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Analytical and Bioanalytical Chemistry

Sheng Guan, Hailong Yu, Guoquan Yan, Mingxia Gao, Weibing Sun, Xiangmin Zhang
Exosomes are cell-derived functional microparticles which exist in most body fluids. They carry abundant signaling molecules to transfer information between cells and microenvironment. Research on exosomes' heterogeneity and constitute variations has been a heated topic in recent years. In this work, size-dependent sub-proteome analysis of urinary exosomes was investigated by size exclusion chromatography (SEC) firstly. The particle size of urinary exosomes is distributed in four main ranges naturally. We found out that these fractions contained sub-proteomes with great difference in constitution...
February 14, 2019: Analytical and Bioanalytical Chemistry
Lirong Liu, Gangbing Zhu, Wei Zeng, Baohe Lv, Yinhui Yi
We present a new "off-on" fluorescence probe for detecting hypochlorite (ClO- ) based on silicon quantum dots coupled with silver nanoparticles (SiQDs/AgNPs) as nanocomplexes. Via introducing N-[3-(trimethoxysilyl)propyl]ethylenediamine and catechol as initial reactants, silicon quantum dots (SiQDs) with excellent properties were synthesized through a simple hydrothermal method. Transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy were used to characterize the morphology and structure of quantum dots...
February 14, 2019: Analytical and Bioanalytical Chemistry
Michael J Dolan, Robert D Blackledge, Kaveh Jorabchi
Fibers are an important form of forensic evidence, but their evidential value can be severely limited when the identified characteristics of the fibers are common, such as blue cotton. Detecting chemical fiber treatments offers an avenue to further classify fibers and to improve their evidential value. In this report, we investigate the potential of fluoropolymer fiber coatings, used to impart oil and water-repellent properties in fabrics, for differentiating between fibers. The thin nature of these fiber surface modifications creates an analytical challenge for their detection on a single fiber, a typical sample size for forensic evidence...
February 14, 2019: Analytical and Bioanalytical Chemistry
Zuzana Gajdosechova, Zoltan Mester
The need to assess the human and environmental risks of nanoparticles (NPs) has prompted an adaptation of existing techniques and the development of new ones. Nanoparticle analysis poses a great challenge as the analytical information has to consider both physical (e.g. size and shape) and chemical (e.g. elemental composition) state of the analyte. Furthermore, one has to contemplate the transformation of NPs during the sample preparation and provide sufficient information about the new species derived from such alteration...
February 14, 2019: Analytical and Bioanalytical Chemistry
Jiao Li, Jie Xu, Wenying Jin, Zhongsheng Yi, Chenbo Cai, Xuefen Huang, Jinfang Nie, Yun Zhang
A method that combines five-way fluorescence kinetics with fourth-order calibration for interference-free quantification of diclofenac sodium in river water was proposed and tested. Traditional fluorescence methods may not be suitable for such measurements since the fluorescence properties of the analyte are highly dependent on both pH and irradiation time in situ. In the method considered here, a five-way emission-excitation-time-pH data array was obtained from the samples by introducing the pH level and irradiation time as two extra modes...
February 13, 2019: Analytical and Bioanalytical Chemistry
Pengcheng Qian, Yingnan Qin, Yanlong Lyu, Yunfei Li, Lei Wang, Shuo Wang, Yaqing Liu
Highly sensitive detection of H2 O2 and glucose is critical for fundamental research and disease diagnosis. A ratiometric sensor can simultaneously afford two readout signals that provide an internally normalized response to change, thereby reducing false results and improving detection accuracy. A novel ratiometric fluorescent nanosensor for ultrasensitive detection of hydrogen peroxide and glucose was constructed on the basis of the peroxidase-like properties of a hierarchical cobalt/carbon nanotube hybrid nanocomplex (Co-CNT)...
February 13, 2019: Analytical and Bioanalytical Chemistry
Anna Laura Capriotti, Chiara Cavaliere, Susy Piovesana
This trends article describes the analytical approaches for the in-depth characterization of the protein corona on liposome nanoparticles. In particular, examples since 2014 are summarized according to the analytical approach. Traditional protein corona characterizations from in vitro static experiments are provided along with the newly introduced experimental setups for characterization of the protein corona by in vitro dynamic and in vivo studies. Additionally, a special attention is also devoted to the need for introduction of new experimental workflows for characterization of a much wider array of biomolecules...
February 13, 2019: Analytical and Bioanalytical Chemistry
Monica Mattarozzi, Maria Careri
The issue of undeclared allergens represents a matter of great concern, being the subject of many alert notifications by the Rapid Alert System for Food and Feed portal of the European Commission, often leading to food recalls. The availability of reliable analytical approaches able to detect and quantify hidden allergens in processed foods is increasingly requested by the food industry, food safety authorities and regulatory bodies to protect sensitive consumers' health. The present review discusses the fundamental role of incurred materials for method development and analytical performance assessment in a metrology perspective on testing for undeclared allergens in processed foodstuffs...
February 13, 2019: Analytical and Bioanalytical Chemistry
Chenyu Zheng, Yufeng Sheng, Yong Liu, Ying Wan, Guang Liu, Xutong Zhang, Meng Yang, Kai Kang, Jingping Liu, Kefeng Ma, Shengyuan Deng
Ultrasensitive electrochemiluminescence (ECL) detection can benefit substantially from the rational configuration of emitter-enhancer stereochemistry. Here, using zinc(II) meso-5,10,15,20-tetra(4-sulfonatophenyl)porphyrin (ZnTSPP) as a model, we demonstrate that both the ECL intensity and the photostability of this emitter were significantly improved when it was trapped in pyridyl-bridged β-cyclodextrin dimer (Py(CD)2 ); a synthetic enhancer that is ECL inactive. Through NMR characterization, we confirmed that ZnTSPP formed a clam-like inclusion complex involving pinning and pinching forces from the biocompatible container Py(CD)2 ...
February 12, 2019: Analytical and Bioanalytical Chemistry
Aaron Timperman
No abstract text is available yet for this article.
February 12, 2019: Analytical and Bioanalytical Chemistry
Casey A Chamberlain, Marguerite Hatch, Timothy J Garrett
Diseases of oxalate, such as nephrolithiasis and primary hyperoxaluria, affect a significant portion of the US population and have limited treatment options. Oxalobacter formigenes, an obligate oxalotrophic bacterium in the mammalian intestine, has generated great interest as a potential probiotic or therapeutic treatment for oxalate-related conditions due to its ability to degrade both exogenous (dietary) and endogenous (metabolic) oxalate, lowering the risk of hyperoxaluria/hyperoxalemia. Although all oxalotrophs degrade dietary oxalate, Oxalobacter formigenes is the only species shown to initiate intestinal oxalate secretion to draw upon endogenous, circulating oxalate for consumption...
February 11, 2019: Analytical and Bioanalytical Chemistry
Jonas Bemetz, Catharina Kober, Verena K Meyer, Reinhard Niessner, Michael Seidel
Analytical microarrays feature great capabilities for simultaneous detection and quantification of multiple analytes in a single measurement. In this work, we present a rapid and simple method for bulk preparation of microarrays on polycarbonate sheets. Succinylated Jeffamine® ED-2003 was screen printed on polycarbonate sheets to create a polyfunctional shielding layer by baking at 100 °C. After microdispension of capture probes (antibodies, oligonucleotides, or small molecules) in a microarray format, chips were assembled with a flow cell from double-sided tape...
February 11, 2019: Analytical and Bioanalytical Chemistry
Sobia Niazi, Imran Mahmood Khan, Lv Yan, Muhammad Issa Khan, Ali Mohsin, Nuo Duan, Shijia Wu, Zhouping Wang
A rapid and highly sensitive time-resolved fluorescence (TRF)-based aptasensor for simultaneous recognition of mycotoxins ochratoxin A (OTA) and fumonisin B1 (FB1 ) was developed using multi-color, Ln3+ -doped time-resolved fluorescence nanoparticles (TRF-NPs) (NaYF4 : Ce, Tb and NH2 -Eu/DPA@SiO2 NPs) coupled with complementary strand DNA (cDNA) as luminescence probe and aptamers-conjugated amine-functionalized Fe3 O4 magnetic nanoparticles (MNPs) act as a capture probe. Under the optimized conditions, the time-resolved fluorescence intensities at 544 and 618 nm corresponded with Tb3+ and Eu3+ , respectively, were used to measure FB1 (Y = 19,177...
February 9, 2019: Analytical and Bioanalytical Chemistry
Fereshteh Chekin, Vladyslav Myshin, Ran Ye, Sorin Melinte, Santosh K Singh, Sreekumar Kurungot, Rabah Boukherroub, Sabine Szunerits
Doxorubicin (DOX), an anthracycline molecule, is currently one of the most widely used anticancer drugs in clinics. Systematic treatment of patients with DOX is known to be accompanied by several unpleasant side effects due to the toxicity of the drug. Thus, monitoring of DOX concentration in serum samples has become increasingly important to avoid side effects and ensure therapeutic efficiency. In this study, we discuss the construction of a disposable electrochemical sensor for the direct monitoring of DOX in clinical blood samples...
February 9, 2019: Analytical and Bioanalytical Chemistry
Yunfei Hua, Xuping Yang, Ruiting Li, Peifang Liu, Peijia Liu, Linrui Li, Xia Yuan, Xiaoyi Hua, Yuan Tian, Zunjian Zhang, Yin Huang
Glutaminolysis is the metabolic pathway that lyses glutamine to glutamate, alanine, citrate, aspartate, and so on. As partially recruiting reaction steps from the tricarboxylic acid (TCA) cycle and the malate-aspartate shuttle, glutaminolysis takes essential place in physiological and pathological situations. We herein developed a sensitive, rapid, and reproducible liquid chromatography-tandem mass spectrometry method to determine the perturbation of glutaminolysis in human plasma by quantifying 13 involved metabolites in a single 20-min run...
February 9, 2019: Analytical and Bioanalytical Chemistry
Carolina V Uliana, Tássia R de Oliveira, Márcia R Cominetti, Ronaldo C Faria
The evaluation of interaction between small molecules and protein is an important step in the discovery of new drugs and to study complex biological systems. In this work, an alternative method was presented to evaluate small-molecule-protein interaction by using ligand capture by protein-coated magnetic particles (MPs) and disposable electrochemical cells. The interaction study was conducted using [10]-gingerol from ginger rhizome and a transmembrane protein αVβ3 integrin. Initially, the electrochemical behavior of the natural compound [10]-gingerol was evaluated with the disposable carbon-based electrodes and presented an irreversible oxidation process controlled by diffusion...
February 9, 2019: Analytical and Bioanalytical Chemistry
Ryan Matsuda, Zhao Li, Xiwei Zheng, David S Hage
The authors would like to call the reader's attention to the following corrections in this article. In the description given for the process of preparing glycated human serum albumin under "In vitro glycation of HSA", the concentrations of D-glucose that were employed were 15 mM and 30 mM.
February 9, 2019: Analytical and Bioanalytical Chemistry
Sheta M Sheta, Said M El-Sheikh, Mokhles M Abd-Elzaher
The analytical quantification and follow-up of the hormone prolactin is very important in clinical diagnosis (e.g., in cases of breast cancer), treatment, and the medical laboratory. The development of a new simple, fast, and less costly method is of considerable importance. Novel praseodymium metal-organic framework nanofibers (Pr-MOF-NFs) were synthesized by a facile and simple method for the determination of human prolactin in serum samples. The Pr-MOF-NFs were well characterized with several spectroscopic tools, such as mass spectrometry, Fourier transform IR spectroscopy, UV-vis spectroscopy, elemental analysis, X-ray diffraction, field-emission scanning electron microscopy combined with energy-dispersive X-ray spectroscopy, and high-resolution transmission electron microscopy...
February 8, 2019: Analytical and Bioanalytical Chemistry
Wendan Zhang, Honghong Jiang, Jianxi Yang, Gengshen Song, Di Wen, Wenqiao Liu, Miaomiao Jin, Qiao Wang, Yingfeng Du, Qian Sun, Liang Cao, Huijun Xu
Pulsatilla Adans (PSA) herbs (Ranunculaceae) have been widely used in traditional medicine in China and other countries. However, the authentication and quality control of PSA herbs have always been a challenging task due to their similar morphological characteristics and the diversity of the multiple components that exist in the complicated matrix. Herein, a novel integrated strategy combining UHPLC/Q-Orbitrap-MS techniques with chemometrics analysis is proposed for the discrimination of PSA materials. We developed a comprehensive method integrating a nontargeted bidirectionally screened (NTBDS) MS data set and a targeted extraction peak area analysis for the characterization of triterpenoid saponins of PSA from different species...
February 8, 2019: Analytical and Bioanalytical Chemistry
Katia Arena, Francesco Cacciola, Domenica Mangraviti, Mariosimone Zoccali, Francesca Rigano, Nino Marino, Paola Dugo, Luigi Mondello
Pistachio (Pistacia vera L.) belongs to the Anacardiaceae family and it is a small tree species. It is native of the Middle East and Central Asia, but currently, it is cultivated also in California and in some Mediterranean countries, such as Greece and Italy. The most important pistachio producers are Iran, the USA, and Turkey. Besides being a delicious nut, pistachio, due to its wholesome nutritional properties, could be considered as a functional food. According to the results of several studies, pistachios have been proven to have various groups of valuable phytochemicals such as anthocyanins, flavan-3-ols, proanthocyanidins, flavonols, isoflavones, flavanones, stilbenes, and phenolic acids, possessing excellent biological activities...
February 8, 2019: Analytical and Bioanalytical Chemistry
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