Silvia Martina Ferrari, Sabrina Rosaria Paparo, Francesca Ragusa, Giusy Elia, Valeria Mazzi, Armando Patrizio, Marco Ghionzoli, Gilda Varricchi, Marco Centanni, Salvatore Ulisse, Alessandro Antonelli, Poupak Fallahi
The chemokine receptor CXCR3 and its chemokines CXCL9, CXCL10, and CXCL11 are involved in the pathogenesis of autoimmune diseases. Th1 lymphocytes are recruited by Th1 chemokines, secreted by damaged cells. In inflamed tissues, the attracted Th1 lymphocytes induce the IFN-gamma and TNF-alpha release, that stimulates the secretion of Th1 chemokines, initiating and reiterating an amplification feedback loop. Autoimmune thyroid disorders (AITD) are the most recurrent autoimmune diseases, including Graves' disease (GD) and autoimmune thyroiditis, clinically defined by thyrotoxicosis and hypothyroidism, respectively...
March 9, 2023: Best Practice & Research. Clinical Endocrinology & Metabolism