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Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging

https://read.qxmd.com/read/36944798/pharmacological-characterization-of-18-f-fnm-and-evaluation-of-nmda-receptors-activation-in-a-rat-brain-injury-model
#1
JOURNAL ARTICLE
Marie Beaurain, Franck Talmont, Damien Pierre, Patrice Péran, Samuel Boucher, Anne Hitzel, Marie-Pierre Rols, Olivier Cuvillier, Pierre Payoux, Anne-Sophie Salabert
PURPOSE: NMDA receptors (NMDARs) dysfunction plays a central role in the physiopathology of psychiatric and neurodegenerative disorders whose mechanisms are still poorly understood. The development of a PET (positron emission tomography) tracer able to selectively bind to the NMDARs intra-channel PCP site may make it possible to visualize NMDARs in an open and active state. We describe the in vitro pharmacological characterization of [18 F]-fluoroethylnormemantine ([18 F]-FNM) and evaluate its ability to localize activated NMDA receptors in a rat preclinical model of excitotoxicity...
March 21, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36941514/2-deoxy-2-18-f-fluoro-d-glucose-positron-emission-tomography-to-monitor-lung-inflammation-and-therapeutic-response-to-dexamethasone-in-a-murine-model-of-acute-lung-injury
#2
JOURNAL ARTICLE
Philip Z Mannes, Clayton E Barnes, Joseph D Latoche, Kathryn E Day, Jessie R Nedrow, Janet S Lee, Sina Tavakoli
PURPOSE: To image inflammation and monitor therapeutic response to anti-inflammatory intervention using 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET) in a preclinical model of acute lung injury (ALI). PROCEDURES: Mice were intratracheally administered lipopolysaccharide (LPS, 2.5 mg/kg) to induce ALI or phosphate-buffered saline as the vehicle control. A subset of mice in the ALI group received two intraperitoneal doses of dexamethasone 1 and 24 h after LPS...
March 20, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36882605/in-vivo-assessment-of-the-impact-of-molecular-weight-on-constructs-of-68-ga-dota-manocept-in-a-syngeneic-mouse-tumor-model
#3
JOURNAL ARTICLE
Jennifer L Bartels, Solana R Fernandez, Jeffrey S Arnold, Candace C Parker, Volkan Tekin, Grace O'Malley, David A Ralph, Suzanne E Lapi
PURPOSE: Manocept™ constructs are mannosylated amine dextrans (MADs) that bind with high affinity to the mannose receptor, CD206. Tumor-associated macrophages (TAMs) are the most numerous immune cells in the tumor microenvironment and a recognized target for tumor imaging and cancer immunotherapies. Most TAMs express CD206, suggesting utility of MADs to deliver imaging moieties or therapeutics to TAMs. The liver Kupffer cells also express CD206, making them an off-target localization site when targeting CD206 on TAMs...
March 7, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36881250/head-to-head-comparison-of-tc-99m-sestamibi-spect-ct-and-c-11-l-methionin-pet-ct-in-parathyroid-scanning-before-operation-for-primary-hyperparathyroidism
#4
JOURNAL ARTICLE
Sys Vestergaard, Oke Gerke, Mette Bay, Anders Rørbæk Madsen, Lis Stilgren, Charlotte Ejersted, Kate Isabella Rewers, Nick Jakobsen, Jon Thor Asmussen, Poul-Erik Braad, Henrik Petersen, Anders Thomassen, Søren Schifter
PURPOSE: The preferred nuclear medicine method for identification of hyperfunctioning parathyroid glands in hyperparathyroidism (HPT) develops continuously in relation to the technological progress. Diagnostic methods based on PET/CT have during recent years evolved with new tracer possibilities competing with traditional scintigraphic methods. This investigation is a head-to-head comparison of Tc-99m-sestamibi SPECT/CT gamma camera scintigraphy (sestamibi SPECT/CT) and C-11-L-methionin PET/CT imaging (methionine PET/CT) for preoperative identification of hyperfunctioning parathyroid glands...
March 7, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36810683/correction-to-18-f-fluorocholine-uptake-of-parathyroid-adenoma-is-correlated-with-parathyroid-hormone-level
#5
Abdullah A Alharbi, Fahad M Alshehri, Abdulrahman A Albatly, Bert-Ram Sah, Christoph Schmid, Gerhard F Huber, Martin W Huellner
No abstract text is available yet for this article.
February 21, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36754935/initial-experience-with-the-radiotracer-18f-fluciclovine-pet-ct-in-ovarian-cancer
#6
JOURNAL ARTICLE
Tina M Buehner, Margaret Liotta, Ronald K Potkul, Robert H Wagner, Bital Savir-Baruch
OBJECTIVE: Early and accurate staging of ovarian cancer is paramount to disease survival. Conventional imaging including FDG PET/CT are limited in the evaluation of small metastatic lesions. 18F-Fluciclovine has minimal urine and bowel excretion allowing optimal visualization of the abdomen and pelvis. This study examines 18F-fluciclovine uptake in known primary and recurrent ovarian cancer. METHODS: Seven patients with a confirmed diagnosis of epithelial ovarian cancer underwent 18F-fluciclovine PET/CT imaging...
February 8, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36745354/practical-guidance-for-developing-small-molecule-optical-probes-for-in-vivo-imaging
#7
REVIEW
Chongzhao Ran, James R Mansfield, Mingfeng Bai, Nerissa T Viola, Abhishek Mahajan, E James Delikatny
The WMIS Education Committee (2019-2022) reached a consensus that white papers on molecular imaging could be beneficial for practitioners of molecular imaging at their early career stages and other scientists who are interested in molecular imaging. With this consensus, the committee plans to publish a series of white papers on topics related to the daily practice of molecular imaging. In this white paper, we aim to provide practical guidance that could be helpful for optical molecular imaging, particularly for small molecule probe development and validation in vitro and in vivo...
February 6, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36729349/editorial-to-the-special-issue-entitled-optical-surgical-navigation
#8
EDITORIAL
Summer L Gibbs, Edward J Delikatny
No abstract text is available yet for this article.
February 2, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36695968/comparison-of-near-infrared-imaging-agents-targeting-the-ptpmu-tumor-biomarker
#9
JOURNAL ARTICLE
Mette L Johansen, Jason Vincent, Marissa Rose, Andrew E Sloan, Susann M Brady-Kalnay
PURPOSE: Maximal, safe resection of solid tumors is considered a critical first step in successful cancer treatment. The advent of fluorescence image-guided surgery (FIGS) using non-specific agents has improved patient outcomes, particularly in the case of glioblastoma. Molecularly targeted agents that recognize specific tumor biomarkers have the potential to augment these gains. Identification of the optimal combination of targeting moiety and fluorophore is needed prior to initiating clinical trials...
January 25, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36695967/halogen-replacement-on-the-lysine-side-chain-of-lys-urea-glu-based-psma-inhibitors-leads-to-significant-changes-in-targeting-properties
#10
JOURNAL ARTICLE
Li Xia, Yang Liu, Ping Cai, Yue Feng, Hongmei Yuan, Sufan Tang, Yin Wen Wang, Nan Liu, Yue Chen, Zhijun Zhou
PURPOSE: Investigate the impact of various halogens on pharmacokinetics, biodistribution, and micro positron emission tomography/computed tomography (PET/CT) imaging of Glu-urea-Lys-based prostate-specific membrane antigen (PSMA) inhibitors. PROCEDURES: Based on the modification of SC691, a small molecule inhibitor of PSMA previously developed by our group, we synthesized 68 Ga-labeled compounds by modifying the lysine terminal amino with different halogenated phenyl substituents...
January 25, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36695966/predicting-soft-tissue-sarcoma-response-to-neoadjuvant-chemotherapy-using-an-mri-based-delta-radiomics-approach
#11
JOURNAL ARTICLE
Brandon K K Fields, Natalie L Demirjian, Steven Y Cen, Bino A Varghese, Darryl H Hwang, Xiaomeng Lei, Bhushan Desai, Vinay Duddalwar, George R Matcuk
OBJECTIVES: To evaluate the performance of machine learning-augmented MRI-based radiomics models for predicting response to neoadjuvant chemotherapy (NAC) in soft tissue sarcomas. METHODS: Forty-four subjects were identified retrospectively from patients who received NAC at our institution for pathologically proven soft tissue sarcomas. Only subjects who had both a baseline MRI prior to initiating chemotherapy and a post-treatment scan at least 2 months after initiating chemotherapy and prior to surgical resection were included...
January 25, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36692661/development-and-biodistribution-of-a-nerve-growth-factor-radioactive-conjugate-for-pet-imaging
#12
JOURNAL ARTICLE
R A Carrasco, A K Salih, M Dominguez Garcia, E S Khozeimeh, G P Adams, C P Phenix, E W Price
PURPOSE: The purpose of these studies was to develop a nerve growth factor (NGF) radiometal-chelator conjugate to determine the biodistribution and brain uptake of NGF by positron emission tomography/computerized tomography (PET-CT). PROCEDURES: Purified NGF from llama seminal plasma was conjugated with FITC, and the chelator NOTA or DFO. NGF conjugates were evaluated for bioactivity. NOTA- and DFO-conjugated NGF were radiolabeled with gallium-68 or zirconium-89 ([68  Ga]GaCl3 , half-life = 68 min; [89 Zr]Zr(oxalate)4 , half-life = 3...
January 24, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36653627/mri-contrasting-agent-based-on-mn-mof-74-nanoparticles-with-coordinatively-unsaturated-sites
#13
JOURNAL ARTICLE
Nobuhiko Iki, Ryuta Nakane, Atsuko Masuya-Suzuki, Yoshikazu Ozawa, Takako Maruoka, Megumi Iiyama, Akira Sumiyoshi, Ichio Aoki
PURPOSE: The development of magnetic resonance imaging (MRI) contrasting agents (CAs) that are safer and have a higher relaxivity than Gd(III)-based agents is a significant research topic. Herein, we propose the use of a Mn-based metal organic framework (MOF), Mn-MOF-74, characterized by a safe paramagnetic center, a coordinatively unsaturated site (CUS) for aquation, and a long rotational correlation time, endowing high relaxivity. Furthermore, biocompatibility and delivery to the tumor are generally expected for MOFs that are obtainable in the nanometer size range...
January 18, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36600172/preclinical-identification-of-tumor-draining-lymph-nodes-using-a-multimodal-non-invasive-in-vivo-imaging-approach
#14
JOURNAL ARTICLE
Philipp Knopf, Dimitri Stowbur, Sabrina H L Hoffmann, Marieke F Fransen, Johannes Schwenck, Bernd J Pichler, Manfred Kneilling
PURPOSE: Resection of the tumor-draining lymph -node (TDLN) represents a standard method to identify metastasis for several malignancies. Interestingly, recent preclinical studies indicate that TDLN resection diminishes the efficacy of immune checkpoint inhibitor-based cancer immunotherapies. Thus, accurate preclinical identification of TDLNs is pivotal to uncovering the underlying immunological mechanisms. Therefore, we validated preclinically, and clinically available non-invasive in vivo imaging approaches for precise TDLN identification...
January 4, 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36575340/data-driven-identification-of-targets-for-fluorescence-guided-surgery-in-non-small-cell-lung-cancer
#15
JOURNAL ARTICLE
Ruben P J Meijer, Lisanne K A Neijenhuis, Annette P Zeilstra, Sophie F Roerink, Shadhvi S Bhairosingh, Denise E Hilling, J Sven D Mieog, Peter J K Kuppen, Cornelis F M Sier, Jerry Braun, Jacobus Burggraaf, Alexander L Vahrmeijer, Danielle Cohen, Merlijn Hutteman
PURPOSE: Intraoperative identification of lung tumors can be challenging. Tumor-targeted fluorescence-guided surgery can provide surgeons with a tool for real-time intraoperative tumor detection. This study evaluated cell surface biomarkers, partially selected via data-driven selection software, as potential targets for fluorescence-guided surgery in non-small cell lung cancers: adenocarcinomas (ADC), adenocarcinomas in situ (AIS), and squamous cell carcinomas (SCC). PROCEDURES: Formalin-fixed paraffin-embedded tissue slides of resection specimens from 15 patients with ADC and 15 patients with SCC were used and compared to healthy tissue...
December 27, 2022: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36575339/imaging-non-alcoholic-fatty-liver-disease-model-using-h-1-and-f-19-mri
#16
JOURNAL ARTICLE
Deanne Lister, Gabrielle Blizard, Mojgan Hosseini, Karen Messer, Jeremy Wellen, Claude B Sirlin, Eric T Ahrens
PURPOSE: We explore the use of intravenously delivered perfluorocarbon (PFC) nanoemulsion and 19 F MRI for detecting inflammation in a mouse model of non-alcoholic fatty liver disease (NAFLD). Correlative studies of 1 H-based liver proton density fat fraction (PDFF) and T1 measurements and histology are also evaluated. PROCEDURES: C57BL/6 mice were fed standard or high-fat diet (HFD) for 6 weeks to induce NAFLD. 1 H MRI measurements of PDFF and T1 relaxation time were performed at baseline to assess NAFLD onset prior to administration of a PFC nanoemulsion to enable 19 F MRI of liver PFC uptake...
December 27, 2022: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/35764908/highlighting-the-undetectable-fluorescence-molecular-imaging-in-gastrointestinal-endoscopy
#17
REVIEW
Judith A Stibbe, Petra Hoogland, Friso B Achterberg, Derek R Holman, Raoul S Sojwal, Jacobus Burggraaf, Alexander L Vahrmeijer, Wouter B Nagengast, Stephan Rogalla
Flexible high-definition white-light endoscopy is the current gold standard in screening for cancer and its precursor lesions in the gastrointestinal tract. However, miss rates are high, especially in populations at high risk for developing gastrointestinal cancer (e.g., inflammatory bowel disease, Lynch syndrome, or Barrett's esophagus) where lesions tend to be flat and subtle. Fluorescence molecular endoscopy (FME) enables intraluminal visualization of (pre)malignant lesions based on specific biomolecular features rather than morphology by using fluorescently labeled molecular probes that bind to specific molecular targets...
February 2023: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36538180/measurement-of-protein-synthesis-rate-in-rat-by-11-c-leucine-pet-imaging-application-to-the-tgf344-ad-model-of-alzheimer-s-disease
#18
JOURNAL ARTICLE
D Bochicchio, L Christie, C B Lawrence, K Herholz, C A Parker, R Hinz, H Boutin
Long-term memory requires stable protein synthesis and is altered in Alzheimer's disease (AD). This study aimed to implement a method to measure the cerebral protein synthesis rate (PSR) with [11 C]leucine PET in vivo in rats and evaluate potential PSR alterations longitudinally (6, 12 and 18 months old) in the TgF344-AD rat model of AD. Wistar, wild-type (WT) and TgF344-AD rats (TG) were scanned for 60 min with [11 C]leucine. Arterial blood activity was monitored online and with discrete whole blood and plasma samples by γ-counting in Wistar rats, WT (n = 4) and TG (n = 5)...
December 20, 2022: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36534331/sodium-multivitamin-transporter-targeted-fluorochrome-facilitates-enhanced-metabolic-evaluation-of-tumors-through-coenzyme-r-dependent-intracellular-signaling-pathways
#19
JOURNAL ARTICLE
Feredun Azari, Gregory T Kennedy, Ashley Chang, Bilal Nadeem, Patrick Bou-Samra, Austin Chang, Alix Segil, Elizabeth Bernstein, Neil T Sullivan, Evgeniy Eruslanov, James Delikatny, Sunil Singhal
BACKGROUND: Intraoperative molecular imaging (IMI)-guided resections have been shown to improve oncologic outcomes for patients undergoing surgery for solid malignancies. The technology utilizes fluorescent tracers targeting cancer cells without the use of any ionizing radiation. However, currently available targeted IMI tracers are effective only for tumors with a highly specific receptor expression profile, and there is an unmet need for IMI tracers to label a broader range of tumor types...
December 19, 2022: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/36525163/radiosynthesis-and-analysis-of-s-4-3-18-f-fluoropropyl-l-glutamic-acid
#20
JOURNAL ARTICLE
Gavin Brown, Dmitry Soloviev, David Y Lewis
PURPOSE: (S)-4-(3-[18 F]Fluoropropyl)-L-glutamic acid ([18 F]FSPG) is an L-glutamate derivative used as a PET biomarker to assess intracellular redox status in vivo through targeting of the cystine/glutamate antiporter protein, xc - transporter. In this report, we describe a radiosynthesis of [18 F]FSPG for use in PET studies that address specific challenges in relation to the radiotracer purity, molar activity, and quality control testing methods. PROCEDURES: The radiosynthesis of [18 F]FSPG was performed using a customised RNPlus Research automated radiosynthesis system (Synthra GmbH, Hamburg, Germany)...
December 16, 2022: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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