Michelle Fiamingo, Sydnie Toler, Kaleb Lee, Wendy Oshiro, Todd Krantz, Paul Evansky, David Davies, M Ian Gilmour, Aimen Farraj, Mehdi S Hazari
Although it is well established that wildfire smoke exposure can increase cardiovascular morbidity and mortality, the combined effects of non-chemical stressors and wildfire smoke remains understudied. Housing is a non-chemical stressor that is a major determinant of cardiovascular health, however, disparities in neighborhood and social status have exacerbated the cardiovascular health gaps within the United States. Further, pre-existing cardiovascular morbidities, such as atherosclerosis, can worsen the response to wildfire smoke exposures...
July 24, 2024: Cardiovascular Toxicology
Geir Bjørklund, Lyudmila Pivina, Yuliya Semenova
The population in the areas neighboring the Semipalatinsk Nuclear Test Site (SNTS) in the eastern region of Kazakhstan faces increased cardiovascular disease (CVD) risk. Previous research has not explored gene polymorphisms related to CVD in this population. Therefore, the present study examines the prevalence of six CVD-associated genotypes in three generations exposed to SNTS radiation. The genotyping of ApoE Leu28 → Pro, AGT Met174 → Thr, AGT Met235 → Thr, eNOS T786 → C, PON1 Gln192 → Arg, and EDN 1 Lys198 → Asn was performed using real-time polymerase chain reaction...
July 19, 2024: Cardiovascular Toxicology
Yanfang Liu, Hui Wu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yi Li, Xiaoting Yang, Jianfeng Sun
Cardiovascular disease remains the leading cause of death worldwide, with acute myocardial infarction and anticancer drug-induced cardiotoxicity being the significant factors. The most effective treatment for acute myocardial infarction is rapid restoration of coronary blood flow by thrombolytic therapy or percutaneous coronary intervention. However, myocardial ischemia-reperfusion injury (MI/RI) after reperfusion therapy is common in acute myocardial infarction, thus affecting the prognosis of patients with acute myocardial infarction...
July 18, 2024: Cardiovascular Toxicology
Alok D Singh, Mukesh B Chawda, Yogesh A Kulkarni
Diabetic cardiomyopathy (DCM) is one of the serious complications of type 2 diabetes mellitus. Vasant Kusumakar Rasa (VKR) is a Herbo-metallic formulation reported in Ayurveda, an Indian system of medicine. The present work was designed to study the effect of VKR in cardiomyopathy in type 2 diabetic rats. Diabetes was induced by feeding a high-fat diet (HFD) for 2 weeks followed by streptozotocin (STZ) administration (35 mg/kg i.p.). VKR was administered orally at dose of 28 and 56 mg/kg once a day for 16 weeks...
July 18, 2024: Cardiovascular Toxicology
Jason B Giles, Kiana L Martinez, Heidi E Steiner, Andrew Klein, Aikseng Ooi, Julie Pryor, Nancy Sweitzer, Deborah Fuchs, Jason H Karnes
Heparin-induced thrombocytopenia (HIT) is an antibody-mediated immune response against complexes of heparin and platelet factor 4 (PF4). The electrostatic interaction between heparin and PF4 is critical for the anti-PF4/heparin antibody response seen in HIT. The binding of metal cations to heparin induces conformational changes and charge neutralization of the heparin molecule, and cation-heparin binding can modulate the specificity and affinity for heparin-binding partners. However, the effects of metal cation binding to heparin in the context of anti-PF4/heparin antibody response have not been determined...
July 17, 2024: Cardiovascular Toxicology
Mohammad Shabani, Saleh Khezri, Ahmad Salimi
The hallmark of aluminum phosphide (AlP) poisoning is heart failure in victims which is associated with reactive oxygen species (ROS), mitochondrial dysfunction, oxidative stress, alteration in antioxidant defense system and depletion of ATP in cardiomyocytes. In the present study, we hypothesized that the injection of isolated mitochondria into blood or mitochondrial transplantation can likely create a primary target for phosphine released from AlP and inhibit AlP-induced mortality and cardiotoxicity in rat...
July 16, 2024: Cardiovascular Toxicology
Na Sun, Yi-Qiang Chen, Yan-Sheng Chen, Lei Gao, Run-Wei Deng, Jing Huang, You-Li Fan, Xuan Gao, Bin-Feng Sun, Na-Na Dong, Bo Yu, Xia Gu, Bing-Xiang Wu
This study aimed to evaluate the correlation of plasma deoxycholic acid (DCA) levels with clinical and hemodynamic parameters in acute pulmonary embolism (APE) patients. Total 149 APE adult patients were prospectively recruited. Plasma DCA levels were measured using rapid resolution liquid chromatography-quadrupole time-of-flight mass spectrometry. Baseline clinical and hemodynamic parameters were evaluated according to plasma DCA levels. The plasma DCA levels were significantly lower in APE patients than in those without APE (P < 0...
July 15, 2024: Cardiovascular Toxicology
Li-Yan Fu, Yu Yang, Rui-Juan Li, Abdoulaye Issotina Zibrila, Hua Tian, Xiu-Yue Jia, Jin-An Qiao, Jin-Min Wu, Jie Qi, Xiao-Jing Yu, Yu-Ming Kang
Hypertension is a globally prevalent disease, but the pathogenesis remains largely unclear. AMP-activated protein kinase (AMPK) is a nutrition-sensitive signal of cellular energy metabolism, which has a certain influence on the development of hypertension. Previously, we found a down-regulation of the phosphorylated (p-) form of AMPK, and the up-regulation of the angiotensin II type 1 receptor (AT1-R) and that of p-ERK1/2 in the hypothalamic paraventricular nucleus (PVN) of hypertensive rats. However, the exact mechanism underlying the relationship between AMPK and AT1-R in the PVN during hypertension remains unclear...
July 15, 2024: Cardiovascular Toxicology
Zeinab Vafaeipour, Mohsen Imenshahidi, Amir Hooshang Mohammadpour, Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Moshiri, Amir Hossein Jafarian, Khalil Abnous
Aluminum phosphide (AlP) is the main component of rice tablets (a pesticide), which produces phosphine gas (PH3) when exposed to stomach acid. The most important symptoms of PH3 toxicity include, lethargy, tachycardia, hypotension, and cardiac shock. It was shown that Iodine can chemically react with PH3, and the purpose of this study is to investigate the protective effects of Lugol solution in poisoning with rice tablets. Five doses (12, 15, 21, 23, and 25 mg/kg) of AlP were selected, for calculating its lethal dose (LD50)...
July 11, 2024: Cardiovascular Toxicology
Xiaobiao Cao, Jun Yang, Lujun He, Cangcang Liu
Atherosclerosis (AS) is an inflammatory disease with multiple causes. Multiple circular RNAs (circRNAs) are known to be involved in the pathogenesis of AS. To explore the function and mechanism of circ_0005699 in oxidative low-density lipoprotein (ox-LDL)-induced human umbilical vein endothelial cells (HUVECs) injury. Ox-LDL treatment restrained HUVECs viability, cell proliferation, and angiogenesis ability, and accelerated HUVECs apoptosis, inflammatory response, and oxidative stress. Circ_0005699 was up-regulated in the serum samples of AS patients and ox-LDL-induced HUVECs...
July 8, 2024: Cardiovascular Toxicology
Russell Hunter, Thomas Wilson, Selita Lucas, David Scieszka, Barry Bleske, Andrew Ottens, Ryan Ashley, Carolyn Pace, Nancy Kanagy, Matthew Campen
The contribution of air pollution-induced cardiopulmonary damage on the development of hypertensive disorders of pregnancy and other adverse outcomes of pregnancy has gained increased attention as epidemiological data continue to highlight spatiotemporal pregnancy trends related to air pollution exposure. However clinical mechanistic data surrounding gestational complications remain sparse, necessitating the need for the use of animal models to study these types of complications of pregnancy. The current study seeks to examine the real-time effects of mid-gestational ozone exposure on maternal blood pressure and body temperature through the use of radiotelemetry in a rat model...
July 4, 2024: Cardiovascular Toxicology
Shih-Yi Lee, Shao-Tung Wu, Chen-Xuan Du, Hui-Chun Ku
Oxidative stress causes mitochondrial damage and bioenergetic dysfunction and inhibits adenosine triphosphate production, contributing to the pathogenesis of cardiac diseases. Dipeptidyl peptidase 4 (DPP4) is primarily a membrane-bound extracellular peptidase that cleaves Xaa-Pro or Xaa-Ala dipeptides from the N terminus of polypeptides. DPP4 inhibitors have been used in patients with diabetes and heart failure; however, they have led to inconsistent results. Although the enzymatic properties of DPP4 have been well studied, the substrate-independent functions of DPP4 have not...
July 2, 2024: Cardiovascular Toxicology
Praveen Gupta, Anunay Gupta, Kapil Gupta, Sandeep Bansal, Monica Sharma, Ira Balakrishnan
The studies regarding prevalence, outcomes, and predictors of prolonged corrected QT (QTc) among COVID-19 patients not on QTc-prolonging medication are not available in the literature. In this retrospective cohort study, the QTc of 295 hospital-admitted COVID-19 patients was analyzed and its association with in-hospital mortality was determined. The QTc was prolonged in 14.6% (43/295) of the study population. Prolonged QTc was seen in patients with older age (P = 0.018), coronary artery disease (P = 0...
July 2, 2024: Cardiovascular Toxicology
Caojian Zuo, Lidong Cai, Ya Li, Chencheng Ding, Guiying Liu, Changmei Zhang, Hexiang Wang, Yang Zhang, Mingyue Ji
Radix Paeoniae Rubra. (Chishao, RPR) and Cortex Moutan. (Mudanpi, CM) are a pair of traditional Chinese medicines that play an important role in the treatment of atherosclerosis (AS). The main objective of this study was to identify potential synergetic function and underlying mechanisms of RPR-CM in the treatment of AS. The main active ingredients, targets of RPR-CM and AS-related genes were obtained from public databases. A Venn diagram was utilized to screen the common targets of RPR-CM in treating AS. The protein-protein interaction network was established based on STRING database...
July 1, 2024: Cardiovascular Toxicology
Jayeeta Samanta, Arunima Mondal, Srimoyee Saha, Santanu Chakraborty, Arunima Sengupta
No abstract text is available yet for this article.
June 25, 2024: Cardiovascular Toxicology
Anatoly Soloviev, Vadym Sydorenko
Oxidative stress results from the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in quantities exceeding the potential activity of the body's antioxidant system and is one of the risk factors for the development of vascular dysfunction in diabetes and exposure to ionizing radiation. Being the secondary products of normal aerobic metabolism in living organisms, ROS and RNS act as signaling molecules that play an important role in the regulation of vital organism functions. Meanwhile, in high concentrations, these compounds are toxic and disrupt various metabolic pathways...
June 25, 2024: Cardiovascular Toxicology
Juanjuan Xu, Manjun Lv, Xiaohong Ni
Doxorubicin (DOX) is an effective anticancer agent, yet its clinical utility is hampered by dose-dependent cardiotoxicity. This study explores the cardioprotective potential of Marein (Mar) against DOX-induced cardiac injury and elucidates underlying molecular mechanisms. Neonatal rat cardiomyocytes (NRCMs) and murine models were employed to assess the impact of Mar on DOX-induced cardiotoxicity (DIC). In vitro, cell viability, oxidative stress were evaluated. In vivo, a chronic injection method was employed to induce a DIC mouse model, followed by eight weeks of Mar treatment...
June 19, 2024: Cardiovascular Toxicology
Jiakun Liu, Zhengyuan Meng, Xv Yidan
The development and use of HER2-targeted drugs has improved the prognosis of HER2-positive cancer patients. However, in addition to improved survival rates, treatment-induced adverse events and nontumor-related deaths have increased. We sought to assess the incidence of cardiovascular adverse events when HER2-targeted drugs are combined with other drugs. We systematically searched the literature on the cardiotoxicity of anti-HER2 drugs in electronic databases, including PubMed, Web of Science, Cochrane Library, OVID and CNKI, from their inception to April 2022...
June 15, 2024: Cardiovascular Toxicology
Sol Guerra-Ojeda, Patricia Marchio, Andrea Suarez, Martin Aldasoro, Soraya L Valles, Patricia Genoves, Jose M Vila, Maria D Mauricio
Levamisole is an anthelmintic drug restricted to veterinary use but is currently detected as the most widely used cocaine cutting agent in European countries. Levamisole-adulterated cocaine has been linked to acute kidney injury, marked by a decrease in glomerular filtration rate, which involves reduced renal blood flow, but data on the alteration of renovascular response produced by levamisole are scarce. Renal arteries were isolated from healthy rabbits and used for isometric tension recording in organ baths and protein analysis...
June 14, 2024: Cardiovascular Toxicology
Yufeng Jiang, Kuangyi Wang, Xiaofei Mei, Yafeng Zhou
This study aims to investigate the potential role of CYP2D6*10 (c.100 C>T) gene polymorphism in renal function injury among hypertensive patients without elevated cystatin C. A cohort of hypertensive patients without elevated cystatin C was enrolled between 2021 and 2024 in the Fourth Affiliated Hospital of Soochow University, and their peripheral venous blood was used for total RNA extraction and CYP2D6*10 genotype analysis. Based on kidney injury status, patients were categorized into two groups, hypertensive patients with kidney injury (n = 94) and those without (n = 893)...
June 12, 2024: Cardiovascular Toxicology
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