Shaochuan Huo, Xinzheng Tang, Weijian Chen, Donghao Gan, Hai Guo, Qing Yao, Rongdong Liao, Tingting Huang, Junxian Wu, Junxing Yang, Guozhi Xiao, Xia Han
Osteoporosis (OP) is a prevalent age-related disease that is characterized by a decrease in bone mineral density (BMD) and systemic bone microarchitectural disorders. With age, senescent cells accumulate and exhibit the senescence-associated secretory phenotype (SASP) in bone tissue, leading to the imbalance of bone homeostasis, osteopenia, changes in trabecular bone structure, and increased bone fragility. Cellular senescence in the bone microenvironment involves osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells (BMSCs), whose effects on bone homeostasis are regulated by epigenetics...
February 15, 2024: Ageing Research Reviews