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Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging

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https://read.qxmd.com/read/30758703/optical-redox-imaging-detects-the-effects-of-dek-oncogene-knockdown-on-the-redox-state-of-mda-mb-231-breast-cancer-cells
#1
Yu Wen, He N Xu, Lisa Privette Vinnedge, Min Feng, Lin Z Li
PURPOSE: Optical redox imaging (ORI), based on collecting the endogenous fluorescence of reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavoproteins (Fp) containing a redox cofactor flavin adenine dinucleotide (FAD), provides sensitive indicators of cellular metabolism and redox status. ORI indices (such as NADH, FAD, and their ratio) have been under investigation as potential progression/prognosis biomarkers for cancer. Higher FAD redox ratio (i.e., FAD/(FAD + NADH)) has been associated with higher invasive/metastatic potential in tumor xenografts and cultured cells...
February 13, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30719695/glucose-6-phosphatase-expression-mediated-18-f-fdg-efflux-in-murine-inflammation-and-cancer-models
#2
Mi Jeong Kim, Chul-Hee Lee, Youngeun Lee, Hyewon Youn, Keon Wook Kang, JoonHo Kwon, Abass Alavi, Sean Carlin, Gi Jeong Cheon, June-Key Chung
PURPOSE: 2-Deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) accumulation in inflammatory lesions can confound the diagnosis of cancer. In this study, we investigated [18 F]FDG accumulation and efflux in relation to the genes and proteins involved in glucose metabolism in murine inflammation and cancer models. PROCEDURES: [18 F]FDG accumulation and [18 F]FDG efflux were measured in cancer cells (breast cancer, glioma, thyroid cancer, and hepatoma cells) and RAW 264.7 cells (macrophages) activated with lipopolysaccharide (LPS)...
February 4, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30710261/radiosynthesis-and-preclinical-evaluation-of-an-%C3%AE-2a-adrenoceptor-tracer-candidate-6-18-f-fluoro-marsanidine
#3
Anna Krzyczmonik, Thomas Keller, Francisco R López-Picón, Sarita Forsback, Anna K Kirjavainen, Jatta S Takkinen, Aleksandra Wasilewska, Mika Scheinin, Merja Haaparanta-Solin, Franciszek Sączewski, Olof Solin
PURPOSE: The α2 -adrenoceptors mediate many effects of norepinephrine and epinephrine, and participate in the regulation of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions. Of the three receptor subtypes, only α2A and α2C are found in the brain in significant amounts. Subtype-selective positron emission tomography (PET) imaging of α2 -adrenoceptors has been limited to the α2C subtype. Here, we report the synthesis of 6-[18 F]fluoro-marsanidine, a subtype-selective PET tracer candidate for α2A -adrenoceptors, and its preclinical evaluation in rats and mice...
February 1, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30706298/proceedings-of-the-world-molecular-imaging-congress-2018-seattle-washington-september-12-15-2018-late-breaking-abstracts
#4
(no author information available yet)
No abstract text is available yet for this article.
January 31, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30706297/proceedings-of-the-world-molecular-imaging-congress-2018-seattle-washington-september-12-15-2018-general-abstracts
#5
(no author information available yet)
No abstract text is available yet for this article.
January 31, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30693432/metabolic-changes-in-different-stages-of-liver-fibrosis-in-vivo-hyperpolarized-13-c-mr-spectroscopy-and-metabolic-imaging
#6
Chung-Man Moon, Sang-Soo Shin, Suk-Hee Heo, Hyo-Soon Lim, Myeong-Ju Moon, Suchithra Poilil Surendran, Ga-Eon Kim, Il-Woo Park, Yong-Yeon Jeong
PURPOSE: The objective was to assess metabolic changes in different stages of liver fibrosis using hyperpolarized C-13 magnetic resonance spectroscopy (MRS) and metabolic imaging. PROCEDURES: Mild and severe liver fibrosis were induced in C3H/HeN mice (n = 14) by injecting thioacetamide (TAA). Other C3H/HeN mice (n = 7) were injected with phosphate buffer saline (PBS) (7.4 pH) as normal controls. Hyperpolarized C-13 MRS was performed on the livers of the mice, which was accompanied by intravoxel incoherent motion (IVIM) diffusion-weighted imaging with 12 b values...
January 28, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30680525/summary-of-imaging-in-2020-visualizing-the-future-of-healthcare-with-mr-imaging
#7
Brooke A Corbin, Alyssa C Pollard, Matthew J Allen, Mark D Pagel
The Imaging in 2020 meeting convenes biannually to discuss innovations in medical imaging. The 2018 meeting, titled "Visualizing the Future of Healthcare with MR Imaging," sought to encourage discussions of the future goals of MRI research, feature important discoveries, and foster scientific discourse between scientists from a variety of fields of expertise. Here, we highlight presented research and resulting discussions of the meeting.
January 24, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30675688/suboptimal-sensitivity-and-specificity-of-pet-and-other-gross-imaging-techniques-in-assessing-lymph-node-metastasis
#8
Abass Alavi, Sean D Carlin, Thomas J Werner, Abdullah Al-Zaghal
No abstract text is available yet for this article.
January 23, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30671741/pet-ct-imaging-of-nsclc-with-a-%C3%AE-v-%C3%AE-6-integrin-targeting-peptide
#9
Paul Flechsig, Thomas Lindner, Anastasia Loktev, Saskia Roesch, Walter Mier, Max Sauter, Michael Meister, Christel Herold-Mende, Uwe Haberkorn, Annette Altmann
PURPOSE: Targeted therapies are regarded as promising approaches to increase 5-year survival rate of non-small cell lung cancer (NSCLC) patients. Here, we investigated the clinical value of the αv β6 integrin-specific peptide SFITGv6 as a diagnostic reagent targeting NSCLC. METHODS: Affinity and binding properties of [125 I]SFITGv6 or [177 Lu]SFITGv6 for αv β6 integrin-expressing NSCLC cell lines were evaluated in cell culture experiments including competition, kinetic, internalization, and efflux...
January 22, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30671740/radiomics-analysis-of-pet-and-ct-components-of-pet-ct-imaging-integrated-with-clinical-parameters-application-to-prognosis-for-nasopharyngeal-carcinoma
#10
Wenbing Lv, Qingyu Yuan, Quanshi Wang, Jianhua Ma, Qianjin Feng, Wufan Chen, Arman Rahmim, Lijun Lu
PURPOSE: To investigate the prognostic performance of radiomics features, as extracted from positron emission tomography (PET) and X-ray computed tomography (CT) components of baseline 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) PET/CT images and integrated with clinical parameters, in patients with nasopharyngeal carcinoma (NPC). PROCEDURES: One hundred twenty-eight NPC patients (85 vs. 43 for training vs. validation), containing a subset of 86 patients with local-regional advanced stage, were enrolled...
January 22, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30671739/clinical-translation-of-68-ga-ga-nota-anti-mmr-sdab-for-pet-ct-imaging-of-protumorigenic-macrophages
#11
Catarina Xavier, Anneleen Blykers, Damya Laoui, Evangelia Bolli, Ilse Vaneyken, Jessica Bridoux, Henri Baudhuin, Geert Raes, Hendrik Everaert, Kiavash Movahedi, Jo A Van Ginderachter, Nick Devoogdt, Vicky Caveliers, Tony Lahoutte, Marleen Keyaerts
PURPOSE: Macrophage mannose receptor (MMR, CD206) expressing tumor-associated macrophages (TAM) are protumorigenic and was reported to negatively impact therapy responsiveness and is associated with higher chances of tumor relapse following multiple treatment regimens in preclinical tumor models. Since the distribution of immune cells within the tumor is often heterogeneous, sampling "errors" using tissue biopsies will occur. In order to overcome this limitation, we propose positron emission tomography (PET)/X-ray computed tomography (CT) imaging using 68 Ga-labeled anti-MMR single-domain antibody fragment (sdAb) to assess the presence of these protumorigenic TAM...
January 22, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30652258/pik3ca-mutational-status-is-associated-with-high-glycolytic-activity-in-er-her2-early-invasive-breast-cancer-a-molecular-imaging-study-using-18-f-fdg-pet-ct
#12
Heinrich Magometschnigg, Katja Pinker, Thomas Helbich, Anita Brandstetter, Margaretha Rudas, Thomas Nakuz, Pascal Baltzer, Wolfgang Wadsak, Marcus Hacker, Michael Weber, Peter Dubsky, Martin Filipits
PURPOSE: In PIK3CA mutant breast cancer, downstream hyperactivation of the PI3K/AKT/mTOR pathway may be associated with increased glycolysis of cancer cells. The purpose of this study was to investigate the functional association of PIK3CA mutational status and tumor glycolysis in invasive ER+/HER2- early breast cancer. PROCEDURES: This institutional review board-approved retrospective study included a dataset of 67 ER+/HER2- early breast cancer patients. All patients underwent 2-deoxy-2-[18 F]fluoro-D-glucose positron emission tomography/X-ray computed tomography ([18 F]FDG PET/CT) and clinico-pathologic assessments as part of a prospective study...
January 16, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30632003/pet-imaging-of-the-p2x7-ion-channel-with-a-novel-tracer-18-f-jnj-64413739-in-a-rat-model-of-neuroinflammation
#13
Tamara Berdyyeva, Chunfang Xia, Natalie Taylor, Yingbo He, Gang Chen, Chaofeng Huang, Wei Zhang, Hartmuth Kolb, Michael Letavic, Anindya Bhattacharya, Anna Katrin Szardenings
PURPOSE: The P2X7 receptor, an adenosine triphosphate (ATP)-gated purinoreceptor, has emerged as one of the key players in neuroinflammatory processes. Therefore, developing a positron emission tomography (PET) tracer for imaging of P2X7 receptors in vivo presents a promising approach to diagnose, monitor, and study neuroinflammation in a variety of brain disorders. To fulfill the goal of developing a P2X7 PET ligand as a biomarker of neuroinflammation, [18 F]JNJ-64413739 has been recently disclosed...
January 10, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30623283/optical-imaging-of-triple-negative-breast-cancer-cells-in-xenograft-athymic-mice-using-an-icam-1-targeting-small-molecule-probe
#14
Yanqiu Zhang, Mengru Wang, Wanhua Liu, Xin Peng
PURPOSE: The development of early, accurate diagnostic strategies for triple-negative breast cancer (TNBC) remains a significant challenge. Intercellular adhesion molecule-1 (ICAM-1) overexpressed in human TNBC cells is a potential molecular target and biomarker for diagnosis. In this study, small-molecule probe (denoted as γ3-Cy5.5) constructed with a short 17-mer linear peptide (γ3) and near-infrared fluorescence (NIRF) dye cyanine 5.5 (Cy5.5) was used to detect the expression of ICAM-1 in vitro and in vivo, and to diagnose TNBC via NIRF imaging...
January 8, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30617730/pet-imaging-of-her2-positive-tumors-with-cu-64-labeled-affibody-molecules
#15
Shibo Qi, Susan Hoppmann, Yingding Xu, Zhen Cheng
PURPOSE: Previous studies has demonstrated the utility of human epidermal growth factor receptor type 2 (HER2) as an attractive target for cancer molecular imaging and therapy. An affibody protein with strong binding affinity for HER2, ZHER2:342 , has been reported. Various methods of chelator conjugation for radiolabeling HER2 affibody molecules have been described in the literature including N-terminal conjugation, C-terminal conjugation, and other methods. Cu-64 has recently been extensively evaluated due to its half-life, decay properties, and availability...
January 7, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30617729/feasibility-of-hyperfunctioning-parathyroid-gland-localization-using-18-f-fluciclovine-pet-ct
#16
Akinyemi A Akintayo, O A Abiodun-Ojo, C Weber, J Sharma, C Cohen, G Sica, R Halkar, M M Goodman, D M Schuster
PURPOSE: To evaluate the ability of anti-1-amino-3-anti-1-amino-3-[18 F]fluorocyclobutane-1-carboxylic acid ([18 F]fluciclovine) positron emission tomography/X-ray computed tomography (PET/CT) in comparison to Technetium-99m 2-methoxy isobutyl isonitrile ([99m Tc]sestamibi) single-photon emission computed tomography/CT (SPECT/CT) for the localization of hyperfunctioning parathyroid glands in patients with hyperparathyroidism. PROCEDURES: Four patients with hyperparathyroidism underwent 60-minutes sequential neck and thorax PET/CT after [18 F]fluciclovine (352 ± 28 MBq) injection...
January 7, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30617728/a-review-of-prostate-specific-membrane-antigen-psma-positron-emission-tomography-pet-in-renal-cell-carcinoma-rcc
#17
Thomas Ahn, Matthew J Roberts, Aous Abduljabar, Andre Joshi, Marlon Perera, Handoo Rhee, Simon Wood, Ian Vela
Metastatic renal cell carcinoma (mRCC) is a disease that portends poor prognosis despite an increasing number of novel systemic treatment options including new targeted therapies and immunotherapy. Ablative intervention directed at oligometastatic RCC has demonstrated survival benefit. Consequently, developing techniques for improved staging of mRCC on contemporary imaging modalities including X-ray computed tomography (CT), magnetic resonance imaging (MRI) and/or bone scan (BS) is a clinical priority. This is relevant for metastatic deposits too small to characterize or lymph nodes within physiological normality...
January 7, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30607526/imaging-of-the-mouse-lymphatic-sinus-during-early-stage-lymph-node-metastasis-using-intranodal-lymphangiography-with-x-ray-micro-computed-tomography
#18
Ryo Iwamura, Maya Sakamoto, Shiro Mori, Tetsuya Kodama
PURPOSE: Lymph node (LN) metastasis is detected prior to distant metastasis in many types of cancer. Detecting early stage LN metastasis can improve treatment outcomes. However, there are few clinical imaging modalities capable of diagnosing metastatic LNs of clinical N0 status (i.e., before their volume increases) with high precision. Here, we report a new method for diagnosing metastatic LNs of clinical N0 status in a mouse model of LN metastasis. PROCEDURES: The method involved using intranodal lymphangiography with x-ray micro-computed tomography (micro-CT)...
January 3, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30535672/quantification-of-positron-emission-tomography-data-using-simultaneous-estimation-of-the-input-function-validation-with-venous-blood-and-replication-of-clinical-studies
#19
Elizabeth A Bartlett, Mala Ananth, Samantha Rossano, Mengru Zhang, Jie Yang, Shu-Fei Lin, Nabeel Nabulsi, Yiyun Huang, Francesca Zanderigo, Ramin V Parsey, Christine DeLorenzo
PURPOSE: To determine if one venous blood sample can substitute full arterial sampling in quantitative modeling for multiple positron emission tomography (PET) radiotracers using simultaneous estimation of the input function (SIME). PROCEDURES: Participants underwent PET imaging with [11 C]ABP688, [11 C]CUMI-101, and [11 C]DASB. Full arterial sampling and additional venous blood draws were performed for quantification with the arterial input function (AIF) and SIME using one arterial or venous (vSIME) sample...
December 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/30478507/development-of-a-non-invasive-assessment-of-hypoxia-and-neovascularization-with-magnetic-resonance-imaging-in-benign-and-malignant-breast-tumors-initial-results
#20
Andreas Stadlbauer, Max Zimmermann, Barbara Bennani-Baiti, Thomas H Helbich, Pascal Baltzer, Paola Clauser, Panagiotis Kapetas, Zsuzsanna Bago-Horvath, Katja Pinker
PURPOSE: To develop a novel magnetic resonance imaging (MRI) approach for the noninvasive assessment of hypoxia and neovascularization in breast tumors. PROCEDURES: In this IRB-approved prospective study, 20 patients with suspicious breast lesions (BI-RADS 4/5) underwent multiparametric breast MRI including quantitative BOLD (qBOLD) and vascular architecture mapping (VAM). Custom-made in-house MatLab software was used for qBOLD and VAM data postprocessing and calculation of quantitative MRI biomarker maps of oxygen extraction fraction (OEF), metabolic rate of oxygen (MRO2 ), and mitochondrial oxygen tension (mitoPO2 ) to measure tissue hypoxia and neovascularization including vascular architecture including microvessel radius (VSI), density (MVD), and type (MTI)...
November 26, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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