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Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia

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https://read.qxmd.com/read/30765895/glutathione-s-transferase-enzyme-activity-and-protein-expression-in-patients-with-recurrent-tonsillitis-and-idiopathic-tonsillar-hypertrophy
#1
Sedat Aydin, Mehmet Gokhan Demir, Serpil Oguztuzun, Murat Kilic, Can Yilmaz, Onur Dirican
OBJECTIVES: The palatine tonsil is a significant part of the secondary immune system. Tonsillitis and idiopathic tonsillar hypertrophy (ITH) are the most common pathologies of this component. Although there are studies on their pathogenesis, there is insufficient study of the role of antioxidant agents. Glutathione S-transferase (GST) isozymes contribute to the antioxidation reactions in the tissue via the glutathione pathway. The purpose in this study was to reveal the levels of the GST enzyme activity and protein expression of GSTP1 and GSTA1 isozymes in patients with tonsillitis and tonsil hypertrophy, and to investigate their role in the pathogenesis of these diseases...
February 12, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30697034/high-prevalence-of-abdominal-aortic-aneurysm-in-patients-with-inguinal-hernia-aortic-aneurysm-in-inguinal-hernia-patients
#2
Angelos Megalopoulos, Orestis Ioannidis, Ioannis Varnalidis, Maria Ntoumpara, Lina Tsigriki, Konstantinos Alexandris, Christiana Anastasiadou, Parpoudi Styliani, George Paraskevas, Ioannis Mantzoros
AIMS: There is increased prevalence of inguinal hernia (ΙΗ) in patients with abdominal aortic aneurysm (AAA). As there is limited data on AAA in patients with ΙΗ our objective was to examine the prevalence of AAA in such patients. METHODS: We prospectively examined 185 consecutive patients for AAA who presented to our department for surgical repair of an ΙΗ. All patients were referred for ultrasound of the abdominal aorta. An AAA was considered to be present when the distal diameter of the abdominal aorta was over 3 cm...
January 30, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30647473/paramyotonia-congenita-in-a-slovak-population-genetic-and-pedigree-analysis-of-3-families
#3
Frantisek Cibulcik, Peter Spalek, Ivan Martinka, Jana Zidkova, Milan Grofik, Stefan Sivak, Egon Kurca
BACKGROUND: Paramyotonia congenita is a non-dystrophic myotonia, in which muscle relaxation is delayed after voluntary or evoked contraction. This condition cannot be distinguished on the basis of symptoms and signs alone. It requires consideration of genetics as more than 100 mutations in the CLCN1 gene and at least 20 mutations in the SCN4A gene are associated with the clinical features of the non-dystrophic myotonias. Only a few families with the described features but no genetic testing have been reported in Slovakia...
January 14, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30647474/surgical-therapy-for-medication-related-osteonecrosis-of-the-jaw-in-osteoporotic-patients-treated-with-antiresorptive-agents
#4
Lukas Hauer, Jan Jambura, Daniel Hrusak, Miroslava Chalupova, Petr Posta, Stepan Rusnak, Vaclav Vyskocil
BACKGROUND: Medication - related osteonecrosis of the jaw (MRONJ) is a rare but serious complication of antiresorptive and/or antiangiogenic therapy. It mainly affects oncological patients, however, it can occur in patients with metabolic bone diseases, although this is less frequent. These lesions not only significantly impair the quality of life but can also have impact on the treatment of any underlying disease. In some rare cases MRONJ can be life-threatening. There is still no ideal consensus for treatment, though surgical therapy has been mostly preferred in recent years...
January 10, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30631211/telomere-dynamics-in-adult-hematological-malignancies
#5
Helena Olbertova, Karla Plevova, Kamila Stranska, Sarka Pospisilova
Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and end-to-end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults...
January 10, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30631210/subclinical-atrial-fibrillation-what-is-the-risk-of-stroke
#6
Jiri Plasek, Milos Taborsky
Atrial fibrillation is the most common arrhythmia and as such, it has become a significant public health issue due to its impact on patient morbidity and mortality. The prevalence of atrial fibrillation (AF) almost doubled in the last decade, being currently 2% in unselected patient populations. Its occurrence varies with age (present in almost 20% of octogenarians) and concomitant diseases. The most prevalent concomitant diseases are hypertension, diabetes, heart failure, renal failure, and cognitive decline...
January 10, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30631209/the-absence-of-high-risk-human-papillomavirus-in-czech-non-small-cell-lung-cancer-cases
#7
Hana Jaworek, Vladimira Koudelakova, Rastislav Slavkovsky, Jiri Drabek, Marian Hajduch
AIMS: The purpose of our study was to examine the presence of human papillomavirus (HPV) DNA in Czech patients with non-small cell lung cancer (NSCLC). METHODS: A highly sensitive quantitative polymerase chain reaction (qPCR) detecting the E6 gene of HPV16, 18, 31, and 56 was designed. The limit of detection was assessed using serial dilutions of HPV-positive plasmids. The qPCR was validated on a set of 402 cervical swabs where the qPCR, Cobas, and PapilloCheck methods were tested in parallel...
January 10, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30631208/assessment-of-the-impact-of-temporomandibular-disorders-on-maximum-bite-force
#8
Jelena Todic, Brankica Martinovic, Jasna Pavlovic, Sasa Tabakovic, Milos Staletovic
AIM: Temporomandibular disorders (TMD) refer to functional disorders of the masticatory system, temporomandibular joint (TMJ) and masticatory muscles. The main objective of this study was to determine whether and to what extent temporomandibular disorders (TMD) affect the maximum bite force (MBF). METHODS: The present study included subjects with and without temporomandibular disorder. The presence of TMD was assessed by means of the Helkimo clinical dysfunction index analysis...
January 10, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30631207/clinical-and-laboratory-characteristics-of-enteroviral-meningitis-in-children-including-qrt-pcr-and-sequencing-analysis
#9
Adriana Braunova, Lenka Krbkova, Petra Rainetova, Martin Musilek, Iva Capovova, Lenka Klapacova, Vaclav Musil, Lukas Homola, Tamara Kravalova, Jana Bednarova, Michal Kyr
AIMS: Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. PATIENTS AND METHODS: This was a prospective study including 147 patients in three groups: EV meningitis, tick-borne encephalitis, and aseptic meningitis with unidentified agent...
January 10, 2019: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30565568/microrna-210-expression-during-childbirth-and-postpartum-as-a-potential-biomarker-of-acute-fetal-hypoxia
#10
Barbara Vonkova, Ivona Blahakova, Lukas Hruban, Petr Janku, Sarka Pospisilova
OBJECTIVE: To explore whether miR-210 expression can be used as a diagnostic and prognostic marker in acute fetal hypoxia. METHODS: Whole blood samples of 29 women and their fetuses without hypoxia and 24 women and their fetuses with hypoxia were analysed in this study. Reverse transcription and quantitative real-time PCR were used to measure the expression of miR-210. Expression level differences between the control and hypoxic group in labour time and postpartum change fold were analyzed by standard statistical tests...
December 18, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30565567/changes-in-subfoveal-choroidal-thickness-after-uncomplicated-cataract-surgery
#11
Gaile Gudauskiene, Indre Matuleviciute, Ruta Mockute, Evelina Maciulaityte, Dalia Zaliuniene
BACKGROUND: Recent investigations show that phacoemulsification causing an inflammatory insult to the eye has an effect not only on retina but on the choroid as well. The purpose of this study was to evaluate the subfoveal choroidal thickness (SFCT) after uneventful phacoemulsification using swept-source optical coherence tomography (SS-OCT). METHODS: This prospective study included 30 eyes of 23 patients with senile cataract undergoing uncomplicated phacoemulsification and intraocular lens implantation...
December 18, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30559492/comparison-of-new-immunoassay-and-pcr-based-method-for-quantification-of-micrornas-in-whole-blood-a-pilot-methodical-study
#12
David Stejskal, Martina Hlozankova, Radka Sigutova, Katerina Andelova, Zdenek Svagera, Marek Svestak
BACKGROUND: MicroRNAs (miRNAs) are new generation biomarkers used in oncology, cardiology, metabolic syndrome, obesity or in neurology. miRNAs are short non-coding RNA molecules that regulate gene expression in eukaryotes. AIM: To compare a new commercial method for establishing miRNA (imunoassay) with a commercial kit RT qPCR. METHODS: RNA was isolated from whole blood samples obtained from four healthy volunteers. The isolates were liquated and miRNA-93-5p and miRNA-23a-3p were measured independently with commercial hsa-miR-93-5p miREIA and hsa-miR-23a-3p miREIA, and commercial RT-qPCR kits...
December 17, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30546152/the-yield-of-structural-magnetic-resonance-imaging-in-autism-spectrum-disorders
#13
Jiri Lisy, Andrea Efremova, Michal Hrdlicka
AIMS: The aim of our study was to assess the yield of routine brain magnetic resonance imaging (MRI) performed at our hospital as part of the diagnostic procedures focused on autism. METHODS: Our retrospective study involved children who had attended a diagnostic examination focused on autism and underwent brain MRIs between 1998-2015. The International Classification of Diseases, 10th edition was used to make clinical diagnoses. In 489 children (404 boys, 85 girls; mean age 8...
December 11, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30546151/hypotension-as-a-symptom-of-autonomic-neuropathy-in-patients-with-advanced-malignancies
#14
Filip Kohutek, Jaroslav Katrlik, Branislav Bystricky
AIMS: Hypotension can be a symptom of paraneoplastic autonomic neuropathy (PAN). Onconeural antibodies (OA) provide strong evidence for the paraneoplastic origin of neurological syndromes. Our goal was to assess the frequency of PAN among patients with advanced malignancies and hypotension using OA. METHODS: Patients with advanced malignancies and hypotension were screened and enrolled as per protocol. Plasma levels of six classical OAs were assessed in these patients...
December 11, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30451243/comparative-efficacy-of-continuous-infusion-of-bupivacaine-fentanyl-and-ropivacaine-fentanyl-for-paediatric-pain-control-after-the-ravitch-procedure-and-thoracotomy-a-prospective-randomized-study
#15
Lucyna Tomaszek, Dariusz Fenikowski, Danuta Gawron, Halina Komotajtys
AIMS: (1) To compare the efficacy of bupivacaine/fentanyl and ropivacaine/fentanyl for postoperative pain control (2). To identify the predictors of acute post-operative pain at rest, during deep breathing and coughing. METHODS: The study was performed in patients aged 6-18 years after thoracic surgery. The subjects were randomized to the bupivacaine 0.125%/fentanyl 5.0 μg/mL (n=46) or ropivacaine 0.2%/fentanyl 5.0 μg/mL (n=48) group; analgesic mixtures were administered through epidural catheter...
November 16, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30439933/various-surgical-techniques-for-the-repair-of-injured-vas-deferens-in-rat-experiments
#16
Radek Stichhauer, Jaroslav Koudelka, Ales Ryska, Helena Zivna, Milan Kaska
OBJECTIVE: The aim of this study was to evaluate whether the different vasovasostomy techniques can be performed using only the operating loupe in a rat model. The secondary aims were to evaluate the patency rate and inflammation of the vas deferens (VD) after contusion and the different vasovasostomy repair techniques. METHODS: A total of 40 male rats were divided into 4 groups based on the type of surgery: 1. contusion of the VD; 2. cutting of the VD and vasovasostomy with absorbable sutures; 3...
November 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30439932/mesenchymal-stem-cells-as-the-near-future-of-cardiology-medicine-truth-or-wish
#17
Michaela Brychtova, Jana-Aletta Thiele, Daniel Lysak, Monika Holubova, Milena Kralickova, Lucie Vistejnova
Cardiac damage is one of major cause of worldwide morbidity and mortality. Despite the development in pharmacotherapy, cardiosurgery and interventional cardiology, many patients remain at increased risk of developing adverse cardiac remodeling. An alternative treatment approach is the application of stem cells. Mesenchymal stem cells are among the most promising cell types usable for cardiac regeneration. Their homing to the damaged area, differentiation into cardiomyocytes, paracrine and/or immunomodulatory effect on cardiac tissue was investigated extensively...
November 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30439931/molecular-mechanisms-of-polymyxin-resistance-and-detection-of-mcr-genes
#18
Patrik Mlynarcik, Milan Kolar
Antibiotic resistance is an ever-increasing global problem. Major commercial antibiotics often fail to fight common bacteria, and some pathogens have become multi-resistant. Polymyxins are potent bactericidal antibiotics against gram-negative bacteria. Known resistance to polymyxin includes intrinsic, mutational and adaptive mechanisms, with the recently described horizontally acquired resistance mechanisms. In this review, we present several strategies for bacteria to develop enhanced resistance to polymyxins, focusing on changes in the outer membrane, efflux and other resistance determinants...
November 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30401990/late-diagnosis-of-complete-androgen-insensitivity-syndrome-and-transmission-carriers-of-the-disease-in-a-family-with-mutation-c-2495g-t-p-arg832leu-in-exon-7-of-the-androgen-receptor-gene-genetic-clinical-and-ethical-aspects
#19
Renata Pomahacova, Jana Zamboryova, Petra Paterova, Anna Krepelova, Ivan Subrt, Radka Jaklova, Petra Vohradska, Eliska Hrdonkova, Josef Sykora
BACKGROUND: The complete androgen insensitivity syndrome (CAIS) is a rare genetic disorder causing insensitivity to androgens in a person with female phenotype and 46,XY karyotype due to a mutation in the androgen receptor gene located on chromosome X. These children are born with female external genitalia, and females are transmitters. CASE REPORT: We illustrate an unexpected diagnosis of CAIS in two siblings during examination for short stature, and describe transmission/carriers in the family along with ethical aspects...
November 6, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/30401989/the-prevalence-of-maternal-hypothyroidism-in-first-trimester-screening-from-11-to-14-weeks-of-gestation
#20
Tomas Salek, Ishraq Dhaifalah, Dagmar Langova, Jana Havalova
AIM: The aim of this study was to determine the prevalence of maternal hypothyroidism in the first trimester from 11 to 14 weeks of gestation according to the American Thyroid Association (ATA) guidelines from 2017 and to compare the rates for singleton and twin pregnancies. METHODS: A total of 4965 consecutive Caucasian singleton pregnancies and 109 Caucasian twin pregnancies were included in the investigation. Patients with a history of thyroid gland disorder were excluded...
November 6, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
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