journal
https://read.qxmd.com/read/38532727/hungry-for-biomarkers-of-aging
#1
EDITORIAL
Nathan K LeBrasseur
No abstract text is available yet for this article.
March 27, 2024: Aging Cell
https://read.qxmd.com/read/38532712/prevention-of-age-related-neuromuscular-junction-degeneration-in-sarcopenia-by-low-magnitude-high-frequency-vibration
#2
JOURNAL ARTICLE
Zhengyuan Bao, Can Cui, Chaoran Liu, Yufeng Long, Ronald Man Yeung Wong, Senlin Chai, Ling Qin, Clinton Rubin, Benjamin Hon Kei Yip, Zhihong Xu, Qing Jiang, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Neuromuscular junction (NMJ) degeneration is one of pathological factors of sarcopenia. Low-magnitude high-frequency vibration (LMHFV) was reported effective in alleviating the sarcopenia progress. However, no previous study has investigated treatment effects of LMHFV targeting NMJ degeneration in sarcopenia. We first compared morphological differences of NMJ between sarcopenic and non-sarcopenic subjects, as well as young and old C57BL/6 mice. We then systematically characterized the age-related degeneration of NMJ in SAMP8 against its control strain, SAMR1 mice, from 3 to 12 months old...
March 27, 2024: Aging Cell
https://read.qxmd.com/read/38529808/human-%C3%AE-synuclein-overexpression-upregulates-skor1-in-a-rat-model-of-simulated-nigrostriatal-ageing
#3
JOURNAL ARTICLE
Noelia Morales-Prieto, Rebekah Bevans, Adam O'Mahony, Aaron Barron, Conor Giles Doran, Erin McCarthy, Ruth M Concannon, Susan R Goulding, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeffe
Parkinson's disease (PD) is characterised by progressive loss of dopaminergic (DA) neurons from the substantia nigra (SN) and α-synuclein (αSyn) accumulation. Age is the biggest risk factor for PD and may create a vulnerable pre-parkinsonian state, but the drivers of this association are unclear. It is known that ageing increases αSyn expression in DA neurons and that this may alter molecular processes that are central to maintaining nigrostriatal integrity. To model this, adult female Sprague-Dawley rats received a unilateral intranigral injection of adeno-associated viral (AAV) vector carrying wild-type human αSyn (AAV-αSyn) or control vector (AAV-Null)...
March 26, 2024: Aging Cell
https://read.qxmd.com/read/38529797/combinatorial-transcriptomic-and-genetic-dissection-of-insulin-igf-1-signaling-regulated-longevity-in-caenorhabditis-elegans
#4
JOURNAL ARTICLE
Seokjin Ham, Sieun S Kim, Sangsoon Park, Hyunwoo C Kwon, Seokjun G Ha, Yunkyu Bae, Gee-Yoon Lee, Seung-Jae V Lee
Classical genetic analysis is invaluable for understanding the genetic interactions underlying specific phenotypes, but requires laborious and subjective experiments to characterize polygenic and quantitative traits. Contrarily, transcriptomic analysis enables the simultaneous and objective identification of multiple genes whose expression changes are associated with specific phenotypes. Here, we conducted transcriptomic analysis of genes crucial for longevity using datasets with daf-2/insulin/IGF-1 receptor mutant Caenorhabditis elegans...
March 26, 2024: Aging Cell
https://read.qxmd.com/read/38520065/humanin-variant-p3s-is-associated-with-longevity-in-apoe4-carriers-and-resists-apoe4-induced-brain-pathology
#5
JOURNAL ARTICLE
Brendan Miller, Su-Jeong Kim, Kevin Cao, Hemal H Mehta, Neehar Thumaty, Hiroshi Kumagai, Tomomitsu Iida, Cassandra McGill, Christian J Pike, Kamila Nurmakova, Zachary A Levine, Patrick M Sullivan, Kelvin Yen, Nilüfer Ertekin-Taner, Gil Atzmon, Nir Barzilai, Pinchas Cohen
The APOE4 allele is recognized as a significant genetic risk factor to Alzheimer's disease (AD) and influences longevity. Nonetheless, some APOE4 carriers exhibit resistance to AD even in advanced age. Humanin, a mitochondrial-derived peptide comprising 24 amino acids, has variants linked to cognitive resilience and longevity. Our research uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele. Through in silico analyses and subsequent experimental validation, we demonstrated a strong affinity between humanin P3S and APOE4...
March 22, 2024: Aging Cell
https://read.qxmd.com/read/38517197/age-related-cholesterol-and-colorectal-cancer-progression-validating-squalene-epoxidase-for-high-risk-cases
#6
JOURNAL ARTICLE
Soo Young Jun, Hyang Ran Yoon, Ji-Yong Yoon, Jeong-Ju Lee, Ji Yeon Kim, Jin-Man Kim, Nam-Soon Kim
As people age, the risk and progression of colorectal cancer (CRC), along with cholesterol levels, tend to increase. Nevertheless, epidemiological studies on serum lipids and CRC have produced conflicting results. We previously demonstrated that the reduction of squalene epoxidase (SQLE) due to accumulated cholesterol within cells accelerates CRC progression through the activation of the β-catenin pathway. This study aimed to investigate the mechanism by which age-related cholesterol accumulation within tissue accelerates CRC progression and to assess the clinical significance of SQLE in older individuals with elevated CRC risk...
March 22, 2024: Aging Cell
https://read.qxmd.com/read/38506610/aging-affiliated-post-translational-modifications-of-skeletal-muscle-myosin-affect-biochemical-properties-myofibril-structure-muscle-function-and-proteostasis
#7
JOURNAL ARTICLE
Clara L Neal, William A Kronert, Jared Rafael T Camillo, Jennifer A Suggs, Tom Huxford, Sanford I Bernstein
The molecular motor myosin is post-translationally modified in its globular head, its S2 hinge, and its thick filament domain during human skeletal muscle aging. To determine the importance of such modifications, we performed an integrative analysis of transgenic Drosophila melanogaster expressing myosin containing post-translational modification mimic mutations. We determined effects on muscle function, myofibril structure, and myosin biochemistry. Modifications in the homozygous state decreased jump muscle function by a third at 3 weeks of age and reduced indirect flight muscle function to negligible levels in young flies, with severe effects on flight muscle myofibril assembly and/or maintenance...
March 20, 2024: Aging Cell
https://read.qxmd.com/read/38504487/genetic-and-pharmacological-modulation-of-lamin-a%C3%A2-farnesylation-determines-its-function-and-turnover
#8
JOURNAL ARTICLE
Mattheus Xing Rong Foo, Peh Fern Ong, Zi Xuan Yap, Martina Maric, Christopher Jue Shi Bong, Peter Dröge, Brian Burke, Oliver Dreesen
Hutchinson-Gilford Progeria syndrome (HGPS) is a severe premature ageing disorder caused by a 50 amino acid truncated (Δ50AA) and permanently farnesylated lamin A (LA) mutant called progerin. On a cellular level, progerin expression leads to heterochromatin loss, impaired nucleocytoplasmic transport, telomeric DNA damage and a permanent growth arrest called cellular senescence. Although the genetic basis for HGPS has been elucidated 20 years ago, the question whether the Δ50AA or the permanent farnesylation causes cellular defects has not been addressed...
March 19, 2024: Aging Cell
https://read.qxmd.com/read/38504468/effect-of-long-term-caloric-restriction-on-telomere-length-in-healthy-adults-calerie%C3%A2-2-trial-analysis
#9
JOURNAL ARTICLE
Waylon J Hastings, Qiaofeng Ye, Sarah E Wolf, Calen P Ryan, Sai Krupa Das, Kim M Huffman, Michael S Kobor, William E Kraus, Julia L MacIsaac, Corby K Martin, Susan B Racette, Leanne M Redman, Daniel W Belsky, Idan Shalev
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21-50y; BMI 22.0-27.9 kg/m2 ), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior analyses of CALERIE™ participants' blood chemistries, immunology, and epigenetic data suggest the 2-year CR intervention slowed biological aging...
March 19, 2024: Aging Cell
https://read.qxmd.com/read/38500398/stem-cell-secretome-treatment-improves-whole-body-metabolism-reduces-adiposity-and-promotes-skeletal-muscle-function-in-aged-mice
#10
JOURNAL ARTICLE
Zachary J Fennel, Paul-Emile Bourrant, Anu Susan Kurian, Jonathan J Petrocelli, Naomi M M P de Hart, Elena M Yee, Sihem Boudina, Hans S Keirstead, Gabrielle Nistor, Scott A Greilach, Nicole C Berchtold, Thomas E Lane, Micah J Drummond
Aging coincides with the progressive loss of muscle mass and strength, increased adiposity, and diminished physical function. Accordingly, interventions aimed at improving muscle, metabolic, and/or physical health are of interest to mitigate the adverse effects of aging. In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth, cytoskeletal remodeling, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls...
March 18, 2024: Aging Cell
https://read.qxmd.com/read/38494663/microrna-7-deficiency-ameliorates-d-galactose-induced-aging-in-mice-by-regulating-senescence-of-kupffer-cells
#11
JOURNAL ARTICLE
Ya Wang, Hui Qiu, Shipeng Chen, Dongmei Li, Xu Zhao, Mengmeng Guo, Nana Li, Chao Chen, Ming Qin, Ya Zhou, Daimin Xiao, Juanjuan Zhao, Lin Xu
Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA-7 (miR-7) as a novel regulator of immune cell function and related diseases. However, the potential role of miR-7 in aging remains unexplored. Here, we investigated the contribution of miR-7 to d-gal-induced aging in mice, focusing on its regulation of senescent Kupffer cells. Our findings revealed that miR-7 deficiency significantly ameliorated the aging process, characterized by enhanced CD4+ T-cell activation...
March 17, 2024: Aging Cell
https://read.qxmd.com/read/38482753/mitophagy-defect-mediates-the-aging-associated-hallmarks-in-hutchinson-gilford-progeria-syndrome
#12
JOURNAL ARTICLE
Yingying Sun, Le Xu, Yi Li, Shunze Jia, Gang Wang, Xufeng Cen, Yuyan Xu, Zhongkai Cao, Jingjing Wang, Ning Shen, Lidan Hu, Jin Zhang, Jianhua Mao, Hongguang Xia, Zhihong Liu, Xudong Fu
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal disease manifested by premature aging and aging-related phenotypes, making it a disease model for aging. The cellular machinery mediating age-associated phenotypes in HGPS remains largely unknown, resulting in limited therapeutic targets for HGPS. In this study, we showed that mitophagy defects impaired mitochondrial function and contributed to cellular markers associated with aging in mesenchymal stem cells derived from HGPS patients (HGPS-MSCs)...
March 14, 2024: Aging Cell
https://read.qxmd.com/read/38481058/the-aged-microenvironment-impairs-bcl6-and-cd40l-induction-in-cd4-t-follicular-helper-cell-differentiation
#13
JOURNAL ARTICLE
Jacob S Fisher, Irene Adán-Barrientos, Naveen R Kumar, Jessica N Lancaster
Weakened germinal center responses by the aged immune system result in diminished immunity against pathogens and reduced efficacy of vaccines. Prolonged contacts between activated B cells and CD4+ T cells are crucial to germinal center formation and T follicular helper cell (Tfh) differentiation, but it is unclear how aging impacts the quality of this interaction. Peptide immunization confirmed that aged mice have decreased expansion of antigen-specific germinal center B cells and reduced antibody titers. Furthermore, aging was associated with accumulated Tfh cells, even in naïve mice...
March 13, 2024: Aging Cell
https://read.qxmd.com/read/38481042/dual-treatment-with-kynurenine-pathway-inhibitors-and-nad-precursors-synergistically-extends-life-span-in-drosophila
#14
JOURNAL ARTICLE
Mariann M Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E Fairman, Anne Le, Ginger L Milne, Fernando J Vonhoff, Jeremy D Walston, Peter M Abadir
Tryptophan catabolism is highly conserved and generates important bioactive metabolites, including kynurenines, and in some animals, NAD+ . Aging and inflammation are associated with increased levels of kynurenine pathway (KP) metabolites and depleted NAD+ , factors which are implicated as contributors to frailty and morbidity. Contrastingly, KP suppression and NAD+ supplementation are associated with increased life span in some animals. Here, we used DGRP_229 Drosophila to elucidate the effects of KP elevation, KP suppression, and NAD+ supplementation on physical performance and survivorship...
March 13, 2024: Aging Cell
https://read.qxmd.com/read/38475941/endothelial-specific-telomerase-inactivation-causes-telomere-independent-cell-senescence-and-multi-organ-dysfunction-characteristic-of-aging
#15
JOURNAL ARTICLE
Zhanguo Gao, Rafael Bravo Santos, Joseph Rupert, Rachel Van Drunen, Yongmei Yu, Kristin Eckel-Mahan, Mikhail G Kolonin
It has remained unclear how aging of endothelial cells (EC) contributes to pathophysiology of individual organs. Cell senescence results in part from inactivation of telomerase (TERT). Here, we analyzed mice with Tert knockout specifically in EC. Tert loss in EC induced transcriptional changes indicative of senescence and tissue hypoxia in EC and in other cells. We demonstrate that EC-Tert-KO mice have leaky blood vessels. The blood-brain barrier of EC-Tert-KO mice is compromised, and their cognitive function is impaired...
March 12, 2024: Aging Cell
https://read.qxmd.com/read/38475908/dermal-stiffness-governs-the-topography-of-the-epidermis-and-the-underlying-basement-membrane-in-young-and-old-human-skin
#16
JOURNAL ARTICLE
Eva Roig-Rosello, Guila Dayan, Simone Bovio, Patricia Manissier, Elisabeth Errazuriz, Patricia Rousselle
The epidermis is a stratified epithelium that forms the outer layer of the skin. It is composed primarily of keratinocytes and is constantly renewed by the proliferation of stem cells and their progeny that undergo terminal differentiation as they leave the basal layer and migrate to the skin surface. Basal keratinocytes rest on a basement membrane composed of an extracellular matrix that controls their fate via integrin-mediated focal adhesions and hemidesmosomes which are critical elements of the epidermal barrier and promote its regenerative capabilities...
March 12, 2024: Aging Cell
https://read.qxmd.com/read/38465473/polr3b-heterozygosity-in-mice-induces-both-beneficial-and-deleterious-effects-on-health-during-ageing-with-no-effect-on-lifespan
#17
JOURNAL ARTICLE
Gillian Borland, Stephen E Wilkie, Jackie Thomson, Zhe Wang, Jennifer M A Tullet, Nazif Alic, Colin Selman
The genetic pathways that modulate ageing in multicellular organisms are typically highly conserved across wide evolutionary distances. Recently RNA polymerase III (Pol III) was shown to promote ageing in yeast, C. elegans and D. melanogaster. In this study we investigated the role of Pol III in mammalian ageing using C57BL/6N mice heterozygous for Pol III (Polr3b+/- ). We identified sexually dimorphic, organ-specific beneficial as well as detrimental effects of the Polr3b+/- mutation on health. Female Polr3b+/- mice displayed improved bone health during ageing, but their ability to maintain an effective gut barrier function was compromised and they were susceptible to idiopathic dermatitis (ID)...
March 11, 2024: Aging Cell
https://read.qxmd.com/read/38459711/chronic-tnf-exposure-induces-glucocorticoid-like-immunosuppression-in-the-alveolar-macrophages-of-aged-mice-that-enhances-their-susceptibility-to-pneumonia
#18
JOURNAL ARTICLE
Katherine L Kruckow, Elizabeth Murray, Elnur Shayhidin, Alexander F Rosenberg, Dawn M E Bowdish, Carlos J Orihuela
Chronic low-grade inflammation, particularly elevated tumor necrosis factor (TNF) levels, occurs due to advanced age and is associated with greater susceptibility to infection. One reason for this is age-dependent macrophage dysfunction (ADMD). Herein, we use the adoptive transfer of alveolar macrophages (AM) from aged mice into the airway of young mice to show that inherent age-related defects in AM were sufficient to increase the susceptibility to Streptococcus pneumoniae, a Gram-positive bacterium and the leading cause of community-acquired pneumonia...
March 8, 2024: Aging Cell
https://read.qxmd.com/read/38454639/a-molecular-index-for-biological-age-identified-from-the-metabolome-and-senescence-associated-secretome-in-humans
#19
JOURNAL ARTICLE
Shruthi Hamsanathan, Tamil Anthonymuthu, Denise Prosser, Anna Lokshin, Susan L Greenspan, Neil M Resnick, Subashan Perera, Satoshi Okawa, Giri Narasimhan, Aditi U Gurkar
Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill-defined. To define a high-resolution signature of biological age, we analyzed metabolome, circulating senescence-associated secretome (SASP)/inflammation markers and the interaction between them, from a cohort of healthy and rapid agers. The balance between two fatty acid oxidation mechanisms, β-oxidation and ω-oxidation, associated with the extent of functional aging...
March 7, 2024: Aging Cell
https://read.qxmd.com/read/38451018/ercc1-dna-repair-deficiency-results-in-vascular-aging-characterized-by-vsmc-phenotype-switching-ecm-remodeling-and-an-increased-stress-response
#20
JOURNAL ARTICLE
Janette van der Linden, Sanne J M Stefens, José María Heredia-Genestar, Yanto Ridwan, Renata M C Brandt, Nicole van Vliet, Isa de Beer, Bibi S van Thiel, Herman Steen, Caroline Cheng, Anton J M Roks, A H Jan Danser, Jeroen Essers, Ingrid van der Pluijm
Cardiovascular diseases are the number one cause of death globally. The most important determinant of cardiovascular health is a person's age. Aging results in structural changes and functional decline of the cardiovascular system. DNA damage is an important contributor to the aging process, and mice with a DNA repair defect caused by Ercc1 deficiency display hypertension, vascular stiffening, and loss of vasomotor control. To determine the underlying cause, we compared important hallmarks of vascular aging in aortas of both Ercc1Δ/- and age-matched wildtype mice...
March 7, 2024: Aging Cell
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