Arpana Agrawal, Sarah J Brislin, Kathleen K Bucholz, Danielle Dick, Ronald P Hart, Emma C Johnson, Jacquelyn Meyers, Jessica Salvatore, Paul Slesinger, Laura Almasy, Tatiana Foroud, Alison Goate, Victor Hesselbrock, John Kramer, Samuel Kuperman, Alison K Merikangas, John I Nurnberger, Jay Tischfield, Howard J Edenberg, Bernice Porjesz
Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders with etiological origins in the brain and the environment. To outline the causes and consequences of alcohol-related milestones, including AUD, and their related psychiatric comorbidities, the Collaborative Study on the Genetics of Alcoholism (COGA) was launched in 1989 with a gene-brain-behavior framework. COGA is a family based, diverse (~25% self-identified African American, ~52% female) sample, including data on 17,878 individuals, ages 7-97 years, in 2246 families of which a proportion are densely affected for AUD...
October 2023: Genes, Brain, and Behavior