18
JOURNAL ARTICLE
Farhad Abolnezhadian, Majid Aminzadeh, Sara Iranparast, Sajad Dehnavi, Fatemeh Dousti, Moosa Sharifat, Hamid Moradzadegan
Sanjad Sakati Syndrome (SSS) is categorized as a neuroendocrine-related disease due to disorders of the nervous and hormonal systems. Since hormonal changes in these patients may affect the nature and function of the immune system. Thus, in this study, cell count and phagocytotic function of neutrophils were evaluated which may be influenced by changes in the hormonal rate and growth factors. In this study, the neutrophil count value and the oxidative burst were evaluated in six patients diagnosed with SSS and six healthy individuals...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485905/unraveling-the-impact-of-blood-transfusion-on-transcription-factors-regulating-t-helper-1-2-17-and-regulatory-t-cells
#19
JOURNAL ARTICLE
Samad Valizadeh, Azita Chegini, Faranak Behnaz, Ali Akbar Pourfatollah, Shahram Samiee, Ronak Karbalaeifar
T helper 1 (TH1) and TH2 lymphocytes are the most important components of the immune system affected by blood transfusion. This study aimed`` to evaluate the effect of blood transfusion on gene expression of transcription factors related to the development of TH1, TH2, TH17 and regulatory T cells (Tregs). In this cross-sectional study, 20 patients diagnosed with abdominal aortic aneurysms requiring surgical repair were studied from January 2018 to August 2020. We utilized real-time PCR to evaluate the expression of transcription factor genes associated with TH1, TH2, TH17, and Treg, namely T-box-expressed-in-T-cells (T-bet), GATA-binding protein 3 (GATA-3), retinoid-related orphan receptor (RORγt), and fork head box protein 3 (Foxp3), respectively...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485904/the-role-of-innate-and-adaptive-immune-system-in-the-pathogenesis-of-schizophrenia
#20
JOURNAL ARTICLE
Marziyeh Soltani, Yousef Mirzaei, Ali Hussein Mer, Mina Mohammad-Rezaei, Zahra Shafaghat, Soheila Fattahi, Fatemeh Azadegan-Dehkordi, Meghdad Abdollahpour-Alitappeh, Nader Bagheri
Schizophrenia is one of the most severely debilitating mental disorders that affects 1.1% of the world's population. The exact cause of the disease is not known, but genetics, environmental factors (such as infectious agents, season and region of birth, exposure to viruses, low birth weight, advanced paternal age, and tobacco), and immune system dysfunction can all contribute to the development of schizophrenia. Recently, the role of the immune system in schizophrenia has received much attention. Both acquired and innate immune systems are involved in the pathogenesis of schizophrenia and facilitate the disease's progression...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
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