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World Journal of Biological Psychiatry

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https://read.qxmd.com/read/30632868/wfsbp-and-iawmh-guidelines-for-the-treatment-of-alcohol-use-disorders-in-pregnant-women
#1
Florence Thibaut, Abdeslam Chagraoui, Leslie Buckley, Florence Gressier, Javier Labad, Sandrine Lamy, Marc N Potenza, Marta Rondon, Anita Rossler, Michael Soyka, Kim Yonkers
OBJECTIVES: These practice guidelines for the treatment of alcohol use disorders during pregnancy were developed by members of the International Task Force of the World Federation of Societies of Biological Psychiatry and the International Association for Women's Mental Health. METHODS: We performed a systematic review of all available publications and extracted data from national and international guidelines. The Task Force evaluated the data with respect to the strength of evidence for the efficacy and safety of each medication...
January 11, 2019: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30623717/pharmacogenetics-of-tardive-dyskinesia-in-schizophrenia-the-role-of-chrm1-and-chrm2-muscarinic-receptors
#2
Anastasiia S Boiko, Svetlana A Ivanova, Ivan V Pozhidaev, Maxim B Freidin, Diana Z Osmanova, Olga Yu Fedorenko, Arkadyi V Semke, Nikolay A Bokhan, Bob Wilffert, Anton J M Loonen
OBJECTIVES: Acetylcholine M (muscarinic) receptors are possibly involved in tardive dyskinesia (TD). The authors tried to verify this hypothesis by testing for possible associations between two muscarinic receptor genes (CHRM1 and CHRM2) polymorphisms and TD in patients with schizophrenia. METHODS: A total of 472 patients with schizophrenia were recruited. TD was assessed cross-sectionally using the Abnormal Involuntary Movement Scale. Fourteen allelic variants of CHRM1 and CHRM2 were genotyped using Applied Biosystems amplifiers (USA) and the MassARRAY System by Agena Bioscience...
January 9, 2019: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30608182/a-positive-association-between-a-polymorphism-in-the-htr2b-gene-and-cocaine-crack-in-a-french-afro-caribbean-population
#3
Jerome Lacoste, Sandrine Lamy, Nicolas Ramoz, Nicolas Ballon, Louis Jehel, Luc Maroteaux, Florence Thibaut
OBJECTIVES: Cocaine dependence has a strong heritability component. The aim of this study was to investigate the putative association between the serotonin 2B receptor gene (HTR2B), crack use disorders and impulsivity. METHODS: A French Afro-Caribbean male population of patients with crack use disorders (n = 80) was compared to healthy Afro-Caribbean male controls (n = 60). Comorbid ADHD and impulsivity were assessed. Five single nucleotide polymorphisms in the HTR2B gene were selected: rs643700, rs6736017, rs1549339, rs17586428 and rs3806545 These SNPs were chosen to include most of the linkage disequilibrium (LD) blocks in the HTR2B gene...
January 4, 2019: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30560709/the-relationship-between-physical-activity-clinical-and-cognitive-characteristics-and-bdnf-mrna-levels-in-patients-with-severe-mental-disorders
#4
Monica Aas, Srdjan Djurovic, Torill Ueland, Ragni H Mørch, Jannicke Fjaera Laskemoen, Elina J Reponen, Annamaria Cattaneo, Nils Eiel Steen, Ingrid Agartz, Ingrid Melle, Ole A Andreassen
BACKGROUND: Here we aimed to clarify the association of physical activity with cognitive function and current mood in severe mental disorders in the most extensive sample to date. Secondly, we aimed to investigate the relationship between physical activity and BDNF mRNA levels. METHODS: Three hundred and six patients with a DSM-IV Schizophrenia (SZ) or Bipolar Disorder spectrum (BD) diagnosis were included. Clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV...
December 18, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30526182/wfsbp-guidelines-on-how-to-grade-treatment-evidence-for-clinical-guideline-development
#5
Alkomiet Hasan, Borwin Bandelow, Lakshmi N Yatham, Michael Berk, Peter Falkai, Hans-Jürgen Möller, Siegfried Kasper
This manuscript reviews sources of data typically used in guideline development, available grading systems, their pros and cons, and the methods for evaluating risks of bias in publications, and proposes a revised method for grading evidence and recommendations for use in development of clinical treatment guidelines. The new World Federation of Societies of Biological Psychiatry (WFSBP) grading system allows guideline developers to follow a multi-step approach of defining Levels of Evidence (LoE), applying criteria for grading (define the acceptability) and the Grading of Recommendations (GoR)...
December 11, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30513253/autoimmune-encephalitis-with-psychosis-warning-signs-step-by-step-diagnostics-and-treatment
#6
Johann Steiner, Harald Prüss, Stephan Köhler, Thomas Frodl, Alkomiet Hasan, Peter Falkai
OBJECTIVES: Despite intensive research, schizophrenia and schizoaffective disorders continue to be theoretical constructs that describe clinical syndromes and no pathophysiologically defined diseases. Moreover, there are no clear biomarkers at hand. Therefore, these diagnoses are still set up based on clinical ICD-10 / DSM-5 criteria and the exclusion of alcohol- / drug-associated, systemic or other brain organic causes. METHODS: Recently, autoimmune encephalitis with psychotic symptoms caused by specific antineuronal antibodies has been identified as rare, but potentially treatable differential diagnosis...
December 4, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30513246/changes-in-cortical-protein-markers-of-iron-transport-with-gender-major-depressive-disorder-and-suicide
#7
Brian Dean, Andrew Tsatsanis, Linh Q Lam, Elizabeth Scarr, James A Duce
OBJECTIVES: The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis could be involved in the pathophysiology of mood disorders. METHODS: Levels of select proteins responsible for cortical iron transport were quantitated by Western blotting of Brodmann's (BA) areas 6 and 10 from patients with major depressive disorder (n = 13), bipolar disorder (n = 12) and age/sex matched controls (n = 13). RESULTS: We found the inactive form of ceruloplasmin was lower in BA 6 from males compared to females...
December 4, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30513034/cigarette-smoking-and-heavy-coffee-consumption-affecting-response-to-olanzapine-the-role-of-genetic-polymorphism
#8
Natasa Djordjevic, Branimir Radmanovic, Jelena Cukic, Dejan Baskic, Slavica Djukic-Dejanovic, Dragan Milovanovic, Eleni Aklillu
OBJECTIVES: To evaluate the effect of cigarette smoking and heavy coffee consumption on efficacy and safety of olanzapine treatment in schizophrenia patients, in relation to genetic polymorphism. METHODS: The study involved 120 patients with schizophrenia, treated with olanzapine for 30 days. Therapy efficacy was determined using three different psychiatric scales, and safety by assessing metabolic adverse effects and extrapyramidal symptoms. Genotyping included CYP1A2*1C, CYP1A2*1F and CYP1A1/1A2 intergenic polymorphism, as well as CYP2D6*3, CYP2D6*4 and CYP2D6*6...
December 4, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30501451/mrna-expression-of-the-p5-atpase-atp13a4-is-increased-in-broca-s-area-from-subjects-with-schizophrenia
#9
Andrew Gibbons, Laura Bell, Madhara Udawela, Brian Dean
OBJECTIVE: ATPase Type 13A4 (ATP13A4) is a cation-transporting, P5 -type ATPase that has been implicated in neurodevelopmental disorders. Our recent microarray study reported a significant increase in ATP13A4 mRNA levels in Brodmann's Area (BA) 9 in subjects with schizophrenia compared to controls. Following this discovery we have sought to determine whether ATP13A4 expression was altered in other regions of the CNS that are affected in schizophrenia. METHODS: Quantitative PCR was used to measure the levels of ATP13A4 in BA 44 and BA 8, collected post-mortem, from 30 subjects with schizophrenia and 30 non-psychiatric control subjects...
December 3, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30489189/weighted-gene-co-expression-network-analysis-identifies-specific-modules-and-hub-genes-related-to-subsyndromal-symptomatic-depression
#10
Ruijie Geng, Zezhi Li, Shunying Yu, Chengmei Yuan, Wu Hong, Zuowei Wang, Qingzhong Wang, Zhenghui Yi, Yiru Fang
OBJECTIVES: The identification of the potential molecule targets for subsyndromal symptomatic depression (SSD) is critical for improving the effective clinical treatment on the mental illness. In the current study, we mined the genome-wide expression profiling and investigated the novel biological pathways associated with SSD. METHODS: Expression of the DEG were analyzed with microarrays of blood tissue cohort of 8 SSD patients and 8 healthy subjects. The gene co - expression is calculated by WGCNA, a R package software...
November 29, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30777810/editorial
#11
Siegfried Kasper
No abstract text is available yet for this article.
January 2019: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30747559/editorial
#12
Siegfried Kasper
No abstract text is available yet for this article.
December 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30230399/randomized-crossover-feasibility-trial-of-helminthic-trichuris-suis-ova-versus-placebo-for-repetitive-behaviors-in-adult-autism-spectrum-disorder
#13
Eric Hollander, Genoveva Uzunova, Bonnie P Taylor, Rachel Noone, Emma Racine, Ellen Doernberg, Katherine Freeman, Casara Jean Ferretti
OBJECTIVES: Inflammatory mechanisms are implicated in the aetiology of autism spectrum disorder (ASD), and use of the immunomodulator Trichuris suis Ova (TSO) is a novel treatment approach. This pilot study determined the effect sizes for TSO versus placebo on repetitive behaviours, irritability and global functioning in adults with ASD. METHODS: A 28-week double-blind, randomised two-period crossover study of TSO versus placebo in ten ASD adults, aged 17-35, was completed, with a 4-week washout between each 12-week period at Montefiore Medical Center, Albert Einstein College of Medicine...
November 16, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30394174/schizophrenia-and-the-microbiome-time-to-focus-on-the-impact-of-antipsychotic-treatment-on-the-gut-microbiota
#14
Timothy G Dinan, John F Cryan
No abstract text is available yet for this article.
November 5, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30381986/expanding-the-collection-of-neuroimaging-tools-in-psychiatry
#15
Georg S Kranz, Jack J Q Zhang
No abstract text is available yet for this article.
November 1, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30230406/effects-of-agomelatine-on-behaviour-circadian-expression-of-period-1-and-period-2-clock-genes-and-neuroplastic-markers-in-the-predator-scent-stress-rat-model-of-ptsd
#16
Hagit Cohen, Joseph Zohar, Lior Carmi
OBJECTIVES: The therapeutic value of the antidepressant agomelatine in the aftermath of traumatic experience and early post-reminder has been questioned. Herein, agomelatine, its vehicle or melatonin agonist were administered either acutely 1 h post-stressor or repeatedly (7 days) after early post-reminder in a post-traumatic stress rat model (PSS) using the scent of predator urine. METHODS: Behavioural responses, and brain molecular and morphological changes were evaluated after each treatment procedure in PSS-exposed and unexposed rats...
November 1, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30051738/can-in-utero-zika-virus-exposure-be-a-risk-factor-for-schizophrenia-in-the-offspring
#17
Johnathan Pierson, Rajashekar Reddy Yeruva, Rif S El-Mallakh
OBJECTIVES: Schizophrenia is a severe psychiatric illness that has been purported to be causally related to in utero infection of neurotropic organisms. For obvious ethical reasons, this hypothesis has never been tested prospectively in humans. However, with the recent introduction of Zika virus into the New World offers the opportunity to test the hypothesis of infection in schizophrenia. METHODS: This is a directed review examining the hypothesis. The literature relevant to Zika virus transmission in the New World, its biology and neurotropy is reviewed...
October 29, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30311817/in-utero-zika-virus-exposure-and-schizophrenia
#18
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
October 12, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30295120/early-versus-late-stage-schizophrenia-what-markers-make-the-difference
#19
L García-Álvarez, M P García-Portilla, J R Caso, L de la Fuente-Tomás, L González-Blanco, P Sáiz Martínez, J C Leza, J Bobes
OBJECTIVES: To identify the psychopathological, cognitive, functional, physical health and inflammatory markers that differentiate between early-stage schizophrenia (ESSCH) and late-stage schizophrenia (LSSCH). METHODS: Cross-sectional, naturalistic study of 104 patients with SCH. The sample was divided in two groups: 35 ESSCH (≤7 years' duration of illness) and 69 LSSCH (>10 years' duration of illness). STATISTICAL ANALYSIS: chi-square test and Student's t-test and ANCOVA (or Quade test) controlling for age, sex, BMI and number of cigarettes/day...
October 8, 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30295116/effects-of-serotonin-depletion-and-dopamine-depletion-on-bimodal-divided-attention
#20
W Königschulte, C Civai, P Hildebrand, T J Gaber, G R Fink, F D Zepf
OBJECTIVES: This study aimed to explore the effects of acute phenylalanine-tyrosine depletion (APTD) and acute tryptophan depletion (ATD) on bimodal divided attention. A balanced amino acid mixture (BAL) served as control condition. METHODS: 54 healthy adults (age: M = 23.8 years) were randomly assigned to APTD, ATD or BAL in a double-blind, between-subject approach. Divided attention was assessed after 4 hours. Blood samples were taken before and 6 hours after challenge intake...
October 8, 2018: World Journal of Biological Psychiatry
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