Journals Hormones : International Journ...

Hormones : International Journal of Endocrinology and Metabolism
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Refaat Fathy Abd Elaal, Mohamed Fawzy
PURPOSE: Patients with congenital adrenal hyperplasia (CAH) have an increased risk of psychological/psychiatric symptoms and disorders. This study aimed to assess the behavior of girls with CAH and its independent risk variables. METHODS: This cross-sectional study included 55 girls with CAH due to 21-hydroxylase deficiency (mean age 12.64 ± 1.52 years; salt-wasting (SW) form = 20, simple virilizing (SV) form = 35). Psychiatric interviewing and the Strength and Difficulties Questionnaire (SDQ) (parent-reporting questionnaires) were used to assess behavior...
August 1, 2020: Hormones: International Journal of Endocrinology and Metabolism
Xia Wu, Heng Wu, Wenjiang Sun, Chen Wang
PURPOSE: Structured exercise is shown to be one of the most effective lifestyle interventions for women with polycystic ovary syndrome (PCOS). Anti-Müllerian hormone (AMH) has been proposed as a marker of ovarian dysfunction, and oxidative stress plays an important role in the development of PCOS. We sought to investigate whether there was any effect of aerobic exercise on AMH levels and oxidative stress in Chinese PCOS women. METHODS: Thirty-eight PCOS women were enrolled and divided into two groups...
July 28, 2020: Hormones: International Journal of Endocrinology and Metabolism
Satyam Singh Jayant, Rahul Gupta, Kanhaiya Agrawal, Liza Das, Pinaki Dutta, Anil Bhansali
INTRODUCTION: Triple A (Allgrove) syndrome is a rare autosomal recessive disorder characterized by cardinal features of primary adrenal insufficiency (AI) due to adrenocorticotropic hormone (ACTH) resistance, achalasia, and alacrima. It is frequently associated with neurological manifestations such as autonomic dysfunction, cognitive dysfunction, cranial nerve, or motor involvement. Amyotrophy/motor neuron disease is a rare association. CASE PRESENTATION: We herein report a 19-year-old boy diagnosed with triple A syndrome (TAS), with the classic triad of ACTH-resistant adrenal insufficiency, achalasia, and alacrima...
July 22, 2020: Hormones: International Journal of Endocrinology and Metabolism
Rosaria Maddalena Ruggeri, Alfredo Campennì, Massimiliano Siracusa, Giuseppe Frazzetto, Damiano Gullo
PURPOSE: Subacute thyroiditis (SAT) is an inflammatory thyroid disorder of viral origin, generally preceded by an upper respiratory tract infection. Since the disorder is self-limiting, it is frequently underdiagnosed. However, the disease should not be overlooked since the associated thyrotoxicosis may worsen the clinical course of concomitant disorders (e.g., respiratory distress) and long-term sequelae, such as autoimmune hypothyroidism, have been reported. METHODS: Here we describe a woman who developed SAT with thyrotoxicosis after SARS-COV-2 infection...
July 16, 2020: Hormones: International Journal of Endocrinology and Metabolism
Ali Seidkhani-Nahal, Asad Mirzaei, Gholam Basati, Davoud Parvizi-Faraz, Ali Noori-Zadeh
PURPOSE: The purpose of the current study was to evaluate thyroid function in terms of serum thyroid-stimulating hormone (TSH, also known as thyrotropin), 3,5,3'-triiodo-L-thyronine (T3), and 3,5,3',5'-tetraiodo-L-thyronine (T4, also known as thyroxine) levels in migraineurs in comparison with non-migraineurs using a systematic review of literature and a meta-analysis. METHODS: This is a systematic review of case-control studies on serum TSH, T3, and T4 concentrations of migraineurs in comparison with non-migraineurs...
July 15, 2020: Hormones: International Journal of Endocrinology and Metabolism
George Trovas, Symeon Tournis
Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive from observational studies. Nevertheless, while awaiting more robust data, clinicians should treat patients with vitamin D deficiency irrespective of whether or not it has a link with respiratory infections.
July 14, 2020: Hormones: International Journal of Endocrinology and Metabolism
Heba Amin Hassan, M L Essawi, M K Mekkawy, I Mazen
PURPOSE: Leydig cell hypoplasia is a rare autosomal recessive 46,XY disorder of sexual development (DSD). It is caused by homozygous or compound heterozygous inactivating mutations in the human luteinizing hormone/chorionic gonadotropin hormone receptor (LHCGR) gene. In Leydig cell hypoplasia type I, patients are characterized by predominantly female external genitalia, which usually go unrecognized until the age of puberty. METHODS: This study reports three patients descending from two unrelated families...
July 14, 2020: Hormones: International Journal of Endocrinology and Metabolism
Lorenzo Scappaticcio, Giuseppe Bellastella, Maria Ida Maiorino, Miriam Longo, Claudia Catalano, Katherine Esposito, Giuseppe Paolisso, Maria Rosaria Rizzo
INTRODUCTION: Occurrence of pancytopenia in patients with untreated hyperthyroidism is extremely rare. To the best of our knowledge, only 30 cases have been reported in the English literature. Accurate diagnosis and appropriate tailored therapy are challenging due to the variegated causes of pancytopenia and the potential hematological toxicity of antithyroid drugs (ATDs). CASE REPORT: We present a 51-year-old Caucasian man with newly diagnosed Graves' disease showing pancytopenia and liver dysfunction...
July 8, 2020: Hormones: International Journal of Endocrinology and Metabolism
Elias E Mazokopakis
No abstract text is available yet for this article.
July 6, 2020: Hormones: International Journal of Endocrinology and Metabolism
Qianlan Guo, Qiu Zhang, Yan He, Jijun Shi, Hongmei Li, Hao Peng
PURPOSE: The natriuretic peptides (NPs) system, and mainly atrial natriuretic peptide (ANP), plays a key role in human metabolism and cardiometabolic disorders. Due to differences in NP levels and in prevalence of metabolic syndrome (MetS) between men and women, we aimed to explore the gender difference of association between N-terminal pro-atrial natriuretic peptide (NT-proANP) and MetS in a general population in China. METHODS: Participants' weight, height, waist circumference, blood pressure, plasma NT-proANP, and other traditional biomarkers were measured...
July 3, 2020: Hormones: International Journal of Endocrinology and Metabolism
Doina Creţu, Simona Cernea, Corina Roxana Onea, Raluca-Monica Pop
As type 2 diabetes mellitus (T2DM) reaches epidemic proportions in the developed world and the age at diagnosis decreases, more women of reproductive age are being affected. In this article, we provide a synoptic view on potential mechanisms and relevant factors underlying menstrual cycle disorders and fertility issues in women with T2DM. The article discusses the function of the hypothalamic-pituitary-ovarian (HPO) axis, the central role of the hypothalamus in the homeostasis of this system, the central modulators of the axis, and the peripheral metabolic signals involved in neuroendocrine control of reproduction...
July 2, 2020: Hormones: International Journal of Endocrinology and Metabolism
Motahareh Hasani, Shirin Djalalinia, Maryam Khazdooz, Hamid Asayesh, Maryam Zarei, Armita Mahdavi Gorabi, Hossein Ansari, Mostafa Qorbani, Ramin Heshmat
The original version of this article, published on 10 December 2019 contained a mistake.
July 1, 2020: Hormones: International Journal of Endocrinology and Metabolism
İ Merve B Uçar, Mehmet Çalan, Erhan Tatar, Roukie Chousein, Özge E Fenercioğlu, Giray Bozkaya, Arif Yüksel
PURPOSE: Recent studies have shown that cytokines secreted from adipose tissues play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). CTRP5 (C1q-TNF-related protein 5) is a novel adipokine that has been shown to be associated with glucose and lipid metabolism. Varying levels of CTRP5 have been reported in individuals with diabetes, obesity and coronary artery disease. The aim of this study was to examine serum levels of CTRP5 and to show the relationship with cardiometabolic parameters in T2DM patients...
June 27, 2020: Hormones: International Journal of Endocrinology and Metabolism
Feng Zhao, Xi Wang, Yan Wang, Jingbo Zhang, Ran Lai, Bei Zhang, Xueyan Zhou
BACKGROUND: The progression of endometrial cancer (EC) is closely related to estrogen levels. UDP-glucuronosyltransferases (UGTs) are an essential class of phase II metabolizing enzymes that play a pivotal role in detoxifying steroid hormone. PURPOSE: In this study, we aimed to uncover the role of UGTs in estrogen metabolism and the pathogenesis of EC. METHODS: A total of 100 unrelated EC patients (mean age 52.15 ± 10.04 y) and 100 healthy subjects (mean age 50...
June 26, 2020: Hormones: International Journal of Endocrinology and Metabolism
Tugce Apaydın, Dilek Gogas Yavuz
Parathyroid cancer is a rare malignancy and an uncommon cause of hyperparathyroidism. In the present study, we present seven cases of parathyroid carcinoma. The female ratio was 5/7 (71.4%). Median age at diagnosis was 47 years, and median follow-up duration was 60 months (IQR 29-75). Mean calcium level at diagnosis was 12.7 mg/dL (range, 11.3-13.9), and mean parathormone level was 1115 ng/L (IQR 287-1470). Two patients (28.5%) had a palpable neck mass. Coexisting brown tumor was present in three patients (42...
June 23, 2020: Hormones: International Journal of Endocrinology and Metabolism
Marissa J Maroni, Kimberly M Capri, Alexis V Cushman, Hannah V Deane, Holly Concepcion, Holly DeCourcey, Joseph A Seggio
PURPOSE: The daily circadian cycle is known to modulate both feeding behavior and metabolism. As such, the timing of food consumption can play a role in regulating overall health. The purpose of this study is to determine whether fasting at different times of the day alters subsequent food consumption and levels of PYY3-36 , a hormone secreted after a meal which inhibits appetite. METHODS: Separate groups of mice were fasted at different times of the day: (1) start of the day, (2) middle of the day, (3) start of the night, and (4) middle of the night, and either injected with vehicle or PYY3-36 to assess their subsequent food consumption patterns, PYY3-36 levels, and glucose and insulin levels...
June 23, 2020: Hormones: International Journal of Endocrinology and Metabolism
Chen Fu, Chen Minjie, Zhang Weichun, Yin Huihuang, Chen Guishan, Huang Qingxia, Yang Xiaoping, Chen Lan, Wang Ping, Lin Chujia, Yin Guoshu
PURPOSE: The aims of this study were to investigate the correlation of sex hormone-binding globulin (SHBG) and the components of metabolic syndrome (MetS) and explore the ability of SHBG to predict MetS in newly diagnosed and untreated patients with polycystic ovary syndrome (PCOS). METHODS: Ninety-eight newly diagnosed and untreated patients with PCOS and 37 healthy volunteers were recruited. A receiver operating characteristic (ROC) curve was used to explore the best cutoff values of SHBG for predicting that the patients with PCOS would fulfill at least one abnormal index of MetS components, at least two abnormal indexes of MetS components, or MetS...
June 20, 2020: Hormones: International Journal of Endocrinology and Metabolism
Hongwei Li, Runlu Sun, Qian Chen, Qi Guo, Junjie Wang, Liming Lu, Yuling Zhang
PURPOSE: Menopause modifies women's lipid profiles. However, the fact that it is still unclear whether high-density lipoprotein-cholesterol (HDL-C) levels decrease in postmenopausal women necessitated a systematic review and meta-analysis. METHODS: The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched and 498 articles published between 1987 and 2020 were retrieved. Studies reporting HDL-C, low-density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels in both postmenopausal and premenopausal populations were included...
June 18, 2020: Hormones: International Journal of Endocrinology and Metabolism
Konstantina Dipla, Robert R Kraemer, Naama W Constantini, Anthony C Hackney
The purpose of this review is to present a different perspective of the relative energy deficiency syndrome, to improve understanding of associated endocrine alterations, and to highlight the need for further research in this area. The term "female athlete triad" was coined over 25 years ago to describe three interrelated components: disordered eating, menstrual dysfunction, and low bone mass. The syndrome's etiology is attributed to energy intake deficiency relative to energy expenditure required for health, function, and daily living...
June 17, 2020: Hormones: International Journal of Endocrinology and Metabolism
Panagiotis Anagnostis, Julia K Bosdou, Konstantina Vaitsi, Dimitrios G Goulis, Irene Lambrinoudaki
Menopausal hormone therapy (MHT) is effective in preventing menopause-related bone loss and decreasing vertebral, non-vertebral and hip fracture risk. MHT contains estrogens that exert both antiosteoclastic and osteoanabolic effects. These effects are dose-dependent, as even ultra-low doses preserve or increase bone mineral density. The transdermal route of administration is effective on cancellous and cortical bone, although fracture data are still lacking. Hormone replacement therapy is the treatment of choice to preserve skeletal health in women with premature ovarian insufficiency and early menopause...
June 9, 2020: Hormones: International Journal of Endocrinology and Metabolism
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