Journals World Journal of Biological Ps...

World Journal of Biological Psychiatry
Kyle Hewitt, Xu-Feng Huang
No abstract text is available yet for this article.
May 1, 2024: World Journal of Biological Psychiatry
Sisi Zheng, Sitong Feng, Nan Song, Guangyao Chen, Yuan Jia, Guofu Zhang, Min Liu, Xue Li, Yanzhe Ning, Dan Wang, Hongxiao Jia
Objectives: Depersonalization-derealization disorder (DPD) is a dissociative disorder that impairs cognitive function and occupational performance. Emerging evidence indicate the levels of tumor necrosis factor-α and interleukin associated with the dissociative symptoms. In this study, we aimed to explore the role of the immune system in the pathology of DPD. Methods: We screened the protein expression in serum samples of 30 DPD patients and 32 healthy controls. Using a mass spectrometry-based proteomic approach, we identified differential proteins that were verified in another group of 25 DPD patients and 30 healthy controls using immune assays...
April 28, 2024: World Journal of Biological Psychiatry
A Klymenko, V Nagibin, A Horlova, Y Dobropolska, R Bohovyk, D Stroy, D Isaev, V Dosenko
Objectives. Molecular mechanisms of post-traumatic stress disorder (PTSD) development have been analyzed by evaluati-ng changes in the expression level of long non-coding RNA (lncRNA) as a potential biomarker of the disease and as one of the molecular aspects associated with the disease development. Methods. In our study, we used quantitative polymerase chain reaction (qPCR) to evaluate changes in the expression level of long non-coding RNA - Gomafu, NONMMUT033604.2, and NONMMUT064397.2 - in the hippocampus of mice that were subjected to an artificially induced middle single prolonged stress (mSPS) model of post-traumatic stress disorder...
April 17, 2024: World Journal of Biological Psychiatry
Zijie Zeng, Weilong Tang
OBJECTIVES: This study aims to explore the potential interconnections among gut microbiota, COVID-19 infection, depression and anxiety disorder. Additionally, it tries to assess potential therapeutic interventions that may improve the dysbiosis of gut microbiota. METHODS: To achieve these objectives, we reviewed existing literature, encompassing studies and critical reviews that intersect the domains of gut microbiota, COVID-19, depression and anxiety disorders...
April 12, 2024: World Journal of Biological Psychiatry
Maike Scherf-Clavel, Heike Weber, Stefan Unterecker, Daniel J Müller, Jürgen Deckert
OBJECTIVES: Previous results demonstrated that CYP2D6 and CYP2C19 gene variants affect serum concentrations of antidepressants. We implemented a PGx service determining gene variants in CYP2D6 and CYP2C19 in our clinical routine care and report on our first patient cohort. METHODS: We analyzed CYP2D6 and CYP2C19 allele, genotype, and phenotype frequencies, and actionable pharmacogenetic variants in this German psychiatric inpatient cohort. Two-tailed z-test was used to investigate for differences in CYP2D6 and CYP2C19 phenotypes and actionable/non-actionable genetic variant frequencies between our cohort and reference cohorts...
March 17, 2024: World Journal of Biological Psychiatry
Elena Michaelovsky, Miri Carmel, Doron Gothelf, Abraham Weizman
Objectives: 22q11.2 deletion is the most prominent risk factor for schizophrenia (SZ). The aim of the present study was to identify unique transcriptome profile for 22q11.2 deletion syndrome (DS)-related SZ spectrum disorder (SZ-SD). Methods: We performed RNA-Seq screening in lymphoblasts collected from 20 individuals with 22q11.2DS (10 men and 10 women, 4 of each sex with SZ-SD and 6 with no psychotic disorders (Np)). Results: Sex effect in RNA-Seq descriptive analysis led to separating the analyses between men and women...
March 17, 2024: World Journal of Biological Psychiatry
Friederike Ehrhart, Ana Silva, Therese van Amelsvoort, Emma vonScheibler, Chris Evelo, David E J Linden
Objectives: Schizophrenia genetics is complex, and the contribution of common and rare variants are not fully understood. Several specific copy number variations (CNVs) confer increased risk, and the study of their effects is central to molecular models of mental disorders. However, these CNVs are spread across the genome and differ in the number of genes affected and classes of coded proteins. This diversity suggests that we need to look beyond the deleted or duplicated genes, to their interaction partners and involved molecular pathways...
March 17, 2024: World Journal of Biological Psychiatry
Mattia Campana, Thomas Schneider-Axmann, Thomas Wobrock, Berend Malchow, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Joachim Cordes, Wolfgang Wölwer, Wolfgang Gaebel, Georg Winterer, Göran Hajak, Christian Ohmann, Pablo E Verde, Marcella Rietschel, Raees Ahmed, Matin Mortazavi, Wolfgang Strube, Peter Falkai, Alkomiet Hasan, Elias Wagner
Background: The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject´s sex critically influences rTMS´ treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ data is scarce. Methods: Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we assessed the impact of sex on rTMS´ clinical response rate from screening up to 105 days after intervention among SCZ patients...
March 17, 2024: World Journal of Biological Psychiatry
Mehmet Kemal Arıkan, Reyhan İlhan, Özden Orhan, Muhammed Taha Esmeray, Şenol Turan, Şakir Gica, Hasan Bakay, Oliver Pogarell, Kâşif Nevzat Tarhan, Barış Metin
OBJECTIVES: Event-related potential measures have been extensively studied in mental disorders. Among them, P300 amplitude and latency reflect impaired cognitive abilities in major depressive disorder (MDD). The present systematic review and meta-analysis was conducted to investigate whether patients with MDD differ from healthy controls (HCs) with respect to P300 amplitude and latency. METHODS: PubMed and Web of Science databases were searched from inception to 15 January 2023 for case-control studies comparing P300 amplitude and latency in patients with MDD and HCs...
March 17, 2024: World Journal of Biological Psychiatry
Mathias DeBock, Pascal Sienaert
Objectives: Corticosteroids are widely prescribed for a variety of medical conditions. Accumulating evidence suggests that their use may be associated with adverse psychiatric effects, including mania. In this systematic review, we aim to critically evaluate the existing literature on the association between corticosteroid use and the emergence of mania. Methods: We conducted a comprehensive search of major electronic databases (PubMed, Embase, Cochrane Library) for relevant studies published up to the date of the search (January 12th , 2023)...
February 16, 2024: World Journal of Biological Psychiatry
Brian Dean, Elizabeth Scarr
OBJECTIVES: This study sought to identify pathways affected by rat cortical RNA that were changed after treatment with fluoxetine or imipramine. METHODS: We measured levels of cortical RNA in male rats using GeneChip® Rat Exon 1.0 ST Arrayafter treatment with vehicle (0.9% NaCl), fluoxetine (10mg/kg/day) or imipramine (20 mg/kg/day) for 28 days. Levels of coding and non-coding RNA in vehicle treated rats were compared to those in treated rats using ANOVA in JMP Genomics 13 and the Panther Gene Ontology Classification System was used to identify pathways involving the changed RNAs...
February 13, 2024: World Journal of Biological Psychiatry
Christopher Gandar, James G Scott, Nicola Warren
OBJECTIVES: Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD) is the most common enzymopathy globally. Early studies suggested an association with severe psychotic illness; however, changes to laboratory testing and diagnostic classification renders the association unclear. This study aims to explore the interaction between G6PD deficiency and psychotic symptoms, in particular to identify specific patterns of presentation or impact on outcomes. METHODS: Pubmed, Embase, and PsycInfo databases were searched from inception to May 2023...
February 2024: World Journal of Biological Psychiatry
Xue Li, Sisi Zheng, Zhengtian Feng, Xinzi Liu, Ying Ding, Lina Zhang, Guofu Zhang, Min Liu, Hong Zhu, Hongxiao Jia
OBJECTIVES: The prevalence of generalised anxiety disorder (GAD) is high. However, the underlying mechanisms remain elusive. Proteomics techniques can be employed to assess the pathological mechanisms involved in GAD. METHODS: Twenty-two drug-naive GAD patients were recruited, their serum samples were used for protein quantification and identified using Tandem Mass Tag and Multiple Reaction Monitoring (MRM). Machine learning models were employed to construct predictive models for disease occurrence by using clinical scores and target proteins as input variables...
January 21, 2024: World Journal of Biological Psychiatry
Rajamannar Ramasubbu, Elliot C Brown, Pauline Mouches, Jasmine A Moore, Darren L Clark, Christine P Molnar, Zelma H T Kiss, Nils D Forkert
OBJECTIVES: This study compared machine learning models using unimodal imaging measures and combined multi-modal imaging measures for deep brain stimulation (DBS) outcome prediction in treatment resistant depression (TRD). METHODS: Regional brain glucose metabolism (CMRGlu), cerebral blood flow (CBF), and grey matter volume (GMV) were measured at baseline using 18F-fluorodeoxy glucose (18F- FDG) positron emission tomography (PET), arterial spin labelling (ASL) magnetic resonance imaging (MRI), and T1-weighted MRI, respectively, in 19 patients with TRD receiving subcallosal cingulate (SCC)-DBS...
January 7, 2024: World Journal of Biological Psychiatry
Na Li, Junjuan Yan, Chang Xu, Ying Li, Yonghua Cui
BACKGROUND: Sleep problems are commonly observed in patients with tic disorders. Nevertheless, studies have demonstrated a wide variation in the prevalence of sleep disturbances among this population. Consequently, it remains ambiguous whether sleep issues are inherently characteristic of tic disorders or are influenced by external factors. METHODS: We conducted a comprehensive search across various databases and performed a meta-analysis to determine the prevalence of sleep problems in tic disorders...
November 27, 2023: World Journal of Biological Psychiatry
Hailong Lyu, Miaomiao Zhao, Pengfeng Xu, Ying Li, Chaonan Jiang, Haoyang Zhao, Wenjing Shen, Xiaohan Hu, Kaiqi Wang, Yi Xu, Manli Huang
BACKGROUND: Gender plays a role in the mechanisms of depression, but fewer studies have focused on gender differences in the abnormal activation of brain regions when patients perform specific cognitive tasks. METHODS: A total of 110 major depressive disorder (MDD) patients and 106 healthy controls were recruited. The relative change in oxygen-haemoglobin (oxy-Hb) concentration during the verbal fluency task were measured by a 52-channel near-infra-red spectroscopy (NIRS) system...
November 24, 2023: World Journal of Biological Psychiatry
Lisa Koole, Pilar Martinez-Martinez, Therese van Amelsvoort, Chris T Evelo, Friederike Ehrhart
Objectives: Schizophrenia is a psychiatric disorder affecting 1% of the population. Accumulating evidence indicates that neuroinflammation is involved in the pathology of these disorders by altering neurodevelopmental processes and specifically affecting glutamatergic signalling and astrocytic functioning. The aim of this study was to curate interactive biological pathways involved in schizophrenia for the identification of novel pharmacological targets implementing pathway, gene ontology, and network analysis...
November 14, 2023: World Journal of Biological Psychiatry
Qianfa Yuan, Yuying Lei, Kai Yu, Junnan Wu, Zhizhong Xu, Chunyan Wen, Yanlong Liu, Wenqiang Wang, Jue He
Repetitive transcranial magnetic stimulation (rTMS) has been considered as an effective antidepressant treatment; however, the mechanism of its antidepressant effect is still unclear. Fluoxetine, a selective serotonin reuptake inhibitor antidepressant, may be neuroprotective. The objective of the present study was to evaluate the effect and underlying possible neuroprotective mechanism of rTMS and fluoxetine on abnormal behaviors in a depressive mouse model induced by chronic unpredictable mild stress (CUMS)...
November 9, 2023: World Journal of Biological Psychiatry
Xiaoli Wang, Jun Xie, Hongyun Ma, Gang Li, Meijuan Li, Shen Li, Xiaoxiao Sun, Yongping Zhao, Wei Sun, Shu Yang, Jie Li
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsychotic-naïve female schizophrenia patients (ANS) and 19 healthy female controls (HC) were recruited. Plasma samples were obtained from all participants, and targeted metabolomics were measured with FIA-MS/MS and LC-MS/MS. The positive and negative syndrome scale (PANSS) was used to assess the severity of psychotic symptoms before and after eight weeks of treatment...
October 22, 2023: World Journal of Biological Psychiatry
Pablo G Vázquez, Susan Whitfield-Gabrieli, Clemens C C Bauer, Fernando A Barrios
OBJECTIVE: During hypnosis, significant changes in the BOLD signal associated with the anterior default mode network (DMN) and prefrontal attentional systems have been reported as evidence of dissociation defined since Charcot. However, it remains uncertain whether these changes are mainly attributable to the hypnotic state per se or to the target suggestions used to verify subject's state during neuroimaging studies. The aim of the present study is to evidence the brain in hypnosis, contrasting the common resting state versus neutral hypnosis (hypnosis in the absence of target suggestions)...
October 2, 2023: World Journal of Biological Psychiatry
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