Massimo Radin, Irene Cecchi, Francesca Crisafulli, Evandro Mendes Klumb, Guilherme Ramires de Jesús, Marcela Ignacchiti Lacerda, Miguel Ángel Saavedra, Geraldine Vanessa Reyes-Navarro, Luca Iaccarino, Maddalena Larosa, Gabriella Moroni, Francesco Tamborini, Dario Roccatello, Laura Andreoli, Savino Sciascia, Cecilia Chighizola
BACKGROUND: Complement levels have been proposed as candidate biomarkers of disease activity and obstetric risk in lupus pregnancies, but their reliability has been questioned due to the physiologic fluctuations of complement levels during gestation. Thus, this network meta-analysis aimed at assessing the clinical significance of complement fluctuations in lupus pregnant women. METHODS: Corresponding authors of 19 studies meeting inclusion criteria were invited to contribute with additional data including C3 and C4 levels [before pregnancy, at conception, in every trimester (T) and 3 months after delivery]; data were pooled together in a network meta-analysis...
October 16, 2023: Autoimmunity Reviews