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Journals Advances in Clinical and Exper...

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University

https://read.qxmd.com/read/38860714/association-of-anion-gap-and-albumin-corrected-anion-gap-with-acute-kidney-injury-in-patients-with-acute-ischemic-stroke
#1
JOURNAL ARTICLE
Haiqian Yao, Jianan Tian, Shi Cheng
BACKGROUND: Acute kidney injury (AKI) has become a common complication of acute ischemic stroke (AIS) and may have a significant impact on clinical outcomes. Anion gap (AG)/albumin corrected anion gap (ACAG) are used to assess acid-base balance status and help identify the severity of metabolic acidosis. OBJECTIVES: To explore the association of AG and ACAG with the risk of AKI in AIS patients admitted to the intensive care unit (ICU). MATERIAL AND METHODS: Data of AIS patients in this retrospective cohort study were extracted from the electronic ICU (eICU) databases (2014-2015)...
June 11, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38860713/supported-transitional-care-applied-to-stroke-survivors-a-meta-analysis
#2
JOURNAL ARTICLE
Shuyin Liang, Huiling Xie, Lili Ye, Caifang Huang, Fengying Yuan, Yanping Tang
BACKGROUND: This meta-analysis aims to assess the outcomes of supported intervention transitional care compared to traditional care for stroke survivors. MATERIAL AND METHODS: A systematic literature review was accomplished and 4,437 stroke patients were recruited for the current study; 2,211 of them were treated with transitional care and 2,226 with traditional care. The inclusion criteria of the current study recruited only randomized clinical trials up until November 2023...
June 11, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38860712/advantages-and-limitations-of-nanostructures-for-biomedical-applications
#3
REVIEW
Szymon Roszkowski, Zofia Durczynska
This review examines recent progress in developing nanoscale drug delivery systems for biomedical applications. Key nanocarriers, including inorganic nanoparticles, dendrimers, protein nanoparticles, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), and biopolymeric nanoparticles, were summarized. Compared with free drugs, the tunable physicochemical properties of these materials allow for the encapsulation of therapeutics and improved pharmacokinetics. However, limitations such as toxicity, poor biodegradability, lack of controlled release, and low encapsulation efficiency remain...
June 11, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38860711/survival-benefits-of-gastrectomy-in-patients-with-metastatic-gastric-cancer-a-meta-analysis
#4
JOURNAL ARTICLE
Lifan Chen, Yu Chen
BACKGROUND: Individuals with metastatic gastric cancer (MGC) are incurable and have a poor prognosis. To date, surgical resection with curative intent is the only treatment providing hope for a cure, but the role of surgical resection is still controversial. OBJECTIVES: To assess the effects of gastrectomy compared to non-resection on MGC patient survival. MATERIAL AND METHODS: PubMed, Embase, Cochrane Library, and Web of Science databases were searched up to October 10, 2023...
June 11, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38819940/comparison-of-t-cell-maturation-profiles-in-the-1st-and-5th-wave-of-covid-19-in-the-polish-population
#5
JOURNAL ARTICLE
Elżbieta Rutkowska, Iwona Kwiecień, Agata Raniszewska, Krzysztof Kłos, Iwona Melnicka, Piotr Rzepecki, Andrzej Chciałowski
BACKGROUND: The coronavirus pandemic has become the most critical global health threat of this century and the greatest challenge to the human population. The search for simple and quick diagnostic methods enabling the identification of patients infected with the SARS-CoV-2 virus may be a valuable method to track infection. OBJECTIVES: The aim of the study was the clinical and immunological characterization of patients by assessing the degrees of maturity of T lymphocytes from the 1st and 5th waves of coronavirus disease 2019 (COVID-19) in comparison to a healthy control group (HC)...
May 31, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38819939/expression-of-cd226-on-%C3%AE-%C3%AE-t-cells-is-lower-in-advanced-chronic-lymphocytic-leukemia-and-correlates-with-iga-igg-and-ldh-levels
#6
JOURNAL ARTICLE
Michał K Zarobkiewicz, Natalia Lehman, Wioleta Kowalska, Izabela Dąbrowska, Agnieszka Bojarska-Junak
BACKGROUND: Gamma-delta (γδ) T cells comprise an important subset of human T cells, responding to viral and bacterial infections, and are significant for cancer immunosurveillance. Human γδ T cells are divided into 5 major subsets, namely Vδ1-Vδ5, of which the latter 3 have limited available literature. At present, Vδ2 is the most studied subpopulation. OBJECTIVES: In the current paper, we focused on non-Vδ2 cells in chronic lymphocytic leukemia (CLL)...
May 31, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38819938/study-on-regulating-aqp1-aqp3-aqp4-5-ht-nos1-in-slow-transit-constipation-rats-by-liqi-tongbian-mixture
#7
JOURNAL ARTICLE
Min Liu, Jianyong Chen, Chenger Zhan, Shuwen Wu, Zhaolin Zhang, Chenyang Wang, Linlin Shi, Dongya Chen
BACKGROUND: Liqi Tongbian is a traditional Chinese medicine (TCM) preparation that contains herbs that may treat slow transit constipation (STC). Atractylodes macrocephala, Astragalus membranaceus, Fructus aurantii, radish seed, uncooked Polygonum multiflorum, and Agastache rugosa were included in the formula for their unique qualities. The control of water transfer in the colon is greatly influenced by aquaporin 3 (AQP3). OBJECTIVES: Based on this, the Liqi Tongbian mixture was used to detect the concentrations of aquaporins (AQPs), 5-HT and nitrix oxide synthase 1 (NOS1) in STC rats, and explore its effect, in order to provide a theoretical basis for the remedy of STC with TCM...
May 31, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38775333/transcriptome-analysis-of-immune-inflammatory-regulation-in-tremella-fuciformis-derived-polysaccharide-reeducated-b16-cells-a-subcutaneous-model
#8
JOURNAL ARTICLE
Xiumin Li, Qiaoling Su, Yutian Pan
BACKGROUND: Circulating cancer cells have characteristics of tumor self-targeting. Modified circulating tumor cells may serve as tumor-targeted cellular drugs. Tremella fuciformis-derived polysaccharide (TFP) is related to immune regulation and tumor inhibition, so could B16 cells reeducated by TFP be an effective anti-tumor drug? OBJECTIVES: To evaluate the intrinsic therapeutic potential of B16 cells exposed to TFP and clarify the therapeutic molecules or pathways altered by this process...
May 22, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38742745/is-there-a-role-of-calprotectin-testing-in-the-diagnosis-of-surgical-site-infections-after-total-hip-and-knee-arthroplasty-a-preliminary-study
#9
JOURNAL ARTICLE
Dariusz Grzelecki, Dariusz Marczak, Piotr Dudek, Tomasz Okoń, Bartłomiej Kordasiewicz, Jacek Kowalczewski
BACKGROUND: Recent studies have revealed the usefulness of synovial calprotectin (CLP) in diagnosing chronic periprosthetic joint infections (PJIs). However, there is still a lack of evidence to support the use of serum CLP in the diagnosis of early PJIs and surgical site infections (SSIs) after total joint arthroplasties (TJAs). OBJECTIVES: The primary aim of this study is to investigate the standard kinetics of CLP concentrations in the blood during the very early postoperative period after non-complicated total hip arthroplasty (THA) and total knee arthroplasty (TKA)...
May 14, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38742739/recombinant-klotho-protein-protects-pulmonary-alveolar-epithelial-cells-against-sepsis-induced-apoptosis-by-inhibiting-the-bcl-2-bax-caspase-3-pathway
#10
JOURNAL ARTICLE
Xiao Bo Li, Jia Li Liu, Shuang Zhao, Jing Li, Guang-Yan Zhang, Qing Tang, Wei Yong Chen
BACKGROUND: Inflammation-induced apoptosis of alveolar type II epithelial cells is a primary contributor to sepsis-induced acute respiratory distress syndrome (ARDS). Klotho is a single-pass transmembrane protein with anti-inflammatory and anti-apoptotic effects. However, the role and mechanism of Klotho in the development of ARDS remains unknown. OBJECTIVES: This study aimed to investigate the effect of Klotho on sepsis-induced apoptosis in human pulmonary alveolar epithelial cells (HPAEpiCs) together with the potential mechanism...
May 14, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38739103/safety-and-efficacy-of-yaobitong-capsules-for-lumbar-disc-herniation-a-multicenter-randomized-double-blinded-parallel-positive-controlled-clinical-trial
#11
JOURNAL ARTICLE
Ye Zhao, Shi Rong Huang, Yu Jie Zhang, Yong Qiang Chen, Wen Gang Liu, Fu Shun Gu, Hui Wen, Xi Lin Xu, Jiu Yi Chen, Da Xiang Jin, Hong Yin, Zhong Dong, Wei An Yuan, Hong Sheng Zhan
BACKGROUND: Lumbar disc herniation (LDH) is one of the most common diseases and is a global medical and socioeconomic problem characterized by leg or back pain, weakness in the lower extremities and paresthesia. OBJECTIVES: A multicenter, randomized, double-blinded, parallel, positive-controlled clinical trial was conducted to evaluate the efficacy and safety of Yaobitong capsules (YBT) for LDH. MATERIAL AND METHODS: Patients (n = 479) were recruited and randomized into YBT and Jingyaokang capsule (JYK) groups (the positive control), and received YBT or JYK at a dose of 3 capsules 3 times per day after a meal for 30 days...
May 13, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38739089/building-diagnostic-neuroimaging-biomarkers-for-psychiatric-disorders-using-reverse-inference-approaches-a-viable-route
#12
EDITORIAL
Donato Liloia, Tommaso Costa, Franco Cauda, Jordi Manuello
The advent of structural magnetic resonance imaging (sMRI) at the end of the 20th century opened the way toward a deeper understanding of the neurophysiology of psychiatric disorders, substantiating regional structural abnormalities underlying this group of clinical conditions. However, despite abundant and flourishing scientific research, sMRI methodologies are not currently integrated into daily diagnostic practice. One reason behind this failed translation may be the prevailing approach to logical reasoning in neuroimaging: The forward inference via frequentist-based statistics...
May 13, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38683047/forensic-value-of-soft-tissue-detachments-from-the-hyoid-bone-in-death-due-to-strangulation-asphyxia
#13
JOURNAL ARTICLE
Giovanna Del Balzo, Guido Pelletti, Dario Raniero, Alessia Farinelli, Andrea Uberti, Elisa Vermiglio, Gabriele Molteni, Riccardo Nocini, Stefano Gobbo, Francesco Taus, Albino Eccher, Claudio Luchini, Matteo Brunelli
BACKGROUND: There are no unequivocal histopathological findings for the diagnosis of fatal asphyxia due to neck compression. From the observation of a series of asphyxiation cases, we noted, during microscopic analysis, a high frequency of "detachment" of soft tissues from the hyoid bone. This specifically refers to the presence of an optical space between the surface of the hyoid bone and soft tissues. OBJECTIVES: We aimed to evaluate the detachment of soft tissues from the hyoid bone as specific histological evidence of death due to strangulation asphyxia...
April 29, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38683046/from-hallucinations-to-delusions-a-narrative-review-of-psychotic-like-experiences-and-their-implications
#14
REVIEW
Katarzyna Logoń, Gabriela J Świrkosz, Krzysztof Kowalski
Psychotic-like experiences (PLEs) refer to sub-threshold hallucinations and delusions observed in both clinical samples and the general population. Psychotic-like experiences have far-reaching implications for an individual's coping strategies and daily functioning. They are associated with both psychotic and non-psychotic disorders. This article presents a comprehensive review of the current literature on PLEs, incorporating a detailed exploration of the definition, prevalence, risk factors, functional impairments, and comorbid psychiatric disorders...
April 29, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38683045/small-rna-sequencing-highlights-a-potential-regulatory-network-mediated-by-gecko-mirna-affecting-the-prognosis-of-hepatocellular-carcinoma
#15
JOURNAL ARTICLE
Zhaosheng Li, Jing Zhao, Linzhu Lu, Dongchang Tong, Zhen Huang, Yongli Wang, Chun Yi, Xuefei Tian
BACKGROUND: Gecko has been widely documented in Chinese scientific literature as an anti-tumor agent for various illnesses for thousands of years, and more recently, it has been examined for its anti-tumor effects on several cancers. The effect of Gecko microRNAs (miRNAs) on hepatocellular carcinoma (HCC) has not yet been reported. OBJECTIVES: This study was designed to identify miRNAs in Gecko through small RNA sequencing and utilize bioinformatics techniques to construct a potential regulatory network and explore the possible mechanisms of exogenous miRNAs involved in HCC...
April 29, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38683044/polycythemia-vera-and-essential-thrombocythemia-of-intermediate-age-a-real-life-multicenter-analysis-of-first-line-treatment-approach
#16
JOURNAL ARTICLE
Patryk Sobieralski, Maria Bieniaszewska, Łukasz Bołkun, Tomasz Sacha, Magdalena Muzalewska-Wolska, Wojciech Homenda, Łucja K Bartkowiak, Justyna Smith, Marcin Rymko, Anna Jachalska, Andrzej R Mital, Witold Prejzner, Jan Zaucha
BACKGROUND: The treatment of patients with polycythemia vera (PV) and essential thrombocythemia (ET) is conducted according to well-defined risk stratification systems. We hypothesized that adherence to the guidelines, namely the decision to refrain from introducing cytoreduction in non-high-risk patients, is particularly difficult in patients diagnosed when they are between 40 and 59 years of age (intermediate-age group). OBJECTIVES: To evaluate the group of intermediate-age PV and ET patients, focusing on a first-line treatment approach adapted at diagnosis...
April 29, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38628109/withania-somnifera-and-trigonella-foenum-graecum-as-ingredients-of-testosterone-boosting-supplements-possible-clinical-implications
#17
REVIEW
Monika Skrzypiec-Spring, Andrzej Pokrywka, Justyna Kuliczkowska-Płaksej, Adam Szeląg, Marek Bolanowski
This narrative review provides an overview of scientific studies on dietary supplements that may affect circulating testosterone (T) levels to explore which substances are scientifically proven to increase T concentration. We also review the scientific literature for their potential mechanisms and laboratory test changes triggered by their use. Based on the analysis of existing data on substances used to increase endogenous T levels, especially double-blind placebo-controlled randomized clinical trials, we selected 2 herbal extracts with the best documented positive effects on T levels, Withania somnifera root and root extracts/leaves and seed extracts of Trigonella foenum-graecum...
April 17, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38628108/validation-of-the-polish-version-of-the-hand-function-scoring-system
#18
JOURNAL ARTICLE
Maciej Belka, Mateusz Koziej, Jan Banach, Marta Dagmara Banach, Marek Trybus
BACKGROUND: The Hand Function Scoring (HFS) system was created to assess the results of rehabilitation treatment after hand injuries. A perceived hand function improvement in patients who underwent carpal tunnel syndrome surgery prompted us to use the Watts HFS questionnaire in our study. OBJECTIVES: The study aimed to: 1) translate and validate the new questionnaire into Polish; 2) analyze the usefulness of the scale in the preand post-operative assessment of patients with carpal tunnel syndrome; and 3) compare the results with other questionnaires recognized as the gold standard in carpal tunnel treatment evaluation...
April 17, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38628107/stabilization-of-the-hypoplastic-thumb-type-blauth-iiib-using-a-non-vascularized-proximal-interphalangeal-joint-from-the-toe-as-an-alternative-reconstruction-when-pollicization-is-not-accepted-description-of-the-surgical-technique
#19
JOURNAL ARTICLE
Michał Górecki, Piotr Czarnecki, Leszek Romanowski
BACKGROUND: A Blauth IIIB hypoplastic thumb is a significant functional and cosmetic problem for the developing hand in children. The gold standard in treatment is amputation and index pollicization. Despite the good functional results, some parents do not consent to the operation, mainly for cosmetic reasons. OBJECTIVES: The aim is to present a detailed description and features of the technique used in our department for stabilization of a hypoplastic thumb type Blauth IIIB with a non-vascularized proximal interphalangeal joint from the toe...
April 17, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38591348/diagnostic-and-prediction-value-of-synthetic-magnetic-resonance-imaging-in-acute-ischemic-stroke-patients
#20
JOURNAL ARTICLE
Ronghui Huang, Lin Zhang, Limeng Deng, Jian-Ou Fang
BACKGROUND: Current knowledge regarding synthetic magnetic resonance imaging in ischemic stroke (MAGiC) is inadequate. OBJECTIVES: The study aimed to investigate the diagnostic and prognostic prediction value of MAGiC in acute ischemic stroke (AIS) patients. MATERIAL AND METHODS: This prospective observational study enrolled 197 AIS patients between January 2022 and May 2023. All patients underwent routine magnetic resonance imaging (MRI), computed tomography (CT) scans, doppler ultrasound, MAGiC, and dynamic contrast-enhanced (DCE)-MRI...
April 9, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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