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Journals Technology in Cancer Research ...

Technology in Cancer Research & Treatment

https://read.qxmd.com/read/38775067/the-application-of-artificial-intelligence-to-cancer-research-a-comprehensive-guide
#1
REVIEW
Amin Zadeh Shirazi, Morteza Tofighi, Alireza Gharavi, Guillermo A Gomez
Advancements in AI have notably changed cancer research, improving patient care by enhancing detection, survival prediction, and treatment efficacy. This review covers the role of Machine Learning, Soft Computing, and Deep Learning in oncology, explaining key concepts and algorithms (like SVM, Naïve Bayes, and CNN) in a clear, accessible manner. It aims to make AI advancements understandable to a broad audience, focusing on their application in diagnosing, classifying, and predicting various cancer types, thereby underlining AI's potential to better patient outcomes...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38773777/analysis-of-the-parotid-glands-on-an-energy-spectrum-ct-iodine-map-to-evaluate-irradiation-induced-acute-xerostomia-in-patients-with-nasopharyngeal-carcinoma
#2
JOURNAL ARTICLE
Runfan Chen, Jiangao Xie, Jianmin Chen, Xiaobo Li, Qingliang Lin, Qizhen Xu, Yanyan Chen, Lili Wang, Rong Zheng, Benhua Xu
Objective: This prospective study aims to evaluate acute irradiation-induced xerostomia during radiotherapy by utilizing the normalized iodine concentration (NIC) derived from energy spectrum computed tomography (CT) iodine maps. Methods: In this prospective study, we evaluated 28 patients diagnosed with nasopharyngeal carcinoma. At 4 distinct stages of radiotherapy (0, 10, 20, and 30 fractions), each patient underwent CT scans to generate iodine maps. The NIC of both the left and right parotid glands was obtained, with the NIC at the 0-fraction stage serving as the baseline measurement...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38773767/comparative-study-of-the-short-term-efficacy-and-safety-between-deb-tace-and-c-tace-in-the-treatment-of-unresectable-hepatocellular-carcinoma-a-retrospective-study
#3
COMPARATIVE STUDY
Long Hai, Shuaiwei Liu, Lina Ma, Xiangchun Ding, Xiaoyang Bai, Xia Luo
Background: This is a retrospective study aimed at comparing the clinical efficacy and safety between drug-eluting bead transcatheter arterial chemoembolization (DEB-TACE) and conventional TACE (C-TACE) in the treatment of unresectable hepatocellular carcinoma. Methods: From July 2019 to April 2021, we enrolled 282 patients with unresectable hepatocellular carcinoma who were admitted to our hospital, of which 179 and 103 were in the DEB-TACE and C-TACE groups, respectively. General information was collected, and treatment effects were evaluated following the modified Response Evaluation Criteria in Solid Tumors...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38773763/assessing-the-impact-of-charged-particle-radiation-therapy-for-head-and-neck-adenoid-cystic-carcinoma-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Mingyu Tan, Yanliang Chen, Tianqi Du, Qian Wang, Xun Wu, Qiuning Zhang, Hongtao Luo, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Xiaohu Wang
Purpose: Head and neck adenoid cystic carcinoma (HNACC) is a radioresistant tumor. Particle therapy, primarily proton beam therapy and carbon-ion radiation, is a potential radiotherapy treatment for radioresistant malignancies. This study aims to conduct a meta-analysis to evaluate the impact of charged particle radiation therapy on HNACC. Methods: A comprehensive search was conducted in Pubmed, Cochrane Library, Web of Science, Embase, and Medline until December 31, 2022. The primary endpoints were overall survival (OS), local control (LC), and progression-free survival (PFS), while secondary outcomes included treatment-related toxicity...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38766867/combined-dna-analysis-from-stool-and-blood-samples-improves-tumor-tracking-and-assessment-of-clonal-heterogeneity-in-localized-rectal-cancer-patients
#5
JOURNAL ARTICLE
Thomas Parigger, Franz Josef Gassner, Stephan Drothler, Christian Scherhäufl, Alexandra Hödlmoser, Lena Schultheis, Aryunni Abu Bakar, Florian Huemer, Richard Greil, Roland Geisberger, Lukas Weiss, Nadja Zaborsky
Objectives: In this study, stool samples were evaluated for tumor mutation analysis via a targeted next generation sequencing (NGS) approach in a small patient cohort suffering from localized rectal cancer. Introduction: Colorectal cancer (CRC) causes the second highest cancer-related death rate worldwide. Thus, improvements in disease assessment and monitoring that may facilitate treatment allocation and allow organ-sparing "watch-and-wait" treatment strategies are highly relevant for a significant number of CRC patients...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38766816/involvement-of-s100a6-s100a11-in-t-cell-immune-regulatory-in-hcc-revealed-by-single-cell-rna-seq
#6
JOURNAL ARTICLE
Rui Zhou, Bo Pei, Xinzhi Li, Xianlin Zhang
Background : Immunotherapy plays a significant role in the treatment of hepatocellular carcinoma (HCC). Members of the S100 protein family (S100s) have been widely implicated in the pathogenesis and progression of tumors. However, the exact mechanism by which S100s contribute to tumor immunity remains unclear. Methods: To explore the role of S100s in HCC immune cells, we collected and comparatively analyzed single-cell RNA sequencing (scRNA-seq) data of HCC and hepatitis B virus-associated HCC. By mapping cell classification and searching for S100s binding targets and downstream targets...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38759699/efficacy-analysis-of-bortezomib-combined-with-lenalidomide-in-newly-diagnosed-multiple-myeloma-with-1q21-gain-amp
#7
JOURNAL ARTICLE
Qiaolin Zhou, Jingjing Wen, Fang Xu, Jing Yue, Ya Zhang, Jing Su, Yiping Liu
OBJECTIVE: 1q21 gain/Amp is one of the most common cytogenetic abnormalities. There are controversies about its effects on prognosis and may be associated with inferior outcomes in patients with newly diagnosed multiple myeloma (NDMM). To explore the optimal induction treatment, we analyzed and compared the efficacy of combinations of bortezomib-lenalidomide-dexamethasone (VRD) and only bortezomib-based triplet regimens without lenalidomide (only bortezomib-based) as induction therapy in patients with NDMM with 1q21 gain/Amp...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752263/small-nucleolar-rnas-as-diagnostic-and-prognostic-biomarkers-in-cancer-a-systematic-review-and-meta-analysis
#8
JOURNAL ARTICLE
Liyun Gao, Junfei Fan, Jiayin He, Xiangxin Che, Xin Wang, Chunhua Han
OBJECTIVES: Small nucleolar RNAs (snoRNAs) form clusters within the genome, representing a mysterious category of small non-coding RNAs. Research has demonstrated that aberrant snoRNAs can contribute to the development of various types of cancers. Recent studies have identified snoRNAs as potentially valuable biomarkers for the diagnosis or/and prognosis of cancers. However, there has been a lack of comprehensive reviews on prognostic and diagnostic snoRNAs across different types of cancers...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752262/deep-learning-model-prediction-of-radiation-pneumonitis-using-pretreatment-chest-computed-tomography-and-clinical-factors
#9
JOURNAL ARTICLE
Jang Hyung Lee, Min Kyu Kang, Jongmoo Park, Seoung-Jun Lee, Jae-Chul Kim, Shin-Hyung Park
Objectives: This study aimed to build a comprehensive deep-learning model for the prediction of radiation pneumonitis using chest computed tomography (CT), clinical, dosimetric, and laboratory data. Introduction: Radiation therapy is an effective tool for treating patients with lung cancer. Despite its effectiveness, the risk of radiation pneumonitis limits its application. Although several studies have demonstrated models to predict radiation pneumonitis, no reliable model has been developed yet. Herein, we developed prediction models using pretreatment chest CT and various clinical data to assess the likelihood of radiation pneumonitis in lung cancer patients...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752261/circagfg1-promotes-ovarian-cancer-progression-through-the-mir-409-3-p-zeb1-axis
#10
JOURNAL ARTICLE
Jie Luo, Hua Zhong, Mei Guo, Peihong Xiao, Rongyu Cao, Mandan Zhao, Yongping Jing
OBJECTIVES: Circular RNAs (circRNAs) serve a crucial regulatory role in ovarian cancer (OC). Circular RNA ArfGAP with FG repeats 1 (circAGFG1) has been shown to be involved in promoting the progression of several cancers, containing triple-negative breast cancer, esophageal cancer and colorectal cancer. However, the function of circAGFG1 in OC is unclear. METHODS: Quantitative real-time reverse transcription PCR (RT-qPCR) was conducted to determine the expression levels of circAGFG1 and miR-409-3p...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38752234/dose-volume-parameters-of-spared-magnetic-resonance-imaging-defined-active-bone-marrow-predict-hematologic-toxicity-in-pelvic-malignancies-patients-undergoing-radiotherapy-a-cohort-study
#11
JOURNAL ARTICLE
Ting Gao, Liqun Wei, Li Jiang, Shanshan Ma, Wei Zhang, Yong Zhang, Fang Wu
Background: The objective of this investigation is to evaluate the superiority of dose-volume parameters relying on magnetic resonance imaging (MRI)-defined active bone marrow (ABM) over those based on total bone marrow (TBM) contoured via CT in the prediction of hematologic toxicity (HT) occurrence among patients with pelvic malignancies undergoing radiotherapy. Methods: The clinical data of 116 patients with pelvic malignancies treated with pelvic radiotherapy were analyzed retrospectively. The ABM areas on T1-weighted MRI were contoured...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38725285/a-competing-risk-nomogram-for-prediction-of-prognosis-in-patients-with-primary-squamous-cell-thyroid-carcinoma
#12
JOURNAL ARTICLE
Ye Tian, Lei He, Bin Zhang, Linfeng Deng, Juan Wang
Objective: Primary squamous cell thyroid carcinoma (PSCTC) is an extremely rare carcinoma, accounting for less than 1% of all thyroid carcinomas. However, the factors contributing to PSCTC outcomes remain unclear. This study aimed to identify the prognostic factors and develop a prognostic predictive model for patients with PSCTC. Methods: The analysis included patients diagnosed with thyroid carcinoma between 1975 and 2016 from the Surveillance, Epidemiology, and End Results database. Prognostic differences among the 5 pathological types of thyroid carcinomas were analyzed...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38725284/identification-of-breast-cancer-subtypes-based-on-endoplasmic-reticulum-stress-related-genes-and-analysis-of-prognosis-and-immune-microenvironment-in-breast-cancer-patients
#13
JOURNAL ARTICLE
Chen Yi, Jun Yang, Ting Zhang, Liu Qin, Dongjuan Chen
Introduction: Endoplasmic reticulum stress (ERS) was a response to the accumulation of unfolded proteins and plays a crucial role in the development of tumors, including processes such as tumor cell invasion, metastasis, and immune evasion. However, the specific regulatory mechanisms of ERS in breast cancer (BC) remain unclear. Methods: In this study, we analyzed RNA sequencing data from The Cancer Genome Atlas (TCGA) for breast cancer and identified 8 core genes associated with ERS: ELOVL2, IFNG, MAP2K6, MZB1, PCSK6, PCSK9, IGF2BP1, and POP1...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38720626/clinical-outcomes-and-prognostic-factors-in-stage-iii%C3%A2-c-cervical-cancer-patients-treated-with-radical-radiotherapy-or-radiochemotherapy
#14
JOURNAL ARTICLE
Wenting Zhang, Hong Yu, Yuting Xiu, Fanxu Meng, Zhuo Wang, Kangkang Zhao, Yunlong Wang, Zhishen Chen, Juntian Liu, Jie Chen, Baosheng Sun
Objective: Since the update of the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging criteria, there have been few reports on the prognosis of stage III C cervical cancer. Moreover, some studies have drawn controversial conclusions, necessitating further verification. This study aims to evaluate the clinical outcomes and determine the prognostic factors for stage III C cervical cancer patients treated with radical radiotherapy or radiochemotherapy. Methods: The data of 117 stage III C cervical cancer patients (98 III C1 and 19 III C2) who underwent radical radiotherapy or radiochemotherapy were retrospectively analyzed...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38706262/pir-1919609-is-an-ideal-potential-target-for-reversing-platinum-resistance-in-ovarian-cancer
#15
JOURNAL ARTICLE
Ying Yan, Dan Tian, Bingbing Zhao, Zhuang Li, Zhijiong Huang, Kuina Li, Xiaoqi Chen, Lu Zhou, Yanying Feng, Zhijun Yang
PURPOSE: PIWI-interacting RNAs (piRNAs) are a type of noncoding small RNA that can interact with PIWI-like RNA-mediated gene silencing (PIWIL) proteins to affect biological processes such as transposon silencing through epigenetic effects. Recent studies have found that piRNAs are widely dysregulated in tumors and associated with tumor progression and a poor prognosis. Therefore, this study aimed to investigate the effect of piR-1919609 on the proliferation, apoptosis, and drug resistance of ovarian cancer cells...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38706247/a-single-arm-multi-center-phase-ii-clinical-trial-of-cadonilimab-anti-pd-1-ctla-4-in-combination-with-or-without-conventional-second-line-treatment-for-patients-with-extensive-stage-small-cell-lung-cancer
#16
MULTICENTER STUDY
Can Chen, Minjun Chen, Yuju Bai, Yajun Li, Jie Peng, Biao Yao, Jiangping Feng, Jian-Guo Zhou, Hu Ma
BACKGROUND: Cadonilimab (AK104) is a bispecific IgG-single-chain Fv fragment (ScFv) antibody that binds to PD-1 and CTLA-4. Cadonilimab has shown encouraging anti-tumour activity and a favourable safety profile in several tumour types. In second-line treatment, there is no defined standard of care for patients with extensive-stage small-cell lung cancer (ES-SCLC). Cadonilimab is expected to show substantial clinical efficacy. OBJECTIVE: To assess the antitumor activity and safety of cadonilimab monotherapy or combination with conventional therapy in ES-SCLC patients who failed first-line treatment...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38706215/usp39-promotes-the-viability-and-migration-of-head-and-neck-squamous-cell-carcinoma-cell-by-regulating-stat1
#17
JOURNAL ARTICLE
Yu Hu, Yang Wang, Wenrui Hu, Chenrui Hu, Bin Wang, Congli Liu, Anqi Deng, Bing Shen, Kaile Wu, Yehai Liu
Objective: Ubiquitin-specific peptidase 39 (USP39) plays a carcinogenic role in many cancers, but little research has been conducted examining whether it is involved in head and neck squamous cell carcinoma (HNSCC). Therefore, this study explored the functional role of USP39 in HNSCC. Method: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify differentially expressed proteins (DEPs) between the HNSCC tumor and adjacent healthy tissues. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to assess the functional enrichment of DEPs...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38693845/laser-interstitial-thermotherapy-litt-in-recurrent-glioblastoma-what-window-of-opportunity-for-this-treatment
#18
REVIEW
Alberto Morello, Andrea Bianconi, Francesca Rizzo, Jacopo Bellomo, Anna Cristina Meyer, Diego Garbossa, Luca Regli, Fabio Cofano
Laser Interstitial Thermotherapy is a minimally invasive treatment option in neurosurgery for intracranial tumors, including recurrent gliomas. The technique employs the thermal ablation of target tissue to achieve tumor control with real-time monitoring of the extent by magnetic resonance thermometry, allowing targeted thermal injury to the lesion. Laser Interstitial Thermotherapy has gained interest as a treatment option for recurrent gliomas due to its minimally invasive nature, shorter recovery times, ability to be used even in patients with numerous comorbidities, and potential to provide local tumor control...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38693842/advances-in-composite-biofilm-biomimetic-nanodrug-delivery-systems-for-cancer-treatment
#19
REVIEW
Yanyan Meng, Shaoqing Chen, Cheli Wang, Xinye Ni
Single biofilm biomimetic nanodrug delivery systems based on single cell membranes, such as erythrocytes and cancer cells, have immune evasion ability, good biocompatibility, prolonged blood circulation, and high tumor targeting. Because of the different characteristics and functions of each single cell membrane, more researchers are using various hybrid cell membranes according to their specific needs. This review focuses on several different types of biomimetic nanodrug-delivery systems based on composite biofilms and looks forward to the challenges and possible development directions of biomimetic nanodrug-delivery systems based on composite biofilms to provide reference and ideas for future research...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38693824/mir-133a-and-mir-135a-regulate-all-trans-retinoic-acid-mediated-differentiation-in-pediatric-acute-myeloid-leukemia-by-inhibiting-cdx2-translation-and-serve-as-prognostic-biomarkers
#20
JOURNAL ARTICLE
Yu-Cai Cheng, Zhong Fan, Cong Liang, Chun-Jin Peng, Yu Li, Li-Na Wang, Jie-Si Luo, Xiao-Li Zhang, Yong Liu, Li-Dan Zhang
Background: Acute myeloid leukemia (AML) is a type of blood cancer characterized by excessive growth of immature myeloid cells. Unfortunately, the prognosis of pediatric AML remains unfavorable. It is imperative to further our understanding of the mechanisms underlying leukemogenesis and explore innovative therapeutic approaches to enhance overall disease outcomes for patients with this condition. Methods: Quantitative reverse-transcription PCR was used to quantify the expression levels of microRNA (miR)-133a and miR-135a in 68 samples from 59 pediatric patients with AML...
2024: Technology in Cancer Research & Treatment
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