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Autoimmunity Reviews

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https://read.qxmd.com/read/30772495/the-study-of-interactions-between-genome-and-exposome-in-the-development-of-systemic-lupus-erythematosus
#1
REVIEW
Henrik Christian Bidstrup Leffers, Theis Lange, Christopher Collins, Constance Jensina Ulff-Møller, Søren Jacobsen
Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by a broad spectrum of clinical and serological manifestations. This may reflect a complex and multifactorial etiology involving several identified genetic and environmental factors, though not explaining the full risk of SLE. Established SLE risk genotypes are either very rare or with modest effect sizes and twin studies indicate that other factors besides genetics must be operative in SLE etiology. The exposome comprises the cumulative environmental influences on an individual and associated biological responses through the lifespan...
February 14, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30772494/juvenile-polyautoimmunity-in-a-rheumatology-setting
#2
REVIEW
Clara Malagón, Maria Del Pilar Gomez, Catalina Mosquera, Camilo Vargas, Tatiana Gonzalez, Cristine Arango, Lorena Martin, Pilar Perez, Laura Amaya-Uribe, Nicolas Molano-Gonzalez, Juan-Manuel Anaya
Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics...
February 14, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30772493/the-european-registry-on-obstetric-antiphospholipid-syndrome-euroaps-a-survey-of-1000-consecutive-cases
#3
REVIEW
Jaume Alijotas-Reig, Enrique Esteve-Valverde, R Ferrer-Oliveras, L Sáez-Comet, E Lefkou, A Mekinian, C Belizna, A Ruffatti, A Tincani, L Marozio, G Espinosa, R Cervera, S de Carolis, O Latino, E LLurba, P L Meroni, C B Chighizola, M Gerosa, V Pengo, K Lundelin, P Rovere-Querini, V Canti, K Mayer-Pickel, T Reshetnyak, A Hoxha, S Tabacco, L Stojanovich, V Gogou, A Varoudis, A Arnau, D Ruiz-Hidalgo, J Trapé, L Sos, C Stoppani, A Martí-Cañamares, Inmaculada Farran-Codina
Aim To analyse the clinical features, laboratory data and foetal-maternal outcomes, and follow them up on a cohort of 1000 women with obstetric antiphospholipid syndrome (OAPS). METHODS: The European Registry of OAPS became a registry within the framework of the European Forum on Antiphospholipid Antibody projects and was placed on a website in June 2010. Thirty hospitals throughout Europe have collaborated to carry out this registry. Cases with obstetric complaints related to antiphospholipid antibodies (aPL) who tested positive for aPL at least twice were included prospectively and retrospectively...
February 14, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30772492/enhanced-type-i-interferon-gene-signature-in-primary-antiphospholipid-syndrome-association-with-earlier-disease-onset-and-preeclampsia
#4
REVIEW
Michelle Remião Ugolini-Lopes, Giovana Tardin Torrezan, Ana Paula Rossi Gândara, Eloisa Helena Ribeiro Olivieri, Iana Souza Nascimento, Erika Okazaki, Eloisa Bonfá, Dirce Maria Carraro, Danieli Castro Oliveira de Andrade
OBJECTIVE: Recently, two studies demonstrated that a relevant percentage of primary antiphospholipid syndrome (PAPS) patients had an upregulation of interferon (IFN) genes. However, 20%-28% of these patients had anti-dsDNA, a highly specific systemic lupus erythematosus (SLE) autoantibody. This study aimed to determine the prevalence of the type I IFN signature in the peripheral blood mononuclear cells of PAPS patients without specific SLE autoantibodies and search for its clinical associations...
February 14, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30772491/lethal-immunoglobulins-autoantibodies-and-sudden-cardiac-death
#5
REVIEW
Varvara A Ryabkova, Yuri V Shubik, Mikhail V Erman, Leonid P Churilov, Darja Kanduc, Yehuda Shoenfeld
Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 h of symptom onset) in a person with known or unknown cardiac disease. Patients with cardiomyopathies, myocarditis, ischemic heart disease and cardiac channelopathies are at risk of SCD. However, a certain percentage of autopsy-negative cases of SCD in the young (<35 years) remain unexplained even after a post-mortem genetic testing. Autoantibodies against cardiac proteins may be potentially involved in the pathogenesis of different heart diseases and in the occurrence of unexplained SCD...
February 14, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30770318/corrigendum-to-prevalence-of-cervical-hpv-infection-in-women-with-systemic-lupus-erythematosus-a-systematic-review-and-meta-analysis-autrev-18-2-2019-184-191
#6
Mario García-Carrasco, Claudia Mendoza-Pinto, Adriana Rojas-Villarraga, Nicolás Molano-González, Verónica Vallejo-Ruiz, Pamela Munguía-Realpozo, Aurelio López Colombo, Ricard Cervera
No abstract text is available yet for this article.
February 12, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30763633/blood-brain-barrier-disruption-and-neuroinflammation-as-pathophysiological-mechanisms-of-the-diffuse-manifestations-of-neuropsychiatric-systemic-lupus-erythematosus
#7
REVIEW
Nancy P Duarte Delgado, Gloria Vásquez, Blanca L Ortiz-Reyes
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE...
February 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30763632/conceptual-statistical-and-clinical-interpretation-of-results-from-a-systematic-review-and-meta-analysis-of-prevalence-of-cervical-hpv-infection-in-women-with-sle
#8
LETTER
Rama Jayaraj, Chellan Kumarasamy
No abstract text is available yet for this article.
February 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30743081/reply-to-the-editor
#9
REVIEW
Mario Garcia-Carrasco, Claudia Mendoza-Pinto, Adriana Rojas-Villarraga, Nicolás Molano-Gonzalez, Verónica Vallejo-Ruiz, Pamela Munguia-Realpozo, Aurelio López Colombo, Ricard Cervera
No abstract text is available yet for this article.
February 8, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30743080/rituximab-therapy-for-primary-central-nervous-system-vasculitis-a-6-patient-experience-and-review-of-the-literature
#10
REVIEW
Carlo Salvarani, Robert D Brown, Francesco Muratore, Teresa J H Christianson, Elena Galli, Nicolò Pipitone, Giulia Cassone, John Huston Iii, Caterina Giannini, Kenneth Warrington, Gene G Hunder
OBJECTIVES: To assess the efficacy and safety of Rituximab (RTX) in adult primary central nervous system vasculitis (PCNSV). METHODS: We retrospectively assessed the effect of RTX in 6 patients with PCNSV. Five of the 6 were refractory to high dose glucocorticoids (GCs) and/or conventional immunosuppressants (IS). The sixth was newly diagnosed and received RTX in combination with GCs. Clinical evaluation, laboratory tests, and imaging modalities were performed at initial RTX administration and during the follow-up...
February 8, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30743079/microvascular-heart-involvement-in-systemic-autoimmune-diseases-the-purinergic-pathway-and-therapeutic-insights-from-the-biology-of-the-diseases
#11
REVIEW
De Lorenzis Enrico, Gremese Elisa, Bosello Silvia, Nurmohamed Michael Tuahier, Sinagra Gianfranco, Ferraccioli Gianfranco
No abstract text is available yet for this article.
February 7, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30738958/pemphigus-and-mucous-membrane-pemphigoid-an-update-from-diagnosis-to-therapy
#12
REVIEW
Alessio Buonavoglia, Patrizia Leone, Rosanna Dammacco, Giuseppe Di Lernia, Massimo Petruzzi, Domenico Bonamonte, Angelo Vacca, Vito Racanelli, Franco Dammacco
Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of immune-mediated mucocutaneous disorders clinically characterized by the formation of blisters, erosions and ulcers. The skin and mucous membranes are predominantly affected, with the oropharyngeal mucosa as the initially involved site. Ocular involvement is also a frequent feature of these diseases. Because of the considerable overlap in their clinical presentations, the diagnosis of PDs vs. MMP can be challenging. A recognition of their specific immunological and histopathologic features is crucial in the differential diagnosis...
February 7, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30738957/immune-checkpoints-and-the-regulation-of-tolerogenicity-in-dendritic-cells-implications-for-autoimmunity-and-immunotherapy
#13
REVIEW
Samanta C Funes, Amaranta Manrique de Lara, María J Altamirano-Lagos, Juan P Mackern-Oberti, Jorge Escobar-Vera, Alexis M Kalergis
The immune system is responsible for defending the host from a large variety of potential pathogens, while simultaneously avoiding immune reactivity towards self-components. Self-tolerance has to be tightly maintained throughout several central and peripheral processes; immune checkpoints are imperative for regulating the immunity/tolerance balance. Dendritic cells (DCs) are specialized cells that capture antigens, and either activate or inhibit antigen-specific T cells. Therefore, they play a key role at inducing and maintaining immune tolerance...
February 7, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30639651/a-review-of-the-evidence-for-a-natalizumab-exit-strategy-for-patients-with-multiple-sclerosis
#14
REVIEW
Johann Sellner, Paulus Stefan Rommer
Natalizumab is an effective treatment for relapsing-remitting multiple sclerosis (RRMS), but treatment for >2 years is associated with an increased risk of opportunistic infection and progressive multifocal leukoencephalopathy (PML). For this reason, patients and physicians may consider discontinuing natalizumab therapy. This article reviews the evidence for the various therapeutic approaches that may be taken in such patients. Stopping therapy altogether is unlikely to be appropriate for most patients, as it is associated with a high rate of relapse or rebound...
January 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30639650/complex-regional-pain-syndrome-false-hopes-and-miscommunications
#15
REVIEW
Christopher Chang, Patrick McDonnell, M Eric Gershwin
Complex regional pain syndrome (CRPS) has been considered to be an autoimmune disease and there have been clinical trials with intravenous immunoglobulin. Often the etiology of the so-called CRPS diagnosis cannot be discerned and there are no validated instruments that provide functional metrics. The term complex regional pain syndrome (CRPS), coined in 1994 to describe patients in whom the pain is out of proportion to the injury, was actually a diagnosis proposed during the American Civil War, but was originally known as causalgia...
January 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30639648/mechanisms-of-action-and-historical-facts-on-the-use-of-intravenous-immunoglobulins-in-systemic-lupus-erythematosus
#16
REVIEW
Tatiana Martínez, Juan Esteban Garcia-Robledo, Ilich Plata, Maria-Alejandra Urbano, Ivan Posso-Osorio, Lady J Rios-Serna, María Claudia Barrera, Gabriel J Tobón
The current existing therapies for severe cases of systemic lupus erythematosus (SLE) patients are still limited. Intravenous immunoglobulin (IVIGs), which are purified from the plasma of thousands of healthy human donors, have been profiled as efficacious and life-saving options for SLE patients refractory to conventional therapy. The specific mechanism of action by which IVIGs generate immunomodulation in SLE is not currently understood. In this manuscript, we reviewed some of the hypothesis that have been postulated to explain the IVIG effects, including those on T and B cell intracellular signalling and activation, as well as the interferon signalling pathways involved in the detection of nucleic acids and the defective removal of immune complexes and debris...
January 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30639645/innate-immune-responses-and-their-role-in-driving-autoimmunity
#17
REVIEW
Elias Toubi, Zahava Vadasz
Autoimmunity and autoimmune diseases were always considered to be driven mainly by adaptive immune responses, namely by auto-reactive B and T cell over-activity. The continuous stimulation of dendritic cells by autoantigens increases B cell activity, driving auto-reactive B cells to increase the production of autoantibodies and of pro-inflammatory cytokines. On the other hand, a subset of dendritic cells is established being of tolerogenic properties thus becoming important in maintaining self-tolerance. However, early innate immune responses are continuously appreciated to be highly important in the development of immune-mediated inflammation in general and autoimmunity in particular...
January 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30639641/take-a-look-at-the-eyes-in-systemic-lupus-erythematosus-a-novel-point-of-view
#18
REVIEW
Paola Conigliaro, Massimo Cesareo, Maria Sole Chimenti, Paola Triggianese, Claudia Canofari, Carmen Barbato, Clarissa Giannini, Ada Giorgia Salandri, Carlo Nucci, Roberto Perricone
Systemic Lupus Erythematosus (SLE) is a connective tissue disease that involves multiple organs. Ocular structures and visual pathways can be affected in SLE because of disease-related eye involvement or drug toxicity. All the part of the eye may be interested with an external, anterior involvement, responsible of the dry eye disease, or posterior (retina) and neuro-ophtalmic manifestations. Retinopathy in SLE is suggestive of high disease activity being a marker of poor visual outcome and prognosis for survival...
January 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30639639/the-changing-face-of-chronic-autoimmune-atrophic-gastritis-an-updated-comprehensive-perspective
#19
REVIEW
Sara Massironi, Alessandra Zilli, Alessandra Elvevi, Pietro Invernizzi
Chronic autoimmune atrophic gastritis (CAAG) is an organ-specific autoimmune disease, which affects the corpus-fundus gastric mucosa. Although it has been described for several years, the real pathophysiological mechanisms, the natural history and the possible neoplastic complications are not completely known. Atrophy of the gastric mucosa is the endpoint of the chronic processes, with the loss of glandular cells and their replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue. As a consequence, hydrochloric acid, pepsin and intrinsic-factor is impaired resulting in pernicious anemia...
January 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30639649/review-myositis-specific-autoantibodies-a-cornerstone-in-immune-mediated-necrotizing-myopathy
#20
REVIEW
Céline Anquetil, Olivier Boyer, Nadège Wesner, Olivier Benveniste, Yves Allenbach
Over the past few years, myositis-specific autoantibodies played an increasing role in the inflammatory idiopathic myositis definition. They became the critical immunological marker for immune-mediated necrotizing myopathy diagnosis (IMNM) since the paradigm switch from histological to serological criteria. This review is focused on the key role of the anti-signal recognition particle (anti-SRP) and the anti-3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase (anti-HMGCR) antibodies in immune-mediated necrotizing myopathy...
January 10, 2019: Autoimmunity Reviews
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