journal
https://read.qxmd.com/read/38632491/neuronal-tlr9-signalling-crucial-for-memory-formation
#1
JOURNAL ARTICLE
Alexandra Flemming
No abstract text is available yet for this article.
April 17, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38632490/bacterial-serotonin-induces-t-reg-cells-in-neonates
#2
JOURNAL ARTICLE
Alexandra Flemming
No abstract text is available yet for this article.
April 17, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38632489/tumour-cell-consumption-of-taurine-exhausts-cd8-t-cells
#3
JOURNAL ARTICLE
Alexandra Flemming
No abstract text is available yet for this article.
April 17, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38594330/rejuvenating-an-old-immune-system
#4
JOURNAL ARTICLE
Yvonne Bordon
No abstract text is available yet for this article.
April 9, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38570719/generating-prophylactic-immunity-against-arboviruses-in-vertebrates-and-invertebrates
#5
REVIEW
Daniel J Rawle, Leon E Hugo, Abigail L Cox, Gregor J Devine, Andreas Suhrbier
The World Health Organization recently declared a global initiative to control arboviral diseases. These are mainly caused by pathogenic flaviviruses (such as dengue, yellow fever and Zika viruses) and alphaviruses (such as chikungunya and Venezuelan equine encephalitis viruses). Vaccines represent key interventions for these viruses, with licensed human and/or veterinary vaccines being available for several members of both genera. However, a hurdle for the licensing of new vaccines is the epidemic nature of many arboviruses, which presents logistical challenges for phase III efficacy trials...
April 3, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38565643/short-chain-fatty-acids-linking-diet-the-microbiome-and-immunity
#6
REVIEW
Elizabeth R Mann, Ying Ka Lam, Holm H Uhlig
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in the gut and other organs is determined by environmental factors, such as diet and use of antibiotics, that shape the diversity and metabolism of the microbiota. SCFAs regulate epithelial barrier function as well as mucosal and systemic immunity via evolutionary conserved processes that involve G protein-coupled receptor signalling or histone deacetylase activity. Indicatively, the anti-inflammatory role of butyrate is mediated through direct effects on the differentiation of intestinal epithelial cells, phagocytes, B cells and plasma cells, and regulatory and effector T cells...
April 2, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38548935/panini-combined-protein-and-nucleic-acid-imaging-in-tissues
#7
JOURNAL ARTICLE
Sizun Jiang
No abstract text is available yet for this article.
March 28, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38504020/a-pre-tcr%C3%AE-independent-pathway-of-%C3%AE-%C3%AE-t-cell-differentiation
#8
JOURNAL ARTICLE
Kirsty Minton
No abstract text is available yet for this article.
March 19, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38491073/bone-marrow-inflammation-in-haematological-malignancies
#9
REVIEW
Madelon M E de Jong, Lanpeng Chen, Marc H G P Raaijmakers, Tom Cupedo
Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-associated inflammation impacts normal niches for haematopoietic progenitor cells and mature immune cells and supports the outgrowth and survival of malignant cells residing in these niche compartments. This Review provides an overview of our current understanding of inflammatory changes in the bone marrow microenvironment of myeloid and lymphoid malignancies, using acute myeloid leukaemia and multiple myeloma as examples and highlights unique and shared features of inflammation in niches for progenitor cells and plasma cells...
March 15, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38486124/strategies-for-targeting-cytokines-in-inflammatory-bowel-disease
#10
REVIEW
Markus F Neurath
Cytokines produced by immune cells contribute to the development and perpetuation of inflammatory bowel disease (IBD), namely Crohn's disease and ulcerative colitis, by regulating various aspects of the inflammatory response. Pro-inflammatory cytokines trigger chronic intestinal inflammation, tissue damage, carcinogenesis and perpetuation of disease and suppress the resolution of inflammation in IBD. The clinical success of antibodies that neutralize tumour necrosis factor (TNF) and the cytokine IL-12p40 in individuals with IBD has underscored this concept...
March 14, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38480899/author-correction-using-bcg-vaccination-to-protect-against-covid-19-when-reality-fails-to-meet-expectation
#11
Laure F Pittet, Christie C A Noble, Nicole L Messina, Nigel Curtis
No abstract text is available yet for this article.
March 13, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38472321/breaking-tolerance-the-autoimmune-aspect-of-atherosclerosis
#12
REVIEW
Amir Khan, Payel Roy, Klaus Ley
Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory disease of the arterial walls and is characterized by the accumulation of lipoproteins that are insufficiently cleared by phagocytes. Following the initiation of atherosclerosis, the pathological progression is accelerated by engagement of the adaptive immune system. Atherosclerosis triggers the breakdown of tolerance to self-components. This loss of tolerance is reflected in defective expression of immune checkpoint molecules, dysfunctional antigen presentation, and aberrations in T cell populations - most notably in regulatory T (Treg ) cells - and in the production of autoantibodies...
March 12, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38467805/regulation-of-innate-like-activities-of-neonatal-cd8-t-cells
#13
JOURNAL ARTICLE
Alexandra Flemming
No abstract text is available yet for this article.
March 11, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38467804/the-eye-provides-an-immunological-gateway-to-the-brain
#14
JOURNAL ARTICLE
Alexandra Flemming
No abstract text is available yet for this article.
March 11, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38467802/made-to-order-emergency-myelopoiesis-and-demand-adapted-innate-immune-cell-production
#15
REVIEW
James W Swann, Oakley C Olson, Emmanuelle Passegué
Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the bone marrow, generate all haematopoietic cell lineages in healthy adults. Although highly regulated to maintain a stable output of blood cells in health, the haematopoietic system is capable of extensive remodelling in response to external challenges, prioritizing the production of certain cell types at the expense of others. In this Review, we consider how acute insults, such as infections and cytotoxic drug-induced myeloablation, cause molecular, cellular and metabolic changes in haematopoietic stem and progenitor cells at multiple levels of the haematopoietic hierarchy to drive accelerated production of the mature myeloid cells needed to resolve the initiating insult...
March 11, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38459143/a-t-reg-cell-duo-for-vat-control
#16
JOURNAL ARTICLE
Maria Papatriantafyllou
No abstract text is available yet for this article.
March 8, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38448634/author-correction-clonal-haematopoiesis-associated-age-related-motor-deficits-caused-by-monocyte-derived-microglia
#17
Austeja Baleviciute, Lily Keane
No abstract text is available yet for this article.
March 6, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38448633/lymph-node-resection-does-not-impair-cancer-immunotherapy-responses
#18
JOURNAL ARTICLE
Lucas Baldran-Groves, Jeroen Melief
No abstract text is available yet for this article.
March 6, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38429531/pre-existing-antibody-allows-for-maturation-of-new-b-cells-in-recall-germinal-centres
#19
JOURNAL ARTICLE
Jake Herb, Maria Curotto de Lafaille
No abstract text is available yet for this article.
March 1, 2024: Nature Reviews. Immunology
https://read.qxmd.com/read/38424204/osteoblast-derived-atp-maintains-bone-marrow-plasma-cells
#20
JOURNAL ARTICLE
Yvonne Bordon
No abstract text is available yet for this article.
February 29, 2024: Nature Reviews. Immunology
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