journal
https://read.qxmd.com/read/38871881/the-path-to-leptomeningeal-metastasis
#1
REVIEW
Jan Remsik, Adrienne Boire
The leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous system, play host to various pathologies including infection, neuroinflammation and malignancy. Spread of systemic cancer into this space, termed leptomeningeal metastasis, occurs in 5-10% of patients with solid tumours and portends a bleak clinical prognosis. Previous, predominantly descriptive, clinical studies have provided few insights. Recent development of preclinical leptomeningeal metastasis models, alongside genomic, transcriptomic and proteomic sequencing efforts, has provided groundwork for mechanistic understanding and identification of long-needed therapeutic targets...
June 13, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38867074/defining-clinically-useful-biomarkers-of-immune-checkpoint-inhibitors-in-solid-tumours
#2
REVIEW
Ashley M Holder, Aikaterini Dedeilia, Kailan Sierra-Davidson, Sonia Cohen, David Liu, Aparna Parikh, Genevieve M Boland
Although more than a decade has passed since the approval of immune checkpoint inhibitors (ICIs) for the treatment of melanoma and non-small-cell lung, breast and gastrointestinal cancers, many patients still show limited response. US Food and Drug Administration (FDA)-approved biomarkers include programmed cell death 1 ligand 1 (PDL1) expression, microsatellite status (that is, microsatellite instability-high (MSI-H)) and tumour mutational burden (TMB), but these have limited utility and/or lack standardized testing approaches for pan-cancer applications...
June 12, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38858510/charting-spatially-resolved-cell-states-with-cytospace
#3
JOURNAL ARTICLE
Erin L Brown
No abstract text is available yet for this article.
June 10, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38858509/eliminating-false-positives
#4
JOURNAL ARTICLE
Daniela Senft
No abstract text is available yet for this article.
June 10, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38834819/bone-voyage-immune-crosstalk-sets-sail
#5
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
June 4, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38811826/no-mutation-tumour-initiation
#6
JOURNAL ARTICLE
Daniela Senft
No abstract text is available yet for this article.
May 29, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38783096/liquid-biopsies-for-hodgkin-lymphoma
#7
JOURNAL ARTICLE
Sojung Lim, Yoon Kyung Jeon
No abstract text is available yet for this article.
May 23, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38773327/author-correction-developmental-origins-shape-the-paediatric-cancer-genome
#8
Xiaolong Chen, Wentao Yang, Charles W M Roberts, Jinghui Zhang
No abstract text is available yet for this article.
May 21, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38755441/taking-a-detour
#9
JOURNAL ARTICLE
Anna Dart
No abstract text is available yet for this article.
May 16, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38755440/finding-the-truth-in-science
#10
JOURNAL ARTICLE
Elisabeth M Bik
No abstract text is available yet for this article.
May 16, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38755439/a-guide-to-artificial-intelligence-for-cancer-researchers
#11
REVIEW
Raquel Perez-Lopez, Narmin Ghaffari Laleh, Faisal Mahmood, Jakob Nikolas Kather
Artificial intelligence (AI) has been commoditized. It has evolved from a specialty resource to a readily accessible tool for cancer researchers. AI-based tools can boost research productivity in daily workflows, but can also extract hidden information from existing data, thereby enabling new scientific discoveries. Building a basic literacy in these tools is useful for every cancer researcher. Researchers with a traditional biological science focus can use AI-based tools through off-the-shelf software, whereas those who are more computationally inclined can develop their own AI-based software pipelines...
May 16, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38740967/cancer-therapy-with-antibodies
#12
REVIEW
Suman Paul, Maximilian F Konig, Drew M Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Katharine M Wright, Sandra B Gabelli, Mitchell Ho, Andrea van Elsas, Shibin Zhou
The greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage to normal cells. Targeted therapy has been developed to meet that challenge, showing a substantially increased therapeutic index compared with conventional cancer therapies. Antibodies are important members of the family of targeted therapeutic agents because of their extraordinarily high specificity to the target antigens. Therapeutic antibodies use a range of mechanisms that directly or indirectly kill the cancer cells...
May 13, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38730113/right-on-target-a-new-ras-gtp-inhibitor
#13
JOURNAL ARTICLE
Daniela Senft
No abstract text is available yet for this article.
May 10, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38719989/aacr-2024
#14
JOURNAL ARTICLE
Gabrielle Brewer
No abstract text is available yet for this article.
May 8, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38714872/a-mega-rna-editing-tool
#15
JOURNAL ARTICLE
Victor Tieu
No abstract text is available yet for this article.
May 7, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38698127/histological-transformation-to-small-cell-carcinoma
#16
JOURNAL ARTICLE
Songji Oh, Tae Min Kim
No abstract text is available yet for this article.
May 2, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38698126/developmental-origins-shape-the-paediatric-cancer-genome
#17
REVIEW
Xiaolong Chen, Wentao Yang, Charles W M Roberts, Jinghui Zhang
In the past two decades, technological advances have brought unprecedented insights into the paediatric cancer genome revealing characteristics distinct from those of adult cancer. Originating from developing tissues, paediatric cancers generally have low mutation burden and are driven by variants that disrupt the transcriptional activity, chromatin state, non-coding cis-regulatory regions and other biological functions. Within each tumour, there are multiple populations of cells with varying states, and the lineages of some can be tracked to their fetal origins...
May 2, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38698125/connie-j-eaves-1944-2024
#18
EDITORIAL
Nagarajan Kannan, Aniruddha J Deshpande
No abstract text is available yet for this article.
May 2, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38689067/too-much-of-a-good-thing
#19
JOURNAL ARTICLE
Anna Dart
No abstract text is available yet for this article.
April 30, 2024: Nature Reviews. Cancer
https://read.qxmd.com/read/38671199/using-the-tumour-microenvironment-to-improve-therapy-efficacy
#20
JOURNAL ARTICLE
Zuzana Tatarova
No abstract text is available yet for this article.
April 26, 2024: Nature Reviews. Cancer
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