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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://read.qxmd.com/read/30888122/evaluation-of-changes-in-enamel-thickness-after-orthodontic-treatment-depending-on-the-force-applied-to-remove-orthodontic-brackets-oct-analysis-and-universal-testing-machine
#1
Monika Elżbieta Machoy, Julia Seeliger, Liliana Szyszka-Sommerfeld, Robert Koprowski, Tomasz Gedrange, Krzysztof Woźniak
BACKGROUND: Adhesive materials used in orthodontics have contributed to the broadening of treatment options with fixed braces. The adhesive materials physically and chemically bond to the enamel surface and orthodontic bracket base, which, apart from offering advantages, also entails the risk of enamel damage when removing these materials from the tissue surface after the treatment is complete. OBJECTIVES: The objective of this study was to assess how the bond strength of adhesive materials affects enamel thickness after removing brackets and whether the type of bonding system affects the amount of adhesive strength of the discussed materials...
March 19, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30888121/association-of-total-acylated-and-unacylated-ghrelin-with-apolipoprotein-a1-and-insulin-concentrations-in-acromegalic-patients
#2
Hanna Komarowska, Barbara Bromińska, Nadia Sawicka-Gutaj, Magdalena Jaskula-Świtek, Ryszard Waśko, Marek Ruchała, Gabriel Bromiński, Małgorzata Kotwicka
BACKGROUND: Ghrelin is a hormone that occurs in acylated (AG) or unacylated (UG) form. Ghrelin strongly stimulates growth hormone (GH) secretion from anterior pituitary, as well as regulates the energy balance and various metabolic parameters. Increased consideration is given to UG, thought to be inactive. OBJECTIVES: We aimed to evaluate the levels of total ghrelin, AG and UG in medically naive and treated patients with biochemically active acromegaly, with respect to variables of lipid and glucose metabolism...
March 19, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30888120/design-and-characteristics-of-new-experimental-chlorhexidine-dental-gels-with-anti-staining-properties
#3
Zbigniew Raszewski, Agnieszka Nowakowska-Toporowska, Joanna Weżgowiec, Danuta Nowakowska
BACKGROUND: Chlorhexidine-based products are often used in medicine and dentistry as dental hygiene and therapeutic products, especially by patients with various oral tissue diseases. However, these products have disadvantages, such as low stability, as well as discoloration of the teeth and dental reconstruction materials. OBJECTIVES: The aim of this study was to create and evaluate experimental chlorhexidine (CHX) gels with anti-staining properties and to compare them with 3 commercially available products...
March 18, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30880375/urinary-bladder-hypertrophy-and-overactive-bladder-determine-urinary-continence-after-radical-prostatectomy
#4
Kajetan Juszczak, Adam Ostrowski, Jan Adamowicz, Piotr Maciukiewicz, Tomasz Drewa
BACKGROUND: Several clinical and biological factors exacerbate urinary incontinence (UI) and reduce the patient's quality of life after radical prostatectomy (RP). OBJECTIVES: The purpose of this study was to evaluate the effects of urinary bladder hypertrophy and overactive bladder (OAB) on UI in patients after RP. MATERIAL AND METHODS: Seventy patients were enrolled in the study and were divided into 2 groups: patients with bladder outlet obstruction (BOO) but without OAB (Group I; n = 20) and patients with BOO and OAB (Group II; n = 50)...
March 14, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30868771/response-to-the-article-perioperative-standards-for-the-treatment-of-coagulation-disorders-and-usage-of-blood-products-in-patients-undergoing-liver-transplantation-used-in-the-clinic-for-transplant-surgery-in-wroc%C3%A5-aw
#5
LETTER
Jan Pluta, Agnieszka Cieniewicz, Janusz Trzebicki
We read with interest the article by Łukaszewski et al. published in Advances in Clinical and Experimental Medicine:1211-1215, published online on July 18th, 2018, as ahead of print). As enthusiasts of promoting global assays of hemostasis, we would like to commend the authors for their commitment and effort in their implementation and clinical application. As the authors rightly pointed out in the article, perioperative care of liver transplantation (OLTx) patients is challenging for transplant team members due to the risk of severe changes in global hemostasis...
March 12, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30868770/the-association-of-serum-soluble-klotho-levels-and-residual-diuresis-and-overhydration-in-peritoneal-dialysis-patients
#6
Dorota Sikorska, Krzysztof Pawlaczyk, Ewa Baum, Maria Wanic-Kossowska, Natasza Czepulis, Joanna Łuczak, Włodzimierz Samborski, Andrzej Oko
BACKGROUND: Klotho, originally identified as an anti-aging factor, is a transmembrane protein expressed in the kidney. It has been reported that Klotho deficiency could be associated with a loss of residual renal function and cardiovascular complications in peritoneal dialysis (PD) patients. OBJECTIVES: The main aim of the study was to evaluate whether serum levels of Klotho correlate with residual diuresis and hydration status in PD patients. MATERIAL AND METHODS: The cross-sectional study involved 57 PD patients ≥18 years of age who had been on PD ≥ 3 months...
March 11, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30855728/correlation-of-rs749292-and-rs700518-polymorphisms-in-the-aromatase-gene-cyp19a1-with-osteoporosis-in-postmenopausal-polish-women
#7
Adam Kamiński, Anna Bogacz, Małgorzata Górska-Paukszta, Agnieszka Seremak-Mrozikiewicz, Bogusław Czerny
MATERIAL AND METHODS: The study included 675 unrelated women (109 women with osteopenia, 333 women with osteoporosis, and 233 healthy women). Genomic DNA was extracted from the blood samples and the CYP19A1 polymorphisms were determined using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Bone mineral density at the lumbar spine (L1-L4) was measured with dual energy X-ray absorptiometry (DEXA). RESULTS: The analysis of the CYP19A1 rs749292 polymorphism showed that there were no statistically significant differences in the distribution of genotypes between the study groups with osteoporosis and osteopenia and the control group...
March 11, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30855727/the-relationships-between-glycemic-index-and-glycemic-load-of-diets-and-nutritional-status-and-antioxidant-oxidant-status-in-the-serum-of-patients-with-lung-cancer
#8
Katarzyna Agnieszka Zabłocka-Słowińska, Katarzyna Skórska, Sylwia Placzkowska, Anna Prescha, Konrad Pawełczyk, Monika Kosacka, Irena Porębska, Halina Grajeta
BACKGROUND: A low glycemic index (GI) and glycemic load (GL) of diets as well as proper nutritional status may partially slow down depletion in antioxidant capacity, and may therefore have an impact on antioxidant/ oxidant status in lung cancer patients. However, no studies concerning these associations had previously been conducted. OBJECTIVES: The aim of this study was to investigate the association between GI or GL and nutritional status and antioxidant/oxidant status in lung cancer patients...
March 9, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30843674/knockdown-of-long-noncoding-rna-malat1-aggravates-hypoxia-induced-cardiomyocyte-injury-by-targeting-mir-217
#9
Yuan Yao, Xiaoying Fan, Bo Yu, Tianfa Li, Yao Zhang
BACKGROUND: Expression of long noncoding (lncRNA) Malat1 can be increased by hypoxia in cardiomyocyte. Downregulation of Malat1 contributes to the reduction of cardiomyocyte apoptosis. However, the function of Malat1 in myocardial ischemia is unclear. OBJECTIVES: This study investigated the functional role of lncRNA Malat1 in hypoxia-induced H9c2 cell injury. MATERIAL AND METHODS: H9c2 cells were exposed to hypoxia treatment. Cell proliferation, migration, invasion, and apoptosis were detected using trypan blue exclusion assay, two-chamber migration/invasion assay, annexin V-FITC/PI staining, and western blotting, respectively...
March 7, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30843673/does-oral-dryness-influence-quality-of-life-current-perspectives-in-elderly-dental-care
#10
Katarzyna Skośkiewicz-Malinowska, Barbara Malicka, Marek Ziętek, Urszula Kaczmarek
BACKGROUND: The oral condition can functionally, socially and psychologically influence the quality of life. Oral dryness often occurs in the elderly due to the presence of systemic diseases and medications, which favors the development of many lesions and complaints, including dental caries, candidiasis, retention of full removable denture, taste disturbance and it enforces a change in nutrition. OBJECTIVES: The aim of this study was to assess the impact of oral dryness on oral health-related quality of life in older subjects...
March 7, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30843672/melatonin-protects-against-streptozotocin-induced-diabetic-cardiomyopathy-through-the-mammalian-target-of-rapamycin-mtor-signaling-pathway
#11
Yasemin Behram Kandemir, Veysel Tosun, Ünal Güntekin
BACKGROUND: Several studies demonstrated that the overexpression of mammalian target of rapamycin (mTOR) signaling protein is associated with cardiomyopathy. However, the effect of mTOR on the heart in hyperglycemic condition is still controversial. OBJECTIVES: We aimed to investigate the expression of mTOR and antioxidant enzyme activity in cardiac hypertrophy in rats with streptozotocin-induced diabetes mellitus (DM), and the effects of the melatonin on diabetic cardiomyopathy (DCM)...
March 7, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30843678/circulating-and-circular-rnas-and-the-need-for-rationalization-and-synthesis-of-the-research-spiral
#12
REVIEW
Pavel Dvorak, Sarah Leupen, Pavel Soucek
In this essay, we aim to draw a short comparison between 2 important research topics - circular and circulating RNAs - and show how they are connected. The findings described here in the field of circular RNAs, which are still quite obscured by the rapidly expanding body of knowledge in biology, have added another dimension to our view of the process of gene expression, which is formed by a more complex network of molecule interactions than we previously thought. The term "circulating RNAs" refers to a broad spectrum of RNA fragments originating from different sources, such as physiologically dying cells, sites of inflammation or cancer cells, and fragments floating in human liquid tissues together with other elements...
March 6, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30843677/expression-profile-of-galp-alarin-and-their-receptors-in-rat-adrenal-gland
#13
Marianna Tyczewska, Paulina Milecka, Marta Szyszka, Piotr Celichowski, Karol Jopek, Hanna Komarowska, Ludwik Kazimierz Malendowicz, Marcin Ruciński
BACKGROUND: Galanin-like peptide (Galp) and alarin (Ala) are 2 new members of the galanin peptide family. Galanin (Gal), the "parental" peptide of the entire family, is known to regulate numerous physiological processes, including energy and osmotic homeostasis, reproduction, food intake, and secretion of adrenocortical hormones. Galp and Ala are known to regulate food intake. In the rat, Galp mRNA has been found in the brain, exclusively in the hypothalamic arcuate nucleus (ARC) and median eminence, which are involved in the regulation of energy homeostasis...
March 6, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30843676/serum-testosterone-depression-as-a-factor-influencing-the-general-condition-in-chronic-obstructive-pulmonary-disease-patients
#14
Renata Rubinsztajn, Tadeusz Przybyłowski, Marta Maskey-Warzęchowska, Krzysztof Karwat, Ryszarda Chazan
BACKGROUND: Testosterone has been recognized for its anabolic properties. It has been documented that in patients with chronic obstructive pulmonary disease (COPD), chronic hypoxia, disease severity, smoking, and corticosteroid treatment may contribute to low testosterone levels. OBJECTIVES: The aim of the study was to evaluate the incidence of decreased serum testosterone concentration in male COPD patients and its influence on their condition. MATERIAL AND METHODS: The study group consisted of 90 male patients, aged 67...
March 6, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30843675/long-term-administration-of-fenspiride-has-no-negative-impact-on-bone-mineral-density-and-bone-turnover-in-young-growing-rats
#15
Agnieszka Matuszewska, Beata Nowak, Diana Jędrzejuk, Marcin Landwójtowicz, Marek Bolanowski, Wojciech Dziewiszek, Anna Merwid-Ląd, Ewa Szeląg, Krzysztof Zduniak, Joanna Kwiatkowska, Adam Szeląg
BACKGROUND: Fenspiride is an antagonist of H1-histamine receptors that is used to treat acute and chronic respiratory tract infections and otitis media in children and adolescents. OBJECTIVES: The aim of the study was to assess the influence of long-term administration of fenspiride on bone mineral density (BMD) and bone turnover in young growing rats. MATERIAL AND METHODS: The experiment was carried out on 18 young (8-week-old) male Wistar rats receiving either fenspiride 15 mg/kg intragastrically (ig) (group F) or saline solution 4 mL/kg ig (group C) for 3 months...
March 6, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30835972/advanced-heart-failure-a-review
#16
REVIEW
Klementyna Kępińska, Daria Maria Adamczak, Marta Kałużna-Oleksy
Heart failure (HF) has been recognized as a pandemic and is a serious clinical and health problem associated with significant mortality, morbidity and expenditure on healthcare, especially among older people. Progress in medicine has made it possible for an increasing number of people with HF to live longer than ever before. Therefore, a new and serious clinical problem has appeared - advanced heart failure (AHF). A better understanding of this issue is very important, because there are many more patients waiting for transplantations than there are available hearts...
March 4, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30811903/biological-and-psychological-components-of-depression-in-patients-receiving-ifn-alpha-therapy-for-hepatitis-c
#17
Krzysztof Małyszczak, Małgorzata Inglot, Dorota Frydecka, Tomasz Hadryś, Tomasz Pawłowski
BACKGROUND: Depressive symptoms are frequent side effects of interferon α therapy (IFN-α). Both biological and psychological processes may occur concomitantly during hepatitis C treatment. OBJECTIVES: This study was carried out to determine the impact of biological (immune response) and psychological factors on formation of depressive symptoms and major depressive disorder (MDD) during hepatitis C treatment. MATERIAL AND METHODS: A total of 99 patients receiving pegylated IFN-α and ribavirin for chronic C type hepatitis participated in the prospective cohort study...
February 27, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30817097/negative-body-image-in-breast-cancer-patients
#18
REVIEW
Agata Kołodziejczyk, Tomasz Pawłowski
The aim of this overview study is to familiarize readers with the impact of changes to body image (BI) among patients treated for breast cancer. Body image is subjected to many changes during oncological treatment and every method of treatment (surgery, chemotherapy, radiotherapy, and hormone therapy) can have a negative impact on the way the treated patients perceive their bodies. The article differentiates the susceptibility of patients to a worsened self-image due to their pre-disease personality, socioeconomic factors, age, and declared sense of control during the oncological treatment...
February 26, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30784239/audiologic-prognostic-factors-for-hearing-preservation-following-vestibular-schwannoma-surgery
#19
Aleksandra Ochal-Choińska, Magdalena Lachowska, Katarzyna Kurczak, Kazimierz Niemczyk
BACKGROUND: Postoperative hearing loss after vestibular schwannoma (VS) removal still remains a lifelong problem for the patients. The present study analyzes the problem of hearing preservation after VS removal from a different angle than available professional literature on this topic. OBJECTIVES: To identify audiologic factors which determine the extent of hearing loss in patients operated on for VS. MATERIAL AND METHODS: The study group included 86 patients operated on due to VS accessed via the middle cranial fossa...
February 19, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30784241/association-of-coronary-artery-disease-with-toll-like-receptor-4-genetic-variants-a-meta-analysis
#20
Jianlong Sheng, Jian Xu
BACKGROUND: Toll-like receptor 4 (TLR4) plays an important role in the formation of coronary atherosclerotic plaque and the pathogenesis of coronary artery disease (CAD). OBJECTIVES: The aim of the study was to conduct a meta-analysis assessing the relationship between 2 common genetic variants in the TLR4 gene (rs4986790 and rs4986791) and susceptibility to CAD. MATERIAL AND METHODS: A systematic search of Web of Science, Embase, Scopus, Pubmed, and Wanfang Med Online was undertaken...
February 18, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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