journal
https://read.qxmd.com/read/37553802/developmental-coordination-disorder-what-can-we-learn-from-ri-mice-using-motor-learning-tasks-and-qtl-analysis
#21
JOURNAL ARTICLE
Kamaldeep Gill, Jeffy Rajan Soundara Rajan, Eric Chow, David G Ashbrook, Robert W Williams, Jill G Zwicker, Daniel Goldowitz
Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder of unknown etiology that affects one in 20 children. There is an indication that DCD has an underlying genetic component due to its high heritability. Therefore, we explored the use of a recombinant inbred family of mice known as the BXD panel to understand the genetic basis of complex traits (i.e., motor learning) through identification of quantitative trait loci (QTLs). The overall aim of this study was to utilize the QTL approach to evaluate the genome-to-phenome correlation in BXD strains of mice in order to better understand the human presentation of DCD...
August 8, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37533187/5-collaborative-study-on-the-genetics-of-alcoholism-functional-genomics
#22
REVIEW
Isabel Gameiro-Ros, Dina Popova, Iya Prytkova, Zhiping P Pang, Yunlong Liu, Danielle Dick, Kathleen K Bucholz, Arpana Agrawal, Bernice Porjesz, Alison M Goate, Xiaoling Xuei, Chella Kamarajan, Jay A Tischfield, Howard J Edenberg, Paul A Slesinger, Ronald P Hart
Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and environmental factors, and their interactions. The Collaborative Study on the Genetics of Alcoholism (COGA) has been investigating these factors and identified putative alcohol use disorder risk genes through genome-wide association studies. In this review, we describe advances made by COGA in elucidating the functional changes induced by alcohol use disorder risk genes using multimodal approaches with human cell lines and brain tissue...
August 2, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37519068/maternal-upbringing-and-selective-breeding-for-voluntary-exercise-behavior-modify-patterns-of-dna-methylation-and-expression-of-genes-in-the-mouse-brain
#23
JOURNAL ARTICLE
Sarah E Latchney, Marcell D Cadney, Anthony Hopkins, Theodore Garland
Selective breeding has been utilized to study the genetic basis of exercise behavior, but research suggests that epigenetic mechanisms, such as DNA methylation, also contribute to this behavior. In a previous study, we demonstrated that the brains of mice from a genetically selected high runner (HR) line have sex-specific changes in DNA methylation patterns in genes known to be genomically imprinted compared to those from a non-selected control (C) line. Through cross-fostering, we also found that maternal upbringing can modify the DNA methylation patterns of additional genes...
July 30, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37519035/partner-seeking-and-limbic-dopamine-system-are-enhanced-following-social-loss-in-male-prairie-voles-microtus-ochrogaster
#24
JOURNAL ARTICLE
Erika M Vitale, Adrianna Kirckof, Adam S Smith
Death of a loved one is recognized as one of life's greatest stresses, and 10%-20% of bereaved individuals will experience a complicated or prolonged grieving period that is characterized by intense yearning for the deceased. The monogamous prairie vole (Microtus ochrogaster) is a rodent species that forms pair bonds between breeding partners and has been used to study the neurobiology of social behaviors and isolation. Male prairie voles do not display distress after isolation from a familiar, same-sex conspecific; however, separation from a bonded female partner increases emotional, stress-related, and proximity-seeking behaviors...
July 30, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37461188/patterns-of-ethanol-intake-in-male-rats-with-partial-dopamine-transporter-deficiency
#25
JOURNAL ARTICLE
L B Kuiper, J B Roberts, P M Estave, D Leo, R R Gainetdinov, S R Jones
Mesolimbic dopamine signaling plays a major role in alcohol and substance use disorders as well as comorbidities such as anxiety and depression. Growing evidence suggests that alcohol drinking is modulated by the function of the dopamine transporter (DAT), which tightly regulates extracellular dopamine concentrations. Adult male rats on a Wistar Han background (DAT+/+) and rats with a partial DAT deletion (DAT+/-) were used in this study. First, using fast-scan cyclic voltammetry in brain slices containing the nucleus accumbens core from ethanol-naïve subjects, we measured greater evoked dopamine concentrations and slower dopamine reuptake in DAT+/- rats, consistent with increased dopamine signaling...
July 17, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37403260/the-impact-of-early-adversity-and-education-on-genetic-and-brain-morphological-predictors-of-cognitive-ability
#26
JOURNAL ARTICLE
Emma Corley, Laura Fahey, Joan Fitzgerald, Laurena Holleran, Esther Walton, Derek W Morris, Gary Donohoe
Cognitive ability is a strong predictor of occupational achievement, quality of life and physical health. While variation in cognition is strongly heritable and has been robustly associated with early environment and brain morphology, little is known about how these factors combine and interact to explain this variation in cognition. To address this, we modelled the relationship between common genetic variation, grey matter volume, early life adversity and education and cognitive ability in a UK Biobank sample of N = 5237 individuals using structural equation modelling...
July 4, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37387240/the-collaborative-study-on-the-genetics-of-alcoholism-genetics
#27
REVIEW
Emma C Johnson, Jessica E Salvatore, Dongbing Lai, Alison K Merikangas, John I Nurnberger, Jay A Tischfield, Xiaoling Xuei, Chella Kamarajan, Leah Wetherill, John P Rice, John R Kramer, Samuel Kuperman, Tatiana Foroud, Paul A Slesinger, Alison M Goate, Bernice Porjesz, Danielle M Dick, Howard J Edenberg, Arpana Agrawal
This review describes the genetic approaches and results from the family-based Collaborative Study on the Genetics of Alcoholism (COGA). COGA was designed during the linkage era to identify genes affecting the risk for alcohol use disorder (AUD) and related problems, and was among the first AUD-focused studies to subsequently adopt a genome-wide association (GWAS) approach. COGA's family-based structure, multimodal assessment with gold-standard clinical and neurophysiological data, and the availability of prospective longitudinal phenotyping continues to provide insights into the etiology of AUD and related disorders...
June 30, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37376966/rapamycin-improves-social-and-stereotypic-behavior-abnormalities-induced-by-pre-mitotic-neuronal-subset-specific-pten-deletion
#28
JOURNAL ARTICLE
David A Narvaiz, Suzanne O Nolan, Gregory D Smith, Andrew J Holley, Conner D Reynolds, Katherine J Blandin, Phuoc H Nguyen, Doan L K Tran, Joaquin N Lugo
The mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to neural growth and migration. In both patients and rodent models, mutations to the phosphatase and tensin homolog gene (PTEN) on chromosome 10 results in hyperactivation of the mTOR pathway, as well as seizures, intellectual disabilities and autistic behaviors. Rapamycin, an inhibitor of mTOR, can reverse the epileptic phenotype of neural subset specific Pten knockout (NS-Pten KO) mice, but its impact on behavior is not known...
June 28, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37370259/extensive-characterization-of-a-williams-syndrome-murine-model-shows-gtf2ird1-mediated-rescue-of-select-sensorimotor-tasks-but-no-effect-on-enhanced-social-behavior
#29
JOURNAL ARTICLE
Kayla R Nygaard, Susan E Maloney, Raylynn G Swift, Katherine B McCullough, Rachael E Wagner, Stuart B Fass, Krassimira Garbett, Karoly Mirnics, Jeremy Veenstra-VanderWeele, Joseph D Dougherty
Williams syndrome is a rare neurodevelopmental disorder exhibiting cognitive and behavioral abnormalities, including increased social motivation, risk of anxiety and specific phobias along with perturbed motor function. Williams syndrome is caused by a microdeletion of 26-28 genes on chromosome 7, including GTF2IRD1, which encodes a transcription factor suggested to play a role in the behavioral profile of Williams syndrome. Duplications of the full region also lead to frequent autism diagnosis, social phobias and language delay...
June 27, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37365873/genetic-and-environmental-influences-on-one-trial-conditioned-context-aversion-in-mice
#30
JOURNAL ARTICLE
Çınar Furkan İlhan, Gonzalo P Urcelay, Sezen Kışlal
Anticipatory nausea (AN) is caused by an association between contextual cues and the experience of nausea (the side effects of chemotherapy or radiation treatment) and it develops predominantly in female patients undergoing chemotherapy. Preclinical studies in rodents show that the administration of an illness-inducing agent in the presence of novel contextual cues can cause conditioned context aversion (CCA) and this has been proposed to model AN. The literature also suggests that brief pre-exposure to a novel context prior to shock delivery is critical in the development of contextual fear conditioning in rodents (a phenomenon known as Immediate Shock Deficit), but this has not been assessed in CCA...
June 26, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37328946/spontaneous-allelic-variant-in-deafness-blindness-gene-ush1g-resulting-in-an-expanded-phenotype
#31
JOURNAL ARTICLE
Vladimir Vartanian, Jocelyn F Krey, Paroma Chatterjee, Allison Curtis, Makayla Six, Sean P M Rice, Sherri M Jones, Harini Sampath, Charles N Allen, Renee C Ryals, R Stephen Lloyd, Peter G Barr-Gillespie
Relationships between novel phenotypic behaviors and specific genetic alterations are often discovered using target-specific, directed mutagenesis or phenotypic selection following chemical mutagenesis. An alternative approach is to exploit deficiencies in DNA repair pathways that maintain genetic integrity in response to spontaneously induced damage. Mice deficient in the DNA glycosylase NEIL1 show elevated spontaneous mutations, which arise from translesion DNA synthesis past oxidatively induced base damage...
June 16, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37278348/melatonin-ameliorates-sleep-wake-disturbances-and-autism-like-behaviors-in-the-ctnnd2-knock-out-mouse-model-of-autism-spectrum-disorders
#32
JOURNAL ARTICLE
Man Xu, Luyi Wang, Yan Wang, Jing Deng, Xiaoya Wang, Feifei Wang, Sen Pan, Yu Zhao, Ailing Liao, Xiaoqing Wang, Di Chen, Jingjing Shen, Feng Yang, Yingbo Li, Shali Wang
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by atypical patterns of social interaction and communication, as well as restrictive and repetitive behaviors. In addition, patients with ASD often presents with sleep disturbances. Delta (δ) catenin protein 2 (CTNND2) encodes δ-catenin protein, a neuron-specific catenin implicated in many complex neuropsychiatric diseases. Our previous study demonstrated that the deletion of Ctnnd2 in mice led to autism-like behaviors...
June 6, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37259642/testing-associations-between-human-anxiety-and-genes-previously-implicated-by-mouse-anxiety-models
#33
JOURNAL ARTICLE
Maizy S Brasher, Travis J Mize, Aimee L Thomas, Charles A Hoeffer, Marissa A Ehringer, Luke M Evans
Anxiety disorders are common and can be debilitating, with effective treatments remaining hampered by an incomplete understanding of the underlying genetic etiology. Improvements have been made in understanding the genetic influences on mouse behavioral models of anxiety, yet it is unclear the extent to which genes identified in these experimental systems contribute to genetic variation in human anxiety phenotypes. Leveraging new and existing large-scale human genome-wide association studies, we tested whether sets of genes previously identified in mouse anxiety-like behavior studies contribute to a range of human anxiety disorders...
May 31, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37114320/the-microbial-community-dynamics-of-cocaine-sensitization-in-two-behaviorally-divergent-strains-of-collaborative-cross-mice
#34
JOURNAL ARTICLE
Thi Dong Binh Tran, Christian Monroy Hernandez, Hoan Nguyen, Susan Wright, Lisa M Tarantino, Elissa J Chesler, George M Weinstock, Yanjiao Zhou, Jason A Bubier
The gut-brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Some reports suggest that cocaine-induced behavioral sensitization is correlated with drug self-administration behavior in mice. Here, we profile the composition of the naïve microbiome and its response to cocaine sensitization in two collaborative cross (CC) strains...
April 27, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37060189/leveraging-related-health-phenotypes-for-polygenic-prediction-of-impulsive-choice-impulsive-action-and-impulsive-personality-traits-in-1534-european-ancestry-community-adults
#35
JOURNAL ARTICLE
Wei Q Deng, Kyla Belisario, Joshua C Gray, Emily E Levitt, Pedrum Mohammadi-Shemirani, Desmond Singh, Guillaume Pare, James MacKillop
Impulsivity refers to a number of conceptually related phenotypes reflecting self-regulatory capacity that are considered promising endophenotypes for mental and physical health. Measures of impulsivity can be broadly grouped into three domains, namely, impulsive choice, impulsive action, and impulsive personality traits. In a community-based sample of ancestral Europeans (n = 1534), we conducted genome-wide association studies (GWASs) of impulsive choice (delay discounting), impulsive action (behavioral inhibition), and impulsive personality traits (UPPS-P), and evaluated 11 polygenic risk scores (PRSs) of phenotypes previously linked to self-regulation...
April 14, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/36977197/multi-omics-cannot-replace-sample-size-in-genome-wide-association-studies
#36
JOURNAL ARTICLE
David A A Baranger, Alexander S Hatoum, Renato Polimanti, Joel Gelernter, Howard J Edenberg, Ryan Bogdan, Arpana Agrawal
The integration of multi-omics information (e.g., epigenetics and transcriptomics) can be useful for interpreting findings from genome-wide association studies (GWAS). It has been suggested that multi-omics could circumvent or greatly reduce the need to increase GWAS sample sizes for novel variant discovery. We tested whether incorporating multi-omics information in earlier and smaller-sized GWAS boosts true-positive discovery of genes that were later revealed by larger GWAS of the same/similar traits. We applied 10 different analytic approaches to integrating multi-omics data from 12 sources (e...
March 28, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/36889983/alteration-of-neural-activity-and-neuroinflammatory-factors-in-the-insular-cortex-of-mice-with-corneal-neuropathic-pain
#37
JOURNAL ARTICLE
Rui Xu, Yu-Wen Zhang, Qing Gu, Tian-Jie Yuan, Bing-Qian Fan, Jun-Ming Xia, Jin-Hong Wu, Ying Xia, Wen-Xian Li, Yuan Han
Dry eye disease (DED) affects nearly 55% of people worldwide; several studies have proposed that central sensitization and neuroinflammation may contribute to the developing corneal neuropathic pain of DED, while the underlying mechanisms of this contribution remain to be investigated. Excision of extra orbital lacrimal glands established the dry eye model. Corneal hypersensitivity was examined through chemical and mechanical stimulation, and open field test measured the anxiety levels. Restingstate fMRI is a method of functional magnetic resonance imaging (rs-fMRI) was performed for anatomical involvement of the brain regions...
March 8, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/36811322/a-genome-wide-association-study-identified-new-variants-associated-with-mathematical-abilities-in-chinese-children
#38
JOURNAL ARTICLE
Liming Zhang, Zhengjun Wang, Zijian Zhu, Qing Yang, Chen Cheng, Shunan Zhao, Chunyu Liu, Jingjing Zhao
Mathematical ability is moderately heritable, and it is a complex trait which can be evaluated in several different categories. A few genetic studies have been published on general mathematical ability. However, no genetic study focused on specific mathematical ability categories. In this study, we separately performed genome-wide association studies on 11 mathematical ability categories in 1146 students from Chinese elementary schools. We identified seven genome-wide significant single nucleotide polymorphisms (SNPs) with strong linkage disequilibrium among each other (all r2  > 0...
February 22, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/36811275/polygenic-risk-score-for-attention-deficit-hyperactivity-disorder-and-brain-functional-networks-segregation-in-a-community-based-sample
#39
JOURNAL ARTICLE
João Ricardo Sato, Claudinei Eduardo Biazoli, Ana Paula Arantes Bueno, Arthur Caye, Pedro Mario Pan, Marcos Santoro, Jessica Honorato-Mauer, Giovanni Abrahão Salum, Marcelo Queiroz Hoexter, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski, Euripedes Constantino Miguel, Sintia Belangero, Luis Augusto Rohde
Neuroimaging studies suggest that brain development mechanisms might explain at least some behavioural and cognitive attention-deficit/hyperactivity disorder (ADHD) symptoms. However, the putative mechanisms by which genetic susceptibility factors influence clinical features via alterations of brain development remain largely unknown. Here, we set out to integrate genomics and connectomics tools by investigating the associations between an ADHD polygenic risk score (ADHD-PRS) and functional segregation of large-scale brain networks...
February 21, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/36807494/conditioned-place-avoidance-is-associated-with-a-distinct-hippocampal-phenotype-partly-preserved-pattern-separation-and-reduced-reactive-oxygen-species-production-after-stress
#40
JOURNAL ARTICLE
D Parker Kelley, Lucas Albrechet-Souza, Shealan Cruise, Rajani Maiya, Aspasia Destouni, Siva S V P Sakamuri, Alexander Duplooy, Meghan Hibicke, Charles Nichols, Prasad V G Katakam, Nicholas W Gilpin, Joseph Francis
Stress is associated with contextual memory deficits, which may mediate avoidance of trauma-associated contexts in posttraumatic stress disorder. These deficits may emerge from impaired pattern separation, the independent representation of similar experiences by the dentate gyrus-Cornu Ammonis 3 (DG-CA3) circuit of the dorsal hippocampus, which allows for appropriate behavioral responses to specific environmental stimuli. Neurogenesis in the DG is controlled by mitochondrial reactive oxygen species (ROS) production, and may contribute to pattern separation...
February 17, 2023: Genes, Brain, and Behavior
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