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Journals Analytical and Bioanalytical C...

Analytical and Bioanalytical Chemistry

https://read.qxmd.com/read/38546794/towards-a-reference-material-for-microplastics-number-concentration-case-study-of-pet-in-water-using-raman-microspectroscopy
#1
JOURNAL ARTICLE
Oliver Jacob, Elżbieta Anna Stefaniak, John Seghers, Rita La Spina, Gabriella F Schirinzi, Konstantinos Chatzipanagis, Andrea Held, Håkan Emteborg, Robert Koeber, Martin Elsner, Natalia P Ivleva
Increasing demand for size-resolved identification and quantification of microplastic particles in drinking water and environmental samples requires the adequate validation of methods and techniques that can be used for this purpose. In turn, the feasibility of such validation depends on the existence of suitable certified reference materials (CRM). A new candidate reference material (RM), consisting of polyethylene terephthalate (PET) particles and a water matrix, has been developed. Here, we examine its suitability with respect to a homogeneous and stable microplastic particle number concentration across its individual units...
March 28, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38530399/improving-predictions-of-compound-amenability-for-liquid-chromatography-mass-spectrometry-to-enhance-non-targeted-analysis
#2
JOURNAL ARTICLE
Nathaniel Charest, Charles N Lowe, Christian Ramsland, Brian Meyer, Vicente Samano, Antony J Williams
Mass-spectrometry-based non-targeted analysis (NTA), in which mass spectrometric signals are assigned chemical identities based on a systematic collation of evidence, is a growing area of interest for toxicological risk assessment. Successful NTA results in better identification of potentially hazardous pollutants within the environment, facilitating the development of targeted analytical strategies to best characterize risks to human and ecological health. A supporting component of the NTA process involves assessing whether suspected chemicals are amenable to the mass spectrometric method, which is necessary in order to assign an observed signal to the chemical structure...
March 26, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38523160/electrochemical-microfluidic-sensing-platforms-for-biosecurity-analysis
#3
REVIEW
Zhaowei Guan, Quanyi Liu, Chong-Bo Ma, Yan Du
Biosecurity encompasses the health and safety of humans, animals, plants, and the environment. In this article, "biosecurity" is defined as encompassing the comprehensive aspects of human, animal, plant, and environmental safety. Reliable biosecurity testing technology is the key point for effectively assessing biosecurity risks and ensuring biosecurity. Therefore, it is crucial to develop excellent detection technologies to detect risk factors that can affect biosecurity. An electrochemical microfluidic biosensing platform integrates fluid control, target recognition, signal transduction, and output and incorporates the advantages of electrochemical analysis technology and microfluidic technology...
March 25, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38523158/development-of-a-rapid-fire-drug-screening-method-by-probe-electrospray-ionization-tandem-mass-spectrometry-for-human-urine-radpi-u
#4
JOURNAL ARTICLE
Kazuaki Hisatsune, Tasuku Murata, Masaru Taniguchi, Tomomi Asano, Koretsugu Ogata, Akira Iguchi, Kei Zaitsu
Drug screening tests are mandatory in the search for drugs in forensic biological samples, and immunological methods and mass spectrometry (e.g., gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry) are commonly used for that purpose. However, these methods have some drawbacks, and developing new screening methods is required. In this study, we develop a rapid-fire drug screening method by probe electrospray ionization tandem mass spectrometry (PESI-MS/MS), which is an ambient ionization mass spectrometry method, for human urine, named RaDPi-U...
March 25, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38523159/presenting-the-2023-awardees-of-robert-kellner-and-dac-euchems-lectures-congratulations-to-abc-s-chair-editor-antje-baeumner-and-long-term-abc-supporter-dami%C3%A3-barcel%C3%A3
#5
EDITORIAL
Nicola Oberbeckmann-Winter
No abstract text is available yet for this article.
March 24, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38520589/inorganic-arsenic-in-seaweed-a-fast-hplc-icp-ms-method-without-coelution-of-arsenosugars
#6
JOURNAL ARTICLE
Rebecca Sim, Marta Weyer, Ásta H Pétursdóttir
Seaweed is becoming increasingly popular in the Western diet as consumers opt for more sustainable food sources. However, seaweed is known to accumulate high levels of arsenic-which may be in the form of carcinogenic inorganic arsenic (iAs). Here we propose a fast method for the routine measurement of iAs in seaweed using HPLC-ICP-MS without coelution of arsenosugars that may complicate quantification. The developed method was optimised using design of experiments (DOE) and tested on a range of reference materials including TORT-3 (0...
March 23, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38520588/the-tightest-self-assembled-ruthenium-metal-organic-framework-combined-with-proximity-hybridization-for-ultrasensitive-electrochemiluminescence-analysis-of-paraquat
#7
JOURNAL ARTICLE
Ling Qin, Wenbin Liang, Weiguo Yang, Shenghan Tang, Ruo Yuan, Jun Yang, Yan Li, Shanshan Hu
Metal-organic frameworks (MOFs), as porous materials, have great potential for exploring high-performance electrochemiluminescence (ECL) probes. However, the constrained applicability of MOFs in the realm of ECL biosensing is primarily attributed to their inadequate water stability, which consequently impairs the overall ECL efficiency. Herein, we developed a competitive ECL biosensor based on a novel tightest structural ruthenium-based organic framework emitter combining the proximity hybridization-induced catalytic hairpin assembly (CHA) strategy and the quenching effect between the Ru-MOF and ferrocene for detecting paraquat (PQ)...
March 23, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38517490/advanced-tools-for-molecular-characterization-of-bio-based-and-biodegradable-polymers
#8
REVIEW
Ndumiso Sibanda, Helen Pfukwa, Paul Eselem Bungu, Harald Pasch
Bio-based and biodegradable materials play a vital role in a sustainable and green economy. These materials must exhibit properties that are similar to or better than the properties of oil- or coal-based materials and require sophisticated synthesis technologies and detailed knowledge of structure-property correlations. For comprehensive molecular structure elucidation, advanced analytical methods, including coupled and hyphenated techniques that combine advanced fractionation and information-rich spectroscopic detectors, are an indispensable tool...
March 22, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38514583/simultaneous-determination-of-diquat-paraquat-glufosinate-and-glyphosate-in-plasma-by-liquid-chromatography-tandem-mass-spectrometry-from-method-development-to-clinical-application
#9
JOURNAL ARTICLE
Maozhu Liu, Fei Fan, Jing Zhang, Shiyong Fang, Yangjuan Bai, Yamei Li, Yuangao Zou, Yunfei An, Xinhua Dai
Diquat (DQ), paraquat (PQ), glufosinate (GLU), and glyphosate (GLYP) are commonly used herbicides that have been confirmed to be toxic to humans. Rapid and accurate measurements of these toxicants in clinical practice are beneficial for the correct diagnosis and timely treatment of herbicide-poisoned patients. The present study aimed to establish an efficient, convenient, and reliable method to achieve the simultaneous quantification of DQ, PQ, GLU, and GLYP in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS) without using derivatization or ion-pairing reagents...
March 22, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38512384/ratiometric-electrochemiluminescence-sensing-and-intracellular-imaging-of-clo-via-resonance-energy-transfer
#10
JOURNAL ARTICLE
Cheng Ma, Yujing Zhu, Zhichen Zhang, Xuan Chen, Zhengping Ji, Lu-Nan Zhang, Qin Xu
Electrochemiluminescence resonance energy transfer (ECL-RET) is a versatile signal transduction strategy widely used in the fabrication of chem/biosensors. However, this technique has not yet been applied in visualized imaging analysis of intracellular species due to the insulating nature of the cell membrane. Here, we construct a ratiometric ECL-RET analytical method for hypochlorite ions (ClO- ) by ECL luminophore, with a luminol derivative (L-012) as the donor and a fluorescence probe (fluorescein hydrazide) as the acceptor...
March 21, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38509355/correction-to-a-new-methodology-to-reveal-potential-nucleic-acid-modifications-associated-with-the-risk-of-endometrial-cancer-through-dispersive-solid%C3%A2-phase-extraction-coupled-with-uhplc%C3%A2-qe%C3%A2-orbitrap%C3%A2-ms-ms-and-hplc-uv
#11
Huanhuan Zhao, Xiaoguang Zhang, Lujie Zuo, Li Li, Hongfang Yang, Mengyu Zhang, Na Wang, Qingzhong Jia, Yan Liu
No abstract text is available yet for this article.
March 21, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38507043/cross-column-density-functional-theory-based-quantitative-structure-retention-relationship-model-development-powered-by-machine-learning
#12
JOURNAL ARTICLE
Sargol Mazraedoost, Petar Žuvela, Szymon Ulenberg, Tomasz Bączek, J Jay Liu
Quantitative structure-retention relationship (QSRR) modeling has emerged as an efficient alternative to predict analyte retention times using molecular descriptors. However, most reported QSRR models are column-specific, requiring separate models for each high-performance liquid chromatography (HPLC) system. This study evaluates the potential of machine learning (ML) algorithms and quantum mechanical (QM) descriptors to develop QSRR models that can predict retention times across three different reversed-phase HPLC columns under varying conditions...
March 20, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38507042/reliable-biological-and-multi-omics-research-through-biometrology
#13
JOURNAL ARTICLE
Lianhua Dong, Yu Zhang, Boqiang Fu, Claudia Swart, Huayan Jiang, Yahui Liu, Jim Huggett, Robert Wielgosz, Chunyan Niu, Qianyi Li, Yongzhuo Zhang, Sang-Ryoul Park, Zhiwei Sui, Lianchao Yu, Yangyang Liu, Qing Xie, Hongfu Zhang, Yueyuxiao Yang, Xinhua Dai, Leming Shi, Ye Yin, Xiang Fang
Metrology is the science of measurement and its applications, whereas biometrology is the science of biological measurement and its applications. Biometrology aims to achieve accuracy and consistency of biological measurements by focusing on the development of metrological traceability, biological reference measurement procedures, and reference materials. Irreproducibility of biological and multi-omics research results from different laboratories, platforms, and analysis methods is hampering the translation of research into clinical uses and can often be attributed to the lack of biologists' attention to the general principles of metrology...
March 20, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38503987/advances-in-d-dimer-testing-progress-in-harmonization-of-clinical-assays-and-innovative-detection-methods
#14
REVIEW
Rong Zhao, Mengran Li, Peng Xiao, Dewei Song, Hongmei Li
The D-dimer is a sensitive indicator of coagulation and fibrinolysis activation, especially valuable as a biomarker of intravascular thrombosis. Measurement of plasma D-dimer levels plays a crucial role in the diagnosis and monitoring of conditions such as deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. A variety of immunoassays, including enzyme-linked immunosorbent assays, latex-enhanced immunoturbidimetric assays, whole-blood aggregation analysis, and immunochromatography assays, are widely used in clinical settings to determine D-dimer levels...
March 20, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38502374/simultaneous-identification-of-three-emergent-stimulant-laxative-adulterants-in-slimming-foods-using-only-one-antibody
#15
JOURNAL ARTICLE
Tian Guan, Sha Chen, Yanhong Chen, Yu Wang, Xiaoqin Yu, Xinan Huang, Qing Liu, Hongtao Lei, Qunhua Yang
Stimulant laxatives were recently found to be abused in slimming foods, resulting in harmful effects on consumers. To ensure the safety of relative products, sensitive yet multiplex immunoassays are crucial in rapid screening of stimulant laxatives. However, there are few immunoassays for these substances, and even less for broad-specific recognition. Thus, in this work, four theoretically promising haptens of emerging stimulant laxative bisacodyl were rationally designed using molecular modeling and synthesized to immune animals, whose feasibility was confirmed by the obtained broad-specific antibody...
March 19, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38492025/elemental-mass-spectrometry-for-bioanalysis
#16
EDITORIAL
Jörg Bettmer, Mario Corte-Rodríguez, Marcia Foster Mesko
No abstract text is available yet for this article.
March 16, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38492024/electron-activated-dissociation-ead-for-the-complementary-annotation-of-metabolites-and-lipids-through-data-dependent-acquisition-analysis-and-feature-based-molecular-networking-applied-to-the-sentinel-amphipod-gammarus-fossarum
#17
JOURNAL ARTICLE
Valentina Calabrese, Thomas Alexandre Brunet, Davide Degli-Esposti, Arnaud Chaumot, Olivier Geffard, Arnaud Salvador, Yohann Clément, Sophie Ayciriex
The past decades have marked the rise of metabolomics and lipidomics as the -omics sciences which reflect the most phenotypes in living systems. Mass spectrometry-based approaches are acknowledged for both quantification and identification of molecular signatures, the latter relying primarily on fragmentation spectra interpretation. However, the high structural diversity of biological small molecules poses a considerable challenge in compound annotation. Feature-based molecular networking (FBMN) combined with database searches currently sets the gold standard for annotation of large datasets...
March 16, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38491149/development-of-alkaline-phosphatase-linked-single-chain-variable-fragment-fusion-proteins-for-one-step-immunodetection-of-deoxynivalenol-in-cereals
#18
JOURNAL ARTICLE
Li Wen, Yirui Huang, Zhichang Sun, Shiyuan Shi, Xiaoxia Xie, Zhenyun He, Xing Liu
Deoxynivalenol (DON) is a mycotoxin that widely distributes in various foods and seriously threatens food safety. To minimize the consumers' dietary exposure to DON, there is an urgent demand for developing rapid and sensitive detection methods for DON in food. In this study, a bifunctional single-chain variable fragment (scFv) linked alkaline phosphatase (ALP) fusion protein was developed for rapid and sensitive detection of deoxynivalenol (DON). The scFv gene was chemically synthesized and cloned into the expression vector pET25b containing the ALP gene by homologous recombination...
March 16, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38488952/towards-clinical-adherence-monitoring-of-oral-endocrine-breast-cancer-therapies-by-lc-hrms-method-development-validation-comparison-of-four-sample-matrices-and-proof-of-concept
#19
JOURNAL ARTICLE
Cathy M Jacobs, Julia C Radosa, Lea Wagmann, Julia S M Zimmermann, Askin C Kaya, Aylin Aygün, Tatjana Edel, Lisa Stotz, Mohamed Ismaeil, Erich-Franz Solomayer, Markus R Meyer
Oral endocrine therapies (OET) for breast cancer treatment need to be taken over a long period of time and are associated with considerable side effects. Therefore, adherence to OET is an important issue and of high clinical significance for breast cancer patients' caregivers. We hypothesized that a new bioanalytical strategy based on liquid chromatography and high-resolution mass spectrometry might be suitable for unbiased adherence monitoring (AM) of OET. Four different biomatrices (plasma, urine, finger prick blood by volumetric absorptive microsampling (VAMS), oral fluid (OF)) were evaluated regarding their suitability for AM of the OET abemaciclib, anastrozole, exemestane, letrozole, palbociclib, ribociclib, tamoxifen, and endoxifen...
March 15, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38488951/advances-in-the-application-of-logic-gates-in-nanozymes
#20
REVIEW
Xiangru Hou, Lu Ga, Xin Zhang, Jun Ai
Nanozymes are a class of nanomaterials with biocatalytic function and enzyme-like activity, whose advantages include high stability, low cost, and mass production. They can catalyze the substrates of natural enzymes based on specific nanostructures and serve as substitutes for natural enzymes. Their applied research involves a wide range of fields such as biomedicine, environmental governance, agriculture, and food. Molecular logic gates are a new cross-disciplinary discipline, which can simulate the function of silicon circuits on a molecular scale, perform single or multiple input logic operations, and generate logic outputs...
March 15, 2024: Analytical and Bioanalytical Chemistry
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