journal
https://read.qxmd.com/read/38102343/next-generation-epidemiologic-cohorts-for-cancer-aetiology
#21
JOURNAL ARTICLE
Scarlett Lin Gomez, Iona Cheng
No abstract text is available yet for this article.
December 15, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/38092855/approaching-cancer-during-pregnancy
#22
JOURNAL ARTICLE
Leticia Varella, Ann H Partridge
No abstract text is available yet for this article.
December 13, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/38082124/spatial-metabolic-patterns
#23
JOURNAL ARTICLE
Anna Dart
No abstract text is available yet for this article.
December 11, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/38057354/removing-barriers-to-address-sex-differences-in-anticancer-drug-toxicity
#24
JOURNAL ARTICLE
Berna C Özdemir
No abstract text is available yet for this article.
December 6, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/38135758/decoding-the-basis-of-histological-variation-in-human-cancer
#25
REVIEW
Masayuki Fujii, Shigeki Sekine, Toshiro Sato
Molecular abnormalities that shape human neoplasms dissociate their phenotypic landscape from that of the healthy counterpart. Through the lens of a microscope, tumour pathology optically captures such aberrations projected onto a tissue slide and has categorized human epithelial neoplasms into distinct histological subtypes based on the diverse morphogenetic and molecular programmes that they manifest. Tumour histology often reflects tumour aggressiveness, patient prognosis and therapeutic vulnerability, and thus has been used as a de facto diagnostic tool and for making clinical decisions...
February 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38062251/targeting-cancer-cell-dormancy
#26
JOURNAL ARTICLE
Judith Agudo, Julio A Aguirre-Ghiso, Mickie Bhatia, Lewis A Chodosh, Ana Luísa Correia, Christoph A Klein
No abstract text is available yet for this article.
February 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38066335/how-chemokines-organize-the-tumour-microenvironment
#27
REVIEW
Thorsten R Mempel, Julia K Lill, Lukas M Altenburger
For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must not only extravasate from the bloodstream into the tumour tissue but also further migrate to various specialized niches of the tumour microenvironment to functionally interact with each other, with non-haematopoietic stromal cells and, ultimately, with cancer cells. These interactions regulate local immune cell survival, proliferative expansion, differentiation and their execution of pro-tumour or antitumour effector functions, which collectively determine the outcome of spontaneous or therapeutically induced antitumour immune responses...
January 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38066334/pressing-defence
#28
JOURNAL ARTICLE
Daniela Senft
No abstract text is available yet for this article.
January 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38062252/fc%C3%AE-receptors-and-immunomodulatory-antibodies-in-cancer
#29
REVIEW
Felipe Galvez-Cancino, Alexander P Simpson, Cristobal Costoya, Ignacio Matos, Danwen Qian, Karl S Peggs, Kevin Litchfield, Sergio A Quezada
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to the development of numerous immunomodulatory antibodies as cancer treatments. Preclinical studies have demonstrated that the efficacy of immunoglobulin G (IgG)-based therapies depends not only on their ability to block or engage their targets but also on the antibody's constant region (Fc) and its interactions with Fcγ receptors (FcγRs)...
January 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38030856/uxs1-a-sweet-spot-for-cell-death
#30
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
January 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/37996538/eph-receptors-and-ephrins-in-cancer-progression
#31
REVIEW
Elena B Pasquale
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together make up the 'Eph system') in cancer development and progression has been accumulating since the discovery of the first Eph receptor approximately 35 years ago. Advances in the past decade and a half have considerably increased the understanding of Eph receptor-ephrin signalling mechanisms in cancer and have uncovered intriguing new roles in cancer progression and drug resistance. This Review focuses mainly on these more recent developments...
January 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38040850/the-dynamic-role-of-platelets-in-cancer-progression-and-their-therapeutic-implications
#32
REVIEW
Suping Li, Zefang Lu, Suying Wu, Tianjiao Chu, Bozhao Li, Feilong Qi, Yuliang Zhao, Guangjun Nie
Systemic antiplatelet treatment represents a promising option to improve the therapeutic outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical contribution of platelets to tumour progression. However, until recently, targeting platelets as a cancer therapeutic has been hampered by the elevated risk of haemorrhagic and thrombocytopenic (low platelet count) complications owing to the lack of specificity for tumour-associated platelets. Recent work has advanced our understanding of the molecular mechanisms responsible for the contribution of platelets to tumour progression and metastasis...
December 1, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37935888/deubiquitinases-in-cancer
#33
REVIEW
Grant Dewson, Pieter J A Eichhorn, David Komander
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in cellular signalling are central to cancer initiation, progression and, eventually, metastasis. The attachment of ubiquitin signals by E3 ubiquitin ligases is directly opposed by the action of approximately 100 deubiquitinating enzymes (DUBs) in humans. Together, DUBs and E3 ligases coordinate ubiquitin signalling by providing selectivity for different substrates and/or ubiquitin signals. The balance between ubiquitination and deubiquitination is exquisitely controlled to ensure properly coordinated proteostasis and response to cellular stimuli and stressors...
December 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37884609/how-protons-pave-the-way-to-aggressive-cancers
#34
REVIEW
Pawel Swietach, Ebbe Boedtkjer, Stine Falsig Pedersen
Cancers undergo sequential changes to proton (H+ ) concentration and sensing that are consequences of the disease and facilitate its further progression. The impact of protonation state on protein activity can arise from alterations to amino acids or their titration. Indeed, many cancer-initiating mutations influence pH balance, regulation or sensing in a manner that enables growth and invasion outside normal constraints as part of oncogenic transformation. These cancer-supporting effects become more prominent when tumours develop an acidic microenvironment owing to metabolic reprogramming and disordered perfusion...
December 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37857840/advances-in-translational-research-of-the-rare-cancer-type-adrenocortical-carcinoma
#35
REVIEW
Chandrayee Ghosh, Jiangnan Hu, Electron Kebebew
Adrenocortical carcinoma is a rare malignancy with an annual worldwide incidence of 1-2 cases per 1 million and a 5-year survival rate of <60%. Although adrenocortical carcinoma is rare, such rare cancers account for approximately one third of patients diagnosed with cancer annually. In the past decade, there have been considerable advances in understanding the molecular basis of adrenocortical carcinoma. The genetic events associated with adrenocortical carcinoma in adults are distinct from those of paediatric cases, which are often associated with germline or somatic TP53 mutations and have a better prognosis...
December 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/38036653/lighting-up-cancer-initiation-with-mutant-p53-reporters
#36
JOURNAL ARTICLE
Xiwen Tang
No abstract text is available yet for this article.
November 30, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37985731/understanding-and-addressing-race-disparities-in-childhood-cancer-outcomes
#37
JOURNAL ARTICLE
M Monica Gramatges
No abstract text is available yet for this article.
November 20, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37968378/translating-tumour-immunity-control
#38
JOURNAL ARTICLE
Glaucia N M Hajj
No abstract text is available yet for this article.
November 15, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37946087/targeting-the-tumour-s-little-helpers
#39
JOURNAL ARTICLE
Linda Gummlich
No abstract text is available yet for this article.
November 9, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37946086/inflammatory-neutrophils
#40
JOURNAL ARTICLE
Daniela Senft
No abstract text is available yet for this article.
November 9, 2023: Nature Reviews. Cancer
journal
journal
39814
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.