Sandra Elizabeth Barbosa da Silva, José Arion da Silva Moura, Jeann Fabiann Branco Júnior, Paulo André Teixeira de Moraes Gomes, Simão Kalebe Silva de Paula, Douglas Carvalho Francisco Viana, Eduardo Augusto Vasconcelos de Freitas Ramalho, João Victor de Melo Gomes, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta, Marina Galdino da Rocha Pitta
BACKGROUND: Inflammation is a series of complex defense-related reactions. The inflammation cascade produces various pro-inflammatory mediators. Unregulated production of these pro-inflammatory mediators can lead to a wide range of diseases, including rheumatoid arthritis, sepsis, and inflammatory bowel disease. In the literature, the anti-inflammatory action of quinoline and thiazolidinedione nuclei are well established, alone, and associated with other nuclei. The synthesis of hybrid molecules is a strategy for obtaining more efficient molecules due to the union of pharmacophoric nuclei known to be related to pharmacological activity...
March 21, 2024: Current Topics in Medicinal Chemistry