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Hormones: International Journal of Endocrinology and Metabolism

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https://read.qxmd.com/read/31399957/the-relevance-of-cortisol-co-secretion-from-aldosterone-producing-adenomas
#1
Padmanabh S Bhatt, Amir H Sam, Karim M Meeran, Victoria Salem
AIMS AND OBJECTIVES: Adrenal adenomas are usually non-functioning, but can secrete aldosterone or cortisol. It has recently been suggested that many more adenomas than previously thought secrete more than one hormone. This has important implications for their clinical management. Our aim was to determine the frequency of cortisol co-secretion in primary hyperaldosteronism at our institution and investigate the difference in metabolic profiles and clinical outcomes between co-secreting and non-co-secreting patients...
August 10, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31388899/selenium-intake-status-and-health-a-complex-relationship
#2
REVIEW
Margaret P Rayman
Both selenium (Se) deficiency and excess are found in natural locations throughout the world, though Se excess can also be caused by supplementation with Se. Both have been associated with adverse health effects that have often been characterized by a U-shaped relationship. Some health effects, such as increased mortality, are associated with both low and high Se status. Certain people and populations are better able to tolerate low or high Se intake than others; there are a number of possible explanations for this fact...
August 6, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31388898/double-adenomas-of-the-pituitary-an-imaging-pathological-and-clinical-diagnostic-challenge
#3
REVIEW
George Kontogeorgos, Eleni Thodou
Double and multiple adenomas of the pituitary are composed of two or more distinct tumors located in the same gland. They represent uncommon lesions measuring less than 1 cm, reported as having a low incidence in autopsies and occurring even more infrequently in surgical series. The histological diagnosis of double adenomas in surgical material is often extremely difficult, and confirmation requires immunohistochemistry and, occasionally, electron microscopy. Fragmented tissue material submitted for histology after transsphenoidal resection complicates the diagnosis...
August 6, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31364024/50-years-of-the-eta-the-selenium-connection
#4
REVIEW
Peter P A Smyth, Leonidas H Duntas
The recent celebration of the 50 years of the ETA closely coincided with that of the 200 years since the discovery and description of selenium, an essential trace element for normal thyroid gland function and thus an adjuvant in the treatment of thyroid diseases. The aim of this commentary is to briefly outline the half centennial of the ETA while also signaling important moments in the history of selenium, developments in its availability round the world, details of its connection with thyroid function and, finally, its current and projected modes of application...
July 30, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31338751/alterations-in-hearing-function-of-patients-with-glucose-disorders
#5
Zeta Vergou, Stavroula A Paschou, Alexandra Bargiota, George N Koukoulis
OBJECTIVE: To study the prevalence of hearing impairment in patients with various glucose disorders. PATIENTS AND METHODS: A total of 499 individuals were studied, 51 patients with type 1 (TIDM), 188 patients with type 2 diabetes mellitus (T2DM), 39 patients with impaired fasting glucose (IFG), and 221 controls. Measurements were performed, blood was drawn, and a relevant questionnaire was completed. Ηearing function was assessed by pure-tone audiometry (PTA) and distortion product otoacustic emissions (DPOAEs)...
July 23, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31332766/surgical-treatment-in-patients-with-single-and-multiple-gland-primary-hyperparathyroidism-with-the-use-of-intraoperative-parathyroid-hormone-monitoring-extensive-single-center-experience
#6
Christos Christoforides, Kyriakos Vamvakidis, Spyridon Miliaras, Georgios Tsoulfas, Georgios Misichronis, Dimitrios G Goulis
PURPOSE: To evaluate a single-center extensive experience and effectiveness in surgical treatment of primary hyperparathyroidism (pHPT) with the use of rapid intraoperative parathyroid hormone (ioPTH) monitoring in patients with single gland (SGpH) or multiple gland (MGpH) disease. METHODS: This retrospective, single-center cohort study included 214 patients with pHPT treated from January 2010 to June 2017. In total, 172 patients fulfilled the inclusion criteria having at least one preoperative localization image study and measurement of ioPTH...
July 22, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31332765/refractory-hypoglycemia-in-an-infant-with-isolated-severe-primary-hypothyroidism
#7
LETTER
Shreya Sharma, Sudha Rao Chandrashekhar
No abstract text is available yet for this article.
July 22, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31292912/reactive-c-cell-hyperplasia-as-an-incidental-finding-after-thyroidectomy-for-papillary-carcinoma
#8
Dimitrios K Manatakis, Apostolos Bakavos, Vasiliki N Soulou, Christodoulos Dimakis, Sofia Tseleni-Balafouta
The biologic and clinical significance of reactive C cell hyperplasia (CCH), adjacent to differentiated thyroid cancers, remains unknown. Our aim was to investigate the presence of CCH in thyroidectomy specimens with papillary thyroid carcinomas (PTC) and discuss its epidemiology and histology. In total, 413 patients were prospectively included in the study (189 benign goiters, 224 PTC). Reactive CCH was observed in 9.8% of PTC cases (32% males, 68% females, mean age 48.3 ± 16.4 years) and usually ipsilateral to the primary tumor (91%)...
July 10, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31273668/selenium-in-colorectal-and-differentiated-thyroid-cancer
#9
REVIEW
Anna P Kipp
The current review aims to provide a brief overview of developments in the research field of selenium and cancer. The focus is on two tissues that show a rising incidence of cancer cases each year, namely the colon and the thyroid. Effects of adequate selenium concentrations on tumor development are most probably mediated by selenoproteins. However, the role of selenoproteins changes during the carcinogenic process as well as in a tissue-specific manner. During the initiation phase, selenoproteins protect cells from oxidative DNA damage and thus appear to inhibit tumor development, whereas, in already existing tumor cells, selenoproteins might, on the contrary, support their growth and thus reduce the survival probability of patients...
July 4, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31256350/the-complex-and-bidirectional-interaction-between-sex-hormones-and-exercise-performance-in-team-sports-with-emphasis-on-soccer
#10
REVIEW
Nikolaos E Koundourakis, Andrew N Margioris
A constant topic reported in the lay press is the effect of sex hormones on athletic performance and their abuse by athletes in their effort to enhance their performance or to either boost or sidestep their hard, protracted, and demanding training regimens. However, an issue that it is almost never mentioned is that the athletic training itself affects the endogenous production of androgens and estrogens, while also being affected by them. Among sports, soccer is a particularly demanding activity, soccer players needing to possess high levels of endurance, strength, and both aerobic and anaerobic capacity, with the very great physiological, metabolic, physical, and psychological exertion required of the players being both influenced by sex steroids and, reciprocally, affecting sex steroid levels...
June 29, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31250406/selenoprotein-p-and-its-potential-role-in-alzheimer-s-disease
#11
REVIEW
Nikolay Solovyev
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with cognitive decline, loss of memory, and progressive cerebral atrophy. The trace element selenium (Se) is known to be involved in brain pathology. Selenoprotein P (SELENOP), as the main Se transport protein, is, to a great extent, responsible for maintaining Se homeostasis and the hierarchy of selenoprotein expression in the body. Adequate Se supply through SELENOP is vital for proper brain development and function. Additionally, SELENOP may be implicated in pathological processes in the central nervous system, including those in AD...
June 27, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31240586/46-xy-complete-gonadal-dysgenesis-in-a-familial-case-with-a-rare-mutation-in-the-desert-hedgehog-dhh-gene
#12
Vassos Neocleous, Pavlos Fanis, Feride Cinarli, Vasilis Kokotsis, Anastasios Oulas, Meropi Toumba, George M Spyrou, Leonidas A Phylactou, Nicos Skordis
PURPOSE: Disorders of sex development (DSD) have been linked to gene defects that lead to gonadal dysgenesis. Herein, we aimed to identify the genetic cause of gonadal dysgenesis in a patient with primary amenorrhoea tracing it to a phenotypic female carrying a 46,XY karyotype of a consanguineous family. METHODS AND RESULTS: Whole exome sequencing (WES) was performed and revealed in homozygosity the rare and only once reported p.Arg164Pro missense mutation in exon 2 of the desert hedgehog (DHH) gene...
June 25, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31228102/irritable-bowel-syndrome-a-new-therapeutic-target-when-treating-obesity
#13
REVIEW
Gabriella Pugliese, Giovanna Muscogiuri, Luigi Barrea, Daniela Laudisio, Silvia Savastano, Annamaria Colao
There is accumulating evidence showing that obesity is due not merely to increased food intake, but could have a more complex pathophysiology possibly originating from the gut. Due to its microbiological, hormonal, and nutritional aspects, the gut could represent a starting point for the treatment of weight excess. Obesity is associated with a change of microbiota composition that not only could increase the calorie extraction from food but also could create a functional derangement resulting in irritable bowel syndrome (IBS)...
June 21, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31154656/methylation-profile-of-genes-involved-in-inflammation-in-the-blood-from-pregnancies-with-maternal-preeclampsia-due-to-untreated-gestational-diabetes-mellitus
#14
Panagiotis Halvatsiotis, Theodora Tsokaki, Charalambos Chrelias, Dimitrios Kassanos, Ekaterini Domali, Maria Gazouli, Georgios Dimitriadis, Sophia Kalantaridou
PURPOSE: To investigate DNA methylation changes in peripheral blood from patients with gestational diabetes mellitus (GDM) and preeclampsia (PE) due to poorly treated GDM. METHODS: Eighteen pregnant women participated in the study: 6 with GDM, 6 with PE, and 6 healthy controls. The promoter methylation status of genes was profiled using the Human Inflammatory Response and Autoimmunity EpiTect Methyl II Signature PCR Array profiles. The results were validated with quantitative real-time polymerase chain reaction (qRT-PCR)...
June 1, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31140157/an-unsuspicious-thyroid-nodule-with-fatal-outcome
#15
REVIEW
Lorenzo Scappaticcio, Camilla Virili, Marco Castellana, Gaetano Paone, Marco Centanni, Pierpaolo Trimboli, Luca Giovanella
INTRODUCTION: Over the last few years, several scientific societies have introduced specific evaluation systems to stratify the risk of malignancy of thyroid nodules. Most of these classifications have been created on the basis of ultrasonographic features of the commonest thyroid carcinoma histotype. Herein, we report a case of anaplastic thyroid carcinoma presenting at ultrasound (US) examination as an unsuspicious thyroid nodule associated with distant metastases, which was followed by the patient's death a short time later...
May 28, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31140156/non-alcoholic-fatty-liver-infiltration-in-children-an-underdiagnosed-evolving-disease
#16
REVIEW
Flora Tzifi, Andreas Fretzayas, George Chrousos, Christina Kanaka-Gantenbein
Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease, one that is still underdiagnosed in pediatric populations (as well as in the general population), this due to the progressive increase in childhood obesity observed both in developed and developing countries during the last few decades. The pathophysiology of the disease has not been thoroughly clarified yet. The condition displays common pathways in adults and children; however, there are age-related differences. Unlike adults, children with NAFLD require extensive laboratory analysis, because underlying pathologies other than obesity may contribute to the evolution of the disease...
May 28, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31087283/a-novel-fgf8-mutation-in-a-female-patient-with-isolated-congenital-anosmia
#17
LETTER
M I Stamou, L Plummer, V Koika, A Galli-Tsinopoulou, N A Georgopoulos
No abstract text is available yet for this article.
May 13, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/31030405/non-functioning-pituitary-macroadenoma-surgical-outcomes-tumor-regrowth-and-alterations-in-pituitary-function-3-year-experience-from-the-iranian-pituitary-tumor-registry
#18
Atousa Najmaldin, Mojtaba Malek, Nahid Hashemi Madani, Mohammad Ghorbani, Hamideh Akbari, Alireza Khajavi, Omolbanin Asadi Qadikolaei, Mohammad Ebrahim Khamseh
PURPOSE: The aim of this study was to assess clinical features and therapeutic outcomes in patients with clinically non-functioning pituitary macroadenomas (NFPMAs). METHOD: This is a retrospective cohort study of NFPMA patients treated surgically and followed periodically between 2015 and 2017 in a tertiary care center in Iran. Descriptive analysis was performed applying appropriate tests. Binary logistic regression models were used to determine the predictive factors for subtotal tumor resection (STR) and hormonal recovery...
April 27, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30989578/-68-ga-psma-pet-thyroid-incidentalomas
#19
REVIEW
Francesco Bertagna, Domenico Albano, Luca Giovanella, Mattia Bonacina, Rexhep Durmo, Raffaele Giubbini, Giorgio Treglia
INTRODUCTION: Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. The aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled prostate-specific membrane antigen (PSMA) uptake in the thyroid gland [PSMA thyroid incidentaloma (PTI)] revealed by PET/CT or PET/MRI. METHODS: A comprehensive literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted to find relevant published articles about the prevalence and clinical significance of PTIs detected by PET/CT or PET/MRI in patients studied for other oncologic purposes...
April 15, 2019: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30980254/selective-antagonism-of-crf1-receptor-by-a-substituted-pyrimidine
#20
Stelios Sakellaris, Minos-Timotheos Matsoukas, Vlasios Karageorgos, Smaragda Poulaki, Bhimanna Kuppast, Andrew Margioris, Maria Venihaki, Hesham Fahmy, George Liapakis
The corticotrophin-releasing factor (CRF) and its type 1 receptor (CRF1 R) regulate the hypothalamic-pituitary-adrenal axis, as well as other systems, thus playing a crucial role in the maintenance of homeostasis. Non-peptide CRF1 R-selective antagonists exert therapeutic effects on experimental animals with abnormal regulation of their homeostatic mechanisms. However, none of them is as yet in clinical use. In an effort to develop novel small non-peptide CRF1 R-selective antagonists, we have synthesized a series of substituted pyrimidines described in a previous study...
April 12, 2019: Hormones: International Journal of Endocrinology and Metabolism
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