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Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences

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https://read.qxmd.com/read/30941633/in-vitro-investigation-of-the-effects-of-boron-nitride-nanotubes-and-curcumin-on-dna-damage
#1
Tuğbagül Çal, Ülkü Ündeğer Bucurgat
BACKROUND: Stem cells provide an opportunity to analyse the effects of xenobiotic on cell viability, differentiation and cell functions. Evaluation of the possible cytotoxic and DNA damaging effects on bone marrow CD34+ stem cells is important for their ability to differentiate into blood cells, and also for bone marrow diseases therapy. Boron nitride nanotubes and curcumin are potential nanoformulation agents that can be used together in the treatment of cancer or bone marrow diseases...
April 2, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30927208/genus-sideritis-section-empedoclia-in-southeastern-europe-and-turkey-studies-in-ethnopharmacology-and-recent-progress-of-biological-activities
#2
Ina Aneva, Peter Zhelev, Ekaterina Kozuharova, Kalina Danova, Seyed Fazel Nabavi, Sahar Behzad
BACKGROUND: Over the last two decades there has been a substantial increase of the number of studies on the species of genus Sideritis. Species of section Empedoclia, occurring in the Eastern Mediterranean region and in part of Western Asia possess some remarkable characteristics and are known as valuable medicinal plants used by local people in the traditional medicine and for herbal tea. The objective of the review is to make a survey on the recent studies on the ethnopharmacology and biological activity of the species in Southeastern Europe and in Turkey, which is the center of distribution and their main occurrence...
March 30, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30903556/policies-to-improve-access-to-pharmaceutical-products-in-shortage-the-experience-of-iran-food-and-drug-administration
#3
Nazila Yousefi, Najmeh Moradi, Rassoul Dinarvand, Golbarg Ghiasi, Hamidreza Inanloo, Farzad Peiravian
BACKGROUND: In the past decades, economic sanctions imposed on Iran for its nuclear program. The embargo made difficulty in foreign trade and led to lack of timely access to medicines. As the internationally-led sanctions caused to the shortage of medicine there, healthcare systems need to applied the new policies for maintaining health service quality especially in pharmaceutical sector. OBJECTIVES: This paper is about policies applied in Iran health system during the crisis reached its peak in 2012 as a good experience for guarantying access to pharmaceutical products...
March 23, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30903555/vitamin-b-combination-reduces-fluconazole-toxicity-in-wistar-rats
#4
Fahad A Al-Abbasi, Saida Sadath, Gauhar Mushtaq, Firoz Anwar
BACKGROUND: The major adverse effect associated with systemic administration of Fluconazole (FLZ), is hepatic toxicity. FLZ is most commonly used antifungal drug in treatment of invasive fungal infections. METHODS: FLZ toxicity was challenged by individual and in combination of three vitamins (B1, B2 B3). Animals were divided nine groups with six animals in each group. FLZ, at a dose of 50 mg/kg b.w, was orally administered for 90 days in experimental animals...
March 22, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30891679/synthesis-and-anti-breast-cancer-activity-of-novel-indibulin-related-diarylpyrrole-derivatives
#5
Ebrahim Saeedian Moghadam, Ernest Hamel, Zahra Shahsavari, Mohsen Amini
BACKGROUND: During recent years, a number of anti-tubulin agents were introduced for treatment of diverse types of cancer. Despite their potential in the treatment of cancer, drug resistance and adverse toxicity, such as peripheral neuropathy, are some of the negative effects of anti-tubulin agents. Among anti-tubulin agents, indibulin was found to cause minimal peripheral neuropathy. Thus far, however, indibulin has not entered clinical usage, caused in part by its poor aqueous solubility and other developmental problems in preclinical evaluation...
March 20, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30887402/in-vitro-anti-proliferative-activities-of-the-sterols-and-fatty-acids-isolated-from-the-persian-gulf-sponge-axinella-sinoxea
#6
Fatemeh Heidary Jamebozorgi, Morteza Yousefzadi, Omidreza Firuzi, Meliika Nazemi, Amir Reza Jassbi
PURPOSE: Marine sponges are rich sources of anticancer metabolites. Axinella sinoxea is a less studied sponge, found in the Larak Island's waters, of the Persian Gulf. In the present study, we have explored the cytotoxic properties and chemical constituents of A. sinoxea. METHODS: Repeated silica gel flash column chromatography of methanol extract of the Axinella sinoxea sponge, yielded fatty acid and sterol fractions. These fractions were analyzed by GC-MS and their anti-proliferative activities were evaluated by MTT assay against three human cancer cell lines including MOLT-4, MCF-7 and HT-29 as well as NIH/3 T3 fibroblast cells...
March 19, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30877484/comparing-duloxetine-and-pregabalin-for-treatment-of-pain-and-depression-in-women-with-fibromyalgia-an-open-label-randomized-clinical-trial
#7
Ali Bidari, Ehsan Moazen-Zadeh, Banafsheh Ghavidel-Parsa, Shahrzad Rahmani, Sajjad Hosseini, Amir Hassankhani
BACKGROUND: Duloxetine and pregabalin are among the most widely used medications in the treatment of patients with fibromyalgia syndrome (FM). OBJECTIVES: To add to the very few lines of evidence that exist on the comparative safety and efficacy of these two medications. METHODS: In this open-label randomized clinical trial, outpatient women, who were diagnosed with FM based on American College of Rheumatology 2010 criteria, and had an age range of 18-65 years old were assigned to either duloxetine 30-60 mg or pregabalin 75-150 mg per day for 4 weeks...
March 14, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30875026/the-impact-of-the-particle-size-of-curcumin-nanocarriers-and-the-ethanol-on-beta_1-integrin-overexpression-in-fibroblasts-a-regenerative-pharmaceutical-approach-in-skin-repair-and-anti-aging-formulations
#8
Shima Tavakol, Samaneh Zare, Elham Hoveizi, Behnaz Tavakol, Seyed Mahdi Rezayat
BACKGROUND: Since women pay more attention to their skin's health, pharmaceutical companies invest heavily on skin care product development. Further, the success of drug nano-carriers in passing through the skin justifies the need to conduct studies at the nano-scale. β1-integrin down regulation has been proposed as a sign of skin aging. METHODS: Six drug nano-carriers (50 and 75 nm) were prepared at three ethanol concentrations (0, 3,and 5%) and different temperatures...
March 14, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30852764/medicinal-plants-and-their-isolated-phytochemicals-for-the-management-of-chemotherapy-induced-neuropathy-therapeutic-targets-and-clinical-perspective
#9
Vahideh Oveissi, Mahboobe Ram, Roodabeh Bahramsoltani, Farnaz Ebrahimi, Roja Rahimi, Rozita Naseri, Tarun Belwal, Hari Prasad Devkota, Zahra Abbasabadi, Mohammad Hosein Farzaei
BACKGROUND: Chemotherapy, as one of the main approaches of cancer treatment, is accompanied with several adverse effects, including chemotherapy-induced peripheral neuropathy (CIPN). Since current methods to control the condition are not completely effective, new treatment options should be introduced. Medicinal plants can be suitable candidates to be assessed regarding their effects in CIPN. Current paper reviews the available preclinical and clinical studies on the efficacy of herbal medicines in CIPN...
March 9, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30850959/binding-of-pb-melatonin-and-pb-melatonin-metabolites-complexes-with-dmt1-and-zip8-implications-for-lead-detoxification
#10
Tayde Villaseñor-Granados, Erik Díaz-Cervantes, Karla J Soto-Arredondo, Minerva Martínez-Alfaro, Juvencio Robles, Marco A García-Revilla
We have applied the docking methodology to characterize the binding modes of the divalent metal transporter 1 (DMT1) and the zinc transporter 8 (ZIP8) protein channels with: melatonin, some melatonin metabolites, and a few lead complexes of melatonin and its metabolites, in three different coordination modes (mono-coordinated, bi-coordinated and tri-coordinated). Our results show that bi-coordinated and tri-coordinated lead complexes prefer to bind inside the central region of ZIP8. Moreover, the interaction strength is larger compared with that of the free melatonin and melatonin metabolites...
March 8, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30847847/a-new-hypothesis-to-investigate-bioequivalence-of-pharmaceutical-inhalation-products
#11
Maryam Khoubnasabjafari, Elaheh Rahimpour, Morteza Samini, Vahid Jouyban-Gharamaleki, Lan Chen, Donghao Chen, Hak-Kim Chan, Abolghasem Jouyban
BACKGROUND: This short communication reports a new hypothesis regarding bioequivalence of inhalation products which can potentially provide a reliable means to compare pharmaceutical aerosol formulations and inhalers. METHODS: Available methods regarding the bioequivalence studies, inhaled drugs and advantages of exhaled breath condensate (EBC) samples were reviewed to develop this hypothesis. RESULTS: It is postulated that two inhalation products providing the same drug concentrations in airway lining fluid (ALF) could be considered bioequivalent...
March 7, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30835081/anti-cancer-effects-of-chemotherapeutic-agent-17-aag-in-combined-with-gold-nanoparticles-and-irradiation-in-human-colorectal-cancer-cells
#12
Zhino Moradi, Mahshid Mohammadian, Hassan Saberi, Meysam Ebrahimifar, Zeinab Mohammadi, Mahnaz Ebrahimpour, Zhaleh Behrouzkia
OBJECTIVE: The present study evaluated the anti-cancer effects of irradiation (Ir) alone, Ir after heat shock protein 90 inhibitor; 17-allylamino-17-demethoxygeldanamycin (17-AAG) and gold nanoparticle (GNP) treatments in human colorectal cancer cell line (HCT-116), with the targeting of related mechanisms. METHODS: Water-soluble tetrazolium salt-1 assay was utilized to study the cytotoxic effects of 17-AAG, GNP, Ir in single and combination cases on the cell viability of HCT-116 cells...
March 5, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30788839/effectiveness-of-audit-and-feedback-in-addressing-over-prescribing-of-antibiotics-and-injectable-medicines-in-a-middle-income-country-an-rct
#13
Fatemeh Soleymani, Arash Rashidian, Mostafa Hosseini, Rassoul Dinarvand, Abbas Kebriaeezade, Mohammad Abdollahi
Overprescribing of antibiotics and injectable medicines is common in ambulatory care in many low- and middleincome countries. We evaluated the effects of three different interventions in improving physician prescribing. We conducted a four-armed randomized controlled trial with one-month and three- months follow-up. General physicians, pediatricians, and infectious disease specialists were included in this study if they had an outpatient office in Tehran, Iran. The study involved two behaviorally guided interventions: "new-design audit and feedback (NA&F)"; "printed educational material (PEM)" and an existing intervention of "routinely conducted audit and feedback (RA&F)"...
February 21, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30784007/optimization-of-structures-biochemical-properties-of-ketorolac-and-its-degradation-products-based-on-computational-studies
#14
Monir Uzzaman, Mohammad Nasir Uddin
BACKGROUND: Ketorolac (KTR) is used as an analgesic drug with an efficacy close to that of the opioid family. It is mainly used for the short term treatment of post-operative pain. It can inhibit the prostaglandin synthesis by blocking cyclooxygenase (COX). METHODS: In this investigation, the inherent stability and biochemical interaction of Ketorolac (KTR) and its degradation products have been studiedon the basis of quantum mechanical approaches. Density functional theory (DFT) with B3LYP/ 6-31G (d) has been employed to optimize the structures...
February 19, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30778915/a-comparative-analysis-of-the-pharmacovigilance-systems-of-brazil-spain-the-european-union-and-the-united-states-based-on-the-information-provided-by-their-regulatory-agency-websites
#15
Marineide Marinho Leal, Mariano Madurga Sanz, Juan Ramón Castillo Ferrando, Fernando Martinez-Martinez
BACKGROUND: Pharmacovigilance (PV) plays an essential role in monitoring and raising awareness of adverse drug reactions (ADRs). Increasingly, ADRs are reported and PV information and activities are circulated via the Internet. PV actions are carried out by the Regulatory Agencies (RAs) responsible for medicinal products in each country. OBJECTIVE: The objective of this study is to ascertain and assess the operation and areas of competence of the PV system in Brazil and to compare them with those of Spain, the European Union (EU) and the United States (USA), through the information available on the websites of the RAs in each country...
February 18, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30729403/using-the-transtheoretical-model-s-stages-of-change-to-predict-medication-adherence-in-patients-with-type-2-diabetes-mellitus-in-a-primary-health-care-setting
#16
Yara Arafat, Mohamed Izham Mohamed Ibrahim, Ahmed Awaisu, Stephen Colagiuri, Yaw Owusu, Donald E Morisky, Mudather AlHafiz, Ahmed Yousif
BACKGROUND: Qatar is currently experiencing a worrying increase in the prevalence of diabetes mellitus (DM). One of the most common reasons for uncontrolled DM is non-adherence to medications. The socio-behavioral intervention has proven effective in some chronic illnesses. OBJECTIVES: To assess the stages of change (SOC) and medication adherence scores of type 2 diabetes mellitus (T2DM) patients visiting primary healthcare institutions in Qatar, and to evaluate the cause and effect relationship between SOC and adherence to antidiabetic medications...
February 7, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30715678/current-status-of-the-acquired-immune-system-of-iranian-patients-with-long-term-complications-of-sulfur-mustard-poisoning
#17
Mahdi Balali-Mood, Bamdad Riahi-Zanjani, Mahmoud Mahmoudi, Mahmood Sadeghi
BACKGROUND: Sulfur mustard (SM) is a powerful blistering chemical warfare agent that has genotoxic effects. Cells with excessive proliferation such as lymphocytes may inherit this cellular toxicity which can lead to their malfunctions in the long-term. This study was designed to evaluate the status of acquired immunity among SM poisoned veterans around three decades after exposure. METHODS: Thirty five male Iranian veterans having at least 25% disability due to SM poisoning with long-term complications in the respiratory system, skin or eyes were investigated...
February 4, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30712231/microwave-assisted-synthesis-of-polyacrylamide-grafted-polymeric-blend-of-fenugreek-seed-mucilage-polyvinyl-alcohol-fsm-pva-g-pam-and-its-characterizations-as-tissue-engineered-scaffold-and-as-a-drug-delivery-device
#18
Trishna Bal, Sabyasachi Swain
Microwave assisted synthesis of graft copolymer of polymeric blend of Fenugreek seed mucilage (FSM)-Polyvinyl alcohol (PVA) with acrylamide (AM) was done by free radical polymerization using ammonium per sulfate (APS) as initiator. Varying amount of AM and APS was used to optimize the best grade based on highest percentage grafting efficiency and investigated with intrinsic viscosity measurement, Fourier Transformation infrared spectroscopy (FTIR),13 C NMR spectra, X-ray diffraction, elemental analysis, Thermogravimetric analysis, Scanning electron microscopy...
February 2, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30706223/iron-oxide-nanoparticulate-system-as-a-cornerstone-in-the-effective-delivery-of-tc-99-m-radionuclide-a-potential-molecular-imaging-probe-for-tumor-diagnosis
#19
Mohamed M Swidan, Omnya M Khowessah, Mohamed Abd El-Motaleb, Ahmed Abd El-Bary, Mohamed T El-Kolaly, Tamer M Sakr
BACKGROUND: The evolution of nanoparticles has gained prominence as platforms for developing diagnostic and/or therapeutic radiotracers. This study aims to develop a novel technique for fabricating a tumor diagnostic probe based on iron oxide nanoparticles excluding the utilization of chelating ligands. METHODS: Tc-99 m radionuclide was loaded into magnetic iron oxide nanoparticles platform (MIONPs) by sonication. 99m Tc-encapsulated MIONPs were fully characterized concerning particles size, charge, radiochemical purity, encapsulation efficiency, in-vitro stability and cytotoxicity...
January 31, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30701460/proniosomal-gel-for-transdermal-delivery-of-lornoxicam-optimization-using-factorial-design-and-in-vivo-evaluation-in-rats
#20
Hiral Shah, Anroop B Nair, Jigar Shah, Praful Bharadia, Bandar E Al-Dhubiab
OBJECTIVE: Clinical utility of lornoxicam in oral therapy is primarily restricted by the low solubility and gastric adverse effects. This study evaluated the prospective of optimized proniosomal gel to improve the clinical efficacy of lornoxicam and compare with oral therapy. METHODS: Proniosomes were formulated by coacervation phase separation technique using span 60, lecithin and cholesterol. A four-factor three-level Box-Behnken design was used to evaluate the effect of amount of four independent variables; span 60 (X1 ), cholesterol (X2 ), lecithin (X3 ) and lornoxicam (X4 ) on response variables; vesicle size (Y1 ), entrapment efficiency (Y2 ) and transdermal flux (Y3 )...
January 30, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
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