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Technology in Cancer Research & Treatment

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https://read.qxmd.com/read/30755102/microrna-143-is-associated-with-pathological-complete-response-and-regulates-multiple-signaling-proteins-in-breast-cancer
#1
Raúl García-Vázquez, Laurence A Marchat, Erika Ruíz-García, Horacio Astudillo-de la Vega, Abelardo Meneses-García, Claudia Arce-Salinas, Enrique Bargallo-Rocha, Ángeles Carlos-Reyes, José Sullivan López-González, Carlos Pérez-Plasencia, Rosalío Ramos-Payán, Maribel Aguilar-Medina, César López-Camarillo
Almost 55% to 80% of patients with breast cancer have an unfavorable pathological complete response to chemotherapy. MicroRNAs are small noncoding RNAs involved in cancer progression; however, their utility as predictors of pathological complete response to neoadjuvant chemotherapy is unclear. Here, we investigated if miR-143 could discriminate between pathological complete response and no-polymerase chain reaction of patients with locally advanced triple negative breast cancer that have received a fluorouracil-cisplatin/paclitaxel-based neoadjuvant treatment...
January 1, 2019: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30486755/identification-of-mir-758-3p-as-potential-modulator-of-cbx5-expression-in-gastric-cancer
#2
Jinxing Guo, Zichao Zhang, Lijie Pan, Yuanhang Zhou
Gastric cancer is one of the most frequently diagnosed cancer types in China and also the leading causes of cancer-related death. Previous study showed chromobox 5 expression was elevated in gastric cancer, but little is known regarding the precise molecular mechanisms by which chromobox 5 expression was modulated. In this study, we revealed that chromobox 5 could promote gastric cancer cell proliferation, migration, and invasion in vitro. We screened and identified microRNA-758-3p, whose expression was downregulated in gastric cancer tissues and cell lines, which was a potential upstream molecule of chromobox 5...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30482097/slc25a22-promotes-proliferation-and-metastasis-of-osteosarcoma-cells-via-the-pten-signaling-pathway
#3
Ming-Wei Chen, Xue-Jian Wu
Osteosarcoma is a highly malignant bone tumor. However, due to the high complexity of the occurrence and metastasis of osteosarcoma, the exact mechanism promoting its development and progression remains to be elucidated. This study highlights the causal link between solute carrier family 25 member 22 (SLC25A22) and the development, progression, and metastasis of osteosarcoma. SLC25A22 is upregulated in human osteosarcoma and predicts a poor prognosis. The upregulation of SLC25A22 in osteosarcoma tissues was significantly associated with cell proliferation, invasion, and metastasis...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30453842/optical-surface-scanning-for-patient-positioning-in-radiation-therapy-a-prospective-analysis-of-1902-fractions
#4
G Carl, D Reitz, S Schönecker, M Pazos, P Freislederer, M Reiner, F Alongi, M Niyazi, U Ganswindt, C Belka, S Corradini
PURPOSE/OBJECTIVE: Reproducible patient positioning remains one of the major challenges in modern radiation therapy. Recently, optical surface scanners have been introduced into clinical practice in addition to well-established positioning systems, such as room laser and skin marks. The aim of this prospective study was to evaluate setup errors of the optical surface scanner Catalyst HD (C-RAD AB) in different anatomic regions. MATERIAL/METHODS: Between October 2016 and June 2017 a total of 1902 treatment sessions in 110 patients were evaluated...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30444190/microrna-regulation-of-energy-metabolism-to-induce-chemoresistance-in-cancers
#5
Jin Ye, Manman Zou, Pei Li, Hui Liu
Since "Warburg effect" has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs' energy metabolic role in chemoresistance has been probed recently. In this review, we summarize 5 microRNAs in regulating glucose and lipid metabolism and other energy metabolism. They partially modulate chemoresistance to cancer treatments...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30415605/salvage-pulmonary-operations-following-stereotactic-body-radiotherapy-for-small-primary-and-metastatic-lung-tumors-evaluation-of-the-operative-procedures
#6
Hiroshi Hamakawa, Yutaka Takahashi, Ichiro Sakanoue, Tomoki Saito, Naoki Date, Keisuke Tomii, Nobuyuki Katakami, Toshiyuki Imagunbai, Masaki Kokubo
Stereotactic body radiotherapy is an alternative treatment option for small-sized, primary lung cancers and pulmonary metastatic diseases. In the case of local relapse after stereotactic body radiotherapy, salvage pulmonary resection is considered cautiously. However, no study has described the difficulty of the salvage operations. This study aimed to assess the difficulty associated with salvage operative procedures. Eight patients who developed local relapse after stereotactic body radiotherapy and had undergone salvage pulmonary operations were enrolled in this study (stereotactic body radiotherapy group)...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30411673/electroporation-of-the-liver-more-than-2-concurrently-active-curved-electrodes-allow-new-concepts-for-irreversible-electroporation-and-electrochemotherapy
#7
Andreas Ritter, Philipp Bruners, Peter Isfort, Alexandra Barabasch, Joachim Pfeffer, Jula Schmitz, Federico Pedersoli, Martin Baumann
Irreversible electroporation and electrochemotherapy are 2 innovative electroporation-based minimally invasive therapies for the treatment of cancer. Combining nonthermal effects of irreversible electroporation with local application of chemotherapy, electrochemotherapy is an established treatment modality for skin malignancies. Since the application of electrochemotherapy in solid organs is a promising approach, this article describes a novel electrode configuration and field generating method. For the treatment of hepatic malignancies, the shape of the electric field should resemble a spherical 3-dimensional geometry around the target tissue inside the liver...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30411666/performance-comparison-of-knowledge-based-dose-prediction-techniques-based-on-limited-patient-data
#8
Angelia Landers, Ryan Neph, Fabien Scalzo, Dan Ruan, Ke Sheng
PURPOSE: The accuracy of dose prediction is essential for knowledge-based planning and automated planning techniques. We compare the dose prediction accuracy of 3 prediction methods including statistical voxel dose learning, spectral regression, and support vector regression based on limited patient training data. METHODS: Statistical voxel dose learning, spectral regression, and support vector regression were used to predict the dose of noncoplanar intensity-modulated radiation therapy (4π) and volumetric-modulated arc therapy head and neck, 4π lung, and volumetric-modulated arc therapy prostate plans...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30411662/prognostic-value-of-mismatch-repair-genes-for-patients-with-colorectal-cancer-meta-analysis
#9
Jiang-Tao Hou, Li-Na Zhao, Ding-Jun Zhang, Dong-Yong Lv, Wei-Ling He, Bin Chen, Hui-Biao Li, Pei-Ru Li, Li-Zhen Chen, Xin-Lin Chen
DNA mismatch repair was proposed to play a pivotal role in the development and prognosis of colorectal cancer. However, the prognostic value of mismatch repair on colorectal cancer is still unknown. The PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched. The articles about mismatch repair (including hMLH1, hMSH2, hMSH3, hMSH6, hPMSH1, and hPMSH2) deficiency for the prognosis of patients with colorectal cancer were included in the study. The hazard ratio and its 95% confidence interval were used to measure the impact of mismatch repair deficiency on survival time...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30407123/real-time-tumor-tracking-radiotherapy-and-general-stereotactic-body-radiotherapy-for-adrenal-metastasis-in-patients-with-oligometastasis
#10
Norio Katoh, Hiroshi Onishi, Yusuke Uchinami, Tetsuya Inoue, Kengo Kuriyama, Kentaro Nishioka, Shinichi Shimizu, Takafumi Komiyama, Naoki Miyamoto, Hiroki Shirato
BACKGROUND: Precise local radiotherapy for adrenal metastasis can prolong the useful life of patients with oligometastasis. The aim of this retrospective, 2-center study was to establish the safety and effectiveness of real-time tumor-tracking radiotherapy and general stereotactic body radiotherapy in treating patients with adrenal metastatic tumors. MATERIALS AND METHODS: Thirteen lesions in 12 patients were treated with real-time tumor-tracking radiotherapy (48 Gy in 8 fractions over 2 weeks) and 8 lesions in 8 patients were treated with general stereotactic body radiotherapy (40-50 Gy in 5-8 fractions over 2 weeks or 60-70 Gy in 10 fractions over 2 weeks)...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30407116/clinicopathologic-analysis-of-oral-squamous-cell-carcinoma-after-125-i-interstitial-brachytherapy
#11
Wei-Ping Jie, Jia-Ying Bai, Bin-Bin Li
Oral squamous cell carcinoma is a common malignancy in the head and neck region. Brachytherapy after radical surgery has achieved much progress as a cancer adjuvant treatment. This study focused on the pathologic characteristics of the patients with oral squamous cell carcinoma who underwent seed implantation after radical surgery, and the relationship of these characteristics with prognosis. Thus, 76 patients with oral squamous cell carcinoma, who were treated with surgery and subsequently with iodine 125 (125 I) radioactive seed implantation, were recruited in this study...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30384810/nicotine-induces-progressive-properties-of-lung-adenocarcinoma-a549-cells-by-inhibiting-cystic-fibrosis-transmembrane-conductance-regulator-cftr-expression-and-plasma-membrane-localization
#12
Hui Li, Ningxia Ma, Jing Wang, Ying Wang, Chao Yuan, Jing Wu, Meihui Luo, Jiali Yang, Juan Chen, Juan Shi, Xiaoming Liu
Lung cancer remains one of the most common cancer-related deaths worldwide. The cigarette smoking is a risk factor for lung cancer development. Interestingly, the cystic fibrosis transmembrane conductance regulator encoded by CFTR gene, an ATP-binding cassette transporter-class ion channel that conducts chloride and bicarbonate anions across membrane of epithelial cells, has recently been suggested to play a role in the development and progression of many types of cancer. It has been well-documented that mutations of CFTR gene are the cause of cystic fibrosis, the most common fatal hereditary lung disease in Caucasian population; the function of cystic fibrosis transmembrane conductance regulator in the development of lung cancer however has not yet been established...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30384806/microrna-22-suppresses-breast-cancer-cell-growth-and-increases-paclitaxel-sensitivity-by-targeting-nras
#13
Ying-Kui Song, Yang Wang, Yi-Yang Wen, Pei Zhao, Zhi-Jie Bian
In recent study, microRNAs have various important functions in diverse biological processes and progression of cancer. In human breast cancer, microRNA-22 has been reported to be downregulated. However, molecular mechanism of microRNA-22 in breast cancer progression and chemosensitivity has not been well studied. In our study, these results demonstrated that microRNA-22 expression levels were significantly reduced in 40 pairs of human breast cancer tissues when compared to normal tissues. Enforced expression of microRNA-22 inhibited activity of cell proliferation and cell migration in breast cancer cells...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30384804/automated-field-in-field-fif-plan-framework-combining-scripting-application-programming-interface-and-user-executed-program-for-breast-forward-imrt
#14
Hojin Kim, Jungwon Kwak, Jinhong Jung, Chiyoung Jeong, Kyoungjun Yoon, Sang-Wook Lee, Seung Do Ahn, Eun Kyung Choi, Su Ssan Kim, Byungchul Cho
PURPOSE: To develop an one-click option on treatment planning system that enables for the automated breast FIF planning by combining the Eclipse Scripting application programming interfaces and user-executed programming in Windows. METHODS: Scripting application programming interfaces were designed to promote automation in clinical workflow associated with radiation oncology. However, scripting cannot provide all functions that users want to perform. Thus, a new framework proposes to integrate the benefits of the scripting application and user-executed programming for the automated field-in-field technique...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30381030/microrna-494-3p-promotes-cell-growth-migration-and-invasion-of-nasopharyngeal-carcinoma-by-targeting-sox7
#15
Huiping He, Xianghui Liao, Qingmei Yang, Yuan Liu, Yan Peng, Hongzhen Zhong, Jun Yang, Huiqing Zhang, Zhonghua Yu, Yufang Zuo, Chengnong Guan, Zumin Xu
BACKGROUND: There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which is widely prevalent in South China and is the most prevalent metastatic cancer among head and neck cancers. Recently, it has been shown that miR-494 is involved in the progression and prognosis of nasopharyngeal carcinoma. However, little is known about the function and mechanism of miR-494-3p in nasopharyngeal carcinoma. In the present study, we aimed to investigate the effects of miR-494-3p on the migration and invasion of nasopharyngeal carcinoma and to further explore the underlying mechanisms of these processes...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30381011/transcutaneous-electrical-acupoint-stimulation-improves-immunological-function-during-the-perioperative-period-in-patients-with-non-small-cell-lung-cancer-undergoing-video-assisted-thoracic-surgical-lobectomy
#16
Qing Tu, Zhou Yang, Jianhui Gan, Jian Zhang, Bin Que, Qiaofeng Song, Yan Wang
The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30380998/radiotherapy-immobilization-mask-molding-through-the-use-of-3d-printed-head-models
#17
Quoc-Viêt Vincent Pham, Annie-Pier Lavallée, Alexandru Foias, David Roberge, Ellis Mitrou, Philip Wong
PURPOSE: To evaluate the feasibility of a workflow free of a simulation appointment using three-dimensional-printed heads and custom immobilization devices. MATERIALS AND METHODS: Simulation computed tomography scans of 11 patients who received radiotherapy for brain tumors were used to create three-dimensional printable models of the patients' heads and neck rests. The models were three-dimensional-printed using fused deposition modeling and reassembled. Then, thermoplastic immobilization masks were molded onto them...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30376767/high-birc7-expression-might-be-an-independent-prognostic-indicator-of-poor-recurrence-free-survival-in-patients-with-prostate-cancer
#18
Yi Yang, Peng Sun, Wei Xu, Wei Xia
BACKGROUND: BIRC7, which encodes Baculoviral inhibitor of apoptosis (IAP) repeat-containing protein 7, is an oncogene in multiple types of cancer. In this study, we examined the association between BIRC7 expression and the clinicopathological characteristics of prostate cancer, the independent prognostic value of BIRC7 in terms of recurrence-free survival, and the molecular mechanisms of its dysregulation. METHODS: Data mining was performed using data from The Cancer Genome Atlas...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30373467/compressed-sensing-with-a-gaussian-scale-mixture-model-for-limited-view-photoacoustic-computed-tomography-in-vivo
#19
Jing Meng, Chengbo Liu, Jeesu Kim, Chulhong Kim, Liang Song
Photoacoustic computed tomography using an ultrasonic array is an attractive noninvasive imaging modality for many biomedical applications. However, the potentially long data acquisition time of array-based photoacoustic computed tomography-usually due to the required time-multiplexing for multiple laser pulses-decreases its applicability for rapid disease diagnoses and the successive monitoring of physiological functions. Compressed sensing is used to improve the imaging speed of photoacoustic computed tomography by decreasing the amount of acquired data; however, the imaging quality can be limited when fewer measurements are used, as traditional compressed sensing considers only the sparsity of the signals in the imaging process...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30355273/deregulation-of-microrna-375-inhibits-proliferation-and-migration-in-gastric-cancer-in-association-with-autophagy-mediated-akt-mtor-signaling-pathways
#20
Kai-Tao Yuan, Bao-Xia Li, Yu-Jie Yuan, Min Tan, Jin-Fu Tan, Wei-Gang Dai, Wei-Dong Feng, Ji-Dong Zuo
Gastric cancer is a deadly disease. Some microRNAs are involved in tumor invasion and metastasis. Underexpression of miR-375 has been correlated with tumorigenesis, treatment resistance, and poor prognosis. In this study, we first analyzed the profiles and prognostic values of miR-375 expression in gastric cancer tissues from a public database, and the expression level of miR-375 in gastric cancer samples and gastric cancer cell lines was then analyzed by quantitative real- time polymerase chain reaction. Significant underexpression of miR-375 was seen in all the gastric cancer samples compared to paired paracarcinoma tissues, and the expression level of miR-375 in the gastric cancer cell lines was negatively associated with the cell migration ability...
January 1, 2018: Technology in Cancer Research & Treatment
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