journal
https://read.qxmd.com/read/38447609/organ-specific-biological-clocks-ageotyping-for-personalized-anti-aging-medicine
#21
REVIEW
Francesco Prattichizzo, Chiara Frigé, Valeria Pellegrini, Lucia Scisciola, Aurelia Santoro, Daniela Monti, Maria Rita Rippo, Mikhail Ivanchenko, Fabiola Olivieri, Claudio Franceschi
Aging is a complex multidimensional, progressive remodeling process affecting multiple organ systems. While many studies have focused on studying aging across multiple organs, assessment of the contribution of individual organs to overall aging processes is a cutting-edge issue. An organ's biological age might influence the aging of other organs, revealing a multiorgan aging network. Recent data demonstrated a similar yet asynchronous inter-organs and inter-individuals progression of aging, thereby providing a foundation to track sources of declining health in old age...
March 4, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38442748/effects-of-clitorienolactones-from-clitoria-ternatea-root-on-calcium-channel-mediating-hippocampal-long-term-potentiation-in-rats-induced-chronic-cerebral-hypoperfusion
#22
REVIEW
Mohamad Anuar Ahad, Nelson Jeng-Yeou Chear, Muhammad Hazim Abdullah, Tan Ai Fein Ching-Ga, Liao Ping, Shunhui Wei, Vikneswaran Murugaiyah, Zurina Hassan
Chronic cerebral hypoperfusion (CCH) is a common mechanism of acute brain injury due to impairment of blood flow to the brain. Moreover, a prolonged lack of oxygen supply may result in cerebral infarction or global ischemia, which subsequently causes long-term memory impairment. Research on using Clitoria ternatea root extract for treating long-term memory has been studied extensively. However, the bioactive compound contributing to its neuroprotective effects remains uncertain. In the present study, we investigate the effects of clitorienolactone A (CLA) and B (CLB) from the roots of Clitoria ternatea extract on hippocampal neuroplasticity in rats induced by CCH...
March 3, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38437884/circulating-biomarkers-of-inflammaging-and-alzheimer-s-disease-to-track-age-related-trajectories-of-dementia-can-we-develop-a-clinically-relevant-composite-combination
#23
REVIEW
Angela Marie Abbatecola, Angelica Giuliani, Leonardo Biscetti, Lucia Scisciola, Petronilla Battista, Michelangela Barbieri, Jacopo Sabbatinelli, Fabiola Olivieri
Alzheimer's disease (AD) is a rapidly growing global concern due to a consistent rise of the prevalence of dementia which is mainly caused by the aging population worldwide. An early diagnosis of AD remains important as interventions are plausibly more effective when started at the earliest stages. Recent developments in clinical research have focused on the use of blood-based biomarkers for improve diagnosis/prognosis of neurodegenerative diseases, particularly AD. Unlike invasive cerebrospinal fluid tests, circulating biomarkers are less invasive and will become increasingly cheaper and simple to use in larger number of patients with mild symptoms or at risk of dementia...
March 2, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38428821/involvement-of-regulated-cell-deaths-in-aging-and-age-related-pathologies
#24
REVIEW
Laura Della Torre, Antonio Beato, Vincenza Capone, Daniela Carannante, Giulia Verrilli, Gregorio Favale, Nunzio Del Gaudio, Wouter Leonard Megchelenbrink, Rosaria Benedetti, Lucia Altucci, Vincenzo Carafa
Aging is a pathophysiological process that causes a gradual and permanent reduction in all biological system functions. The phenomenon is caused by the accumulation of endogenous and exogenous damage as a result of several stressors, resulting in significantly increased risks of various age-related diseases such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases. In addition, aging appears to be connected with mis-regulation of programmed cell death (PCD), which is required for regular cell turnover in many tissues sustained by cell division...
February 28, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38417711/hepatopancreatic-metabolic-disorders-and-their-implications-in-the-development-of-alzheimer-s-disease-and-vascular-dementia
#25
REVIEW
Francisco Irochima Pinheiro, Irami Araújo-Filho, Amália Cinthia Meneses do Rego, Eduardo Pereira de Azevedo, Ricardo Ney Cobucci, Fausto Pierdona Guzen
Dementia has been faced with significant public health challenges and economic burdens that urges the need to develop safe and effective interventions. In recent years, an increasing number of studies have focused on the relationship between dementia and liver and pancreatic metabolic disorders that result in diseases such as diabetes, obesity, hypertension and dyslipidemia. Previous reports have shown that there is a plausible correlation between pathologies caused by hepatopancreatic dysfunctions and dementia...
February 26, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38408490/the-effect-of-ferroptosis-related-mitochondrial-dysfunction-in-the-development-of-temporal-lobe-epilepsy
#26
REVIEW
Yang Su, Ningrui Cao, Dingkun Zhang, Minjin Wang
Temporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an important neuronal death mechanism in TLE, which is primarily influenced by lipid accumulation and oxidative stress. In previous studies of ferroptosis, more attention has been focused on the impact of changes in the levels of proteins related to the redox equilibrium and signaling pathways on epileptic seizures...
February 24, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38401571/understanding-age-related-pathologic-changes-in-tdp-43-functions-and-their-consequence-on-rna-splicing-and-signalling-in-health-and-disease
#27
REVIEW
Flora Cheng, Tyler Chapman, Selina Zhang, Marco Morsch, Roger Chung, Albert Lee, Stephanie L Rayner
TAR DNA binding protein-43 (TDP-43) is a key component in RNA splicing which plays a crucial role in the aging process. In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Limbic-predominant age-related TDP-43 Encephalopathy (LATE), TDP-43 can be mutated, mislocalised out of the nucleus of neurons and glial cells and form cytoplasmic inclusions. These TDP-43 alterations can lead to its RNA splicing dysregulation and contribute to mis-splicing of various types of RNA, such as mRNA, microRNA, and circRNA...
February 22, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38401570/multiomics-insights-into-the-female-reproductive-aging
#28
REVIEW
Simin Wei, Weicheng Tang, Dan Chen, Jiaqiang Xiong, Liru Xue, Yun Dai, Yican Guo, Chuqing Wu, Jun Dai, Meng Wu, Shixuan Wang
The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities have facilitated the emergence of multiomics deep phenotyping. Through the application and refinement of various high-throughput histological methods, a substantial volume of omics data has been generated, deepening our comprehension of the pathogenesis and molecular underpinnings of reproductive aging...
February 22, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38395200/a-multimodal-meta-analytical-evidence-of-functional-and-structural-brain-abnormalities-across-alzheimer-s-disease-spectrum
#29
REVIEW
Xinyue Tang, Zixuan Guo, Guanmao Chen, Shilin Sun, Shu Xiao, Pan Chen, Guixian Tang, Li Huang, Ying Wang
BACKGROUND: Numerous neuroimaging studies have reported that Alzheimer's disease (AD) spectrum have been linked to alterations in intrinsic functional activity and cortical thickness (CT) of some brain areas. However, the findings have been inconsistent and the correlation with the transcriptional profile and neurotransmitter systems remain largely unknown. METHODS: We conducted a meta-analysis to identify multimodal differences in the amplitude of low-frequency fluctuation (ALFF)/fractional ALFF (fALFF) and CT in patients with AD and preclinical AD compared to healthy controls (HCs), using the Seed-based d Mapping with Permutation of Subject Images software...
February 21, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38395199/vitamin-d-and-ischemic-stroke-association-mechanisms-and-therapeutics
#30
REVIEW
Pan Cui, Haiman Hou, Bo Song, Zongping Xia, Yuming Xu
Confronting the rising tide of ischemic stroke and its associated mortality and morbidity with ageing, prevention and acute management of ischemic stroke is of paramount importance. Mounting observational studies have established a non-linear association of vitamin D status with cardiovascular diseases, including ischemic stroke. Paradoxically, current clinical trials fail to demonstrate the cardiovascular benefits of vitamin D supplementation. We aim to update recent clinical and experimental findings on the role of vitamin D in the disease course of ischemic stroke, from its onset, progression, recovery, to recurrence, and the established and alternative possible pathophysiological mechanisms...
February 21, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38395198/the-measurement-properties-and-feasibility-of-frail-scale-in-older-adults-a-systematic-review-and-meta-analysis
#31
REVIEW
N G Yu Xuan, Ling Jie Cheng, Yu Yi Quek, Ruby Yu, W U Xi Vivien
Frailty is a prevalent condition amongst older adults, significantly affecting their quality of life. The FRAIL tool has been purposefully designed for clinical application by assisting healthcare professionals in identifying and managing frailty-related issues in older adults, making it a preferred choice for assessing frailty across diverse older populations. This review aimed to synthesize the measurement properties and feasibility of FRAIL. Guided by COSMIN guidelines, seven databases were searched from inception to 31 Mar 2023...
February 21, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38387517/role-of-succinylation-modification-in-central-nervous-system-diseases
#32
REVIEW
Chao Wang, Weigang Cui, Bing Yu, Han Zhou, Zhenwen Cui, Pin Guo, Tao Yu, Yugong Feng
Diseases of the central nervous system (CNS), including stroke, brain tumors, and neurodegenerative diseases, have a serious impact on human health worldwide, especially in elderly patients. The brain, which is one of the body's most metabolically dynamic organs, lacks fuel stores and therefore requires a continuous supply of energy substrates. Metabolic abnormalities are closely associated with the pathogenesis of CNS disorders. Post-translational modifications (PTMs) are essential regulatory mechanisms that affect the functions of almost all proteins...
February 20, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38387516/macrophage-membrane-camouflaged-biomimetic-nanovesicles-for-targeted-treatment-of-arthritis
#33
REVIEW
Xin Huang, Weiyue Zhang
Arthritis has become the most common joint disease globally. Current attention has shifted towards preventing the disease and exploring pharmaceutical and surgical treatments for early-stage arthritis. M2 macrophages are known for their anti-inflammatory properties and their ability to support cartilage repair, offering relief from arthritis. Whereas, it remains a great challenge to promote the beneficial secretion of M2 macrophages to prevent the progression of arthritis. Therefore, it is warranted to investigate new strategies that could use the functions of M2 macrophages and enhance its therapeutic effects...
February 20, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38382678/therapeutic-effect-of-dietary-ingredients-on-cellular-senescence-in-animals-and-humans-a-systematic-review
#34
REVIEW
Lihuan Guan, Anna Eisenmenger, Karen C Crasta, Elena Sandalova, Andrea B Maier
BACKGROUND: Cellular senescence has been regarded as a therapeutic target for ageing and age-related diseases. Several senotherapeutic agents have been proposed, including compounds derived from natural products which hold the translational potential to promote healthy ageing. This systematic review examined the association of dietary ingredients with cellular senescence in animals and humans, with an intent to identify dietary ingredients with senotherapeutic potential. METHODS: This systematic review was registered at PROSPERO International prospective register of systematic reviews (Reg #: CRD42022338885)...
February 19, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38382677/social-determinants-of-intrinsic-capacity-a-systematic-review-of-observational-studies
#35
REVIEW
Zi-Ting Huang, Eric T C Lai, Yan Luo, Jean Woo
BACKGROUND: The World Health Organization defined healthy ageing as the maintenance of functional ability with ageing. Intrinsic capacity is a measurement of healthy ageing, and can be shaped by social determinants. However, an overall understanding of how multiple social determinants contribute to intrinsic capacity remains unclear. We aim to summarize observational studies investigating the relationships of social determinants and intrinsic capacity among community-dwelling adults. METHODS: A systematic search was conducted through Medline, Embase, PsycInfo, Web of Science, and CINAHL until August 14, 2023...
February 19, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38369026/opening-avenues-for-treatment-of-neurodegenerative-disease-using-post-biotics-breakthroughs-and-bottlenecks-in-clinical-translation
#36
REVIEW
Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, Sukriti Vishwas, Narendra Kumar Pandey, Gaurav Gupta, Keshav Raj Paudel, Harish Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia Zacconi, Terezinha de Jesus Andreoli Pinto, Muralikrishnan Dhanasekaran, Monica Gulati, Kamal Dua, Sachin Kumar Singh
Recent studies have indicated the significant involvement of the gut microbiome in both human physiology and pathology. Additionally, therapeutic interventions based on microbiome approaches have been employed to enhance overall health and address various diseases including aging and neurodegenerative disease (ND). Researchers have explored potential links between these areas, investigating the potential pathogenic or therapeutic effects of intestinal microbiota in diseases. This article provides a summary of established interactions between the gut microbiome and ND...
February 16, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38367814/epigenetic-regulations-of-cellular-senescence-in-osteoporosis
#37
REVIEW
Shaochuan Huo, Xinzheng Tang, Weijian Chen, Donghao Gan, Hai Guo, Qing Yao, Rongdong Liao, Tingting Huang, Junxian Wu, Junxing Yang, Guozhi Xiao, Xia Han
Osteoporosis (OP) is a prevalent age-related disease that is characterized by a decrease in bone mineral density (BMD) and systemic bone microarchitectural disorders. With age, senescent cells accumulate and exhibit the senescence-associated secretory phenotype (SASP) in bone tissue, leading to the imbalance of bone homeostasis, osteopenia, changes in trabecular bone structure, and increased bone fragility. Cellular senescence in the bone microenvironment involves osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells (BMSCs), whose effects on bone homeostasis are regulated by epigenetics...
February 15, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38367813/the-role-and-mechanism-of-rna-binding-proteins-in-bone-metabolism-and-osteoporosis
#38
REVIEW
Jiaqiang Wu, Liyan Niu, Kangping Yang, Jingdong Xu, Deju Zhang, Jitao Ling, Panpan Xia, Yuting Wu, Xiao Liu, Jianping Liu, Jing Zhang, Peng Yu
Osteoporosis is a prevalent chronic metabolic bone disease that poses a significant risk of fractures or mortality in elderly individuals. Its pathophysiological basis is often attributed to postmenopausal estrogen deficiency and natural aging, making the progression of primary osteoporosis among elderly people, especially older women, seemingly inevitable. The treatment and prevention of osteoporosis progression have been extensively discussed. Recently, as researchers delve deeper into the molecular biological mechanisms of bone remodeling, they have come to realize the crucial role of posttranscriptional gene control in bone metabolism homeostasis...
February 15, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38367812/efficacy-of-deprescribing-on-health-outcomes-an-umbrella-review-of-systematic-reviews-with-meta-analysis-of-randomized-controlled-trials
#39
REVIEW
Nicola Veronese, Umberto Gallo, Virginia Boccardi, Jacopo Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Campbell, Marco Chiumente, Francesca Venturini, Alberto Pilotto
BACKGROUND: Deprescribing is an important intervention across different settings in medicine, but the literature supporting such a practice is still conflicting. Therefore, we aimed to capture the breadth of outcomes reported and assess the strength of evidence of the use of deprescribing for health outcomes. METHODS: Umbrella review of systematic reviews of the use of deprescribing searching in Medline, Scopus, and Web of Science until 01 November 2023. The grading of evidence was carried out using the GRADE for intervention studies, whilst data regarding systematic reviews were reported as narrative findings...
February 15, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38364915/circadian-regulation-of-microglia-function-potential-targets-for-treatment-of-parkinson-s-disease
#40
REVIEW
Liang Kou, Xiaosa Chi, Yadi Sun, Sijia Yin, Jiawei Wu, Wenkai Zou, Yiming Wang, Zongjie Jin, Jinsha Huang, Nian Xiong, Yun Xia, Tao Wang
Circadian rhythms are involved in the regulation of many aspects of the body, including cell function, physical activity and disease. Circadian disturbance often predates the typical symptoms of neurodegenerative diseases and is not only a non-motor symptom, but also one of the causes of their occurrence and progression. Glial cells possess circadian clocks that regulate their function to maintain brain development and homeostasis. Emerging evidence suggests that the microglial circadian clock is involved in the regulation of many physiological processes, such as cytokine release, phagocytosis, and nutritional and metabolic support, and that disruption of the microglia clock may affect multiple aspects of Parkinson's disease, especially neuroinflammation and α-synuclein processes...
February 14, 2024: Ageing Research Reviews
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