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Circulation Journal: Official Journal of the Japanese Circulation Society

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https://read.qxmd.com/read/31006734/first-hospitalization-tells-us-everything-about-heart-failure
#1
Shintaro Kinugawa, Arata Fukushima
No abstract text is available yet for this article.
April 20, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/31006733/temporal-trends-in-acute-myocardial-infarction-incidence-and-mortality-between-2006-and-2016-in-tokyo-report-from-the-tokyo-ccu-network
#2
Takeshi Yamamoto, Nobuko Yoshida, Morimasa Takayama
BACKGROUND: Temporal trends in the incidence and mortality of acute myocardial infarction (AMI) have not been fully clarified in Japan.Methods and Results:The Tokyo CCU network collects information every 3 months regarding the number of AMI cases, age of patients and in-hospital mortality. Age-adjusted hospitalized AMI numbers were unchanged from 2006 to 2016 (40.7/100,000 persons/year in 2016). Annual age-adjusted in-hospital mortality decreased slightly (5.8% in 2006 to 5.2% in 2016)...
April 20, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/31006732/plasma-renin-activity-is-an-independent-prognosticator-in-patients-with-myocardial-infarction
#3
Daisuke Kamon, Hiroyuki Okura, Akihiko Okamura, Yasuki Nakada, Yukihiro Hashimoto, Yu Sugawara, Tomoya Ueda, Taku Nishida, Kenji Onoue, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
BACKGROUND: Plasma renin activity (PRA) is associated with cardiovascular events in patients with heart failure (HF), but its prognostic role in acute myocardial infarction (AMI) is unclear.Methods and Results:A total of 878 patients with information on baseline PRA on admission were selected from 1,055 AMI patients who underwent emergency coronary angiography between 2007 and 2016. The patients were divided into 2 groups according to their median PRA (2.0 ng/mL/h). The primary endpoint was major adverse cardiac events (MACE), defined as a composite of cardiovascular death and hospitalization because of HF...
April 20, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/31006731/association-of-cyp2c19-polymorphisms-with-clopidogrel-reactivity-and-clinical-outcomes-in-chronic-ischemic-stroke
#4
Tomotaka Tanaka, Hiroshi Yamagami, Masafumi Ihara, Toshiyuki Miyata, Shigeki Miyata, Toshimitsu Hamasaki, Shu Amano, Kazuki Fukuma, Haruko Yamamoto, Jyoji Nakagawara, Eisuke Furui, Shinichiro Uchiyama, Boohan Hyun, Yasumasa Yamamoto, Yasuhiro Manabe, Yasuhiro Ito, Ryuzo Fukunaga, Takeo Abumiya, Masahiro Yasaka, Kazuo Kitagawa, Kazunori Toyoda, Kazuyuki Nagatsuka
BACKGROUND: CYP2C19variants are associated with the antiplatelet effects of clopidogrel against recurrent cardiovascular events. However, it remains unknown whether the elapsed time from stroke onset affects the relationship between the genetic variants and such events. To address this, we conducted a prospective cohort study to determine the effect ofCYP2C19variants on clinical outcomes in the chronic phase.Methods and Results:In total, 518 Japanese non-acute stroke patients treated with clopidogrel were registered at 14 institutions...
April 19, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/31006730/relative-effect-of-current-intensive-lipid-lowering-drugs-on-cardiovascular-outcomes-in-secondary-prevention-a-meta-analysis-of-12-randomized-trials
#5
Shifei Wang, Jiancheng Xiu, Wangjun Liao, Yulin Liao, Jianping Bin
BACKGROUND: We aimed to investigate the comparative cardiovascular benefits of high-dose statin, ezetimibe-statin, and PCSK9 inhibitor-statin treatments in secondary prevention patients.Methods and Results:We selected 12 randomized controlled trials (n=131,978 patients) using PubMed and Embase (inception-June 1, 2018). Subgroup differences were explored by meta-regression and Cochran Q test. The relative effects of high-dose statin, ezetimibe-statin, and PCSK9 inhibitor-statin on major cardiovascular events (MACE), and revascularization were varied and decreased gradually, of which high-dose statin resulted in lower risk of MACE and revascularization than PCSK9 inhibitor-statin per 1 mmol/L reduction of low-density lipoprotein cholesterol (LDL-C): risk ratio (RR) for MACE, 0...
April 19, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/31006729/cardiovascular-risk-assessment-chart-by-dietary-factors-in-japan-nippon-data80
#6
Keiko Kondo, Katsuyuki Miura, Sachiko Tanaka-Mizuno, Aya Kadota, Hisatomi Arima, Nagako Okuda, Akira Fujiyoshi, Naoko Miyagawa, Katsushi Yoshita, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima
BACKGROUND: Many studies show that dietary factors such as vegetables, fruit, and salt are associated with cardiovascular disease (CVD) risk. However, a risk assessment chart for CVD mortality according to combinations of dietary factors has not been established.Methods and Results:Participants were 9,115 men and women aged 30-79 years enrolled in the National Nutritional Survey of Japan in 1980 with a 29-year follow-up. Dietary intake was assessed using a 3-day weighed dietary record at baseline...
April 19, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/31006728/long-term-comparison-of-ethyl-icosapentate-vs-omega-3-acid-ethyl-in-patients-with-cardiovascular-disease-and-hypertriglyceridemia-defat-trial
#7
Akira Sezai, Satoshi Unosawa, Makoto Taoka, Shunji Osaka, Kazuaki Obata, Sakie Kanno, Hisakuni Sekino, Masashi Tanaka
BACKGROUND: Numerous studies have demonstrated a reduction in cardiovascular events when the low-density lipoprotein cholesterol (LDL) level is decreased by statin therapy. However, despite good control of LDL, cardiovascular events may increase if the triglyceride (TG) level is high. We conducted a long-term comparison of treatment of hypertriglyceridemia with ethyl icosapentate (EPA) vs. omega-3-acid ethyl (EPA+docosahexaenoic acid [DHA]).Methods and Results:Cardiac surgery patients with hypertriglyceridemia were randomized to an EPA group (1...
April 19, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30996151/remnant-lipoproteins-are-residual-risk-factor-for-future-cardiovascular-events-in-patients-with-stable-coronary-artery-disease-and-on-statin-low-density-lipoprotein-cholesterol-levels-70-mg-dl
#8
Yuki Fujihara, Takamitsu Nakamura, Takeo Horikoshi, Jun-Ei Obata, Daisuke Fujioka, Yosuke Watanabe, Kazuhiro Watanabe, Kiyotaka Kugiyama
BACKGROUND: This study examined the predictive value of remnant lipoprotein levels for cardiovascular events (CVEs) in patients with stable coronary artery disease (CAD) and low-density lipoprotein cholesterol (LDL-C) levels <70 mg/dL on statin treatment.Methods and Results:Serum levels of remnant lipoproteins (remnant-like lipoprotein particles cholesterol: RLP-C) were measured by an immunoseparation method in 247 consecutive patients with CAD who had on-statin LDL-C levels <70 mg/dL...
April 18, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30996150/clinical-impact-of-coronary-computed-tomography-angiography-derived-fractional-flow-reserve-on-japanese-population-in-the-advance-registry
#9
Yasutsugu Shiono, Hitoshi Matsuo, Tomohiro Kawasaki, Tetsuya Amano, Hironori Kitabata, Takashi Kubo, Yoshihiro Morino, Shunichi Yoda, Tomohiro Sakamoto, Hiroshi Ito, Junya Shite, Hiromasa Otake, Nobuhiro Tanaka, Mitsuyasu Terashima, Kazushige Kadota, Manesh R Patel, Koen Nieman, Campbell Rogers, Bjarne L Nørgaard, Jeroen J Bax, Gilbert L Raff, Kavitha M Chinnaiyan, Daniel S Berman, Timothy A Fairbairn, Lynne M Hurwitz Koweek, Jonathon Leipsic, Takashi Akasaka
BACKGROUND: Coronary computed tomography angiography (cCTA)-derived fractional flow reserve (FFRCT ) is a promising diagnostic method for the evaluation of coronary artery disease (CAD). However, clinical data regarding FFRCT in Japan are scarce, so we assessed the clinical impact of using FFRCT in a Japanese population.Methods and Results:The ADVANCE registry is an international prospective FFRCT registry of patients suspected of CAD. Of 5,083 patients, 1,829 subjects enrolled from Japan were analyzed...
April 18, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30996156/prognostic-value-of-phase-contrast-cine-magnetic-resonance-imaging-derived-global-coronary-flow-reserve-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome-treated-with-urgent-percutaneous-coronary-intervention
#10
Yoshihisa Kanaji, Taishi Yonetsu, Rikuta Hamaya, Tadashi Murai, Eisuke Usui, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Yoshinori Kanno, Hiroaki Ohya, Youhei Sumino, Hidenori Hirano, Haruhito Yuki, Tomoki Horie, Akinori Sugano, Tetsumin Lee, Kenzo Hirao, Tsunekazu Kakuta
BACKGROUND: Phase-contrast cine-magnetic resonance imaging (PC-CMR) of the coronary sinus (CS) is a promising approach for quantifying coronary sinus flow (CSF) and global coronary flow reserve (G-CFR). We evaluated the prognostic value of G-CFR using PC-CMR in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).Methods and Results:The study prospectively enrolled 116 NSTE-ACS patients who underwent uncomplicated urgent PCI within 48 h of symptom onset. Post-PCI (median, 20 days) PC-CMR images of the CS were acquired to assess absolute CSF at rest and during maximum hyperemia...
April 17, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30996155/characterization-of-residual-conduction-gaps-after-hotballoon-based-antral-ablation-of-atrial-fibrillation-evidence-from-ultra-high-resolution-3-dimensional-mapping
#11
Shiro Nakahara, Yuichi Hori, Reiko Fukuda, Naoki Nishiyama, Sayuki Kobayashi, Yoshihiko Sakai, Isao Taguchi
BACKGROUND: The electrophysiological characteristics of residual conduction gaps between the left atrium (LA) and pulmonary veins (PVs) after HotBalloon-based wide antral ablation (HBWA) of atrial fibrillation (AF) remain incompletely understood. This study aimed to characterize the residual gaps by means of ultra-high-resolution mapping.Methods and Results:A total of 55 AF patients underwent HBWA by a predetermined protocol (6-shot total-based antral approach). LA-PV maps were created using 64-electrode minibasket catheters...
April 17, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30996147/announcement-of-the-2019-jcs-meeting-activities-2
#12
Toyoaki Murohara
No abstract text is available yet for this article.
April 16, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30982788/three-dimensional-fibrous-cap-structure-of-coronary-lipid-plaque-st-elevation-myocardial-infarction-vs-stable-angina
#13
Krzysztof L Bryniarski, Zhao Wang, Francesco Fracassi, Tomoyo Sugiyama, Erika Yamamoto, Hang Lee, James Fujimoto, Ik-Kyung Jang
BACKGROUND: Fibrous cap thickness (FCT) is one of the key features of coronary vulnerable plaque. FCT is measured at an arbitrary point, determined on visual assessment of 2-D cross-sectional imaging. This method has poor reproducibility. The aim of this study was to compare the 3-D structure of FC in non-culprit lipid plaques between patients with ST-elevation myocardial infarction (STEMI) and with stable angina (SA) on optical coherence tomography. Methods and Results: A total of 54 non-culprit plaques from 23 STEMI and 23 SA patients were evaluated...
April 13, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30971637/impact-of-total-antithrombotic-effect-on-bleeding-complications-in-patients-receiving-multiple-antithrombotic-agents
#14
Shinya Ichikawa, Kengo Tsukahara, Shinnosuke Kikuchi, Yugo Minamimoto, Yuichiro Kimura, Kozo Okada, Yasushi Matsuzawa, Masaaki Konishi, Nobuhiko Maejima, Noriaki Iwahashi, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura, Kazuo Kimura
BACKGROUND: Few reports have evaluated the total antithrombotic effect of multiple antithrombotic agents. Methods and Results: Thrombus formation was evaluated with the Total Thrombus-formation Analysis System (T-TAS® ) using 2 types of microchips in 145 patients with stable coronary artery disease receiving oral anticoagulants plus single- or dual-antiplatelet therapy. The PL-chip coated with collagen is designed for analysis of the platelet thrombus formation process under shear stress condition (18 µL/min)...
April 11, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30971626/correlation-of-right-ventricular-wall-stress-with-plasma-b-type-natriuretic-peptide-levels-in-patients-with-pulmonary-hypertension
#15
Nami Uchiyama, Toshinori Yuasa, Masaaki Miyata, Yoshihisa Horizoe, Hideto Chaen, Kayoko Kubota, Kunitsugu Takasaki, Naoko Mizukami, Akira Kisanuki, Mitsuru Ohishi
BACKGROUND: This study was designed to investigate the relationship between right ventricular wall stress (RVWS) and plasma B-type natriuretic peptide (BNP) levels in patients with pulmonary hypertension (PH). Methods and Results: The 57 consecutive PH patients and 8 control subjects were enrolled. Right heart catheterization (RHC), echocardiography, and BNP measurements were performed, and RVWS and left ventricular wall stress (LVWS) were calculated with the formula based on Laplace's law...
April 9, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30956268/risk-factors-and-prevalence-of-deep-vein-thrombosis-after-the-2016-kumamoto-earthquakes
#16
Koji Sato, Kenji Sakamoto, Yoichiro Hashimoto, Kazuhiko Hanzawa, Daisuke Sueta, Sunao Kojima, Masaya Fukuda, Hiroki Usuku, Fumie Kihara, Hiroshi Hosokawa, Yohei Nagai, Makoto Nakajima, Yoshiharu Saito, Kayoko Sakai, Sumio Masunaga, Shinji Tanaka, Kazuteru Fujimoto, Kenji Morihisa, Katsuo Noda, Kazuhiro Nishigami, Kohei Nagata, Koichiro Fujisue, Noriaki Tabata, Yukio Ando, Kenichi Tsujita, Hisao Ogawa, Seiji Hokimoto
BACKGROUND: After previous earthquakes, a high prevalence of deep vein thrombosis (DVT) has been reported. We examined DVT prevalence and risk factors in evacuees of the Kumamoto earthquakes by performing mobile DVT screening at various evacuation centers around the epicenter. Methods and Results: For 1 month after the Kumamoto earthquake on 14 April 2016, mobile DVT screening using portable ultrasonography (US) was performed at 80 evacuation centers. Questionnaires, physical examination, and US of the lower limb were carried out, and simple D-dimer measurements were undertaken for DVT-positive examinees...
April 6, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30956267/tolerability-efficacy-and-safety-of-bisoprolol-vs-carvedilol-in-japanese-patients-with-heart-failure-and-reduced-ejection-fraction-the-cibis-j-trial
#17
Hiroyuki Tsutsui, Shin-Ichi Momomura, Tohru Masuyama, Yoshihiko Saito, Issei Komuro, Toyoaki Murohara, Shintaro Kinugawa
BACKGROUND: The comparative tolerability, efficacy, and safety of bisoprolol and carvedilol have not been established in Japanese patients with heart failure and reduced ejection fraction (HFrEF). Methods and Results: The CIBIS-J trial is a multicenter, open-label, non-inferiority randomized controlled trial of bisoprolol vs. carvedilol in 217 patients with HFrEF (EF ≤40%). The primary endpoint was tolerability, defined as reaching and maintaining the maximum maintenance dose (bisoprolol 5 mg/day or carvedilol 20 mg/day) during 48 weeks of treatment...
April 6, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30956266/years-of-life-lost-analysis-may-promote-governmental-policy-to-prevent-atherosclerotic-cardiovascular-disease
#18
Yoshiyuki Ikeda, Mitsuru Ohishi
No abstract text is available yet for this article.
April 6, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30956265/current-key-issues-in-transcatheter-aortic-valve-replacement-undergoing-a-paradigm-shift
#19
In-Chang Hwang, Kentaro Hayashida, Hyo-Soo Kim
As a new technology in the management of valvular heart disease, transcatheter aortic valve replacement (TAVR) has drawn much attention since its emergence. To date, numerous studies have investigated the safety and efficacy of TAVR in patients of various risk profiles with severe aortic stenosis (AS) and demonstrated comparable or superior outcomes of TAVR when compared with surgical aortic valve replacement (SAVR). The favorable outcomes of TAVR in inoperable patients, as well as in high- and intermediate-risk patients, are endorsed in current guidelines, and trials of low-risk patients have shown non-inferior or even superior results of TAVR than for SAVR, suggesting that the clinical indications of TAVR can be expanded to low-risk patients...
April 5, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30944264/clinical-impact-and-significance-of-serum-lipoprotein-a-levels-on-cardiovascular-risk-in-patients-with-coronary-artery-disease
#20
Hiroshi Yoshida
No abstract text is available yet for this article.
April 4, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
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