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International Journal of Lower Extremity Wounds

Jiaojiao Zhong, Yu Lan, Shuying Fu, Jing Zhang, Sha Lu, Yunan He, Jun-Min Zhang
Chronic skin ulcer (CSU) often combines with a variety of refractory factors that respond poorly to routine treatments. Botulinum toxin A (BTX-A) can be injected subcutaneously to improve the local blood supply, to reduce pain, and to promote wound healing. At present, few reports have mentioned BTX-A injection for chronic skin ulcer treatment. We observed the effect of four cases that used BTX-A to treat CSU and provided a brief review of the literature. Four cases of CSUs with 4 different causes were treated with BTX-A injection (4 U/cm2 )...
January 29, 2019: International Journal of Lower Extremity Wounds
Joshua Luck, Timo Rodi, Alexander Geierlehner, Afshin Mosahebi
Outcomes following standard wound care (SWC) for diabetic foot ulcers (DFUs) remain suboptimal. Supplementing SWC with tissue engineered allogeneic cellular wound therapies represents an emerging treatment strategy. This review aimed to evaluate the efficacy and safety of allogeneic skin substitutes and human placental membrane allografts in the management of DFUs. Ovid MEDLINE and Embase databases were searched from inception to October 2017. Any randomized controlled trial (RCT) with an allogeneic skin substitute or placental membrane allograft intervention group was included...
January 20, 2019: International Journal of Lower Extremity Wounds
Zengding Zhou, Feng Guo, Jingning Huan
Fournier's gangrene is a rare, rapidly progressing, and life-threatening infection associated with necrotizing fasciitis in the perineal, genital, and/or lower abdominal regions. Septic shock and multiple organ dysfunction syndrome due to the condition are even rarer events. We describe the case of a 58-year-old man who visited the emergency department with severely painful swelling in the scrotal, perianal, and lower abdominal regions. Physical examination combined with computed tomography and clinical findings led to the diagnosis of Fournier's gangrene with septic shock and multiple organ dysfunction syndrome...
January 8, 2019: International Journal of Lower Extremity Wounds
Binghui Li, Hang Xue, Xiaobo Zhao, Yuxiong Weng, Gongchi Li, Kun Wang, Pan Zhou, Youtong Wu, Hugo Vankelecom, Jianghai Chen
Full-thickness skin wounds are common accidents. Although healing can be achieved by treatments like autologous skin grafts, donor site morbidity is hardly evitable. In this article, we provide compelling evidence demonstrating that artificial dermal template (ADT)-treated wound healing is achieved by regrowth of skin epidermis as well as adnexa without skin grafts by use of rodent models. First, by fixating a chamber to the wound edge, we confirmed that wound healing was achieved by regeneration instead of contracture...
January 8, 2019: International Journal of Lower Extremity Wounds
Gulsah Gundogdu, Koksal Gundogdu, Kemal Alp Nalci, Alper Kursat Demirkaya, Seymanur Yılmaz Tascı, Fatma Demirkaya Miloglu, Onur Senol, Ahmet Hacimuftuoglu
Parietin is one of the well-known anthraquinone compounds that can be extracted from Rheum ribes L. In this study, we aimed to investigate the effects of parietin isolated from Rheum ribes L on an in vitro wound model using human dermal fibroblast cells and compare its effectiveness against zinc. The antioxidant effect of parietin was determined by using the 1,1-diphenyl-2-picrylhydrazine (DPPH) method. Human dermal fibroblast cells were cultured in proculture medium and were kept until 100% confluence was achieved...
January 7, 2019: International Journal of Lower Extremity Wounds
Jon Holmes, Sandra Schuh, Frank Lee Bowling, Raj Mani, Julia Welzel
Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin, can provide new insights into the pathology...
January 7, 2019: International Journal of Lower Extremity Wounds
Biao Cheng, Xiaobing Fu
In recent years, wound repair, especially chronic and refractory wounds, is still a growing worldwide health problem that concerns the physical and mental health of patients and the productivity of society as a whole. In many developed countries and developing countries, such as China, rapid economic growth, negative lifestyle changes (such as increased dietary fat intake and reduced physical activity), and increasingly serious aging problems have led to more and more refractory wounds caused by chronic diseases, such as diabetes and microvascular diseases...
December 3, 2018: International Journal of Lower Extremity Wounds
Francisco Javier Álvaro-Afonso, José Luis Lázaro-Martínez, Nikolaos Papanas
Diabetic foot ulcers (DFUs) have a complex pathophysiology and require an expert multidisciplinary treatment. There are several, both systemic and local, risk factors for DFUs. A recent meta-analysis of 18 studies has now provided robust evidence on the detrimental effect of smoking on healing of DFUs. Indeed, healing rates were consistently lower among smokers than among nonsmokers. Based on this new evidence, it is reasonable to consider the utility of smoking cessation programs. Incorporation of the latter into the holistic therapeutic strategy for DFUs may be anticipated to improve healing rates, but this remains to be shown...
December 2018: International Journal of Lower Extremity Wounds
Raj Mani
No abstract text is available yet for this article.
December 2018: International Journal of Lower Extremity Wounds
Eran Shavit, Afsaneh Alavi, R Gary Sibbald
Cutaneous and other vasculitides are specific inflammations of the blood vessel wall that can take place in any organ system of the body including the skin. Vasculitis has been traditionally divided according to the size of the vessel involved (small, medium, and large). Vasculitis is more of a reaction pattern rather than a specific disease entity. Therefore, the clinical presentation of vasculitis (most commonly palpable purpura on the lower extremities) dictates a thorough history, review of systems, and a meticulous physical examination...
December 2018: International Journal of Lower Extremity Wounds
Mohita Singh, Khurrum Khan, Evan Fisch, Christopher Frey, Kristen Mathias, Hani Jneid, Daniel M Musher, Neal R Barshes
Recent studies have shown an association between infections, such as influenza, pneumonia, or bacteremia, and acute cardiac events. We studied the association between foot infection and myocardial infarction, arrhythmia, and/or congestive heart failure. We analyzed the records of 318 consecutive episodes of deep soft tissue infection, gangrene, and/or osteomyelitis in 274 patients referred to a vascular surgery service at a tertiary center. We identified 24 acute cardiac events in 21 of 318 (6.6%) episodes of foot infection or foot gangrene...
December 2018: International Journal of Lower Extremity Wounds
Daniel L Kapp, Montanah Rogers, Michel H E Hermans
Necrotizing fasciitis is the generic term for a series of progressive gangrenous infections of the skin and subcutaneous tissues. Typically, necrotizing fasciitis start with an, often small, infected lesion with atypical symptoms, which then quickly develops into a rapidly spreading, massive infection. The primary therapy is excision of all necrotic tissue in combination with treatment of systemic symptoms such as shock. The defects resulting from rigorous excision are often very large. Once they are clean, they require closure with an autograft...
December 2018: International Journal of Lower Extremity Wounds
Elisabetta Iacopi, Lorenza Abbruzzese, Chiara Goretti, Nicola Riitano, Alberto Piaggesi
There are still many unmet needs in the treatment of chronic wounds, especially regarding microenvironment modulation. Nexodyn is a novel super-oxidized solution capable of contrast bacterial proliferation. We aimed to evaluate if this solution, on top of standard of care, was safe and effective in improving diabetic foot outcome. We selected 50 patients admitted in our department to be submitted to surgery for acute diabetic foot infection. All patients were left open to heal for secondary intent. We divided patients into 2 groups: Group A (n = 25, male/female = 17/8, age = 67...
December 2018: International Journal of Lower Extremity Wounds
Yufeng Jiang, Meirong Li, Xiaobing Fu
Angiopathic wound is a wound that develops as a result of a local vascular lesion. Angiogenesis is an important aspect underlying repair, and increased angiogenesis could accelerate and improve the healing outcome. Biotherapy has been used more and more in clinic and brings hope for angiopathic wound treatment, through the rapid recovery of angiogenesis and regulation and correction of the whole wound microenvironment. In this article, we discuss the advantages and disadvantages of various technologies ranging from presentation of angiogenic growth factors, genetic strategies, stem cells, and biomaterials engineering in angiopathic wound treatment...
November 25, 2018: International Journal of Lower Extremity Wounds
Xue-Lei Fu, Hui Ding, Wei-Wei Miao, Hong-Lin Chen
The role of smoking for wound healing in patients with diabetic foot has been unclear. This meta-analysis examined the relationship between cigarette smoking and diabetic foot wound healing. Observational studies for the association between smoking and diabetic foot wound healing of patients were systematically searched through PubMed and Wanfang Data, published up to June 2018. Healing rates of wounds were recognized as outcomes. Meta-analysis models were chosen by heterogeneity. A total of 3388 eligible studies were identified, of which 18 met all our inclusion criteria...
November 21, 2018: International Journal of Lower Extremity Wounds
Bommie Florence Seo, Kyo Joon Kang, Hyuk Joon Choi, Kyung Jin Seo, Sung-No Jung, Jongweon Shin
Lymphatic malformations are benign vascular malformations rarely seen in adults. There have been only around 100 cases reported in the literature, most of them located in the head and neck area. The etiology is poorly understood but trauma, infection, or tumors have been suggested as possible causes. We present an unusual case of lymphatic malformations in the lower extremity of a 56-year-old male patient after minor trauma. The masses were asymptomatic but progressively enlarged for a period of 2 months, developing into a mass with a 21-cm-long axis in computed tomography images...
November 19, 2018: International Journal of Lower Extremity Wounds
Skuli Magnusson, Hilmar Kjartansson, Baldur Tumi Baldursson, Katrin Astradsdottir, Magnus S Ågren, Hilmar Hilmarsson, Gudmundur Fertram Sigurjonsson
It is vital that cellular- and tissue-based products (CTPs) used for wound treatment do not provoke autoimmunity. In this study, the immunogenic response to extracts of 2 CTPs of piscine and porcine origin was assessed in the collagen-induced arthritis model. Male DBA/1J mice were divided into 4 groups, each composed of 7 to 9 animals. Each animal was injected with one of following to assess their immune responses: (1) bovine type II collagen (100 µg) in Freund's adjuvant, (2) extract of piscine skin (100 µg) in Freund's adjuvant, (3) extract of porcine urinary bladder matrix (100 µg) in Freund's adjuvant, or (4) Freund's adjuvant alone (control) at the beginning of the experiment and 3 weeks later...
October 18, 2018: International Journal of Lower Extremity Wounds
Massimo Papi, Kittipan Rerkasem, Raj Mani
No abstract text is available yet for this article.
October 4, 2018: International Journal of Lower Extremity Wounds
Evren Odyakmaz Demirsoy, Cansu Çatal, Ayten Yazıcı, Dilek Bayramgurler
Leg ulcers are not a disease themselves, they are a symptom of a disease. To manage them properly, finding the correct diagnosis of the disease is mandatory. Our case is a model to underline that leg ulcers are a significant burden for the patient, because leg ulcer got ahead of the patient's other serious complaints such as Raynaud's phenomenon or sclerodactyly. Furthermore, our patient is also a model, and an attentive clinical evaluation is inevitable to find the correct diagnosis. We present our case aiming to underline the significance of full dermatologic examination in each ulceration to discover underlying disease...
October 1, 2018: International Journal of Lower Extremity Wounds
Yufeng Jiang, Shuliang Lu, Bin Wen, Xiaobing Fu
In China, chronic wounds are an important issue. However, wound care knowledge and the skill of health care professionals varies among hospitals and cities. A training program in wound care in China was completed in 2015 and achieved great success. To facilitate expertise in wound healing in China, a sequential training project supported by the Wound Healing Union and the Chinese Medical Doctor Association was initiated. The aim of the training program was mainly to improve experience and skills in wound healing...
September 4, 2018: International Journal of Lower Extremity Wounds
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