journal
https://read.qxmd.com/read/37268781/traject3d-for-studying-3d-cellular-heterogeneity
#1
JOURNAL ARTICLE
Eva C Freckmann
No abstract text is available yet for this article.
June 2, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37258875/advances-in-pet-imaging-of-cancer
#2
REVIEW
Johannes Schwenck, Dominik Sonanini, Jonathan M Cotton, Hans-Georg Rammensee, Christian la Fougère, Lars Zender, Bernd J Pichler
Molecular imaging has experienced enormous advancements in the areas of imaging technology, imaging probe and contrast development, and data quality, as well as machine learning-based data analysis. Positron emission tomography (PET) and its combination with computed tomography (CT) or magnetic resonance imaging (MRI) as a multimodality PET-CT or PET-MRI system offer a wealth of molecular, functional and morphological data with a single patient scan. Despite the recent technical advances and the availability of dozens of disease-specific contrast and imaging probes, only a few parameters, such as tumour size or the mean tracer uptake, are used for the evaluation of images in clinical practice...
May 31, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37231146/impaired-rna-clearance
#3
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
May 25, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37217781/endocytosis-in-cancer-and-cancer-therapy
#4
REVIEW
Blerida Banushi, Shannon R Joseph, Benedict Lum, Jason J Lee, Fiona Simpson
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the extracellular environment are packaged, sorted and internalized into cells. Endocytosis is also a mechanism of drug internalization into cells. There are multiple routes of endocytosis that determine the fate of molecules, from degradation in the lysosomes to recycling back to the plasma membrane. The overall rates of endocytosis and temporal regulation of molecules transiting through endocytic pathways are also intricately linked with signalling outcomes...
May 22, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37198325/nerve-driven-metastasis
#5
JOURNAL ARTICLE
Daniela Senft
No abstract text is available yet for this article.
May 17, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37173415/cafs-promote-crpc
#6
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
May 12, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37142795/the-role-of-eif4f-driven-mrna-translation-in-regulating-the-tumour-microenvironment
#7
REVIEW
Margarita Bartish, Madelyn J Abraham, Christophe Gonçalves, Ola Larsson, Charlotte Rolny, Sonia V Del Rincón
Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA translation. There is mounting evidence that dysregulation of mRNA translation supports the survival and adaptation of cancer cells, which has stimulated clinical interest in targeting elements of the translation machinery and, in particular, components of the eukaryotic initiation factor 4F (eIF4F) complex such as eIF4E. However, the effect of targeting mRNA translation on infiltrating immune cells and stromal cells in the tumour microenvironment (TME) has, until recently, remained unexplored...
May 4, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37142794/air-pollution-promotes-tumorigenesis-through-pre-existing-oncogenic-mutations
#8
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
May 4, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37138029/dissecting-metastasis-using-preclinical-models-and-methods
#9
REVIEW
Jess D Hebert, Joel W Neal, Monte M Winslow
Metastasis has long been understood to lead to the overwhelming majority of cancer-related deaths. However, our understanding of the metastatic process, and thus our ability to prevent or eliminate metastases, remains frustratingly limited. This is largely due to the complexity of metastasis, which is a multistep process that likely differs across cancer types and is greatly influenced by many aspects of the in vivo microenvironment. In this Review, we discuss the key variables to consider when designing assays to study metastasis: which source of metastatic cancer cells to use and where to introduce them into mice to address different questions of metastasis biology...
May 3, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37130968/untangling-the-mechanisms-of-cancer-predisposition
#10
JOURNAL ARTICLE
Giovana Tardin Torrezan
No abstract text is available yet for this article.
May 2, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37117275/identifying-spatial-cellular-structures-with-space-gm
#11
JOURNAL ARTICLE
Zhenqin Wu
No abstract text is available yet for this article.
April 28, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37106250/emt-in-chemoresistance
#12
JOURNAL ARTICLE
Anna Dart
No abstract text is available yet for this article.
April 27, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37101004/stromal-cells-drive-tumorigenesis-in-brca1-mutation-carriers
#13
JOURNAL ARTICLE
Felicity Tournant
No abstract text is available yet for this article.
April 26, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37095242/the-journey-from-melanocytes-to-melanoma
#14
REVIEW
Patricia P Centeno, Valeria Pavet, Richard Marais
Over the past decade, melanoma has led the field in new cancer treatments, with impressive gains in on-treatment survival but more modest improvements in overall survival. Melanoma presents heterogeneity and transcriptional plasticity that recapitulates distinct melanocyte developmental states and phenotypes, allowing it to adapt to and eventually escape even the most advanced treatments. Despite remarkable advances in our understanding of melanoma biology and genetics, the melanoma cell of origin is still fiercely debated because both melanocyte stem cells and mature melanocytes can be transformed...
April 24, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37081118/author-correction-fighting-rare-cancers-lessons-from-fibrolamellar-hepatocellular-carcinoma
#15
Sanford M Simon
No abstract text is available yet for this article.
April 20, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37081117/innate-lymphoid-cells-and-innate-like-t-cells-in-cancer%C3%A2-at-the-crossroads-of-innate-and-adaptive-immunity
#16
REVIEW
Benjamin Ruf, Tim F Greten, Firouzeh Korangy
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for many cancers, yet only a subset of patients benefit from these approaches. A better understanding of the complex immune microenvironment of tumours is needed to design the next generation of immunotherapeutics. Innate lymphoid cells (ILCs) and innate-like T cells (ILTCs) are abundant, tissue-resident lymphocytes that have recently been shown to have critical roles in many types of cancers. ILCs and ILTCs rapidly respond to changes in their surrounding environment and act as the first responders to bridge innate and adaptive immunity...
April 20, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37076612/humanized-minipigs-to-assess-drug-safety
#17
JOURNAL ARTICLE
Tatiana Flisikowska
No abstract text is available yet for this article.
April 19, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37059823/multiomics-guided-cellular-immunotherapies
#18
JOURNAL ARTICLE
Mateusz Legut
No abstract text is available yet for this article.
April 14, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37046001/dynamics-and-specificities-of-t-cells-in-cancer-immunotherapy
#19
REVIEW
Giacomo Oliveira, Catherine J Wu
Recent advances in cancer immunotherapy - ranging from immune-checkpoint blockade therapy to adoptive cellular therapy and vaccines - have revolutionized cancer treatment paradigms, yet the variability in clinical responses to these agents has motivated intense interest in understanding how the T cell landscape evolves with respect to response to immune intervention. Over the past decade, the advent of multidimensional single-cell technologies has provided the unprecedented ability to dissect the constellation of cell states of lymphocytes within a tumour microenvironment...
April 12, 2023: Nature Reviews. Cancer
https://read.qxmd.com/read/37041409/the-neural-addiction-of-cancer
#20
REVIEW
Claire Magnon, Hubert Hondermarck
The recently uncovered key role of the peripheral and central nervous systems in controlling tumorigenesis and metastasis has opened a new area of research to identify innovative approaches against cancer. Although the 'neural addiction' of cancer is only partially understood, in this Perspective we discuss the current knowledge and perspectives on peripheral and central nerve circuitries and brain areas that can support tumorigenesis and metastasis and the possible reciprocal influence that the brain and peripheral tumours exert on one another...
April 11, 2023: Nature Reviews. Cancer
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