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Journals Technology in Cancer Research ...

Technology in Cancer Research & Treatment

https://read.qxmd.com/read/38780516/based-on-gadolinium-ethoxybenzyl-dtpa-enhanced-mri-diagnostic-performance-of-the-category-modified-lr-5-criteria-in-patients-at-risk-for-hepatocellular-carcinoma
#21
JOURNAL ARTICLE
Shaopeng Li, Kexue Deng, Jun Qiu, Peng Wang, Dawei Yin, Yiju Xie, Yongqiang Yu
Introduction: We aimed to modify the LR-5 strategy to improve the diagnostic sensitivity for hepatocellular carcinoma (HCC) in high-risk patients while maintaining specificity. Methods: This study retrospectively analyzed 412 patients with 445 liver observations who underwent preoperative gadolinium ethoxybenzyl DTPA (GD-EOB-DTPA)-enhanced MRI followed by surgical procedures or biopsies. All observations were classified according to LI-RADS v2018, and the classifications were adjusted by modifying major features (MF)(substituting threshold growth with a more HCC-specific ancillary features (AF): presence of blood products within the mass, arterial phase hyperenhancement (APHE) was interpreted with hypointensity on precontrast imaging- isointensity in arterial phase (AP) and extending washout to transitional phase (TP)(2 min))...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38780512/dosimetric-effect-of-target-position-accuracy-on-single-isocenter-multiple-liver-metastases-sbrt
#22
JOURNAL ARTICLE
Yun Zhang, Shanzhou Niu, Jun Yuan, Xiaoping Wang, Changfei Gong, Chunbo Tang
Purpose: To evaluate the dosimetric effects of intrafraction baseline shifts combined with rotational errors on Four-dimensional computed tomography-guided stereotactic body radiotherapy for multiple liver metastases (MLMs). Methods: A total of 10 patients with MLM (2 or 3 lesions) were selected for this retrospective study. Baseline shift errors of 0.5, 1.0, and 2.0 mm; and rotational errors of 0.5°, 1°, and 1.5°, were simulated about all axes. All of the baseline shifts and rotation errors were simulated around the planned isocenter using a matrix transformation of 6° of freedom...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38780506/noninvasive-assessment-of-tumor-histological-grade-in-invasive-breast-carcinoma-based-on-ultrasound-radiomics-and-clinical-characteristics-a-multicenter-study
#23
MULTICENTER STUDY
Lifang Ge, Jiangfeng Wu, Yun Jin, Dong Xu, Zhengping Wang
Rationale and Objectives: We aimed to develop and validate prediction models for histological grade of invasive breast carcinoma (BC) based on ultrasound radiomics features and clinical characteristics. Materials and Methods: A number of 383 patients with invasive BC were retrospectively enrolled and divided into a training set (207 patients), internal validation set (90 patients), and external validation set (86 patients). Ultrasound radiomics features were extracted from all the eligible patients. The Boruta method was used to identify the most useful features...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38780486/lncrna-ap000842-3-triggers-the-malignant-progression-of-prostate-cancer-by-regulating-cuproptosis-related-gene-nfat5
#24
JOURNAL ARTICLE
Gaobo Zhou, Chaoqian Chen, Hongjian Wu, Jiao Lin, Hang Liu, Yiran Tao, Bin Huang
OBJECTIVES: Prostate cancer (PRAD) is a highly malignant disease with poor prognosis, and its development is regulated by a complex network of genes and signaling pathways. LncRNAs and miRNAs have significant regulatory roles in PRAD through the ceRNA network. Cuproptosis is a unique form of programmed cell death that is involved in various signaling pathways and biological processes related to tumor development. Nuclear factor of activated T cells 5 (NFAT5), a transcription factor that activates T cells, has been implicated in cuproptosis...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38780484/calcium-sensing-receptor-a-potential-biomarker-revealed-by-large-scale-public-databases-and-experimental-verification-in-metastatic-breast-cancer
#25
JOURNAL ARTICLE
Wanlin Xie, Huimin Xu, Yangyang Cheng, Xin Lin, Jingya Zeng, Yihua Sun
INTRODUCTION: Breast cancer (BC) is a common cancer characterized by a high molecular heterogeneity. Therefore, understanding its biological properties and developing effective treatments for patients with different molecular features is imperative. Calcium-sensing receptor (CaSR) has been implicated in several regulatory functions in various types of human cancers. However, its underlying pathological mechanism in BC progression remains elusive. METHODS: We utilized The Cancer Genome Atlas and Gene Expression Omnibus databases to explore the function of CaSR in the metastasis of BC...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38780251/deciphering-the-epigenetic-symphony-of-cancer-insights-and-epigenetic-therapies-implications
#26
REVIEW
Fatima Akram, Rida Tanveer, Sahar Andleeb, Fatima Iftikhar Shah, Tayyab Ahmad, Somia Shehzadi, Abdul Majeed Akhtar, Ghania Syed
Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-specific gene expression in mammalian cells. Aberrations in this intricate landscape drive substantial changes in gene function, emerging as a linchpin in cancer etiology and progression. While cancer was conventionally perceived as solely a genetic disorder, its contemporary definition encompasses genetic alterations intertwined with disruptive epigenetic abnormalities. This review explores the profound impact of DNA methylation, histone modifications, and noncoding RNAs on fundamental cellular processes...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38775067/the-application-of-artificial-intelligence-to-cancer-research-a-comprehensive-guide
#27
REVIEW
Amin Zadeh Shirazi, Morteza Tofighi, Alireza Gharavi, Guillermo A Gomez
Advancements in AI have notably changed cancer research, improving patient care by enhancing detection, survival prediction, and treatment efficacy. This review covers the role of Machine Learning, Soft Computing, and Deep Learning in oncology, explaining key concepts and algorithms (like SVM, Naïve Bayes, and CNN) in a clear, accessible manner. It aims to make AI advancements understandable to a broad audience, focusing on their application in diagnosing, classifying, and predicting various cancer types, thereby underlining AI's potential to better patient outcomes...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38773777/analysis-of-the-parotid-glands-on-an-energy-spectrum-ct-iodine-map-to-evaluate-irradiation-induced-acute-xerostomia-in-patients-with-nasopharyngeal-carcinoma
#28
JOURNAL ARTICLE
Runfan Chen, Jiangao Xie, Jianmin Chen, Xiaobo Li, Qingliang Lin, Qizhen Xu, Yanyan Chen, Lili Wang, Rong Zheng, Benhua Xu
Objective: This prospective study aims to evaluate acute irradiation-induced xerostomia during radiotherapy by utilizing the normalized iodine concentration (NIC) derived from energy spectrum computed tomography (CT) iodine maps. Methods: In this prospective study, we evaluated 28 patients diagnosed with nasopharyngeal carcinoma. At 4 distinct stages of radiotherapy (0, 10, 20, and 30 fractions), each patient underwent CT scans to generate iodine maps. The NIC of both the left and right parotid glands was obtained, with the NIC at the 0-fraction stage serving as the baseline measurement...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38773767/comparative-study-of-the-short-term-efficacy-and-safety-between-deb-tace-and-c-tace-in-the-treatment-of-unresectable-hepatocellular-carcinoma-a-retrospective-study
#29
COMPARATIVE STUDY
Long Hai, Shuaiwei Liu, Lina Ma, Xiangchun Ding, Xiaoyang Bai, Xia Luo
Background: This is a retrospective study aimed at comparing the clinical efficacy and safety between drug-eluting bead transcatheter arterial chemoembolization (DEB-TACE) and conventional TACE (C-TACE) in the treatment of unresectable hepatocellular carcinoma. Methods: From July 2019 to April 2021, we enrolled 282 patients with unresectable hepatocellular carcinoma who were admitted to our hospital, of which 179 and 103 were in the DEB-TACE and C-TACE groups, respectively. General information was collected, and treatment effects were evaluated following the modified Response Evaluation Criteria in Solid Tumors...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38773763/assessing-the-impact-of-charged-particle-radiation-therapy-for-head-and-neck-adenoid-cystic-carcinoma-a-systematic-review-and-meta-analysis
#30
JOURNAL ARTICLE
Mingyu Tan, Yanliang Chen, Tianqi Du, Qian Wang, Xun Wu, Qiuning Zhang, Hongtao Luo, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Xiaohu Wang
Purpose: Head and neck adenoid cystic carcinoma (HNACC) is a radioresistant tumor. Particle therapy, primarily proton beam therapy and carbon-ion radiation, is a potential radiotherapy treatment for radioresistant malignancies. This study aims to conduct a meta-analysis to evaluate the impact of charged particle radiation therapy on HNACC. Methods: A comprehensive search was conducted in Pubmed, Cochrane Library, Web of Science, Embase, and Medline until December 31, 2022. The primary endpoints were overall survival (OS), local control (LC), and progression-free survival (PFS), while secondary outcomes included treatment-related toxicity...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38766867/combined-dna-analysis-from-stool-and-blood-samples-improves-tumor-tracking-and-assessment-of-clonal-heterogeneity-in-localized-rectal-cancer-patients
#31
JOURNAL ARTICLE
Thomas Parigger, Franz Josef Gassner, Stephan Drothler, Christian Scherhäufl, Alexandra Hödlmoser, Lena Schultheis, Aryunni Abu Bakar, Florian Huemer, Richard Greil, Roland Geisberger, Lukas Weiss, Nadja Zaborsky
Objectives: In this study, stool samples were evaluated for tumor mutation analysis via a targeted next generation sequencing (NGS) approach in a small patient cohort suffering from localized rectal cancer. Introduction: Colorectal cancer (CRC) causes the second highest cancer-related death rate worldwide. Thus, improvements in disease assessment and monitoring that may facilitate treatment allocation and allow organ-sparing "watch-and-wait" treatment strategies are highly relevant for a significant number of CRC patients...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38766816/involvement-of-s100a6-s100a11-in-t-cell-immune-regulatory-in-hcc-revealed-by-single-cell-rna-seq
#32
JOURNAL ARTICLE
Rui Zhou, Bo Pei, Xinzhi Li, Xianlin Zhang
Background : Immunotherapy plays a significant role in the treatment of hepatocellular carcinoma (HCC). Members of the S100 protein family (S100s) have been widely implicated in the pathogenesis and progression of tumors. However, the exact mechanism by which S100s contribute to tumor immunity remains unclear. Methods: To explore the role of S100s in HCC immune cells, we collected and comparatively analyzed single-cell RNA sequencing (scRNA-seq) data of HCC and hepatitis B virus-associated HCC. By mapping cell classification and searching for S100s binding targets and downstream targets...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38759699/efficacy-analysis-of-bortezomib-combined-with-lenalidomide-in-newly-diagnosed-multiple-myeloma-with-1q21-gain-amp
#33
JOURNAL ARTICLE
Qiaolin Zhou, Jingjing Wen, Fang Xu, Jing Yue, Ya Zhang, Jing Su, Yiping Liu
OBJECTIVE: 1q21 gain/Amp is one of the most common cytogenetic abnormalities. There are controversies about its effects on prognosis and may be associated with inferior outcomes in patients with newly diagnosed multiple myeloma (NDMM). To explore the optimal induction treatment, we analyzed and compared the efficacy of combinations of bortezomib-lenalidomide-dexamethasone (VRD) and only bortezomib-based triplet regimens without lenalidomide (only bortezomib-based) as induction therapy in patients with NDMM with 1q21 gain/Amp...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752263/small-nucleolar-rnas-as-diagnostic-and-prognostic-biomarkers-in-cancer-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Liyun Gao, Junfei Fan, Jiayin He, Xiangxin Che, Xin Wang, Chunhua Han
OBJECTIVES: Small nucleolar RNAs (snoRNAs) form clusters within the genome, representing a mysterious category of small non-coding RNAs. Research has demonstrated that aberrant snoRNAs can contribute to the development of various types of cancers. Recent studies have identified snoRNAs as potentially valuable biomarkers for the diagnosis or/and prognosis of cancers. However, there has been a lack of comprehensive reviews on prognostic and diagnostic snoRNAs across different types of cancers...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752262/deep-learning-model-prediction-of-radiation-pneumonitis-using-pretreatment-chest-computed-tomography-and-clinical-factors
#35
JOURNAL ARTICLE
Jang Hyung Lee, Min Kyu Kang, Jongmoo Park, Seoung-Jun Lee, Jae-Chul Kim, Shin-Hyung Park
Objectives: This study aimed to build a comprehensive deep-learning model for the prediction of radiation pneumonitis using chest computed tomography (CT), clinical, dosimetric, and laboratory data. Introduction: Radiation therapy is an effective tool for treating patients with lung cancer. Despite its effectiveness, the risk of radiation pneumonitis limits its application. Although several studies have demonstrated models to predict radiation pneumonitis, no reliable model has been developed yet. Herein, we developed prediction models using pretreatment chest CT and various clinical data to assess the likelihood of radiation pneumonitis in lung cancer patients...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752261/circagfg1-promotes-ovarian-cancer-progression-through-the-mir-409-3-p-zeb1-axis
#36
JOURNAL ARTICLE
Jie Luo, Hua Zhong, Mei Guo, Peihong Xiao, Rongyu Cao, Mandan Zhao, Yongping Jing
OBJECTIVES: Circular RNAs (circRNAs) serve a crucial regulatory role in ovarian cancer (OC). Circular RNA ArfGAP with FG repeats 1 (circAGFG1) has been shown to be involved in promoting the progression of several cancers, containing triple-negative breast cancer, esophageal cancer and colorectal cancer. However, the function of circAGFG1 in OC is unclear. METHODS: Quantitative real-time reverse transcription PCR (RT-qPCR) was conducted to determine the expression levels of circAGFG1 and miR-409-3p...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752234/dose-volume-parameters-of-spared-magnetic-resonance-imaging-defined-active-bone-marrow-predict-hematologic-toxicity-in-pelvic-malignancies-patients-undergoing-radiotherapy-a-cohort-study
#37
JOURNAL ARTICLE
Ting Gao, Liqun Wei, Li Jiang, Shanshan Ma, Wei Zhang, Yong Zhang, Fang Wu
Background: The objective of this investigation is to evaluate the superiority of dose-volume parameters relying on magnetic resonance imaging (MRI)-defined active bone marrow (ABM) over those based on total bone marrow (TBM) contoured via CT in the prediction of hematologic toxicity (HT) occurrence among patients with pelvic malignancies undergoing radiotherapy. Methods: The clinical data of 116 patients with pelvic malignancies treated with pelvic radiotherapy were analyzed retrospectively. The ABM areas on T1-weighted MRI were contoured...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38725285/a-competing-risk-nomogram-for-prediction-of-prognosis-in-patients-with-primary-squamous-cell-thyroid-carcinoma
#38
JOURNAL ARTICLE
Ye Tian, Lei He, Bin Zhang, Linfeng Deng, Juan Wang
Objective: Primary squamous cell thyroid carcinoma (PSCTC) is an extremely rare carcinoma, accounting for less than 1% of all thyroid carcinomas. However, the factors contributing to PSCTC outcomes remain unclear. This study aimed to identify the prognostic factors and develop a prognostic predictive model for patients with PSCTC. Methods: The analysis included patients diagnosed with thyroid carcinoma between 1975 and 2016 from the Surveillance, Epidemiology, and End Results database. Prognostic differences among the 5 pathological types of thyroid carcinomas were analyzed...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38725284/identification-of-breast-cancer-subtypes-based-on-endoplasmic-reticulum-stress-related-genes-and-analysis-of-prognosis-and-immune-microenvironment-in-breast-cancer-patients
#39
JOURNAL ARTICLE
Chen Yi, Jun Yang, Ting Zhang, Liu Qin, Dongjuan Chen
Introduction: Endoplasmic reticulum stress (ERS) was a response to the accumulation of unfolded proteins and plays a crucial role in the development of tumors, including processes such as tumor cell invasion, metastasis, and immune evasion. However, the specific regulatory mechanisms of ERS in breast cancer (BC) remain unclear. Methods: In this study, we analyzed RNA sequencing data from The Cancer Genome Atlas (TCGA) for breast cancer and identified 8 core genes associated with ERS: ELOVL2, IFNG, MAP2K6, MZB1, PCSK6, PCSK9, IGF2BP1, and POP1...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38720626/clinical-outcomes-and-prognostic-factors-in-stage-iii%C3%A2-c-cervical-cancer-patients-treated-with-radical-radiotherapy-or-radiochemotherapy
#40
JOURNAL ARTICLE
Wenting Zhang, Hong Yu, Yuting Xiu, Fanxu Meng, Zhuo Wang, Kangkang Zhao, Yunlong Wang, Zhishen Chen, Juntian Liu, Jie Chen, Baosheng Sun
Objective: Since the update of the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging criteria, there have been few reports on the prognosis of stage III C cervical cancer. Moreover, some studies have drawn controversial conclusions, necessitating further verification. This study aims to evaluate the clinical outcomes and determine the prognostic factors for stage III C cervical cancer patients treated with radical radiotherapy or radiochemotherapy. Methods: The data of 117 stage III C cervical cancer patients (98 III C1 and 19 III C2) who underwent radical radiotherapy or radiochemotherapy were retrospectively analyzed...
2024: Technology in Cancer Research & Treatment
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