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Asian Pacific Journal of Cancer Prevention: APJCP

Sovannara Thay, Sally Ann Peprah, Chin Hur, Angela C Tramontano, Ellen Maling, Andrew T Goldstein, Christina Hong
Introduction: There is a high burden of cervical cancer in Cambodia, yet published data on the prevalence of cervical dysplasia and the risk factors contributing to the development of pre-cancerous lesions in Cambodian women is very limited. In addition, as it is well known that HIV positivity increases cervical cancer risk, it is important to quantify the prevalence of cervical dysplasia and carcinoma among Cambodian women living with HIV disease. Methods: A cross-sectional study was conducted with a sample of 499 HIV+ and 501 HIV- Cambodian women at the Sihanouk Hospital Center of HOPE...
February 28, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Chontira Kawthaisong, Supannee Promthet, Supot Kamsa-Ard, Rujira Duangsong
Background: Colorectal cancer is an important public health problem worldwide. Although progress in screening and treatment has considerably improved the prognosis in the developed world, in developing countries colorectal cancer mortality rate remains relatively high. Colorectal cancer screening literacy is an important initial step in overcoming this problem. Development of a validated assessment instrument is therefore important for implementation of appropriate health education programs to facilitate early detection...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Isnaini Isnaini, Alfi Yasmina, Hendra Wana Nur’amin
Melastoma malabathricum L. is a type of plant naturally grows in Kalimantan that has medicinal properties. Ethanolic extract of M. malabathricum L. flower has quercetin and kaempferol contents that have antioxidant and anticancer activities. But the antioxidant and cytotoxicity activities of M. malabathricum L. fruit ethanolic extract were not known. This study measured the quercetin and kaempferol level in M. malabathricum L. fruit ethanolic extract using HPLC MS/MS, antioxidant activity using DPPH method, and cytotoxicity activity using Brine Shrimp Lethality Test (BSLT) method...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Manjunath K N, Siddalingaswamy P C, G K Prabhu
Background: The purpose of the research was to improve the polyp detection accuracy in CT Colonography (CTC) through effective colon segmentation, removal of tagged fecal matter through Electronic Cleansing (EC), and measuring the smaller polyps. Methods: An improved method of boundary-based semi-automatic colon segmentation with the knowledge of colon distension, an adaptive multistep method for the virtual cleansing of segmented colon based on the knowledge of Hounsfield Units, and an automated method of smaller polyp measurement using skeletonization technique have been implemented...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Gamal Amira, Ahmed Morsi, Ihab Samy Fayek, Osman Mansour, Heba Nader
Objectives: To assess the efficacy of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in recurrent platinum-sensitive ovarian cancer patients in comparison with standard intravenous chemotherapy in terms of progression free survival and overall survival. Methods: Retrospective case control study matching 15 cases with 20 controls with at least 24 months of follow up. Results: The two groups were comparable and well matched in all aspects. Median follow up was 36 months in cases and 38 months in controls...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Tarek Aboushousha, Rana Lashen, Khadega Abdelnaser, Noha Helal, Mona Moussa, Zeinab Omran, Samir Eldahshan, Hossam El Ganzoury
Background: Prostate cancer (PCa) is a common health problem in elderly. RAGE (Receptor for advanced glycation end products) is overexpressed in multiple human cancers. SOX2 (Sex-determining region Y box 2) also functions as an oncoprotein and promotes cancer progression but the mechanisms involved remain largely unknown. Aim: The current study investigated the expression patterns of RAGE and SOX2 in benign and malignant prostate samples in correlation with the histopathological findings in order to evaluate their role as prognostic markers or therapeutic targets...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Seyed Mohsen Miresmaeili, Fatemeh Jafari
Background: Breast cancer is the most common cancer diagnosed among women, Tumor suppressor genes such as BRCA1 involved in cell cycle control and repairing of DNA damage. BRCA1 is a risk factor gene that alteration in its protein cause in susceptibility to breast or ovarian cancer. Short tandem repeat (STR) polymorphism is linked to some disease. Objective: The aim of this study was screening a new mutation in patients with familial breast cancer. Materials and Methods: In this study, 200 women with breast cancer were participated...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Nor Hasyimah Haron, Zaleha Md Toha, Rafedah Abas, Mohammad Razak Hamdan, Nizuwan Azman, Melati Khairuddean, Hasni Arsad
Objective: This study was conducted to investigate the antiproliferative activity of extracts of Clinacanthus nutans leaves against human cervical cancer (HeLa) cells. Methods: C. nutans leaves were subjected to extraction using 80% methanol or water. The methanol extract was further extracted to obtain hexane, dichloromethane (DCM), and aqueous fractions. The antiproliferative activity of the extracts against HeLa cells was determined. The most cytotoxic extract was furthered analyzed by apoptosis and cell cycle assays, and the phytochemical constituents were screened by gas chromatography-mass spectrometry (GC-MS)...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
E Kucuktulu, A F Yurekli, M Topbas, C Kece, A Guner, U Kucuktulu
Introduction: Previous studies comparing tomotherapy (TOMO) and three dimensional (3D) conformal radiotherapy (3DCRT) in gastric radiotherapy are limited and tend to be based on dosimetry. The aim of the present study was to evaluate the clinical outcomes of these two treatment modalities. Methods: A total of 51 patients diagnosed with gastric cancer who were treated with postoperative adjuvant chemoradiotherapy and had subtotal/total gastrectomy and D2 lymphatic dissection were recruited to the present study: 30 patients were treated with TOMO and 21 patients were treated with 3DCRT...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Thitsamay Luangxay, Siriphone Virachith, Kiyomi Hando, Soulideth Vilayvong, Phaengvilay Xaysomphet, Phetsamone Arounlangsy, Keokedthong Phongsavan, Makiko Naka Mieno, Naoko Honma, Masanobu Kitagawa, Motoji Sawabe
Aim: The purpose of this study is to evaluate the prevalence of the immunohistochemical subtypes of breast cancer among Lao women by using immunohistochemistry (according to the St. Gallen 2017 guidelines) and to study their correlation to clinicopathological features in order to help guide better treatment plans for patients. Materials and methods: Formalin-fixed and paraffin embedded tissue blocks of 76 cases of primary invasive breast cancer were retrieved from the University of Health Sciences, Vientiane, Lao PDR, from 2013 to 2016...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Rakhi Dandona, Manu Raj Mathur, G Anil Kumar, Lalit Dandona
Background: We analyzed in detail the studies utilized in most recent global systematic review of risk of cancer mortality with smokeless tobacco (SLT) use to report challenges in the available data that limit the understanding of association between SLT use and cancer mortality. Methods: For each study, we documented study design, reporting of mortality risk by type of SLT variant, SLT use frequency, and sex of SLT user for oral, oesophageal, pharyngeal, laryngeal and orolaryngeal cancers. These findings are discussed within the context of prevalence of SLT use by geographic regions and sex...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Satadru Roy, Vikram Shetty, Vishwanath Sherigar, Padmaraj Hegde, Rajendra Prasad
Objective: To evaluate the four commonly used incisions for Radical Neck Dissection on the basis of certain defined parameters. Patients and Methods: The investigators designed and implemented a prospective comparative study composed of patients with oral squamous cell carcinoma. The predictor variable was time taken to raise and close the flaps, accessibility to the neck lymph nodes, injury to vital structures and scar cosmesis followed up to a period of three months. Descriptive statistics were computed. Results: The sample was composed of 40 patients grouped as follows: Macfee Incision (=10 patients), Modified Macfee Incision (=10 patients), Modified Schobinger Incision (=10 patients) and Reverse Hockey Stick Incision (=10 patients)...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Balaji Babu Bangi, Uday Ginjupally, Lakshmi Kavitha Nadendla, Mounika Reddy Mekala, Jaya Lakshmi B, Aswani Kakumani
Aim: The aim of the study is to assess and compare taste perception among Oral submucous fibrosis (OSMF) patients, Gutka chewers without OSMF and healthy subjects. Materials and methods: Ninety subjects (30 OSMF, 30 Gutka chewers without OSMF and 30 controls) were enrolled in the study for assessing taste perception by filter paper strips impregnated with different taste qualities. Taste perception assessment was also done in stage I, II and III OSMF subjects. The obtained data were analyzed using SPSS 20.0 software...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Khairun Najwa Zakaria, Azura Amid, Zubaidah Zakaria, Parveen Jamal, Azli Ismail
Problem statement: Clinicanthus nutans has been used by Malaysian since long time ago. It is used to treat many diseases including cancer. Many studies carried out on its crude extract but no clear report on the specific secondary metabolites responsible for its nature in treating selected diseases. Objective: This study aims to confirm the practice carried out by many people on the usage of Clinicanthus nutans in treating cancer. Methods: C. nutans leaves were extracted by methanol. Thin layer chromatography was used to identify the suitable solvent for fractions separation...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Zohreh Khoshnood, Mahlegha Dehghan, Sedigheh Iranmanesh, Masoud Rayyani
One of the most important needs of patients with cancer is informational needs. Getting relevant information about the disease can lead to a proper decision making, better response to treatment, lower levels of anxiety, and higher levels of quality of life. Therefore, the current study aimed to determine the informational needs of patients with cancer in southeast Iran. Materials and Methods: This conventional qualitative content analysis was done using a descriptiveexplorative design. Data collection was done through conducting deep semi-structured interviews from September 2017 to March 2018 in cancer treatment centers of Kerman University of Medical Science, Iran...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
D Ghosh, A K Roy, N Murmu, S Mandal, A Roy
Objective: To identify high risk HPV associations by evaluating linked p16 overexpression and also the expression of p53 and RARβ together with histopathology for risk categorization of cervical pre-neoplastic lesions. Materials and Methods: Immunohistochemical staining was performed on 100 cases of cervical pre- neoplastic lesions for expression of biomarkers like p16, p53 and RARβ for comparison with haematoxylin/eosin (HE) findings. All the experimentally generated data were statistically analyzed. Results: In this study 70% cases showed overexpression of p16INK4A increasing progressively from CIN I to CIN II but reduced in CIN III (p <0...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Zohreh Jaafari- Ashkavandi, Bijan Khademi, Mahyar Malekzadeh, Zeinab Shahmoradi
Background: Variation in serum levels of trace elements including zinc, copper and ferritin has been reported in cancer patients. The aim of this study was to evaluate these trace elements in the patients’ sera with benign and malignant salivary gland tumors (SGTs) and compare them with normal individuals. Methods: In this cross-sectional study, 60 patients with SGTs including 16 pleomorphic adenoma and 44 malignant SGTs, as well as 28 healthy controls, were enrolled. Serum levels of zinc, copper and ferritin were determined by atomic absorption and ELISA methods...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Norhashimah Mohd Norsuddin, Claudia Mello-Thoms, Warren Reed, Sarah Lewis
Rationale and objectives: Target recall rates are often used as a performance indicator in mammography screening programs with the intention of reducing false positive decisions, over diagnosis and anxiety for participants. However, the relationship between target recall rates and cancer detection is unclear, especially when readers are directed to adhere to a predetermined rate. The purpose of this study was to explore the effect of setting different recall rates on radiologist’s performance. Materials and Methods: Institutional ethics approval was granted and informed consent was obtained from each participating radiologist...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Noel Angelo Kalacas, Julius Adrie Garcia, Teresa Sy Ortin, Alfredo Valdez Jr, Allan Fellizar, Maria Cristina Ramos, Pia Marie Albano
Background: The association of genetic polymorphisms with cancer development has been shown to be race- and tumor site-specific. Thus, this study aimed to determine whether polymorphisms in the GSTM1 and GSTT1 genes are associated with breast cancer among selected Filipinos. Methods: A total of 136 histologically confirmed breast cancer cases were age- and sex-matched with 136 clinically healthy controls. Genomic DNA extracted from blood samples of participants were screened for GSTM1 and GSTT1 genetic polymorphisms by multiplex PCR...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Susana Moreira de Souza, Adriana Estela Flores Valiente, Kélvia Miranda Sá, Camila de Carvalho Juanes, Bruno Jucá Rodrigues, Amanda Cristina Crispim Farias, Caroline Cavalcante Campelo, Paulo Goberlânio de Barros Silva, Paulo Roberto Carvalho de Almeida
Background: We evaluated the immunoexpression of LGR4 and β-catenin in primary gastric carcinomas, lymph node metastases and histologically normal gastric mucosa in the surgical margins of gastric primary tumours. Methods: We performed a cross-sectional, observational study, based on 75 gastric carcinoma specimens from gastrectomies conducted at the hospital of the Federal University of Ceará, Brazil. The samples were analysed by tissue microarray and immunohistochemistry. Chi-square, Fisher’s exact test and Pearson’s linear regression were used in this study...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
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