journal
https://read.qxmd.com/read/38987628/a-rush-of-crispr-to-the-lungs
#1
M Teresa Villanueva
No abstract text is available yet for this article.
July 10, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38982305/targeting-ros-in-cancer-rationale-and-strategies
#2
REVIEW
Christophe Glorieux, Shihua Liu, Dunyaporn Trachootham, Peng Huang
Reactive oxygen species (ROS) in biological systems are transient but essential molecules that are generated and eliminated by a complex set of delicately balanced molecular machineries. Disruption of redox homeostasis has been associated with various human diseases, especially cancer, in which increased ROS levels are thought to have a major role in tumour development and progression. As such, modulation of cellular redox status by targeting ROS and their regulatory machineries is considered a promising therapeutic strategy for cancer treatment...
July 9, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38969747/fda-approves-third-anti-amyloid-antibody-for-alzheimer-disease
#3
Asher Mullard
No abstract text is available yet for this article.
July 5, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38969746/rebalancing-calcium-in-alzheimer-disease
#4
Katie Kingwell
No abstract text is available yet for this article.
July 5, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38965378/the-60-year-evolution-of%C3%A2-lipid-nanoparticles-for%C3%A2-nucleic-acid-delivery
#5
REVIEW
P R Cullis, P L Felgner
Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being overcome, owing in part to dramatic advances made by lipid-based systems that have led to lipid nanoparticles (LNPs) that enable delivery of nucleic acid-based vaccines and therapeutics. Examples include the clinically approved COVID-19 LNP mRNA vaccines and Onpattro (patisiran), an LNP small interfering RNA therapeutic to treat transthyretin-induced amyloidosis (hATTR)...
July 4, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38951662/enhancing-in-situ-cancer-vaccines-using-delivery-technologies
#6
REVIEW
Ningqiang Gong, Mohamad-Gabriel Alameh, Rakan El-Mayta, Lulu Xue, Drew Weissman, Michael J Mitchell
In situ cancer vaccination refers to any approach that exploits tumour antigens available at a tumour site to induce tumour-specific adaptive immune responses. These approaches hold great promise for the treatment of many solid tumours, with numerous candidate drugs under preclinical or clinical evaluation and several products already approved. However, there are challenges in the development of effective in situ cancer vaccines. For example, inadequate release of tumour antigens from tumour cells limits antigen uptake by immune cells; insufficient antigen processing by antigen-presenting cells restricts the generation of antigen-specific T cell responses; and the suppressive immune microenvironment of the tumour leads to exhaustion and death of effector cells...
July 1, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38937618/when-chronic-and-rare-disease-worlds-converge
#7
Asher Mullard
No abstract text is available yet for this article.
June 27, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38937617/a-selective-microbiome-sparing-antibiotic
#8
Sarah Crunkhorn
No abstract text is available yet for this article.
June 27, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38937616/machine-learning-identifies-amps
#9
Sarah Crunkhorn
No abstract text is available yet for this article.
June 27, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38937615/ets2-drives-ibd
#10
Sarah Crunkhorn
No abstract text is available yet for this article.
June 27, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38937614/discovering-cftr-modulators
#11
Sarah Crunkhorn
No abstract text is available yet for this article.
June 27, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38918582/gene-therapies-start-the-climb-from-rare-disease-base-camps-to-common-disease-peaks
#12
Asher Mullard
No abstract text is available yet for this article.
June 25, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38906988/menin-inhibitors-seek-to-debut-as-newest-targeted-therapy-for-leukaemia
#13
Ken Garber
No abstract text is available yet for this article.
June 21, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38906987/fda-approves-21-valent-pneumococcal-vaccine
#14
Asher Mullard
No abstract text is available yet for this article.
June 21, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38898270/car-t-cells-take-to-the-airways
#15
Yvonne Bordon
No abstract text is available yet for this article.
June 19, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38890494/know-your-molecule-pharmacological-characterization-of-drug-candidates-to-enhance-efficacy-and-reduce-late-stage-attrition
#16
REVIEW
Terry Kenakin
Despite advances in chemical, computational and biological sciences, the rate of attrition of drug candidates in clinical development is still high. A key point in the small-molecule discovery process that could provide opportunities to help address this challenge is the pharmacological characterization of hit and lead compounds, culminating in the selection of a drug candidate. Deeper characterization is increasingly important, because the 'quality' of drug efficacy, at least for G protein-coupled receptors (GPCRs), is now understood to be much more than activation of commonly evaluated pathways such as cAMP signalling, with many more 'efficacies' of ligands that could be harnessed therapeutically...
June 18, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38890450/extracellular-targeted-protein-degrader-removes-antibodies-in-first-test-in-humans
#17
Asher Mullard
No abstract text is available yet for this article.
June 18, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38886593/author-correction-the-state-of-the-art-in-secondary-pharmacology-and-its-impact-on-the-safety-of-new-medicines
#18
Richard J Brennan, Stephen Jenkinson, Andrew Brown, Annie Delaunois, Bérengère Dumotier, Malar Pannirselvam, Mohan Rao, Lyn Rosenbrier Ribeiro, Friedemann Schmidt, Alicia Sibony, Yoav Timsit, Vicencia Toledo Sales, Duncan Armstrong, Armando Lagrutta, Scott W Mittlestadt, Russell Naven, Ravikumar Peri, Sonia Roberts, James M Vergis, Jean-Pierre Valentin
No abstract text is available yet for this article.
June 17, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38877327/fda-approves-first-telomerase-inhibitor
#19
Asher Mullard
No abstract text is available yet for this article.
June 14, 2024: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/38866952/upcoming-market-catalysts-in-q3-2024
#20
Kaniaw Dilzer
No abstract text is available yet for this article.
June 12, 2024: Nature Reviews. Drug Discovery
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