Ruben P J Meijer, Lisanne K A Neijenhuis, Annette P Zeilstra, Sophie F Roerink, Shadhvi S Bhairosingh, Denise E Hilling, J Sven D Mieog, Peter J K Kuppen, Cornelis F M Sier, Jerry Braun, Jacobus Burggraaf, Alexander L Vahrmeijer, Danielle Cohen, Merlijn Hutteman
PURPOSE: Intraoperative identification of lung tumors can be challenging. Tumor-targeted fluorescence-guided surgery can provide surgeons with a tool for real-time intraoperative tumor detection. This study evaluated cell surface biomarkers, partially selected via data-driven selection software, as potential targets for fluorescence-guided surgery in non-small cell lung cancers: adenocarcinomas (ADC), adenocarcinomas in situ (AIS), and squamous cell carcinomas (SCC). PROCEDURES: Formalin-fixed paraffin-embedded tissue slides of resection specimens from 15 patients with ADC and 15 patients with SCC were used and compared to healthy tissue...
December 27, 2022: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging