Emma C Johnson, Jessica E Salvatore, Dongbing Lai, Alison K Merikangas, John I Nurnberger, Jay A Tischfield, Xiaoling Xuei, Chella Kamarajan, Leah Wetherill, John P Rice, John R Kramer, Samuel Kuperman, Tatiana Foroud, Paul A Slesinger, Alison M Goate, Bernice Porjesz, Danielle M Dick, Howard J Edenberg, Arpana Agrawal
This review describes the genetic approaches and results from the family-based Collaborative Study on the Genetics of Alcoholism (COGA). COGA was designed during the linkage era to identify genes affecting the risk for alcohol use disorder (AUD) and related problems, and was among the first AUD-focused studies to subsequently adopt a genome-wide association (GWAS) approach. COGA's family-based structure, multimodal assessment with gold-standard clinical and neurophysiological data, and the availability of prospective longitudinal phenotyping continues to provide insights into the etiology of AUD and related disorders...
June 30, 2023: Genes, Brain, and Behavior