Darwin R Reyes, Mandy B Esch, Lorna Ewart, Rohollah Nasiri, Anna Herland, Kyung Sung, Monica Piergiovanni, Carolina Lucchesi, James T Shoemaker, Jelena Vukasinovic, Hiroki Nakae, James Hickman, Kapil Pant, Anne Taylor, Niki Heinz, Nureddin Ashammakhi
Limitations with cell cultures and experimental animal-based studies have had the scientific and industrial communities searching for new approaches that can provide reliable human models for applications such as drug development, toxicological assessment, and in vitro pre-clinical evaluation. This has resulted in the development of microfluidic-based cultures that may better represent organs and organ systems in vivo than conventional monolayer cell cultures. Although there is considerable interest from industry and regulatory bodies in this technology, several challenges need to be addressed for it to reach its full potential...
February 19, 2024: Lab on a Chip