Zi-Yun Yi, Qiu-Xia Liang, Tie-Gang Meng, Jian Li, Ming-Zhe Dong, Yi Hou, Ying-Chun Ouyang, Chun-Hui Zhang, Heide Schatten, Qing-Yuan Sun, Jie Qiao, Wei-Ping Qian
PKCβI, a member of the classical protein kinase C family, plays key roles in regulating cell cycle transition. Here, we report the expression, localization and functions of PKCβI in mouse oocyte meiotic maturation. PKCβI and p-PKCβI (phosphor-PKCβI) were expressed from germinal vesicle (GV) stage to metaphase II (MII) stage. Confocal microscopy revealed that PKCβI was localized in the GV and evenly distributed in the cytoplasm after GV breakdown (GVBD), and it was concentrated at the midbody at telophase in meiotic oocytes...
February 7, 2019: Cell Cycle