journal
https://read.qxmd.com/read/38040850/the-dynamic-role-of-platelets-in-cancer-progression-and-their-therapeutic-implications
#1
REVIEW
Suping Li, Zefang Lu, Suying Wu, Tianjiao Chu, Bozhao Li, Feilong Qi, Yuliang Zhao, Guangjun Nie
Systemic antiplatelet treatment represents a promising option to improve the therapeutic outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical contribution of platelets to tumour progression. However, until recently, targeting platelets as a cancer therapeutic has been hampered by the elevated risk of haemorrhagic and thrombocytopenic (low platelet count) complications owing to the lack of specificity for tumour-associated platelets. Recent work has advanced our understanding of the molecular mechanisms responsible for the contribution of platelets to tumour progression and metastasis...
December 1, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/38036653/lighting-up-cancer-initiation-with-mutant-p53-reporters
#2
JOURNAL ARTICLE
Xiwen Tang
No abstract text is available yet for this article.
November 30, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/38030856/uxs1-a-sweet-spot-for-cell-death
#3
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
November 29, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37996538/eph-receptors-and-ephrins-in-cancer-progression
#4
REVIEW
Elena B Pasquale
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together make up the 'Eph system') in cancer development and progression has been accumulating since the discovery of the first Eph receptor approximately 35 years ago. Advances in the past decade and a half have considerably increased the understanding of Eph receptor-ephrin signalling mechanisms in cancer and have uncovered intriguing new roles in cancer progression and drug resistance. This Review focuses mainly on these more recent developments...
November 23, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37985731/understanding-and-addressing-race-disparities-in-childhood-cancer-outcomes
#5
JOURNAL ARTICLE
M Monica Gramatges
No abstract text is available yet for this article.
November 20, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37968378/translating-tumour-immunity-control
#6
JOURNAL ARTICLE
Glaucia N M Hajj
No abstract text is available yet for this article.
November 15, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37946087/targeting-the-tumour-s-little-helpers
#7
JOURNAL ARTICLE
Linda Gummlich
No abstract text is available yet for this article.
November 9, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37946086/inflammatory-neutrophils
#8
JOURNAL ARTICLE
Daniela Senft
No abstract text is available yet for this article.
November 9, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37935888/deubiquitinases-in-cancer
#9
REVIEW
Grant Dewson, Pieter J A Eichhorn, David Komander
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in cellular signalling are central to cancer initiation, progression and, eventually, metastasis. The attachment of ubiquitin signals by E3 ubiquitin ligases is directly opposed by the action of approximately 100 deubiquitinating enzymes (DUBs) in humans. Together, DUBs and E3 ligases coordinate ubiquitin signalling by providing selectivity for different substrates and/or ubiquitin signals. The balance between ubiquitination and deubiquitination is exquisitely controlled to ensure properly coordinated proteostasis and response to cellular stimuli and stressors...
November 7, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37907620/metabolic-pathway-analysis-using-stable-isotopes-in-patients-with-cancer
#10
REVIEW
Caroline R Bartman, Brandon Faubert, Joshua D Rabinowitz, Ralph J DeBerardinis
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense investigation. Tumour metabolism is determined by a complex and incompletely defined combination of factors intrinsic and extrinsic to cancer cells. This complexity increases the value of assessing cancer metabolism in disease-relevant microenvironments, including in patients with cancer. Stable-isotope tracing is an informative, versatile method for probing tumour metabolism in vivo...
October 31, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37884609/how-protons-pave-the-way-to-aggressive-cancers
#11
REVIEW
Pawel Swietach, Ebbe Boedtkjer, Stine Falsig Pedersen
Cancers undergo sequential changes to proton (H+ ) concentration and sensing that are consequences of the disease and facilitate its further progression. The impact of protonation state on protein activity can arise from alterations to amino acids or their titration. Indeed, many cancer-initiating mutations influence pH balance, regulation or sensing in a manner that enables growth and invasion outside normal constraints as part of oncogenic transformation. These cancer-supporting effects become more prominent when tumours develop an acidic microenvironment owing to metabolic reprogramming and disordered perfusion...
October 26, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37872444/wilddisco-hd-whole-body-imaging
#12
JOURNAL ARTICLE
Hongcheng Mai
No abstract text is available yet for this article.
October 23, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37872443/the-microbiome-as-a-determinant-of-racial-and-ethnic-cancer-disparities
#13
JOURNAL ARTICLE
Doratha Byrd, Patricia Wolf
No abstract text is available yet for this article.
October 23, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37857840/advances-in-translational-research-of-the-rare-cancer-type-adrenocortical-carcinoma
#14
REVIEW
Chandrayee Ghosh, Jiangnan Hu, Electron Kebebew
Adrenocortical carcinoma is a rare malignancy with an annual worldwide incidence of 1-2 cases per 1 million and a 5-year survival rate of <60%. Although adrenocortical carcinoma is rare, such rare cancers account for approximately one third of patients diagnosed with cancer annually. In the past decade, there have been considerable advances in understanding the molecular basis of adrenocortical carcinoma. The genetic events associated with adrenocortical carcinoma in adults are distinct from those of paediatric cases, which are often associated with germline or somatic TP53 mutations and have a better prognosis...
October 19, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37848574/breast-milk-for-breast-cancer-detection
#15
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
October 17, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37821656/stem-like-exhausted-and-memory-cd8-t-cells-in-cancer
#16
REVIEW
Thomas Gebhardt, Simone L Park, Ian A Parish
T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells equipped with effector machinery and more quiescent, long-lived cells with heightened proliferative potential and stem cell-like developmental plasticity. The latter encompass stem-like exhausted T cells and memory T cells, both of which have recently emerged as key determinants of cancer immunity and response to immunotherapy. Here, we discuss key similarities and differences in the regulation and function of stem-like exhausted CD8+  T cells and memory CD8+ T cells, and consider their context-specific contributions to protective immunity in diverse outcomes of cancer, including tumour escape, long-term control and eradication...
October 11, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37814109/transfer-rnas-as-dynamic-and-critical-regulators-of-cancer-progression
#17
REVIEW
Alexandra M Pinzaru, Sohail F Tavazoie
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for these fascinating molecules. Advances in tRNA detection methods have revealed that specific tRNAs can become modulated upon DNA copy number and chromatin alterations and can also be perturbed by oncogenic signalling and transcriptional regulators in cancer cells or the tumour microenvironment. Such alterations in the levels of specific tRNAs have been shown to causally impact cancer progression, including metastasis...
October 9, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37770768/prime-editing-gemms-to-model-cancer-mutations
#18
JOURNAL ARTICLE
Nicolas Mathey-Andrews
No abstract text is available yet for this article.
September 28, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37758860/enhanced-transposable-elements
#19
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
September 27, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37758859/tertiary-lymphoid-structures-as-hubs-of-antitumour-immunity
#20
JOURNAL ARTICLE
Gabriela Sarti Kinker, Tiago da Silva Medina
No abstract text is available yet for this article.
September 27, 2023: Nature Reviews. Cancer
journal
journal
39814
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.