journal
https://read.qxmd.com/read/38040101/invariant-natural-killer-t-cells-in-autoimmune-cholangiopathies-mechanistic-insights-and-therapeutic-implications
#1
REVIEW
Roopa Hebbandi Nanjundappa, Kun Shao, Prasanna Krishnamurthy, M Eric Gershwin, Patrick S C Leung, Channakeshava Sokke Umeshappa
Invariant natural killer T cells (iNKT cells) constitute a specialized subset of lymphocytes that bridges innate and adaptive immunity through a combination of traits characteristic of both conventional T cells and innate immune cells. iNKT cells are characterized by their invariant T cell receptors and discerning recognition of lipid antigens, which are presented by the non-classical MHC molecule, CD1d. Within the hepatic milieu, iNKT cells hold heightened prominence, contributing significantly to the orchestration of organ homeostasis...
November 29, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/38040100/from-asca-breakthrough-in-crohn-s-disease-and-candida-albicans-research-to-thirty-years-of-investigations-about-their-meaning-in-human-health
#2
REVIEW
Boualem Sendid, Marjorie Cornu, Camille Cordier, Julie Bouckaert, Jean Frederic Colombel, Daniel Poulain
Anti-Saccharomyces cerevisiae antibodies (ASCA) are human antibodies that can be detected using an enzyme-linked immunosorbent assay involving a mannose polymer (mannan) extracted from the cell wall of the yeast S. cerevisiae. The ASCA test was developed in 1993 with the aim of differentiating the serological response in two forms of inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis. The test, which is based on the detection of anti-oligomannosidic antibodies, has been extensively performed worldwide and there have been hundreds of publications on ASCA...
November 29, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/38040099/relevance-of-vein-wall-thickness-in-behcet-s-disease-a-systematic-review-and-meta-analysis
#3
REVIEW
Mira Merashli, Tommaso Bucci, Jose Delgado-Alves, Paul R J Ames
OBJECTIVES: To perform a meta-analysis on articles evaluating the common femoral vein wall thickness (VWT) in Behcet's disease and its possible clinical, laboratory and treatment correlates (BD). METHODS: Systematic search of EMBASE and PubMed databases from inception to October 2023; we employed random effect meta-analyses for continuous outcomes. RESULTS: The meta-analysis included 9 case-control and 1 cohort study: the VWT was greater in BD (n = 650) than in controls (n = 396) (p < 0...
November 29, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/38016575/brain-regional-characteristics-and-neuroinflammation-in-me-cfs-patients-from-neuroimaging-a-systematic-review-and-meta-analysis
#4
REVIEW
Jin-Seok Lee, Wakiro Sato, Chang-Gue Son
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by an elusive etiology and pathophysiology. This study aims to evaluate the pathological role of neuroinflammation in ME/CFS by conducting an exhaustive analysis of 65 observational studies. Four neuroimaging techniques, including magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), electroencephalography (EEG), and positron emission tomography (PET), were employed to comparatively assess brain regional structure, metabolite profiles, electrical activity, and glial activity in 1529 ME/CFS patients (277 males, 1252 females) and 1715 controls (469 males, 1246 females)...
November 26, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/38016574/takotsubo-syndrome-occurring-in-systemic-diseases-a-french-multicenter-retrospective-case-control-study-and-literature-review
#5
REVIEW
Julien Culerrier, Benjamin Terrier, Matthieu Groh, Marilucy Lopez-Sublet, Benjamin De Sainte Marie, Géraldine Falgarone, Olivier Lidove, Patrick Mercie, Luc Mouthon, Christophe Meune, Robin Dhote
OBJECTIVE: Describe the characteristics of patients presenting with TTS during the course of a broad spectrum of systemic diseases, in comparison to classic TTS. METHODS: French multicenter retrospective case-control study completed by a literature review. RESULTS: 19 new cases were included in the study. The literature review identified 25 previously published cases. Among the 44 patients, 41 were females, with a median age of 67 years...
November 26, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/38008300/current-knowledge-on-multiple-sclerosis-pathophysiology-disability-progression-assessment-and-treatment-options-and-the-role-of-autologous-hematopoietic-stem-cell-transplantation
#6
REVIEW
Georgios Gakis, Ioannis Angelopoulos, Ioannis Panagoulias, Athanasia Mouzaki
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that affects nearly 2.8 million people each year. MS distinguishes three main types: relapsing-remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS). RRMS is the most common type, with the majority of patients eventually progressing to SPMS, in which neurological development is constant, whereas PPMS is characterized by a progressive course from disease onset. New or additional insights into the role of effector and regulatory cells of the immune and CNS systems, Epstein-Barr virus (EBV) infection, and the microbiome in the pathophysiology of MS have emerged, which may lead to the development of more targeted therapies that can halt or reverse neurodegeneration...
November 24, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/38008299/new-onset-sarcoidosis-following-biologic-treatment-in-patients-with-seronegative-inflammatory-arthritis-a-case-series-and-systematic-literature-review
#7
REVIEW
Denise Donzella, Elisa Bellis, Paola Campisi, Gloria Crepaldi, Valeria Data, Paolo Dapavo, Claudia Lomater, Elena Marucco, Marta Saracco, Mariele Gatto, Annamaria Iagnocco
OBJECTIVE: To report cases of new onset sarcoidosis upon biologic (bDMARDs) treatment administration in patients with seronegative inflammatory arthritis in a real-life cohort, alongside a systematic literature review (SLR) on this topic. METHODS: We performed a retrospective analysis on clinical records of patients with seronegative arthritis followed up in a monocentric cohort who underwent bDMARDs treatment due to the underlying rheumatic disease and described any newly diagnosed sarcoidosis in this cohort...
November 24, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37967782/recommendations-for-the-use-of-anti-dsdna-autoantibodies-in-the-diagnosis-and-follow-up-of-systemic-lupus-erythematosus-a-proposal-from-an-expert-panel
#8
REVIEW
Ricardo Rojo, Jaime Calvo Alén, Álvaro Prada, Santiago Valor, Garbiñe Roy, Marcos López-Hoyos, Ricard Cervera, Paloma Sánchez Mateos, Aurora Jurado Roger
Anti-dsDNA autoantibodies are listed as one of the classification criteria for systemic lupus erythematosus (SLE) and are relatively effective indicators for monitoring disease activity and treatment response. Therefore, clinicians rely on them to diagnose and adjust medication and treatment strategies for SLE patients. However, the use of anti-dsDNA antibodies is not free from controversy. Part of this controversy stems from the fact that anti-dsDNA antibodies are found in several disorders, besides SLE. In addition to this, anti-dsDNA antibodies are a heterogeneous group of antibodies, and their determination still lacks proper standardization...
November 13, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37956778/effects-of-cytotoxic-t-lymphocyte-associated-protein-4-compared-to-tnf-inhibitors-on-lipid-profile-results-from-an-observational-multicentre-rheumatoid-arthritis-cohort
#9
LETTER
Fabiola Atzeni, Fabio Cacciapaglia, James Galloways, Andreina Manfredi, Garifallia Sakellariou, Sam Norton, Elisa Gremese, Francesca Romana Spinelli, Ombretta Viapiana, Matteo Piga, Gian Luca Erre, Elena Bartoloni
AIM: To evaluate the impact of selective cytotoxic T-lymphocyte-associated protein 4 (CTLA-4Ig) compared to tumor necrosis factor inhibitors (TNFi) on cardiovascular (CV) clinical and laboratory outcomes in patients with rheumatoid arthritis (RA). METHODS: We performed a prospective observational multicenter study of RA patients included in the "Cardiovascular Obesity and Rheumatic DISease (CORDIS)" Study Group database, collecting demographic, clinical, and laboratory data of those starting a CTLA-4Ig or TNFi at baseline, 6-month, and 12-month follow-up...
November 11, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37884202/sle-classification-criteria-is-the-causality-principle-integrated-and-operative-and-do-the-molecular-and-genetical-network-on-which-criteria-depend-on-support-the-definition-of-sle-as-a-one-disease-entity-a-theoretical-discussion
#10
REVIEW
Ole Petter Rekvig
Molecular and cellular aspects of the autoimmune pathophysiology in SLE is linked to the "The causality principle". SLE Classification Criteria identify per definition disease measures (here: synonymous with classification criteria), but not diagnostic criteria within a classical framework. These two mostly theoretical criteria collections represent a salient conflict between phenomenology and the causality principle - between disease measures and molecular interactions that promote such measures, in other words their cause(s)...
October 24, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37884201/serum-calprotectin-is-a-marker-of-disease-activity-in-giant-cell-arteritis
#11
LETTER
Antoine Saut, Marie-Hélène Paclet, Candice Trocmé, Bertrand Toussaint, Alexis Bocquet, Laurence Bouillet, Athan Baillet
No abstract text is available yet for this article.
October 24, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37884200/anti-hmgcr-immune-mediated-necrotising-myopathy-addressing-the-remaining-issues
#12
REVIEW
Thomas Khoo, Hector Chinoy
The discovery of autoantibodies directed against the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme has defined a sub-set of immune-mediated necrotising myopathy (IMNM) which is strongly associated with exposure to statin medications. Although understanding of anti-HMGCR IMNM has grown considerably with the reporting of multiple cohorts in North America, Europe, Asia and Oceania, there remain many unanswered questions. The true incidence of anti-HMGCR IMNM is not known and heterogeneity of phenotype and treatment response within this autoantibody sub-group is being increasingly recognised...
October 24, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37863375/clinical-features-of-dermatomyositis-patients-with-anti-tif1-antibodies-a-case-based-comprehensive-review
#13
REVIEW
Ozgur C Kilinc, Serdal Ugurlu
BACKGROUND AND OBJECTIVES: Dermatomyositis is chronic autoimmune disease primarily affecting skin and muscles. Antibodies are key players of pathogenesis and are in strong correlation with distinct clinical phenotypes. We present a case and a comprehensive review of the literature on dermatomyositis patients with Anti TIF1 antibodies. METHODS: PubMed and Web of Science databases were reviewed. 166 articles were identified; 95 of them were evaluated; 79 of them included to the study...
October 19, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37852515/complement-levels-during-the-first-trimester-predict-disease-flare-and-adverse-pregnancy-outcomes-in-systemic-lupus-erythematosus-a-network-meta-analysis-on-532-pregnancies
#14
REVIEW
Massimo Radin, Irene Cecchi, Francesca Crisafulli, Evandro Mendes Klumb, Guilherme Ramires de Jesús, Marcela Ignacchiti Lacerda, Miguel Ángel Saavedra, Geraldine Vanessa Reyes-Navarro, Luca Iaccarino, Maddalena Larosa, Gabriella Moroni, Francesco Tamborini, Dario Roccatello, Laura Andreoli, Savino Sciascia, Cecilia Chighizola
BACKGROUND: Complement levels have been proposed as candidate biomarkers of disease activity and obstetric risk in lupus pregnancies, but their reliability has been questioned due to the physiologic fluctuations of complement levels during gestation. Thus, this network meta-analysis aimed at assessing the clinical significance of complement fluctuations in lupus pregnant women. METHODS: Corresponding authors of 19 studies meeting inclusion criteria were invited to contribute with additional data including C3 and C4 levels [before pregnancy, at conception, in every trimester (T) and 3 months after delivery]; data were pooled together in a network meta-analysis...
October 16, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37852514/a-comprehensive-review-of-the-advances-in-neuromyelitis-optica-spectrum-disorder
#15
REVIEW
Pakeeran Siriratnam, Saif Huda, Helmut Butzkueven, Anneke Van der Walt, Vilija Jokubaitis, Mastura Monif
Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing neuroinflammatory autoimmune astrocytopathy, with a predilection for the optic nerves and spinal cord. Most cases are characterised by aquaporin-4-antibody positivity and have a relapsing disease course, which is associated with accrual of disability. Although the prognosis in NMOSD has improved markedly over the past few years owing to advances in diagnosis and therapeutics, it remains a severe disease. In this article, we review the evolution of our understanding of NMOSD, its pathogenesis, clinical features, disease course, treatment options and associated symptoms...
October 16, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37848157/from-inflammation-to-renal-fibrosis-a-one-way-road-in-autoimmunity
#16
REVIEW
Dario Roccatello, Hui-Yao Lan, Savino Sciascia, Sanjeev Sethi, Alessia Fornoni, Richard Glassock
Renal fibrosis is now recognized as a main determinant of renal pathology to include chronic kidney disease. Deposition of pathological matrix in the walls of glomerular capillaries, the interstitial space, and around arterioles predicts and contributes to the functional demise of the nephron and its surrounding vasculature. The recent identification of the major cell populations of fibroblast precursors in the kidney interstitium such as pericytes and tissue-resident mesenchymal stem cells, or bone-marrow-derived macrophages, and in the glomerulus such as podocytes, parietal epithelial and mesangial cells, has enabled the study of the fibrogenic process thought the lens of involved immunological pathways...
October 15, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37844857/should-we-use-nintedanib-as-early-therapy-in-patients-with-ssc-ild
#17
REVIEW
Elisabetta Zanatta, Beatrice Moccaldi, Gabriella Szucs, Paolo Spagnolo
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease, where a significant proportion of patients develop interstitial lung disease (ILD), which is the major cause of mortality. In recent years, the diagnosis of SSc-ILD has improved a lot, and caring rheumatologists, together with pulmonologists, regularly screen and follow the development and course of ILD. Considerable progress has also been made in the treatment of SSc-ILD based on several clinical trials. The recommendations for immunosuppressive treatment have been modified and supplemented with targeted agents (tocilizumab, rituximab), and antifibrotic drugs such as nintedanib registered as a new treatment for SSc-ILD...
October 14, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37793491/aberrant-n-myristoylation-as-a-prelude-to-autoimmune-manifestations-in-patients-with-shoc2-mutations
#18
LETTER
Donato Rigante, Chiara Leoni, Roberta Onesimo, Valentina Giorgio, Valentina Trevisan, Giuseppe Zampino
No abstract text is available yet for this article.
October 2, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37778406/idiopathic-inflammatory-myopathies-the-burden-of-disease-cohort-analysis-focusing-on-damage-and-comorbidities
#19
REVIEW
Ana Campar, Inês Alves, Ana Martins da Silva, Fátima Farinha, Carlos Vasconcelos
INTRODUCTION/BACKGROUND: Idiopathic Inflammatory Myopathies (IIM) continue to be a major clinical challenge worldwide. The exact aetiopathogenesis of this chronic and disabling disease remains elusive, preventing the development of novel and effective therapeutic strategies and leading to a high incidence of damage. The complexity of treating these diseases is even greater due to the numerous comorbidities that affect these patients. METHODS: Retrospective review of the cohort of patients diagnosed with IIM and followed in a dedicated unit of a tertiary hospital between 1971 and December 2022, with particular attention to damage and comorbidities...
September 29, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37748542/low-dose-intravenous-immunoglobulin-ivig-in-different-immune-mediated-conditions
#20
REVIEW
Maria Giovanna Danieli, Eleonora Antonelli, Stefania Auria, Elena Buti, Yehuda Shoenfeld
IVIg has been used for a long time as a replacement therapy for primary and secondary immunodeficiencies. Beside this supplementary role, when used at higher doses (i.e., 2 g/kg/monthly) it exerts an immunomodulatory role able to control multiple autoimmune and systemic inflammatory diseases. Several mechanisms of action have been described and hypothesized, nonetheless a synergistic action on the different component of the immune response seems to be crucial. The other side of the coin are the costs which showed an increase during the years due to the production of highly purified preparations which limit side reactions...
September 23, 2023: Autoimmunity Reviews
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