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Nature Reviews. Cancer

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https://read.qxmd.com/read/30755690/the-evolving-landscape-of-biomarkers-for-checkpoint-inhibitor-immunotherapy
#1
REVIEW
Jonathan J Havel, Diego Chowell, Timothy A Chan
Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4 (CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success in the treatment of different cancer types. Yet, only a subset of patients derive clinical benefit. It is thus critical to understand the determinants driving response, resistance and adverse effects. In this Review, we discuss recent work demonstrating that immune checkpoint inhibitor efficacy is affected by a combination of factors involving tumour genomics, host germline genetics, PD1 ligand 1 (PDL1) levels and other features of the tumour microenvironment, as well as the gut microbiome...
February 12, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30737456/shaping-a-nature-reviews-cancer-article
#2
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30733590/targeting-endovascular-progenitors-controls-cancer
#3
Jordan Hindson
A new study has shown that endovascular progenitor cells, which are precursors of the endothelial cells that make up tumour blood vessels, are inhibited by conditional ablation of Notch signalling, leading to inhibition of melanoma metastasis in mice.
February 7, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30723290/epigenetic-therapy-in-immune-oncology
#4
REVIEW
Peter A Jones, Hitoshi Ohtani, Ankur Chakravarthy, Daniel D De Carvalho
DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilities to reactivate genes, including tumour suppressors, that have acquired DNA methylation during carcinogenesis, they induce the expression of thousands of transposable elements including endogenous retroviruses and latent cancer testis antigens normally silenced by DNA methylation in most somatic cells. This results in a state of viral mimicry in which treated cells mount an innate immune response by turning on viral defence genes and potentially expressing neoantigens...
February 5, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30723289/senolytic-helpers
#5
Ulrike Harjes
No abstract text is available yet for this article.
February 5, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30705433/methylated-clusters
#6
Anna Dart
No abstract text is available yet for this article.
January 31, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30705432/glioblastoma-is-hot-for-personalized-vaccines
#7
Maria Giuseppina Baratta
No abstract text is available yet for this article.
January 31, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30705431/unmasking-cancer-cell-character
#8
M Teresa Villanueva
No abstract text is available yet for this article.
January 31, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30705430/author-correction-every-step-of-the-way-integrins-in-cancer-progression-and-metastasis
#9
Hellyeh Hamidi, Johanna Ivaska
In the originally published article, pertuzumab was incorrectly described as an anti-PI3K therapy in the section 'Integrins in anticancer therapy'. The sentence should read 'In mouse mammary tumour models, increased collagen levels and increased β1 integrin and SRC activity have been demonstrated to accompany, and promote, combined resistance to anti-human epidermal growth factor receptor 2 (HER2; also known as ERBB2) (trastuzumab and pertuzumab) and anti-PI3K (buparlisib) therapies164.' This has now been corrected in all versions of the original article...
January 31, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30705429/author-correction-cancer-in-wildlife-patterns-of-emergence
#10
Patricia A Pesavento, Dalen Agnew, Michael K Keel, Kevin D Woolard
In the originally published article, the aetiology of the single case of B cell lymphoma found in the Mountain gorilla was incorrectly referred to as Gibbon lymphocryptovirus 1 in Table 1. The correct aetiology is Gbb lymphocryptovirus 1. This has now been corrected in both the html and PDF versions of the article.
January 31, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30696923/immune-control-by-amino-acid-catabolism-during-tumorigenesis-and-therapy
#11
REVIEW
Henrique Lemos, Lei Huang, George C Prendergast, Andrew L Mellor
Immune checkpoints arise from physiological changes during tumorigenesis that reprogramme inflammatory, immunological and metabolic processes in malignant lesions and local lymphoid tissues, which constitute the immunological tumour microenvironment (TME). Improving clinical responses to immune checkpoint blockade will require deeper understanding of factors that impact local immune balance in the TME. Elevated catabolism of the amino acids tryptophan (Trp) and arginine (Arg) is a common TME hallmark at clinical presentation of cancer...
January 29, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30696922/trafficking-signals-for-metastasis
#12
Katharine H Wrighton
No abstract text is available yet for this article.
January 29, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30683893/the-global-cancer-burden-necessity-is-the-mother-of-prevention
#13
Christopher P Wild
No abstract text is available yet for this article.
January 25, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30670821/organoid-2-0
#14
Anna Dart
No abstract text is available yet for this article.
January 22, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30670820/rare-ribosomopathies-insights-into-mechanisms-of-cancer
#15
REVIEW
Anna Aspesi, Steven R Ellis
Long thought to be too big and too ubiquitous to fail, we now know that human cells can fail to make sufficient amounts of ribosomes, causing a number of diseases collectively known as ribosomopathies. The best characterized ribosomopathies, with the exception of Treacher Collins syndrome, are inherited bone marrow failure syndromes, each of which has a marked increase in cancer predisposition relative to the general population. Although rare, emerging data reveal that the inherited bone marrow failure syndromes may be underdiagnosed on the basis of classical symptomology, leaving undiagnosed patients with these syndromes at an elevated risk of cancer without adequate counselling and surveillance...
January 22, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30655608/publisher-correction-expanding-the-search
#16
Anna Dart
The originally published Research Highlight incorrectly credited the image. The correct credit line should read Dennis Hallinan/Alamy Stock Photo. This has now been corrected in all versions of the original article.
January 17, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30651606/fasting-in-oncology-a-word-of-caution
#17
LETTER
Riccardo Caccialanza, Giuseppe Aprile, Emanuele Cereda, Paolo Pedrazzoli
No abstract text is available yet for this article.
January 16, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30651605/reply-to-fasting-in-oncology-a-word-of-caution
#18
LETTER
Alessio Nencioni, Irene Caffa, Salvatore Cortellino, Valter D Longo
No abstract text is available yet for this article.
January 16, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30617269/get-to-know-your-epigenetic-target
#19
Sarah Seton-Rogers
No abstract text is available yet for this article.
January 7, 2019: Nature Reviews. Cancer
https://read.qxmd.com/read/30617268/expanding-the-search
#20
Anna Dart
No abstract text is available yet for this article.
January 7, 2019: Nature Reviews. Cancer
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