Zoltán Szekanecz
Accelerated, inflammatory atherosclerosis and cardiovascular disease have been associated with several autoimmune diseases including RA, AS, SLE, APS and SSc. Non-invasive, ultrasound- based techniques are suitable for the assessment of preclinical vascular pathophysiology. Multiple vascular and other biomarkers including vitamin D, ferritin, prolactin, suPAR, BNP fragments, oxLDL/β2GPI complexes, anti-Hsp60 and others have been associated with cardiometabolic comorbidities. The control of the underlying inflammatory disease is crucial for minimising cardiovascular risk in autoimmune diseases...
May 25, 2024: Autoimmunity Reviews
Shuang Xu, William F Jiemy, Elisabeth Brouwer, Janette K Burgess, Peter Heeringa, Kornelis S M van der Geest, Roser Alba-Rovira, Marc Corbera-Bellalta, Annemieke H Boots, Maria C Cid, Maria Sandovici
Large-vessel vasculitides (LVV) comprise a group of chronic inflammatory diseases of the aorta and its major branches. The most common forms of LVV are giant cell arteritis (GCA) and Takayasu arteritis (TAK). Both GCA and TAK are characterized by granulomatous inflammation of the vessel wall accompanied by a maladaptive immune and vascular response that promotes vascular damage and remodeling. The inflammatory process in LVV starts in the adventitia where fibroblasts constitute the dominant cell population...
May 21, 2024: Autoimmunity Reviews
Yutong Wu, Qiaolin Wang, Sujie Jia, Qianjin Lu, Ming Zhao
Gut-tropic T cells primarily originate from gut-associated lymphoid tissue (GALT), and gut-tropic integrins mediate the trafficking of the T cells to the gastrointestinal tract, where their interplay with local hormones dictates the residence of the immune cells in both normal and compromised gastrointestinal tissues. Targeting gut-tropic integrins is an effective therapy for inflammatory bowel disease (IBD). Gut-tropic T cells are further capable of entering the peripheral circulatory system and relocating to multiple organs...
April 9, 2024: Autoimmunity Reviews
Naim Mahroum, Mona Habra, Mohamad Aosama Alrifaai, Yehuda Shoenfeld
In addition to the respiratory symptoms associated with COVID-19, the disease has consistently been linked to many autoimmune diseases such as systemic lupus erythematous and antiphospholipid syndrome (APS). APS in particular was of paramount significance due to its devastating clinical sequela. In fact, the hypercoagulable state seen in patients with acute COVID-19 and the critical role of anticoagulant treatment in affected individuals shed light on the possible relatedness between APS and COVID-19. Moreover, the role of autoimmunity in the assumed association is not less important especially with the accumulated data available regarding the autoimmunity-triggering effect of SARS-CoV-2 infection...
April 9, 2024: Autoimmunity Reviews
Mayka Freire, Bernardo Sopeña, Arturo González-Quintela, Alfredo Guillén Del Castillo, Eduardo Callejas Moraga, Gema M Lledó-Ibañez, Manuel Rubio-Rivas, Luis Trapiella, Ana Argibay, Carles Tolosa, Begoña Marí Alfonso, Jose Antonio Vargas-Hitos, Xavier Pla Salas, Cristina González-Echávarri, Antonio-J Chamorro, Isabel Perales Fraile, Andrés González García, Gloria de la Red Bellvis, David Bernal Bello, Antoni Castro Salomó, Iratxe Jiménez Pérez de Heredia, Adela Marín-Ballve, Ignasi Rodríguez-Pintó, Luis Saez-Comet, Norberto Ortego-Centeno, José Antonio Todolí-Parra, Vicent Fonollosa Pla, Carmen Pilar Simeón-Aznar
No abstract text is available yet for this article.
April 8, 2024: Autoimmunity Reviews
Isa Seida, Maisam Al Shawaf, Naim Mahroum
The role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the "friendly" living bacteria, (microbiome) and its correlation to immune balance and dysregulation have drawn the attention of researchers for decades. Nevertheless, only recently, scientific papers regarding the potential role of transferring microbiome from healthy donor subjects to patients with autoimmune diseases has been proposed. Fecal microbiota transplantation or FMT, carries the logic of transferring microorganisms responsible for immune balance from healthy donors to individuals with immune dysregulation or more accurately for our paper, autoimmune diseases...
April 7, 2024: Autoimmunity Reviews
Verónica Gómez-Caverzaschi, Jordi Yagüe, Gerard Espinosa, Isabet Mayordomo-Bofill, Ricardo Bedón-Galarza, Olga Araújo, Laura Pelegrín, Elena Arbelo, Xavier Morales, Olga Balagué, Ignasi Figueras-Nart, José M Mascaró, Irene Fuertes, Priscila Giavedoni, Africa Muxí, Isam Alobid, Isabel Vilaseca, Ricard Cervera, Juan I Aróstegui, Anna Mensa-Vilaró, José Hernández-Rodríguez
BACKGROUND: Undifferentiated autoinflammatory diseases are characterized by recurrent or persistent fever, usually combined with other inflammatory manifestations, and negative or inconclusive genetic studies for monogenic autoinflammatory disorders. AIMS: To define and characterize disease phenotypes in adult patients diagnosed in an adult reference center with undifferentiated autoinflammatory diseases, and to analyze the efficacy of the drugs used in order to provide practical diagnostic and therapeutic recommendations...
March 30, 2024: Autoimmunity Reviews
Meng-Di Zhang, Wan-Ying Huang, Jia-Yuan Luo, Rong-Quan He, Zhi-Guang Huang, Jian-Di Li, Fang Qin, Gang Chen, Ling Lei
OBJECTIVE: This study aimed to analyse existing research on systemic sclerosis (SSc) conducted over the past 73 years to develop an essential reference for a comprehensive and objective understanding of this field of inquiry. METHODS: Using the Web of Science Core Collection, PubMed, and Scopus databases as data sources for the bibliometric analysis, we searched for published literature related to SSc over the past 73 years. The Bibliometrix package was used to analyse key bibliometric indicators, such as annual publication volume, countries, journals, author contributions, and research hotspots...
March 29, 2024: Autoimmunity Reviews
Marie-Elise Martel, Amélie Leurs, David Launay, Hélène Behal, Aurélien Chepy, Aurore Collet, Sébastien Sanges, Eric Hachulla, Sylvain Dubucquoi, Luc Dauchet, Vincent Sobanski
OBJECTIVES: Estimate the global prevalence of anti-Ro52-kDa/SSA (TRIM21) autoantibodies in systemic sclerosis (SSc), and describe the associated clinical phenotype, through a systematic review and meta-analysis of published reports and new data from our French cohort. METHODS: Anti-TRIM21 seropositivity and associated SSc characteristics were assessed in a cross-sectional study including 300 patients of Lille University Hospital. A systematic review of the literature was performed in Pubmed and Embase, followed by a meta-analysis, using data on prevalence, clinical/demographical/biological characteristics of SSc patients and the type of assay used for anti-TRIM21 antibodies detection (PROSPERO n° CRD42021223719)...
March 28, 2024: Autoimmunity Reviews
Joana Caetano, Luís Monteiro Rodrigues, José Delgado Alves
OBJECTIVE: Microvascular dysfunction is an early event in the pathogenesis of systemic sclerosis (SSc). The objective of this scoping review is to update the current information and the level of knowledge about the mechanisms of microvascular dysfunction in pre-SSc, very early diagnosis of SSc (VEDOSS) and early SSc. METHODS: A PubMed® database search allowed us to include original data from full-length articles in English in which the main topic was microvascular dysfunction in pre-SSC, VEDOSS or early SSc...
May 2024: Autoimmunity Reviews
Yasaman Hajiesmaeili, Preeti Tamhankar, Saverio Stranges, Lillian Barra
INTRODUCTION: Rheumatoid arthritis (RA) is the most common form of autoimmune inflammatory arthritis and is associated with various comorbidities including cardiovascular disease (CVD). This scoping review summarizes the current evidence on longitudinal cohort studies assessing potential factors associated with the incidence of cardiovascular events among patients with RA. METHODS: Scopus, PubMed, Ovid MEDLINE and Cochrane databases were used to identify longitudinal cohort studies investigating the incidence of CVD among RA patients...
May 2024: Autoimmunity Reviews
Kevin D Deane, Lieve Van Hoovels, Veena E Joy, Nina Olschowka, Xavier Bossuyt
Autoantibodies are important laboratory markers to support diagnosis of autoimmune diseases. Interpretation of autoantibodies is classically done in a dichotomous way (positive versus negative). Yet, interpretation of autoantibody test results can be improved by reporting likelihood ratios. Likelihood ratios convey information on how much more/less likely a test result is in individuals with the disease compared to individuals without the disease. It incorporates information on the antibody level (the higher the antibody level, the higher the association with the disease), which is helpful for (differential) diagnosis...
May 2024: Autoimmunity Reviews
Maurizio Bruschi, Andrea Angeletti, Marco Prunotto, Pier Luigi Meroni, Gian Marco Ghiggeri, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Andrea Cavalli, Leonardo Scapozza, Jigar J Patel, John C Tan, Ken C Lo, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Domenico Giannese, Angelo Manfredi, Giuseppe A Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Federica Bui, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Paride Fenaroli, Isabella Pisan, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Federica Mescia, Stefano Volpi, Marta Mosca, Angela Tincani, Angelo Ravelli, Corrado Murtas, Giovanni Candiano, Gianluca Caridi, Edoardo La Porta, Enrico Verrina
Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the list of autoantibidies that have renal tropism and deposit in the kidney in LN is increasing and the link between anti-dsDNA and renal pathology is weak due to potential confounders. Aspecific bindings of dsDNA with cationic antibodies and of anti-dsDNA with several renal antigens such as actinin, laminin, entactin, and annexinA2 raised doubts about the specific target of these antibodies in the kidney...
May 2024: Autoimmunity Reviews
Alberto Terminiello, Edoardo Marrani, Ilaria Pagnini, Ilaria Maccora, Valerio Maniscalco, Sarah Abu Rumeileh, Maria Vincenza Mastrolia, Gabriele Simonini
OBJECTIVE: Childhood Mixed Connective Tissue Disease (cMCTD) is the rarest pediatric connective tissue disease that includes features of systemic lupus erythematosus, polymyositis/dermatomyositis, juvenile idiopathic arthritis, and systemic sclerosis, identified by Sharp in 1972 and whose diagnosis remains challenging. This systematic review aims to identify clinical features at the onset of cMCTD and manifestations not currently included into the available diagnostic criteria. METHODS: A systematic literature review was performed in accordance with PRISMA guidelines 2020 using bibliographic databases: MEDLINE via PubMed and EMBASE...
April 2024: Autoimmunity Reviews
Francesco Buonfiglio, Katharina A Ponto, Norbert Pfeiffer, George J Kahaly, Adrian Gericke
Thyroid eye disease (TED) is an autoimmune condition affecting the orbit and the eye with its adnexa, often occurring as an extrathyroidal complication of Graves' disease (GD). Orbital inflammatory infiltration and the stimulation of orbital fibroblasts, triggering de novo adipogenesis, an overproduction of hyaluronan, myofibroblast differentiation, and eventual tissue fibrosis are hallmarks of the disease. Notably, several redox signaling pathways have been shown to intensify inflammation and to promote adipogenesis, myofibroblast differentiation, and fibrogenesis by upregulating potent cytokines, such as interleukin (IL)-1β, IL-6, and transforming growth factor (TGF)-β...
March 23, 2024: Autoimmunity Reviews
Fabio Salvatore Macaluso, Flavio Caprioli, Laura Benedan, Cristina Bezzio, Roberto Caporali, Alberto Cauli, Maria Sole Chimenti, Francesco Ciccia, Salvatore D'Angelo, Massimo Claudio Fantini, Stefano Festa, Florenzo Iannone, Ennio Lubrano, Paolo Mariani, Claudio Papi, Giuseppe Provenzano, Daniela Pugliese, Antonio Rispo, Simone Saibeni, Carlo Salvarani, Angela Variola, Mariangela Zenga, Alessandro Armuzzi, Ambrogio Orlando, Roberto Gerli
Spondyloarthritis (SpA) is the most frequent extraintestinal manifestation in patients with inflammatory bowel diseases (IBD). When IBD and spondyloarthritis coexist, musculoskeletal and intestinal disease features should be considered when planning a therapeutic strategy. Treatment options for IBD and SpA have expanded enormously over the last few years, but randomized controlled trials with specific endpoints focused on SpA are not available in the IBD setting. To address this important clinical topic, the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) and the Italian Society of Rheumatology (SIR) jointly planned to draw updated therapeutic recommendations for IBD-associated SpA using a pseudo-Delphi method...
March 21, 2024: Autoimmunity Reviews
Mirre De Bondt, Janne Renders, Sofie Struyf, Niels Hellings
Bruton's tyrosine kinase (BTK) is a cytoplasmic, non-receptor signal transducer, initially identified as an essential signaling molecule for B cells, with genetic mutations resulting in a disorder characterized by disturbed B cell and antibody development. Subsequent research revealed the critical role of BTK in the functionality of monocytes, macrophages and neutrophils. Various immune cells, among which B cells and neutrophils, rely on BTK activity for diverse signaling pathways downstream of multiple receptors, which makes this kinase an ideal target to treat hematological malignancies and autoimmune diseases...
March 21, 2024: Autoimmunity Reviews
Xiaoying Sun, Ziyang Cui, Qingyun Wang, Liu Liu, Xiaojie Ding, Jiao Wang, Xiaoce Cai, Bin Li, Xin Li
BACKGROUND: Formation of anti-drug antibodies (ADAs) against biologics is an important cause of psoriasis treatment failure. OBJECTIVE: This study aimed to summarize the characteristics of ADAs formation under different biological therapies and the influence of ADAs on the clinical effects and safety of biologics in patients with psoriasis. METHODS: PubMed, Embase, and Web of Science databases were searched from their inception to August 2022...
March 16, 2024: Autoimmunity Reviews
Yaroslav Winter, Sergiu Groppa, Timo Uphaus, Erik Ellwardt, Sven Fuest, Sven Meuth, Stefan Bittner, Eyad Hayani
The occurrence of cerebral vasculitis in individuals with neurosarcoidosis (NS) is considered to be rare. Although the number of relevant publications has increased in recent years, evidence is mostly limited to case reports. To obtain a better understanding of this rare and severe manifestation of disease, we carried out a scoping review on cerebral vasculitis in patients diagnosed with NS. The results of the review indicate that the diagnosis of cerebral vasculitis in patients with NS is made especially in patients with systemic sarcoidosis...
March 16, 2024: Autoimmunity Reviews
Huang Kuang, Nan Jiang, Xiao-Yu Jia, Zhao Cui, Ming-Hui Zhao
Anti-glomerular basement membrane (GBM) disease is a small-vessel vasculitis that represents the most aggressive form of autoimmune glomerulonephritis. The study aimed to investigate the prevalence, clinical characteristics, risk factors, and outcomes of anti-GBM disease through a systematic review and meta-analysis involving 47 studies with 2830 patients. The overall incidence of anti-GBM disease ranged from 0.60 to 1.79 per million population per annum. In rapidly progressive glomerulonephritis and crescentic glomerulonephritis, the pooled incidence rates were 8...
March 15, 2024: Autoimmunity Reviews
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