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Aging Clinical and Experimental Research

Pattranid Mueangpaisarn, Sumapa Chaiamnuay
BACKGROUND: Vitamin D inadequacy is common in institutionalized post-menopausal women who are at the highest risk for osteoporotic fracture. AIM: To evaluate efficacy and safety of ergocalciferol 40,000 versus 100,000 IU per week for 12 weeks for vitamin D inadequacy in institutionalized postmenopausal women. METHOD: A randomized double-blinded placebo-controlled trial was conducted in 94 institutionalized subjects with baseline 25(OH)D levels < 30 ng/mL...
February 19, 2019: Aging Clinical and Experimental Research
Jolan Dupont, Lenore Dedeyne, Sebastiaan Dalle, Katrien Koppo, Evelien Gielen
Sarcopenia is a geriatric syndrome with increasing importance due to the aging of the population. It is known to impose a major burden in terms of morbidity, mortality and socio-economic costs. Therefore, adequate preventive and treatment strategies are required. Progressive resistance training and protein supplementation are currently recommended for the prevention and treatment of sarcopenia. Omega-3 polyunsaturated fatty acids (PUFAs) might be an alternative therapeutic agent for sarcopenia due to their anti-inflammatory properties, which target the 'inflammaging', the age-related chronic low-grade inflammation which is assumed to contribute to the development of sarcopenia...
February 19, 2019: Aging Clinical and Experimental Research
Luca Agosta, Mario Bo, Lara Bianchi, Pasquale Abete, Giuseppe Belelli, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Giovanna Maria Manca, Maria Rosaria Rizzo, Andrea Rossi, Francesco Landi, Stefano Volpato
BACKGROUND: Recently the Berlin Aging Study II (BASE-II) showed that polypharmacy is associated with clinically relevant sarcopenia among community-dwelling older persons. Here we report findings from the GLISTEN study about the association of polypharmacy with sarcopenia among older medical in-patients. METHODS: The GLISTEN study investigated prevalence and clinical correlates of sarcopenia in older patients admitted to geriatric and internal medicine acute care wards of 12 Italian hospitals...
February 18, 2019: Aging Clinical and Experimental Research
A M Lee, M Sénéchal, T J Hrubeniuk, D R Bouchard
BACKGROUND: Little is known about the sitting time in long-term care (LTC) facilities, or if sedentary behaviour affects changes in mobility over time. AIMS: The objectives were to document the sitting time of LTC residents and to examine if sitting time could predict changes in mobility. METHODS: Twenty residents of an LTC facility, representing three mobility statuses (independent, assisted transfer, and dependent transfer) were included...
February 18, 2019: Aging Clinical and Experimental Research
Abdulrahman M Alfuraih, Ai Lyn Tan, Philip O'Connor, Paul Emery, Richard J Wakefield
BACKGROUND: Skeletal muscle undergoes structural changes with ageing which may alter its biomechanical properties. Shear wave elastography (SWE) may detect these changes by measuring muscle stiffness. AIMS: To investigate muscle stiffness in healthy young, middle-aged and elderly cohorts using SWE and correlate it with muscle strength and mass. METHODS: Shear wave velocity (SWV) was measured in the quadriceps, hamstrings and biceps brachii of 26 young (range 20-35 years), 21 middle-aged (40-55) and 30 elderly (77-94) volunteers...
February 14, 2019: Aging Clinical and Experimental Research
Meltem Koca, Gözde Şengül Ayçiçek, Pelin Ünsal, Olgun Deniz, Ayşe Şendur, Mert Eşme, Burcu Balam Yavuz, Meltem Gülhan Halil, Mustafa Cankurtaran
No abstract text is available yet for this article.
February 13, 2019: Aging Clinical and Experimental Research
Olivier Bruyère, Jean-Yves Reginster, Germain Honvo, Johann Detilleux
BACKGROUND: The economic evaluation of treatments usually requires access to individual patient data, which is difficult to obtain. Moreover, in osteoarthritis, health utility scores are unavailable and can be assessed only using a validated equation model based on various clinical data. We aimed to develop and validate a methodology to simulate individual health utility scores from aggregated clinical data available in published studies to calculate the cost-effectiveness of different glucosamine preparations (i...
February 12, 2019: Aging Clinical and Experimental Research
Bergthora Baldursdottir, Susan L Whitney, Alfons Ramel, Palmi V Jonsson, Brynjolfur Mogensen, Hannes Petersen, Ella K Kristinsdottir
BACKGROUND: Asymmetric vestibular function, decreased plantar sensation, postural control and functional ability have been associated with fall-related wrist fractures. OBJECTIVE: To investigate whether multi-sensory training (MST) improves postural control, vestibular function, foot sensation and functional ability among people with fall-related wrist fractures compared to wrist stabilization training (WT). METHODS: This was an assessor-blinded, randomized controlled trial...
February 11, 2019: Aging Clinical and Experimental Research
Shuo Wang, Huiru Yin, Xinxin Wang, Yong Jia, Chunyan Wang, Lisheng Wang, Li Chen
OBJECTIVE: To compare the efficacy of different types of exercises on global cognition in adults with mild cognitive impairment. METHODS: We systematically searched six databases from their inception to December 14, 2018, for randomized controlled trials evaluating the efficacy of exercise on global cognition in adults with mild cognitive impairment. For the included studies, the mean changes in global cognition from baseline to endpoint were analyzed. A random-effects model was used to conduct pairwise meta-analyses to directly examine the efficacy of different types of exercises...
February 9, 2019: Aging Clinical and Experimental Research
Sandro Giuffrida
Recently, the National Immunization Plan (NIP) in Italy has highlighted the importance of immunization practices also for adults, including vaccinations against influenza, Pneumococcus (PNO) and HZ. In response to the NIP, the Calabria region decided to offer HZ vaccination to the two cohorts of 65- and 70-year-old subjects. We at the Reggio Calabria Local Health Services, concentrated our efforts on addressing all the above-mentioned shortcomings and, as a first measure, we addressed the convenience problem by scheduling the HZ vaccine administration during the same visit as the pneumococcal vaccination (PCV13 vaccine)...
February 8, 2019: Aging Clinical and Experimental Research
René Rizzoli
Gut microbiota (GM) located within the intestinal tract lumen comprises the largest number of cells (10E 14) in the human body. The gut microbiome refers to the collection of genomes and genes present in gut microbiota. GM can vary according to age, sex, genetic background, immune status, geography, diet, prebiotics, which are non-digestible fibers metabolized in the distal part of the gastrointestinal tract, probiotics, which are micro-organisms conferring a health benefit on the host when administered in adequate amounts, living conditions, diseases and drugs...
February 1, 2019: Aging Clinical and Experimental Research
Erkan Yıldırım, Emrah Ermis, Samir Allahverdiyev, Hakan Ucar, Serap Yavuzer, Hakan Yavuzer, Mahir Cengiz
BACKGROUND: Hypertension is an important risk factor for cardiovascular diseases and cognitive function. Blood pressure (BP) variability has been associated with cognitive dysfunction, but data are sparse regarding the relationship between BP variability and cognitive function in geriatric patients with well-controlled BP. AIM: The aim of this study was to demonstrate the relationship between blood pressure variability and cognitive functions in geriatric hypertensive patients with well-controlled BP...
February 1, 2019: Aging Clinical and Experimental Research
Debbie Norring-Agerskov, Lise Bathum, Ole B Pedersen, Bo Abrahamsen, Jes B Lauritzen, Niklas R Jørgensen, Henrik L Jørgensen
PURPOSE: The purpose of this study was to examine the possible association between mortality following a hip fracture and known biochemical markers of inflammation. METHODS: The study population was identified using two local databases from Bispebjerg Hospital (Copenhagen, Denmark): the Hip Fracture Database containing all patients admitted to the hospital with a fractured hip from 1996 to 2012 and the Hip Fracture Biobank, containing whole blood, serum and plasma taken in relation to admission on a subgroup of patients from the Hip Fracture Database, consecutively collected over a period of 2...
February 1, 2019: Aging Clinical and Experimental Research
Mario Ulises Pérez-Zepeda, Carmen García-Peña, María Fernanda Carrillo-Vega
Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican Health and Aging Study. A sub-sample of 60-year or older adults with anthropometric measurements was analyzed. Frailty was defined with a 31-item frailty index and those considered frail had a score ≥ 0...
January 31, 2019: Aging Clinical and Experimental Research
Konstantinos Dretakis, Vasilios G Igoumenou
BACKGROUND: Fragility fractures of the hip are associated with high morbidity and mortality, and represent a rather devastating consequence of osteoporosis. Hip fractures are traditionally investigated as a whole, although it has been recently implied that distinct pathogenic mechanisms may lead either to trochanteric or subcapital fractures. AIMS: To investigate whether differences exist by hip fracture type with respect to serum 25(OH)D (vitamin D) and parathyroid hormone (PTH) levels, in addition to epidemiological and demographic data, including history of falls...
January 30, 2019: Aging Clinical and Experimental Research
Yujiao Sun, Haiyan Zhang, Wen Tian, Liye Shi, Ling Chen, Jinyang Li, Shijie Zhao, Guoxian Qi
BACKGROUND: The association between uric acid (UA) and coronary artery disease (CAD) was controversial. It was still unclear how the UA level changes with age and gender. AIMS: To confirm the relationship between the change of UA with age and gender and CAD, especially in elderly people. METHODS: 8285 individuals were investigated. The changes of UA and hyperuricemia in female and male with age were analyzed. The associations of UA, and hyperuricemia with CAD in different age and sex were assessed...
January 29, 2019: Aging Clinical and Experimental Research
Chie Fukui, Mahiro Fujisaki-Sueda-Sakai, Nobutada Yokouchi, Yuka Sumikawa, Fumika Horinuki, Ayako Baba, Makoto Suto, Hiroko Okada, Ryogo Ogino, Hyosook Park, Junichiro Okata
BACKGROUND AND AIMS: Several studies have shown the effectiveness and diversity of dementia cafés, whereas there are few published articles in academic research focusing on what persons with dementia and their family caregivers need and whether the services provided satisfy their needs. This study aimed to identify the needs of persons with dementia and their family caregivers participating in dementia cafés in Japan. METHODS: Interviews and participant observations were conducted in nine dementia cafés...
January 29, 2019: Aging Clinical and Experimental Research
Young Woong Son, Ain Kim, Han Ho Jeon
BACKGROUND: Endoscopic submucosal dissection (ESD) has been widely used in gastric tumor as a minimally invasive treatment. The efficacy and safety of ESD is still unclear in the elderly who have high frequency comorbidities. The aim of this study is to evaluate the efficacy and safety of ESD for gastric epithelial neoplasia in patients aged 80 years and older. METHODS: Between March 2013 and July 2017, a total of 438 gastric epithelial neoplasia patients treated with ESD were analyzed...
January 29, 2019: Aging Clinical and Experimental Research
Ayman Zant, Hussain M Awwad, Jürgen Geisel, Markus Keller, Rima Obeid
BACKGROUND: Elderly people are at risk for vitamin B12 deficiency. AIMS: We studied the ability of vitamin B12-enriched toothpaste vs. placebo to increase vitamin B12 status in elderly subjects. METHODS: We conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects. Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months...
January 24, 2019: Aging Clinical and Experimental Research
Marina De Rui, Emine Meral Inelmen, Sabrina Pigozzo, Caterina Trevisan, Enzo Manzato, Giuseppe Sergi
The synchronic loss of bone mineral density and decrease in muscle mass, strength, and function defines the scenario of osteosarcopenia, which is associated with an increased risk of falls and fractures in older adults. An important role in preventing muscle and bone loss is played by nutritional factors, in particular the intake of proteins, calcium, magnesium and vitamin D. This review summarizes the available literature concerning the influence of protein intake and supplementation (vitamin D, Ca, Mg, branched-chain amino acids) on the decline of musculoskeletal integrity in healthy older adults...
January 23, 2019: Aging Clinical and Experimental Research
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