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AIDS Reviews

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https://read.qxmd.com/read/29938707/hot-news-dr-robert-redfield-appointed-as-new-cdc-director
#1
Pablo Barreiro
Well-known AIDS researcher Robert Redfield picked to lead the CDC on March 2018. He is one of the HIV/AIDS pioneers in the United States. During two decades at the Walter Reed Army Institute of Research, in Bethesda, MD, he made pivotal contributions, highlighting the importance of heterosexual HIV transmission, developing the Walter Reed staging system for HIV infection, and demonstrating that active HIV replication takes place during all stages of HIV disease. In 1996, he was one of the cofounders of the Institute of Human Virology in Baltimore, MD...
April 2018: AIDS Reviews
https://read.qxmd.com/read/29938706/hot-news-hepatitis-b-gene-therapy-coming-to-age
#2
REVIEW
Vicente Soriano
The major pandemics caused by chronic viral infections is produced by HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV), with estimates of 38, 70, and 250 million people worldwide, respectively (Fig. 1). During the last couple of years, the advent of direct oral antivirals has allowed pursuing global HCV eradication. In an unprecedented manner, these drugs cure more than 95% of hepatitis C patients when given for only 2-3 months. The enthusiasm on HCV has renewed the interest for curative strategies for both HIV and HBV...
April 2018: AIDS Reviews
https://read.qxmd.com/read/29938705/prevalence-of-tuberculosis-in-hiv-positive-prisoners-a-systematic-review-and-meta-analysis
#3
REVIEW
Mostafa Dianatinasab, Hassan Joulaei, Mohammad Ghorbani, Nooshin Zarei, Shahab Rezaeian, Mohammad Fararouei, Zoë R Greenwald
Tuberculosis (TB) and HIV constitute the main burden of infectious diseases worldwide. Imprisonment is an important risk factor for contracting TB, especially among those living with HIV. This systematic review summarizes the available data on the prevalence of TB among HIV-positive prisoners; which may support improved targeted TB/HIV prevention plans. We electronically examined published studies up to December 2017 with the aim of finding articles that investigated the prevalence of TB in HIV-positive prisoners...
April 2018: AIDS Reviews
https://read.qxmd.com/read/29938704/hiv-aids-in-sierra-leone-characterizing-the-hidden-epidemic
#4
REVIEW
George A Yendewa, Eva Poveda, Sahr A Yendewa, Foday Sahr, Miguel E Quiñones-Mateu, Robert A Salata
Sierra Leone is a low-income West African country that has dealt with waves of economic, political, and public health challenges in its recent past, including a decade-long brutal civil war and the Ebola epidemic of 2014-2016. The HIV/AIDS epidemic, which has raged on in the country since 1987, has long been characterized as stable. The latest UNAIDS report estimates a countrywide HIV prevalence rate of 1.7% in 2016 among adults aged 15-49 years. However, there are indications that the epidemic may be in fact escalating and unless arrested urgently, has the potential to deteriorate into a major public health emergency...
April 2018: AIDS Reviews
https://read.qxmd.com/read/29938703/the-role-of-hiv-in-the-progression-through-the-stages-of-the-human-papillomavirus-to-cervical-cancer-pathway
#5
REVIEW
Kristopher O Myers, Nasar U Ahmed
Globally, an estimated 36.9 million persons are living with HIV/AIDS, and approximately 291 million women worldwide are carriers of human papillomavirus (HPV). A large number of women currently infected with either or both viruses constitute a large burden on the national health care system. Women with HIV have significantly higher rates of HPV infections than women without HIV. Approximately 77% of women with HIV are carriers of HPV. While research has established a linkage between HIV and progression to cervical cancer in general, there are currently no review articles exploring the role HIV has in the progression from HPV to each stage of carcinogenesis that leads to cervical cancer...
April 2018: AIDS Reviews
https://read.qxmd.com/read/29938702/is-unaids-90-90-90-target-a-dream-or-a-reality-for-middle-east-and-north-africa-region-on-ending-the-aids-epidemic-a-review-study
#6
REVIEW
Hassan Joulaei, Sowgol Shooshtarian, Mostafa Dianatinasab
Middle East and North Africa (MENA) region is lagging far behind the global average to reach 90-90-90 targets. This study uses the UNAIDS 90-90-90 program to evaluate the HIV current situation in MENA countries, and understand the challenges that exist in the way of approaching the program goals. All articles and publications were searched based on the 90-90-90 program indexes among national and international data resources such as official national reports and online scientific databases such as PubMed, Medline, and Scopus up to December 2017...
April 2018: AIDS Reviews
https://read.qxmd.com/read/29938701/a-comprehensive-development-agenda-on-tenofovir-alafenamide-in-clinical-practice
#7
REVIEW
Antonio Di Biagio, Niccolò Riccardi, Stefano Rusconi, Giovanni Guaraldi, Marco Borderi, Andrea De Luca, Nicola Gianotti, Sergio Lo Caputo, Paolo Maggi, Renato Maserati, Franco Maggiolo
The introduction of tenofovir (TFV) alafenamide (TAF) into clinical practice will be a further revolution in antiretroviral therapy. Currently available HIV-1 regimens are wide enough to allow diversified usage in different settings. Despite the fact that TAF is not capillary accessible, even in industrialized countries, ultimate International Guidelines have already included TAF in backbone or in single-tablet regimens. Due to a better safety profile, TAF will progressively replace TFV disoproxil fumarate, both in naïve and experienced patients...
April 2018: AIDS Reviews
https://read.qxmd.com/read/30548026/hepatitis-delta-could-be-more-frequent-than-previously-thought
#8
Jose V Fernandez-Montero, Vicente Soriano
No abstract text is available yet for this article.
2018: AIDS Reviews
https://read.qxmd.com/read/30548025/hepatitis-e-virus-the-uninvited-intruder-in-western-kitchens
#9
Pablo Barreiro
No abstract text is available yet for this article.
2018: AIDS Reviews
https://read.qxmd.com/read/30548024/new-dual-combination-of-dolutegravir-rilpivirine-for-switching-to-maintenance-antiretroviral-therapy
#10
Esteban Ribera
Advances in antiretroviral therapy have led to dramatic improvements in survival of HIV-infected persons. However, HIV cure remains elusive and lifelong treatment is needed. Attempts for reducing long-term drug exposure, toxicities, and cost, while maintaining viral suppression, have led to explore whether maintenance strategies with less than triple therapy could be feasible using the newest more potent antiretrovirals. While monotherapies have failed to do so with selection of drug resistance, some dual combinations have proven its efficacy when used sequentially in patients with viral suppression under standard triple regimens...
2018: AIDS Reviews
https://read.qxmd.com/read/30548023/rebound-in-sexually-transmitted-infections-following-the-success-of-antiretrovirals-for-hiv-aids
#11
Vicente Soriano, Jorge Del Romero
Nearly 1 million people become infected every day with any of the four major curable sexually transmitted infections (STIs), namely trichomoniasis, chlamydia, gonorrhea, and syphilis. Despite huge global incidence, STIs remain as neglected diseases. The success of antiretrovirals for halting progression to AIDS in HIV-infected individuals and for stopping HIV transmission to uninfected contacts, either as pre- or post-exposure -prophylaxis, has to lead to increased risky sexual behaviors through risk compensation...
2018: AIDS Reviews
https://read.qxmd.com/read/30548022/toward-the-cure-of-hiv-1-infection-lessons-learned-and-yet-to-be-learned-as-new-strategies-are-developed
#12
Jeffrey M Jacobson, Kamel Khalili
Here, we review the progress that has been made in achieving a cure of HIV-1 infection. To date, this has only occurred in one person after he received allogeneic stem cell transplants from a CCR5 ∆32 homozygous donor in addition to chemotherapy and radiation to treat his acute myelocytic leukemia. The general consensus is that achieving a sustained remission of infection in the absence of antiretroviral therapy will involve a combination of strategies that involve both the targeting of the latent proviral genome and the induction of more effective anti-HIV-1 immune responses...
2018: AIDS Reviews
https://read.qxmd.com/read/30548021/should-hiv-patients-be-concerned-about-occult-hepatitis-b
#13
Antonio Aguilera, Vicente Soriano
No abstract text is available yet for this article.
2018: AIDS Reviews
https://read.qxmd.com/read/30548020/longer-life-expectancy-but-still-accelerating-aging-in-hiv-patients-under-antiretroviral-therapy
#14
Vicente Soriano, Octavio Corral
No abstract text is available yet for this article.
2018: AIDS Reviews
https://read.qxmd.com/read/30548019/economic-impact-of-hiv-in-the-highly-active-antiretroviral-therapy-era-reflections-looking-forward
#15
Juan Oliva-Moreno, Marta Trapero-Bertran
The main data on HIV in high-income countries from the standpoint of health economics are updated and discussed. Specifically, issues surrounding the economic impact of HIV are addressed for health care and occupational perspectives. We review the main epidemiological data on the prevalence of disease and foreseeable changes in patterns within the coming years. Recent research on health care costs of HIV/AIDS and the occupational situation of HIV+ people are discussed. In high-income countries, there is an incipient change in trends that indicate that an increasing percentage of the intermediate-age HIV+ population will age prematurely, presenting more frequently comorbidities and becoming more exposed to frailty situations...
2018: AIDS Reviews
https://read.qxmd.com/read/30548018/overcoming-obstacles-in-lipid-lowering-therapy-in-patients-with-hiv-a-systematic-review-of-current-evidence
#16
Coco C Dekkers, Jan Westerink, Andy I M Hoepelman, Joop E Arends
Cardiovascular risk management in human immunodeficiency virus (HIV)-infected individuals is gaining increased attention due to the rising incidence and prevalence of cardiovascular disease in this population. Despite the availability of efficacious treatment strategies, implementation of guideline advocated preventive therapy, such as lipid-lowering therapy with statins, is hampered by perceived, expected, and real side effects as well as by expected interactions with combination antiretroviral therapy. These obstacles to optimal treatment have resulted in a large gap between the number of patients in whom lipid-lowering therapy is indicated and those actually taking lipid-lowering medication...
2018: AIDS Reviews
https://read.qxmd.com/read/30328844/hot-news-htlv-1-infection-still-a-neglected-disease
#17
Vicente Soriano
No abstract text is available yet for this article.
2018: AIDS Reviews
https://read.qxmd.com/read/30264829/hot-news
#18
George A Yendewa
No abstract text is available yet for this article.
2018: AIDS Reviews
https://read.qxmd.com/read/30264828/non-alcoholic-fatty-liver-disease-in-patients-with-hiv-infection
#19
Marianthi Papagianni, Konstantinos Tziomalos
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with HIV infection and appears to be more severe than in HIV-uninfected patients. Both metabolic (e.g., obesity and insulin resistance) and HIV-related factors (e.g., antiretroviral treatment and inflammation) play a role in the pathogenesis of NAFLD in this population. Accordingly, all patients with HIV infection should be evaluated for the presence of NAFLD. Ultrasound is the first-line diagnostic procedure, but non-alcoholic steatohepatitis has to be diagnosed with liver biopsy...
2018: AIDS Reviews
https://read.qxmd.com/read/30264827/treatment-as-prevention-for-hiv-infection-current-data-challenges-and-global-perspectives
#20
Jean C Yombi, Helena Mertes
In 2008, the Swiss National AIDS Commission issued a statement about the safety of HIV treatment in terms of reduced transmission in serodiscordant couples to reduce transmission in serodiscordant couples. This was subjected to debate until 2011 when the HIV prevention trial network 052 published the first randomized study about HIV transmission in serodiscordant couples, where no transmission was observed when the infected person was under effective antiretroviral treatment (ART). Later, the Partners of People on ART-A New Evaluation of the Risks (PARTNER) and the opposites attract studies, which first involved a large number of men who have sex with men (MSM), also showed no transmission, even in condomless receptive anal intercourse (CLAI)...
2018: AIDS Reviews
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