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Epilepsy Currents

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https://read.qxmd.com/read/30838931/one-hit-wonders-and-2-hit-tubers-a-second-hit-to-tsc2-causes-tuber-like-cells-in-spheroids
#1
Sonal Goswami, Jenny Hsieh
Genetically Engineered Human Cortical Spheroid Models of Tuberous Sclerosis Blair JD, Hockemeyer D, Bateup HS. Nat Med. 2018;24(10):1568-1578. doi:10.1038/s41591-018-0139-y. Epub 2018 Aug 20. PubMed PMID: 30127391; PubMed Central PMCID: PMC6261470. Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by mutations in the TSC1 or TSC2 genes, whose protein products are negative regulators of mechanistic target of rapamycin complex 1 signaling. Hallmark pathologies of TSC are cortical tubers-regions of dysmorphic, disorganized neurons, and glia in the cortex that are linked to epileptogenesis...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838930/continuous-eeg-monitoring-the-neurologist-s-crystal-ball
#2
Aatif M Husain
Time to Epileptiform Activity and EEG Background Recovery Are Independent Predictors After Cardiac Arrest Westhall E, Rose I, Rundgren M, Bro-Jeppesen J, Kjaergaard J, Hassager C, Lindehammar H, Horn J, Ullen S, Nielsen N, Friberg H, Cronberg T. Clin Neurophysiol. 2018;129:1660-1668. https://doi.org/10.1016/j.clinph.2018.05.016 Objective: To investigate the temporal development of electroencephalogram (EEG) and prognosis. METHODS: Prospective observational substudy of the Target Temperature Management trial...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838929/dravet-syndrome-a-developmental-and-epileptic-encephalopathy
#3
Luis Lopez-Santiago, Lori L Isom
Selective Nav1.1 Activation Rescues Dravet Syndrome Mice From Seizures and Premature Death Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S. PNAS. 2018;115:E8077-E8085. Dravet syndrome is a catastrophic, pharmaco-resistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838928/the-space-time-continuum-of-cortical-dysplasia
#4
Laura A Jansen
Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias D'Gama AM, Woodworth MB, Hossain AA, Bizzotto S, Hatem NE, LaCoursiere CM, Najm I, Ying Z, Yang E, Barkovich AJ, Kwiatkowski DJ, Vinters HV, Madsen JR, Mathern GW, Blümcke I, Poduri A, Walsh CA. Cell Rep. 2017;21:3754-3766. Focal cortical dysplasia (FCD) and hemimegalencephaly (HME) are epileptogenic neurodevelopmental malformations caused by mutations in mTOR pathway genes. Deep sequencing of these genes in FCD/HME brain tissue identified an etiology in 27 (41%) of 66 cases...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838927/seizures-nonepileptic-events-trauma-anxiety-or-all-of-the-above
#5
Jay Salpekar
Psychiatric Comorbidity and Traumatic Brain Injury Attribution in Patients With Psychogenic Nonepileptic or Epileptic Seizures: A Multicenter Study of US Veterans Salinsky M, Rutecki P, Parko K, Goy E, Storzbach D, O'Neil M, Binder L, Joos S. Epilepsia. 2018. Epub ahead of print. https://doi.org/10.1111/epi.14542 Objective: To determine the frequency and severity of psychiatric disorders and attribution of seizures to traumatic brain injury (TBI) in veterans with verified psychogenic nonepileptic seizures (PNES) versus epileptic seizures (ES)...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838926/understanding-the-cognitive-side-effects-of-antiepileptic-drugs-can-functional-imaging-be-helpful
#6
William B Barr
Effects of Carbamazepine and Lamotrigine on Functional Magnetic Resonance Imaging Cognitive Networks Xiao F, Caciagli L, Wandschneider B, Sander JW, Sidhu M, Winston G, Burdett J, Trimmel K, Hill A, Vollmar C, Vos SB, Ourselin S, Thompson PJ, Zhou D, Duncan JS, Koepp MJ. Epilepsia. 2018;59:1362-1371. OBJECTIVE: To investigate the effects of sodium channel-blocking antiepileptic drugs (AEDs) on functional magnetic resonance imaging (fMRI) language network activations in patients with focal epilepsy...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838925/double-agent-mtor
#7
Steve C Danzer
Remodeled Cortical Inhibition Prevents Motor Seizures in Generalized Epilepsy Jiang X, Lupien-Meilleur A, Tazerart S, Lachance M, Samarova E, Araya R, Lacaille JC, Rossignol E. Ann Neurol. 2018 Sep;84(3):436-451. OBJECTIVE: Deletions of CACNA1A, encoding the α1 subunit of CaV 2.1 channels, cause epilepsy with ataxia in humans. Whereas the deletion of Cacna1a in γ-aminobutyric acidergic (GABAergic) interneurons (INs) derived from the medial ganglionic eminence (MGE) impairs cortical inhibition and causes generalized seizures in Nkx2...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838924/are-seizure-detection-devices-ready-for-prime-time
#8
Paul C Van Ness
Standards for testing and clinical validation of seizure detection Beniczky S, Ryvlin P. Epilepsia. 2018;59(S1):9-13. https://doi.org/10.1111/epi.14049 To increase the quality of studies on seizure detection devices, we propose standards for testing and clinical validation of such devices. We identified 4 key features that are important for studies on seizure detection devices: subjects, recordings, data analysis and alarms, and reference standard. For each of these features, we list the specific aspects that need to be addressed in the studies, and depending on these, studies are classified into 5 phases (0-4)...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838923/perceptions-in-pnes-a-bidirectional-problem
#9
Barbara Dworetzky
Health Care Practitioners' Perceptions of Psychogenic Nonepileptic Seizures: A Systematic Review of Qualitative and Quantitative Studies Rawlings GH, Reuber M. Epilepsia. 2018;59(6):1109-1123. doi:10.1111/epi.14189. Epub 2018 May 11. A recent systematic synthesis of qualitative research demonstrated that patients with psychogenic nonepileptic seizures (PNES) often experience unsatisfactory encounters with health-care practitioners (HCPs). It is important to understand such interactions from the perspective of those responsible for delivering care...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838922/thar-she-blows-the-search-for-the-great-spermine-whale-of-carbamazepine-resistance
#10
Isabel D Derera, Chris G Dulla
Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy Beckonert NM, Opitz T, Pitsch J, Soares da Silva P, Beck H. J Neurosci. 2018;38(24):5596-5605. https://doi.org/10.1523/JNEUROSCI.0640-18.2018 . Despite the development of numerous novel anticonvulsant drugs, ∼30% of patients with epilepsy remain refractory to antiepileptic drugs (AEDs). Many established and novel AEDs reduce hyperexcitability via voltage- and use-dependent inhibition of voltage-gated Na+ channels...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838921/from-dreadd-to-treatment-in-temporal-lobe-epilepsy
#11
Jennifer C Wong, Andrew Escayg
Pharmaco-Genetic Therapeutics Targeting Parvalbumin Neurons Attenuate Temporal Lobe Epilepsy Wang Y, Liang J, Chen L, Shen Y, Zhao J, Xu C, Wu X, Cheng H, Ying X, Guo Y, Wang S, Zhou Y, Wang Y, Chen Z. Neurobiol Dis. 2018;117:149-60. Epub 2018/06/13. doi: 10.1016/j.nbd.2018.06.006. PubMed PMID: 29894753. Temporal lobe epilepsy (TLE) is the most common type of epilepsy and is often medically refractory. Previous studies suggest that selective pharmaco-genetic inhibition of pyramidal neurons has therapeutic value for the treatment of epilepsy; however, there is a risk of disrupting normal physical functions...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838920/the-insula-and-its-epilepsies
#12
Barbara C Jobst, Jorge Gonzalez-Martinez, Jean Isnard, Philippe Kahane, Nuria Lacuey, Samden D Lahtoo, Dang K Nguyen, Chengyuan Wu, Fred Lado
Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian spread, for example, manifest first as throat constriction, followed next by perioral and hemisensory symptoms, and then by unilateral motor symptoms. On the other hand, insular seizures may spread instead to the temporal and frontal lobes and present like seizures originating from these regions...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838919/-are-we-there-yet-quest-for-treatment-of-refractory-epilepsy
#13
Libor Velíšek
Biochemical Autoregulatory Gene Therapy for Focal Epilepsy Lieb A, Qiu Y, Dixon CL, Heller JP, Walker MC, Schorge S, Kullmann DM. Nat Med. 2018;24:1324-1329. Despite the introduction of more than one dozen new antiepileptic drugs in the past 20 years, approximately one-third of people who develop epilepsy continue to have seizures on mono- or polytherapy. Viral-vector-mediated gene transfer offers the opportunity to design a rational treatment that builds on mechanistic understanding of seizure generation and that can be targeted to specific neuronal populations in epileptogenic foci...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838918/a-matter-of-genes-the-hurdles-of-gene-therapy-for-epilepsy
#14
Selene Ingusci, Stefano Cattaneo, Gianluca Verlengia, Silvia Zucchini, Michele Simonato
Gene therapy has recently advanced to the level of standard of care for several diseases. However, its application to neurological disorders is still in the experimental phase. In this review, we discuss recent advancements in the field that provide optimism on the possibility to have first-in-human studies for gene therapy of some forms of epilepsy in the not so distant future.
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838917/seize-the-day-for-a-day-with-no-seizures-modifiable-midlife-risk-factors-identified
#15
Mohamad Koubeissi
Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study Johnson EL, Krauss GL, Lee AK, Schneider ALC, Dearborn JL, Kucharska-Newton AM, Huang J, Alonso A, Gottesman RF. JAMA Neurol. 2018 Jul 23 [Epub ahead of print] Importance: The incidence of epilepsy is higher in older age than at any other period of life. Stroke, dementia, and hypertension are associated with late-onset epilepsy; however, the role of other vascular and lifestyle factors remains unclear...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30838916/medications-for-early-life-epilepsy-evidence-versus-experience
#16
Katherine Nickels
Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT. JAMA Pediatr. 2018 Apr 1;172(4):352-360. doi: 10.1001/jamapediatrics.2017.5211. IMPORTANCE: More than half of infants with new-onset epilepsy have electroencephalographic and clinical features that do not conform to known electroclinical syndromes (ie, nonsyndromic epilepsy)...
January 2019: Epilepsy Currents
https://read.qxmd.com/read/30568561/summary-of-the-pame-2018-meeting
#17
Elizabeth J Donner, Tom F Stanton, George B Richerson
No abstract text is available yet for this article.
November 2018: Epilepsy Currents
https://read.qxmd.com/read/30568560/pannexin1-as-a-possible-panacea-for-intractable-epilepsy
#18
COMMENT
Kyle A Lyman, Dane M Chetkovich
No abstract text is available yet for this article.
November 2018: Epilepsy Currents
https://read.qxmd.com/read/30568559/jumping-to-conclusions-about-focal-seizure-spread
#19
COMMENT
Matthew Weston
No abstract text is available yet for this article.
November 2018: Epilepsy Currents
https://read.qxmd.com/read/30568558/-can-you-hear-me-now-ampa-receptor-mediated-tonotopy-disruption-by-early-life-seizures
#20
COMMENT
Libor Velíšek
No abstract text is available yet for this article.
November 2018: Epilepsy Currents
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