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Integrative Cancer Therapies

Tantry Maulina, Retno Widayanti, Andri Hardianto, Endang Sjamsudin, Bambang Pontjo, Harmas Yazid Yusuf
BACKGROUND: Curcumin, a natural herb that can be isolated from turmeric has been known for its therapeutic potential, including its chemopreventive potential, while heme oxygenase-1 (HO-1) is an antioxidant enzyme that can act as the biomarker for the progression of oral squamous cell carcinoma (OSCC). The current study investigated the efficacy of curcumin as a chemopreventive agent for OSCC by evaluating the immunoexpression of HO-1 at epithelial dysplasia stage. METHODS: The current experimental study was conducted at the Veterinary Medicine Faculty, Bogor Agricultural Institute, Indonesia, using 40 Sprague-Dawley rats...
January 7, 2019: Integrative Cancer Therapies
M Robyn Andersen, Erin Sweet, Shelly Hager, Marcia Gaul, Fred Dowd, Leanna J Standish
BACKGROUND: Vitamin D supplements may prevent recurrence, prolong survival, and improve mood for women with breast cancer, although evidence for these effects is preliminary. METHODS: This report describes vitamin D supplement use by 553 breast cancer patient/survivors (193 who used a naturopathic oncology [NO] provider and 360 who did not) participating in a matched cohort study of breast cancer outcomes. RESULTS: We found that more than half of breast cancer patients reported using vitamin D supplements...
January 7, 2019: Integrative Cancer Therapies
Dongrong Zhu, Chen Chen, Yuanzheng Xia, Ling-Yi Kong, Jianguang Luo
Pharbitidis Semen has worldwide recognition in traditional medicine for the treatment of several illnesses apart from its purgative properties, and it is also reported to show anticancer effect. However, limited pharmacological studies are available on the extract or resin glycosides fraction of Pharbitidis Semen. The purpose of this study was to determine the mechanism of the colon cancer cell cytotoxic effect of a purified resin glycoside fraction from Pharbitidis Semen (RFP). Our results showed that the RFP-induced cell death was mediated by the caspase-independent and autophagy-protective paraptosis, a type of cell death that is characterized by the accumulation of cytoplasmic vacuoles and mitochondria swelling...
January 7, 2019: Integrative Cancer Therapies
Désirée Poier, Arndt Büssing, Daniela Rodrigues Recchia, Yvonne Beerenbrock, Marcus Reif, Andreas Nikolaou, Roland Zerm, Christoph Gutenbrunner, Matthias Kröz
CONTEXT: Cancer-related fatigue (CRF) is one of the most burdensome symptoms in breast cancer survivors (BCSs), accompanied by reduced health-related quality of life (HRQOL). OBJECTIVES: This study investigated the influence of a multimodal therapy (MT; psychoeducation, eurythmy therapy, painting therapy, and sleep education/restriction), or a combination therapy (CT; MT plus aerobic training [AT]) on HRQOL in BCS with chronic CRF in comparison with AT alone. METHODS: One hundred and twenty-six BCSs with CRF were included in a pragmatic comprehensive cohort study and allocated either per randomization or by preference to MT, CT, or AT...
December 25, 2018: Integrative Cancer Therapies
Tueanjai Khunluck, Veerapol Kukongviriyapan, Laddawan Senggunprai, Wutthipong Duangarsong, Auemduan Prawan
Altered expression of a cytosolic flavoenzyme NAD(P)H:quinone oxidoreductase-1 (NQO1) has been seen in many human tumors. Its remarkable overexpression in cholangiocarcinoma (CCA; an aggressive malignancy of the biliary duct system) was associated with poor prognosis and short survival of the patients. Inhibition of NQO1 has been proposed as a potential strategy to improve the efficacy of anticancer drugs in various cancers including CCA. This study investigated novel NQO1 inhibitors and verified the mechanisms of their enzyme inhibition...
December 25, 2018: Integrative Cancer Therapies
Giammaria Fiorentini, Donatella Sarti, Carlo Milandri, Patrizia Dentico, Andrea Mambrini, Caterina Fiorentini, Gianmaria Mattioli, Virginia Casadei, Stefano Guadagni
BACKGROUND: There are interesting studies on glioma therapy with modulated electrohyperthermia (mEHT), which combines heat therapy with an electric field. Clinical researchers not only found the mEHT method feasible for palliation but also reported evidence of therapeutic response. PURPOSE: To study the efficacy and safety of mEHT for the treatment of relapsed malignant glioma and astrocytoma versus best supportive care (BSC). METHODS: We collected data retrospectively on 149 patients affected by malignant glioma and astrocytoma...
December 22, 2018: Integrative Cancer Therapies
Yihong Liu, Brian H May, Anthony Lin Zhang, Xinfeng Guo, Chuanjian Lu, Charlie Changli Xue, Haibo Zhang
OBJECTIVES: To assess the clinical evidence for integrative herbal medicine therapy in the management of chemotherapy-induced peripheral neuropathy (CIPN) and hand-foot syndrome (HFS) resulting from treatments for colorectal cancer (CRC). DESIGN: Randomized controlled trials (RCTs) were identified from major English and Chinese databases. Participants had been diagnosed with CRC by pathology and had received or were undergoing chemotherapy. Interventions included herbal medicines administered orally or topically...
December 10, 2018: Integrative Cancer Therapies
Shuyu Liu, Dan Zhang, Jiarui Wu, Kaihuan Wang, Yi Zhao, Mengwei Ni, Ziqi Meng, Xiaomeng Zhang
OBJECTIVE: This meta-analysis synthesized the available evidence on the effectiveness and safety of Shenqi Fuzheng injection (SQFZI) combined with chemotherapy for breast cancer. METHOD: A comprehensive systematic literature search was conducted to identify the randomized controlled trials (RCTs) on breast cancer treated by SQFZI in several electronic database up to October 29, 2017. The included RCTs were assessed using the Cochrane Collaboration tool; data were extracted and analyzed via RevMan 5...
December 4, 2018: Integrative Cancer Therapies
Sung Hwan Lee, Ho Kyoung Hwang, Chang Moo Kang, Woo Jung Lee
BACKGROUND: Surgical resection followed by adjuvant chemotherapy is the only therapeutic option in pancreatic cancer. However, there is limited research evaluating methods of improving adherence to adjuvant treatment after curative resection. METHODS: From January 1995 to December 2014, 323 patients with pancreatic cancer who underwent pancreatectomy at the Severance Hospital were enrolled in this study. We retrospectively analyzed clinicopathologic factors with propensity score matching method...
December 3, 2018: Integrative Cancer Therapies
Gang Xie, Zhihua Cui, Kai Peng, Xiehai Zhou, Quan Xia, Dujuan Xu
BACKGROUND: Clinical research has paid increasing attention to quality of life (QoL) in recent years, but the assessment of QoL is difficult, hampered by the subjectivity, complexity, and adherence of patients and physicians. According to previous studies, QoL in cancer patients is related to performance status (PS) and influenced by chemotherapy-related toxicity. Aidi injection, a traditional Chinese medicine injection, is used as an adjuvant drug to enhance effectiveness of chemotherapy...
November 27, 2018: Integrative Cancer Therapies
Decai Tang, Shuo Zhang, Xiaoxia Shi, Jiafei Wu, Gang Yin, Xiying Tan, Fuyan Liu, Xingdong Wu, Xiangyu Du
Normalizing the disordered tumor vasculature, rather than blocking it, is a novel method for anticancer therapy. Astragali polysaccharide (APS) and curcumin were reported to be active against carcinomas. However, the effect and mechanism of the combination of APS and curcumin on vascular normalization in hepatocellular carcinoma (HCC) was not clear. In the present study, effects of combined APS and curcumin on tumor vascular normalization were evaluated in HepG2 tumor-bearing mice. Photoacoustic tomography (PAT) was performed to observe the morphological structure of tumor vessels in vivo...
January 2019: Integrative Cancer Therapies
Michelle Marie Holmes
People living with and beyond cancer suffer with a wide range of physical and psychological symptoms. To manage the challenges associated with cancer, patients use a variety of self-management resources, including the Internet. People living with and beyond cancer use the Internet to make decisions regarding their self-care, through information provision, online communities, and support groups. Using the Internet may empower patients, enabling them to feel they have the required knowledge to discuss complementary and alternative treatment options with their health care team...
January 2019: Integrative Cancer Therapies
Chunfeng Yu, Wei Liu, Yuejun Mu, Aihua Hou, Yin Li
BACKGROUND: To observe clinical effects of Shen Cao granules on thrombocytopenia in patients with gastrointestinal cancer undergoing chemotherapy. PATIENTS AND METHODS: Patients under a FOLFIRI chemotherapy regimen (n = 92) were randomly divided into study and control groups (n = 46 for each group) and were given 10 g of Shen Cao granules and a placebo, respectively, once daily on chemotherapy treatment days. Platelet counts were measured every other day and any adverse reaction recorded during the study and at follow-up...
January 2019: Integrative Cancer Therapies
Scott M Monfort, Xueliang Pan, Charles L Loprinzi, Maryam B Lustberg, Ajit M W Chaudhari
Individuals diagnosed with chemotherapy-induced peripheral neuropathy (CIPN) demonstrate impaired balance and carry an increased risk of falling. However, prior investigations of postural instability have only compared these individuals against healthy controls, limiting the understanding of impairments associated with CIPN. Therefore, the purpose of this study was to better isolate postural control impairments that are associated with CIPN. Twenty cancer survivors previously diagnosed with breast or colorectal cancer participated...
January 2019: Integrative Cancer Therapies
Ralph Muecke, Knut Waldschock, Lutz Schomburg, Oliver Micke, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz, Jutta Huebner
INTRODUCTION: The supply of selenium (Se) varies widely in Germany. Therefore, a laboratory study was conducted in patients treated at a family doctor practice in Brandenburg, Germany, to determine whether there is a general Se deficiency in this area; specifically, whether Se concentrations differ with age, sex, or presence of cancer. Moreover, we tested the effects of a Se supplementation on whole blood Se levels (WBSL). METHODS: In 2006, WBSL were analyzed in 871 patients (496 females, 375 males, median age: 67 years)...
December 2018: Integrative Cancer Therapies
Yi-Hua Lee, Gi-Ming Lai, De-Chih Lee, Lee-Jang Tsai Lai, Yuan-Ping Chang
OBJECTIVES: Cancer-related fatigue and fear of recurrence (FOR) are the most common symptoms in cancer survivors and severely affect quality of life (QOL). This study aims to promote and evaluate the effectiveness of physical and psychological rehabilitation activities for cancer survivors. METHODS: A longitudinal study with an interventional research design was conducted. A total of 80 participants were randomly assigned to experimental groups E1 (Qigong exercise [QE]) or E2 (stress management [SM]) or the control group...
December 2018: Integrative Cancer Therapies
Jun Ni, Jian Feng, Linda Denehy, Yi Wu, Liqin Xu, Catherine L Granger
PURPOSE: This study aimed to measure symptoms of posttraumatic stress disorder (PTSD) in Chinese patients following a new diagnosis of lung cancer. Secondary aims were to explore factors at diagnosis that may predict PTSD symptoms at 6 months. METHODS: This was a prospective longitudinal observational study that included 93 patients with newly diagnosed lung cancer. PTSD symptomology was assessed using the PTSD Checklist Civilian Version (PCL-C) and health-related quality of life (HRQoL) was assessed with the European Organisation for the Research and Treatment of Cancer questionnaire...
December 2018: Integrative Cancer Therapies
Jiro Nakano, Kaori Hashizume, Takuya Fukushima, Kazumi Ueno, Emi Matsuura, Yuta Ikio, Shun Ishii, Satoru Morishita, Koji Tanaka, Yoko Kusuba
OBJECTIVE: This study aimed to conduct a meta-analysis to establish the effect of exercise interventions on physical symptoms, including fatigue, nausea/vomiting, pain, dyspnea, insomnia, loss of appetite, constipation, and diarrhea in cancer patients and survivors. METHODS: We searched articles published before April 2017 using the following databases: Cochrane Library, PubMed/MEDLINE, CINAHL, Scopus, PEDro, Health & Medical Collection, and Psychology Database...
December 2018: Integrative Cancer Therapies
Markus Horneber, Gerd van Ackeren, Felix Fischer, Herbert Kappauf, Josef Birkmann
PURPOSE: To report on a telephone consultation service with cancer patients and their relatives about complementary and alternative medicine (CAM) between 1999 and 2011. METHODS: We offered a Germany-wide, free-of-charge telephone consultation service about CAM led by oncology clinicians from a comprehensive cancer center. The consultations followed a patient-centered approach with the aim to provide guidance and evidence-based information. Sociodemographic, disease-related data as well as information about the consultations' content were collected in a standardized manner, and feedback questionnaires were sent out immediately after the consultations...
December 2018: Integrative Cancer Therapies
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