journal
https://read.qxmd.com/read/38438907/transmembrane-protein-176b-regulates-amino-acid-metabolism-through-the-pi3k-akt-mtor-signaling-pathway-and-promotes-gastric-cancer-progression
#21
JOURNAL ARTICLE
Jing Li, ZiQing Fang, Emre Dal, Hao Zhang, KeXun Yu, MengDi Ma, MingLiang Wang, Ruochuan Sun, MingDian Lu, HuiZhen Wang, YongXiang Li
BACKGROUND: The present study aimed to investigate the expression level, biological function, and underlying mechanism of transmembrane protein 176B (TMEM176B) in gastric cancer (GC). METHODS: TMEM176B expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting (WB). The function of TMEM176B was determined by various in vitro assays including colony formation, 5-ethynyl-2'-deoxyuridine (EdU), Transwell, and flow cytometry...
March 4, 2024: Cancer Cell International
https://read.qxmd.com/read/38431620/a-cuproptosis-related-gene-expression-signature-predicting-clinical-prognosis-and-immune-responses-in-intrahepatic-cholangiocarcinoma-detected-by-single-cell-rna-sequence-analysis
#22
JOURNAL ARTICLE
Hefei Ren, Chang Liu, Cheng Zhang, Hongkun Wu, Jiafeng Zhang, Zhenhua Wang, Lei Chen, Huiquan Wang, Chenghao Shao, Lin Zhou
BACKGROUND: Cholangiocarcinoma represents a malignant neoplasm originating from the hepatobiliary tree, with a subset of tumors developing inside the liver. Intrahepatic cholangiocarcinomas (ICC) commonly exhibit an asymptomatic presentation, rendering both diagnosis and treatment challenging. Cuproptosis, an emerging regulated cell death pathway induced by copper ions, has garnered attention recently. As cancer cells show altered copper metabolism and comparatively higher copper needs, cuproptosis may play a role in the development of ICC...
March 2, 2024: Cancer Cell International
https://read.qxmd.com/read/38431613/targeting-her2-positive-breast-cancer-cells-by-a-combination-of-dasatinib-and-bms-202-insight-into-the-molecular-pathways
#23
JOURNAL ARTICLE
Hadeel Kheraldine, Ishita Gupta, Farhan Sachal Cyprian, Semir Vranic, Halema F Al-Farsi, Maysaloun Merhi, Said Dermime, Ala-Eddin Al Moustafa
BACKGROUND: Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast cancer. Nevertheless, the outcome of the combination of these inhibitors on HER2-positive breast cancer is not explored yet. METHODS: Herein, we investigated the impact of DA and PD-L1 inhibitor (BMS-202) combination on HER2-positive breast cancer cell lines, SKBR3 and ZR75...
March 2, 2024: Cancer Cell International
https://read.qxmd.com/read/38431606/rgs20-promotes-non-small-cell-lung-carcinoma-proliferation-via-autophagy-activation-and-inhibition-of-the-pka-hippo-signaling-pathway
#24
JOURNAL ARTICLE
Xiaoyan Ding, Xiaoxia Li, Yanxia Jiang, Yujun Li, Hong Li, Lipeng Shang, Guilin Feng, Huhu Zhang, Ziyuan Xu, Lina Yang, Bing Li, Robert Chunhua Zhao
BACKGROUND: Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung cancer (NSCLC) and overcoming drug resistance to molecular-targeted therapies. Regulator of G protein signaling 20 (RGS20) is identified as an upregulated factor in many cancers, yet its specific role and the mechanism through which RGS20 functions in NSCLC remain unclear. Our study aimed to identify the role of RGS20 in NSCLC prognosis and delineate associated cellular and molecular pathways...
March 2, 2024: Cancer Cell International
https://read.qxmd.com/read/38429830/the-circrna-hsa-circ-0013561-regulates-head-and-neck-squamous-cell-carcinoma-development-via-the-mir-7-5p-pdk3-axis
#25
JOURNAL ARTICLE
Kaisai Tian, Liying Zheng, Tailei Yuan, Xiaoping Chen, Qun Chen, Xiaocheng Xue, Shuixian Huang, Weining He, Mingming Jin, Yi Zhang
BACKGROUND: Circular RNAs (circRNAs) belong to a class of covalently closed single stranded RNAs that have been implicated in cancer progression. Former investigations showed that hsa-circ-0013561 is abnormally expressed in head and neck squamous cell carcinoma (HNSCC). Nevertheless, the role of hsa-circ-0013561 during the progress of HNSCC still unclear. METHODS: Present study applied FISH and qRT-PCR to examine hsa-circ-0013561 expression in HNSCC cells and tissue samples...
March 1, 2024: Cancer Cell International
https://read.qxmd.com/read/38429738/ppp2r1b-abolishes-colorectal-cancer-liver-metastasis-and-sensitizes-oxaliplatin-by-inhibiting-mapk-erk-signaling-pathway
#26
JOURNAL ARTICLE
Wei Liu, Jingtong Tang, Wei Gao, Jian Sun, Gang Liu, Jianping Zhou
BACKGROUND: Patients with colorectal cancer (CRC) with liver metastasis or drug resistance have a poor prognosis. Previous research has demonstrated that PPP2R1B inactivation results in the development of CRC. However, the role of PPP2R1B in CRC metastasis and drug resistance is unclear. METHODS: Venny 2.1 was used to determine the intersection between survival-related differentially expressed genes (DEGs) and liver metastasis-related DEGs according to RNA-seq data from The Cancer Genome Atlas (TCGA) and the GEO database (GSE179979)...
March 1, 2024: Cancer Cell International
https://read.qxmd.com/read/38419070/the-emerging-roles-of-sphingosine-1-phosphate-and-sphk1-in-cancer-resistance-a-promising-therapeutic-target
#27
REVIEW
Samar Sami Alkafaas, Mohamed I Elsalahaty, Doha F Ismail, Mustafa Ali Radwan, Sara Samy Elkafas, Samah A Loutfy, Rami M Elshazli, Narjes Baazaoui, Ahmed Ezzat Ahmed, Wael Hafez, Mohanad Diab, Mohamed Sakran, Mohamed T El-Saadony, Khaled A El-Tarabily, Hani K Kamal, Mohamed Hessien
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous cancer management protocols. It can promote cancer recurrence, spreading of cancer, and finally, mortality. Accordingly, enhancing the responsiveness of cancer cells towards chemotherapies could be a vital approach to overcoming cancer chemoresistance. Tumour cells express a high level of sphingosine kinase-1 (SphK1), which acts as a protooncogenic factor and is responsible for the synthesis of sphingosine-1 phosphate (S1P)...
February 28, 2024: Cancer Cell International
https://read.qxmd.com/read/38419052/dormancy-of-cutaneous-melanoma
#28
REVIEW
Kathrin Singvogel, Birgit Schittek
Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most effective drugs and immune therapies rarely eradicate all tumor cells. Instead, they strongly reduce cancer burden, permitting dormant cancer cells to persist in niches, where they establish a cellular homeostasis with their host without causing clinical symptoms. Dormant cancers respond poorly to most drugs and therapies since they do not proliferate and hide in niches...
February 28, 2024: Cancer Cell International
https://read.qxmd.com/read/38419028/lass2-suppresses-metastasis-in-multiple-cancers-by-regulating-the-ferroptosis-signalling-pathway-through-interaction-with-tfrc
#29
JOURNAL ARTICLE
Yunfei Huang, Jie Du, Dan Li, Wei He, Zhouheng Liu, Li Liu, Xiaoli Yang, Xiaoming Cheng, Rui Chen, Yan Yang
BACKGROUND: As a key enzyme in ceramide synthesis, longevity assurance homologue 2 (LASS2) has been indicated to act as a tumour suppressor in a variety of cancers. Ferroptosis is involved in a variety of tumour processes; however, the role of LASS2 in regulating ferroptosis has yet to be explored. This article explores the potential underlying mechanisms involved. METHODS: Bioinformatics tools and immunohistochemical staining were used to evaluate LASS2 expression, and the results were analysed in relation to overall survival and clinical association in multiple cancers...
February 28, 2024: Cancer Cell International
https://read.qxmd.com/read/38402402/genome-wide-crispr-screen-identifies-espl1-limits-the-response-of-gastric-cancer-cells-to-apatinib
#30
JOURNAL ARTICLE
Bei Zhang, Yan Chen, Xinqi Chen, Zhiyao Ren, Hong Xiang, Lipeng Mao, Guodong Zhu
Apatinib was the first anti-angiogenic agent approved for treatment of metastatic gastric cancer (GC). However, the emergence of resistance was inevitable. Thus investigating new and valuable off-target effect of apatinib directly against cancer cells is of great significance. Here, we identified extra spindle pole bodies-like 1 (ESPL1) was responsible for apatinib resistance in GC cells through CRISPR genome-wide gain-of-function screening. Loss of function studies further showed that ESPL1 inhibition suppressed cell proliferation, migration and promoted apoptosis in vitro, and accordingly ESPL1 knockdown sensitized GC cells to apatinib...
February 24, 2024: Cancer Cell International
https://read.qxmd.com/read/38402182/emerging-trends-in-the-coexistence-of-primary-lung-cancer-and-hematologic-malignancy-a-comprehensive-analysis-of-clinicopathological-features-and-genetic-abnormalities
#31
JOURNAL ARTICLE
Mengchen Lyu, Lifeng Luo, Ling Zhou, Xiangran Feng, Jin Yang, Ziwei Xu, Xianwen Sun, Zhiyao Bao, Xiaofei Wang, Beili Gao, Yi Xiang
BACKGROUND: The incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic malignancies (PHM), is rising. This study aims to analyze clinicopathological features, gene abnormalities, and prognostic outcomes in individuals diagnosed with PLC-PHM MPC. METHODS: A retrospective analysis included 89 patients diagnosed with PLC-PHM MPC at the Respiratory or Hematology Departments of Ruijin Hospital from 2003 to 2022 (a total of 842,047 people)...
February 24, 2024: Cancer Cell International
https://read.qxmd.com/read/38402174/acadl-yap-axis-activity-in-non-small-cell-lung-cancer-carcinogenicity
#32
JOURNAL ARTICLE
Kegong Chen, Chunqiao Hong, Weibo Kong, Guanghua Li, Zhuang Liu, Kechao Zhu, Chen Lu, Panpan Si, Pan Gao, Guangyao Ning, Renquan Zhang
BACKGROUND: The role of Acyl-CoA dehydrogenase long chain (ACADL) in different tumor types had different inhibiting or promoting effect. However, its role in non-small cell lung cancer (NSCLC) carcinogenicity is not clear. METHOD: In this study, we utilized The Cancer Genome Atlas (TCGA) database to analyze ACADL expression in NSCLC and its correlation with overall survival. Furthermore, we investigated the function of ACADL on cellular proliferation, invasion, colony, apoptosis, cell cycle in vitro with NSCLC cells...
February 24, 2024: Cancer Cell International
https://read.qxmd.com/read/38402166/slc25a17-inhibits-autophagy-to-promote-triple-negative-breast-cancer-tumorigenesis-by-ros-mediated-jak2-stat3-signaling-pathway
#33
JOURNAL ARTICLE
Haiting Zhou, Jiahao Li, Yi He, Xiaohui Xia, Junxia Liu, Huihua Xiong
BACKGROUND: SLC25A17, a peroxisomal solute carrier, has been implicated in various physiological and pathological processes. However, its precise roles and underlying mechanisms in triple-negative breast cancer (TNBC) remain incompletely understood. METHODS: The expression and survival data of breast cancer were derived from TCGA and GEO databases. A variety of in vitro assays were conducted, including proliferation, apoptosis, cell cycle, migration, and invasion...
February 24, 2024: Cancer Cell International
https://read.qxmd.com/read/38388890/retraction-note-gpx8-is-transcriptionally-regulated-by-foxc1-and-promotes-the-growth-of-gastric-cancer-cells-through-activating-the-wnt-signaling-pathway
#34
Hong Chen, Lu Xu, Zhi-Li Shan, Shu Chen, Hao Hu
No abstract text is available yet for this article.
February 22, 2024: Cancer Cell International
https://read.qxmd.com/read/38383388/super-enhancer-related-gene-anp32b-promotes-the-proliferation-of-acute-myeloid-leukemia-by-enhancing-myc-through-histone-acetylation
#35
JOURNAL ARTICLE
Xiaomei Wan, Jianwei Wang, Fang Fang, Yixin Hu, Zimu Zhang, Yanfang Tao, Yongping Zhang, Juanjuan Yu, Yumeng Wu, Bi Zhou, Hongli Yin, Li Ma, Xiaolu Li, Ran Zhuo, Wei Cheng, Shuqi Zhang, Jian Pan, Jun Lu, Shaoyan Hu
BACKGROUND: Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has been found to regulate hematopoiesis and CML leukemogenesis by inhibiting p53 activity. However, recent study suggests that ANP32B exerts a suppressive effect on B-cell acute lymphoblastic leukemia (ALL) in mice by activating PU.1. Nevertheless, the precise underlying mechanism of ANP32B in AML remains elusive...
February 22, 2024: Cancer Cell International
https://read.qxmd.com/read/38383371/rna-binding-proteins-signature-is-a-favorable-biomarker-of-prognosis-immunotherapy-and-chemotherapy-response-for-cervical-cancer
#36
JOURNAL ARTICLE
Xiaomei Chen, Xunhu Dong, Hong Li, Tingting Wu, Haoyin Liu, Jie Wu, Wei Ge, Lingji Hao, Zhe Zhang
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) still present a huge threaten to women's health, especially the local advanced patients. Hence, developing more effectiveness prognostic signatures is urgently needed. This study constructed and verified a robust RNA-binding proteins (RBPs) related signature through a series of bioinformatics methods and explored the biological function of hub RBP in vitro experiments. As a result, the 10 RBPs signature was successfully established and could act as an independent prognostic biomarker in CESC patients, which displayed the highest sensitivity and specificity in prognosis prediction compared with other clinicopathological parameters...
February 21, 2024: Cancer Cell International
https://read.qxmd.com/read/38374122/signature-construction-and-molecular-subtype-identification-based-on-liver-specific-genes-for-prediction-of-prognosis-immune-activity-and-anti-cancer-drug-sensitivity-in-hepatocellular-carcinoma
#37
JOURNAL ARTICLE
Xiuzhi Zhang, Zhefeng Xiao, Xia Zhang, Ningning Li, Tao Sun, JinZhong Zhang, Chunyan Kang, Shasha Fan, Liping Dai, Xiaoli Liu
BACKGROUND: Liver specific genes (LSGs) are crucial for hepatocyte differentiation and maintaining normal liver function. A deep understanding of LSGs and their heterogeneity in hepatocellular carcinoma (HCC) is necessary to provide clues for HCC diagnosis, prognosis, and treatment. METHODS: The bulk and single-cell RNA-seq data of HCC were downloaded from TCGA, ICGC, and GEO databases. Through unsupervised cluster analysis, LSGs-based HCC subtypes were identified in TCGA-HCC samples...
February 19, 2024: Cancer Cell International
https://read.qxmd.com/read/38374035/platycodin-d2-enhances-p21-cyclina2-mediated-senescence-of-hcc-cells-by-regulating-nix-induced-mitophagy
#38
JOURNAL ARTICLE
Lili Sun, Yaru Li, Renshuang Zhao, Qinlei Fan, Fei Liu, Yilong Zhu, Jicheng Han, Yunyun Liu, Ningyi Jin, Xiao Li, Yiquan Li
BACKGROUND: Hepatocellular carcinoma (HCC) cells usually show strong resistance to chemotherapy, which not only reduces the efficacy of chemotherapy but also increases the side effects. Regulation of autophagy plays an important role in tumor treatment. Cell senescence is also an important anti-cancer mechanism, which has become an important target for tumor treatment. Therefore, it is of great clinical significance to find anti-HCC drugs that act through this new mechanism. Platycodin D2 (PD2) is a new saponin compound extracted from the traditional Chinese medicine Platycodon grandiflorum...
February 19, 2024: Cancer Cell International
https://read.qxmd.com/read/38369484/the-clustering-status-of-detached-gastric-cancer-cells-inhibits-anoikis-induced-ferroptosis-to-promote-metastatic-colonization
#39
JOURNAL ARTICLE
Juan Sun, Jie Li, Kostas Pantopoulos, Yuqin Liu, Yixuan He, Weiming Kang, Xin Ye
BACKGROUND AND PURPOSE: Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. Its role in cancer metastasis remains unclear. In this study, we aimed to investigate the potential involvement of ferroptosis in gastric cancer (GC) metastasis. METHODS: GC cells (AGS, MKN45, HGC27) were used to explore the role of ferroptosis in single and clustered cells with extracellular matrix (ECM) detachment in vitro. We overexpressed glutathione peroxidase 4 (GPX4) to inhibit ferroptosis and assessed the changes in cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT)...
February 18, 2024: Cancer Cell International
https://read.qxmd.com/read/38368331/correction-a-novel-mechanism-by-which-acta2-as1-promotes-cervical-cancer-progression-acting-as-a-cerna-of-mir-143-3p-to-regulate-smad3-expression
#40
Lingli Luo, Min Wang, Xianping Li, Can Luo, Shan Tan, Sheng Yin, Lei Liu, Xiaolin Zhu
No abstract text is available yet for this article.
February 17, 2024: Cancer Cell International
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