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Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging

https://read.qxmd.com/read/38017353/reprogramming-a-doxycycline-inducible-gene-switch-system-for-bacteria-mediated-cancer-therapy
#1
JOURNAL ARTICLE
Hien Thi-Thu Ngo, Dinh-Huy Nguyen, Sung-Hwan You, Khuynh Van Nguyen, So-Young Kim, Yeongjin Hong, Jung-Joon Min
PURPOSE: Attenuated Salmonella typhimurium is a potential biotherapeutic antitumor agent because it can colonize tumors and inhibit their growth. The present study aimed to develop a doxycycline (Doxy)-inducible gene switch system in attenuated S. typhimurium and assess its therapeutic efficacy in various tumor-bearing mice models. PROCEDURES: A Doxy-inducible gene switch system comprising two plasmids was engineered to trigger the expression of cargo genes (Rluc8 and clyA)...
November 28, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/38012510/the-first-human-application-of-an-f-18-labeled-tryptophan-analog-for-pet-imaging-of-cancer
#2
JOURNAL ARTICLE
Otto Muzik, Anthony F Shields, Geoffrey R Barger, Huailei Jiang, Parthasarathi Chamiraju, Csaba Juhász
PURPOSE: Preclinical studies showed the tryptophan analog PET radiotracer 1-(2-18 F-fluoroethyl)-L-tryptophan (18 F-FETrp) to accumulate in various tumors, including gliomas, and being metabolized via the immunosuppressive kynurenine pathway. In this first-in-human study, we tested the use 18 F-FETrp-PET in patients with neuroendocrine and brain tumors. PROCEDURES: We applied dynamic brain imaging in patients with gliomas (n = 2) and multi-pass 3D whole-body PET scans in patients with neuroendocrine tumors (n =4)...
November 27, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37964036/mib-guides-preclinical-radiopharmaceutical-dosimetry
#3
JOURNAL ARTICLE
Lukas M Carter, Pat B Zanzonico
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating efficacy and/or toxicities in such experiments, ensuring compliance with ethical standards for animal research, and, perhaps most importantly, providing reasonable initial estimates of normal-organ doses in humans, required for clinical translation of new radiopharmaceuticals. This MIB Guide provides a basic protocol for obtaining preclinical dosimetry estimates with organ-level dosimetry software...
November 14, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37950084/correction-to-magnetic-particle-imaging-guided-hyperthermia-for-precise-treatment-of-cancer-review-challenges-and-prospects
#4
Siao Lei, Jie He, Pengli Gao, Yueqi Wang, Hui Hui, Yu An, Jie Tian
No abstract text is available yet for this article.
November 10, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37945972/physiological-uptake-characteristics-of-breast-on-68-ga-fapi-04-pet-ct
#5
JOURNAL ARTICLE
Yue Zhang, Yushan Zhou, Rong Tian, Minggang Su
PURPOSE: Gallium 68 (68 Ga)-labeled fibroblast activation protein inhibitor (FAPI) PET/CT is sensitive on breast cancer staging, but its clinical utility may be limited by the high physiological 68 Ga-FAPI-04 uptake in normal breast tissue that can obscure primary tumors. The aim of this study was to elucidate the characteristics of physiological 68 Ga-FAPI-04 uptake in normal breast. PROCEDURES: A total of 143 consecutive women with 68 Ga-FAPI-04 PET/CT data were reviewed retrospectively...
November 9, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37945971/sox71-a-biocompatible-succinyl-derivative-of-the-triarylmethyl-radical-ox071-for-in-vivo-quantitative-oxygen-mapping-using-electron-paramagnetic-resonance
#6
JOURNAL ARTICLE
Misa A Shaw, Martin Poncelet, Navin Viswakarma, Gian Paolo Vallerini, Safa Hameed, Teresa D Gluth, Werner J Geldenhuys, Emily H Hoblitzell, Timothy D Eubank, Boris Epel, Mrignayani Kotecha, Benoit Driesschaert
PURPOSE: This study aimed to develop a biocompatible oximetric electron paramagnetic resonance (EPR) spin probe with reduced self-relaxation, and sensitivity to oxygen for a higher signal-to-noise ratio and longer relaxation times at high oxygen concentration, compared to the reference spin probe OX071. PROCEDURES: SOX71 was synthesized by succinylation of the twelve alcohol groups of OX071 spin probe and characterized by EPR at X-Band (9.5 GHz) and at low field (720 MHz)...
November 9, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37934378/imaging-in-type-1-diabetes-current-perspectives-and-directions
#7
JOURNAL ARTICLE
Jay Tinklepaugh, Nicholas E Mamrak
Type 1 diabetes (T1D) is characterized by the autoimmune-mediated attack of insulin-producing beta cells in the pancreas, leading to reliance on exogenous insulin to control a patient's blood glucose levels. As progress is being made in understanding the pathophysiology of the disease and how to better develop therapies to treat it, there is an increasing need for monitoring technologies to quantify beta cell mass and function throughout T1D progression and beta cell replacement therapy. Molecular imaging techniques offer a possible solution through both radiologic and non-radiologic means including positron emission tomography, magnetic resonance imaging, electron paramagnetic resonance imaging, and spatial omics...
November 7, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37932610/radiomics-based-on-contrast-enhanced-ct-for-recognizing-c-met-positive-hepatocellular-carcinoma-a-noninvasive-approach-to-predict-the-outcome-of-sorafenib-resistance
#8
JOURNAL ARTICLE
Jingxiao Gu, Shanlei Bao, Reaoxian Akemuhan, Zhongzheng Jia, Yu Zhang, Chen Huang
OBJECTIVES: The purpose of our project was to investigate the effectiveness of radiomic features based on contrast-enhanced computed tomography (CT) that can detect the expression of c-Met in hepatocellular carcinoma (HCC) and to validate its efficacy in predicting the outcome of sorafenib resistance. MATERIALS AND METHODS: In total, 130 patients (median age, 60 years) with pathologically confirmed HCC who underwent contrast material-enhanced CT from October 2012 to July 2020 were randomly divided into a training set (n = 91) and a test set (n = 39)...
November 6, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37932609/quantitative-and-qualitative-assessment-of-urinary-activity-of-18-f-flotufolastat-pet-ct-in-patients-with-prostate-cancer-a-post-hoc-analysis-of-the-lighthouse-and-spotlight-studies
#9
JOURNAL ARTICLE
Phillip H Kuo, Rick Hermsen, Ross Penny, Ernst J Postema
PURPOSE: To evaluate the impact of urinary activity on interpretation of 18 F-flotufolastat (18 F-rhPSMA-7.3) PET/CT, we conducted a post hoc qualitative and quantitative analysis of scans acquired in two phase 3 studies of 18 F-flotufolastat. PROCEDURES: Newly diagnosed or recurrent prostate cancer patients enrolled in LIGHTHOUSE (NCT04186819) or SPOTLIGHT (NCT04186845), respectively, underwent PET/CT 50-70 min after intravenous administration of 296 MBq 18 F-flotufolastat...
November 6, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37875748/image-denoising-of-low-dose-pet-mouse-scans-with-deep-learning-validation-study-for-preclinical-imaging-applicability
#10
JOURNAL ARTICLE
Florence M Muller, Boris Vervenne, Jens Maebe, Eric Blankemeyer, Mark A Sellmyer, Rong Zhou, Joel S Karp, Christian Vanhove, Stefaan Vandenberghe
PURPOSE: Positron emission tomography (PET) image quality can be improved by higher injected activity and/or longer acquisition time, but both may often not be practical in preclinical imaging. Common preclinical radioactive doses (10 MBq) have been shown to cause deterministic changes in biological pathways. Reducing the injected tracer activity and/or shortening the scan time inevitably results in low-count acquisitions which poses a challenge because of the inherent noise introduction...
October 24, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37872462/sub-chronic-ketamine-administration-increases-dopamine-synthesis-capacity-in-the-mouse-midbrain-a-preclinical-in-vivo-pet-study
#11
JOURNAL ARTICLE
Alice Petty, Anna Garcia-Hidalgo, Els F Halff, Sridhar Natesan, Dominic J Withers, Elaine E Irvine, Michelle Kokkinou, Lisa A Wells, David R Bonsall, Sac-Pham Tang, Mattia Veronese, Oliver D Howes
PURPOSE: There is robust evidence that people with schizophrenia show elevated dopamine (DA) synthesis capacity in the striatum. This finding comes from positron emission tomography (PET) studies using radiolabelled l-3,4-dihydroxyphenylalanine (18 F-DOPA). DA synthesis capacity also appears to be elevated in the midbrain of people with schizophrenia compared to healthy controls. We therefore aimed to optimise a method to quantify 18 F-DOPA uptake in the midbrain of mice, and to utilise this method to quantify DA synthesis capacity in the midbrain of the sub-chronic ketamine model of schizophrenia-relevant hyperdopaminergia...
October 23, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37870648/toward-a-nanoencapsulated-epr-imaging-agent-for-clinical-use
#12
JOURNAL ARTICLE
Rhia M Martin, Samantha Diaz, Martin Poncelet, Benoit Driesschaert, Eugene Barth, Mrignayani Kotecha, Boris Epel, Gareth R Eaton, Joshua R Biller
PURPOSE: Progress toward developing a novel radiocontrast agent for determining pO2 in tumors in a clinical setting is described. The imaging agent is designed for use with electron paramagnetic resonance imaging (EPRI), in which the collision of a paramagnetic probe molecule with molecular oxygen causes a spectroscopic change which can be calibrated to give the real oxygen concentration in the tumor tissue. PROCEDURES: The imaging agent is based on a nanoscaffold of aluminum hydroxide (boehmite) with sizes from 100 to 200 nm, paramagnetic probe molecule, and encapsulation with a gas permeable, thin (10-20 nm) polymer layer to separate the imaging agent and body environment while still allowing O2 to interact with the paramagnetic probe...
October 23, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37848641/assessment-of-brain-tumour-perfusion-using-early-phase-18-f-fet-pet-comparison-with-perfusion-weighted-mri
#13
JOURNAL ARTICLE
Christian P Filss, Julian Cramer, Saskia Löher, Philipp Lohmann, Gabriele Stoffels, Carina Stegmayr, Martin Kocher, Alexander Heinzel, Norbert Galldiks, Hans J Wittsack, Michael Sabel, Bernd Neumaier, Jürgen Scheins, N Jon Shah, Philipp T Meyer, Felix M Mottaghy, Karl-Josef Langen
PURPOSE: Morphological imaging using MRI is essential for brain tumour diagnostics. Dynamic susceptibility contrast (DSC) perfusion-weighted MRI (PWI), as well as amino acid PET, may provide additional information in ambiguous cases. Since PWI is often unavailable in patients referred for amino acid PET, we explored whether maps of relative cerebral blood volume (rCBV) in brain tumours can be extracted from the early phase of PET using O-(2-18 F-fluoroethyl)-L-tyrosine (18 F-FET). PROCEDURE: Using a hybrid brain PET/MRI scanner, PWI and dynamic 18 F-FET PET were performed in 33 patients with cerebral glioma and four patients with highly vascularized meningioma...
October 17, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37845582/alpha-particle-emitting-radiopharmaceuticals-as-cancer-therapy-biological-basis-current-status-and-future-outlook-for-therapeutics-discovery
#14
REVIEW
Ryan P Coll, Scott J Bright, David K J Martinus, Dimitra K Georgiou, Gabriel O Sawakuchi, H Charles Manning
Critical advances in radionuclide therapy have led to encouraging new options for cancer treatment through the pairing of clinically useful radiation-emitting radionuclides and innovative pharmaceutical discovery. Of the various subatomic particles used in therapeutic radiopharmaceuticals, alpha (α) particles show great promise owing to their relatively large size, delivered energy, finite pathlength, and resulting ionization density. This review discusses the therapeutic benefits of α-emitting radiopharmaceuticals and their pairing with appropriate diagnostics, resulting in innovative "theranostic" platforms...
October 16, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37821714/imaging-reactive-oxygen-radicals-in-excised-mouse-lung-trapped-by-reaction-with-hydroxylamine-probes-using-1-ghz-rapid-scan-electron-paramagnetic-resonance
#15
JOURNAL ARTICLE
Hanan B Elajaili, Lukas B Woodcock, Tanden A Hovey, George A Rinard, Samuel DeGraw, Autumn Canny, Nathan M Dee, Joseph P Y Kao, Eva S Nozik, Sandra S Eaton, Gareth R Eaton
PURPOSE: Oxidative stress is proposed to be critical in acute lung disease, but methods to monitor radicals in lungs are lacking. Our goal is to develop low-frequency electron paramagnetic resonance (EPR) methods to monitor radicals that contribute to the disease. PROCEDURES: Free radicals generated in a lipopolysaccharide-induced mouse model of acute respiratory distress syndrome reacted with cyclic hydroxylamines CPH (1-hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine hydrochloride) and DCP-AM-H (4-acetoxymethoxycarbonyl-1-hydroxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid), which were converted into the corresponding nitroxide radicals, CP• and DCP•...
October 11, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37801196/parametric-imaging-of-p-glycoprotein-function-at-the-blood-brain-barrier-using-k-e-brain-maps-generated-from-11-c-metoclopramide-pet-data-in-rats-nonhuman-primates-and-humans
#16
JOURNAL ARTICLE
Louise Breuil, Myriam El Biali, Dominique Vodovar, Solène Marie, Sylvain Auvity, Martin Bauer, Sébastien Goutal, Sebastian Rodrigo, Oliver Langer, Nicolas Tournier
PURPOSE: PET imaging using [11 C]metoclopramide revealed the importance of P-glycoprotein (P-gp, ABCB1) in mediating the brain-to-blood efflux of substrates across the blood-brain barrier (BBB). In this work, the elimination rate constant from the brain (kE,brain ), calculated from dynamic PET images without the need for arterial blood sampling, was evaluated as an outcome parameter for the interpretation of [11 C]metoclopramide PET data. PROCEDURES: kE,brain parameter was obtained by linear regression of log-transformed brain time-activity curves (TACs)...
October 6, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37789104/correction-high-vascular-delivery-of-egf-but-low-receptor-binding-rate-is-observed-in-aspc-1-tumors-as-compared-to-normal-pancreas
#17
Kimberley S Samkoe, Kristian Sexton, Kenneth M Tichauer, Shannon K Hextrum, Omar Pardesi, Scott C Davis, Julia A O'Hara, P Jack Hoopes, Tayyaba Hasan, Brian W Pogue
No abstract text is available yet for this article.
October 3, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37789103/magnetic-particle-imaging-guided-hyperthermia-for-precise-treatment-of-cancer-review-challenges-and-prospects
#18
REVIEW
Siao Lei, Jie He, Pengli Gao, Yueqi Wang, Hui Hui, Yu An, Jie Tian
Magnetic particle imaging (MPI) is a novel quantitative imaging technique using the nonlinear magnetization behavior of magnetic nanoparticles (MNPs) to determine their local concentration. Magnetic fluid hyperthermia (MFH) is a promising non-invasive therapy using the heating effects of MNPs. MPI-MFH is expected to enable real-time MPI guidance, localized MFH, and non-invasive temperature monitoring, which shows great potential for precise treatment of cancer. In this review, we introduce the fundamentals of MPI and MFH and their applications in the treatment of cancer...
October 3, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37784004/pulse-and-cw-epr-oximetry-using-oxychip-in-gemcitabine-treated-murine-pancreatic-tumors
#19
JOURNAL ARTICLE
Gabriela Dziurman, Agnieszka Drzał, Aleksandra Anna Murzyn, Maciej Mikolaj Kmiec, Martyna Elas, Martyna Krzykawska-Serda
PURPOSE: The goal of this work was to compare pO2 measured using both continuous wave (CW) and pulse electron paramagnetic resonance (EPR) spectroscopy. The Oxychip particle spin probe enabled longitudinal monitoring of pO2 in murine pancreatic tumor treated with gemcitabine during the course of therapy. PROCEDURES: Pancreatic PanO2 tumors were growing in the syngeneic mice, in the leg. Five doses of saline in control animals or gemcitabine were administered every 3 days, and pO2 was measured after each dose at several time points...
October 2, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/37749438/urokinase-type-plasminogen-activator-receptor-upar-expression-and-64-cu-cu-dota-ae105-upar-pet-ct-in-patient-derived-xenograft-models-of-oral-squamous-cell-carcinoma
#20
JOURNAL ARTICLE
Mads Lawaetz, Tina Binderup, Anders Christensen, Karina Juhl, Giedrius Lelkaitis, Eva Lykke, Line Knudsen, Christian von Buchwald, Andreas Kjaer
PURPOSE: [64 Cu]Cu-DOTA-AE105 urokinase-type plasminogen activator receptor (uPAR)-PET/CT is a novel and promising imaging modality for cancer visualization, although it has not been tested in head and neck cancer patients nor in preclinical models that closely resemble these heterogenous tumors, i.e., patient-derived xenograft (PDX) models. The aim of the present study was to establish and validate oral squamous cell carcinoma (OSCC) PDX models and to evaluate [64 Cu]Cu-uPAR-PET/CT for tumor imaging in these models...
September 25, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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