Maurizio Chioccioli, Shuyu Liu, Sumner Magruder, Aleksandra Tata, Lucia Borriello, John E McDonough, Arvind Konkimalla, Sang-Hun Kim, Jessica Nouws, David G Gonzalez, Brian Traub, Xianjun Ye, Tao Yang, David R Entenberg, Smita Krishnaswamy, Caroline E Hendry, Naftali Kaminski, Purushothama Rao Tata, Maor Sauler
Tissue repair requires a highly coordinated cellular response to injury. In the lung, alveolar type 2 cells (AT2s) act as stem cells to replenish both themselves and alveolar type 1 cells (AT1s); however, the complex orchestration of stem cell activity after injury is poorly understood. Here, we establish longitudinal imaging of AT2s in murine intact tissues ex vivo and in vivo in order to track their dynamic behavior over time. We discover that a large fraction of AT2s become motile following injury and provide direct evidence for their migration between alveolar units...
February 14, 2024: Developmental Cell