Journals Current Topics in Medicinal Ch...

Current Topics in Medicinal Chemistry
Małgorzata Geszke-Moritz, Gerard Nowak, Michał Moritz, Barbara Feist, Jacek E Nycz
Osteoarthritis (OA) is a common chronic articular degenerative disease characterized by articular cartilage degradation, synovial inflammation/immunity, and subchondral bone lesions. Recently, increasing interest has been devoted to treating or preventing OA with herbal medicines. The mechanism of action of plant raw materials used in osteoarthrosis treatment is well documented. They are sought after because of the high frequency of inflammation of the knee joint among both elderly and young people engaged in sports in which their knee joints are often exposed to high-stress conditions...
June 11, 2024: Current Topics in Medicinal Chemistry
Vishal Chavda, Dhananjay Yadav, Harisinh Parmar, Raxit Brahmbhatt, Bipin Patel, Kajal Madhwani, Meenu Jain, Minseok Song, Snehal Patel
The global pandemic known as coronavirus disease (COVID-19) is causing morbidity and mortality on a daily basis. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) virus has been around since December 2019 and has infected a high number of patients due to its idiopathic pathophysiology and rapid transmission. COVID-19 is now deemed a newly identified "syndrome" condition since it causes a variety of unpleasant symptoms and systemic side effects following the pandemic. Simultaneously, it always becomes potentially hazardous when new variants develop during evolution...
June 10, 2024: Current Topics in Medicinal Chemistry
Saurabh G Londhe, Mangala Shenoy, Suvarna G Kini, Vinayak Walhekar, Dileep Kumar
BACKGROUND: Alzheimer's disease (AD) stands out as one of the most devastating and prevalent neurodegenerative disorders known today. Researchers have identified several enzymatic targets associated with AD among which Glycogen synthase kinase-3β (GSK-3β) and Acetylcholinesterase (AChE) are prominent ones. Unfortunately, the market offers very few drugs for treating or managing AD, and none have shown significant efficacy against it. OBJECTIVES: To address this critical issue, the design and discovery of dual inhibitors will represent a potential breakthrough in the fight against AD...
June 7, 2024: Current Topics in Medicinal Chemistry
Anjali Mahavar, Atul Patel, Ashish Patel
Alzheimer's Disease (AD) is a serious neurological illness that causes memory loss gradually by destroying brain cells. This deadly brain illness primarily strikes the elderly, impairing their cognitive and bodily abilities until brain shrinkage occurs. Modern techniques are required for an accurate diagnosis of AD. Machine learning has gained attraction in the medical field as a means of determining a person's risk of developing AD in its early stages. One of the most advanced soft computing neural network-based Deep Learning (DL) methodologies has garnered significant interest among researchers in automating early-stage AD diagnosis...
June 6, 2024: Current Topics in Medicinal Chemistry
Saba Farooq, Zainab Ngaini
Flavonoids belong to the polyphenol group that naturally exists in fruits, vegetables, tea, and grains. Flavonoids, as secondary metabolites, show indispensable contributions to biolog-ical processes and the responses of plants to numerous environmental factors. The bioactivity of flavonoids depends on C6-C3-C6 ring substitution patterns that exhibit bioactive antioxidant, an-timicrobial, antifungal, antitumor, and anti-inflammatory properties. The synthesis of flavonoids has been reported by various methodologies...
June 5, 2024: Current Topics in Medicinal Chemistry
Batoul Kavyani, Ali Afgar, Sajjad Kavyani, Masoud Rezaei, Fatemeh Sharifi, Roya Ahmadrajabi, Fereshteh Saffari
BACKGROUND: Colorectal cancer (CRC) treatment using time-saving and cost-effective targeted therapies with high selectivity and low toxicity drugs, is a great challenge. In primary investigations on Gallocin, as a most proposed factor in CRC pathogenesis caused by Streptococcus gallolyticus, it was surprisingly found that this bacteriocin has four α-helix structures and some anti- cancer sequences. OBJECTIVE: The aim of this study was to determine the ability of Gallocin-based anticancer peptides (ACPs) against epidermal growth factor receptor (EGFR) and vascular epidermal growth factor receptor (VEGFR) and the evaluation of their pharmacokinetics properties using bioinformatics approaches...
June 4, 2024: Current Topics in Medicinal Chemistry
Nidhika Rana, Aditi Kaushik, M S Ashawat, Amardeep Ankalgi, Ankit Sharma
Dentoalveolar abscesses are localized infections within the tooth or the surrounding alveolar bone, often resulting from untreated dental caries or dental trauma causing alveolar bone resorption or even loss. Serious consequences arising from the spread of a dental abscess can often lead to significant morbidity and mortality. The acute dentoalveolar abscess is a polymicro-bial infection comprising strict anaerobes, such as anaerobic cocci i.e., Prevotella fusobacterium species, and facultative anaerobes i...
June 4, 2024: Current Topics in Medicinal Chemistry
Tatsunosuke Tomita, Renu Wadhwa, Yoshiaki Onishi
Circadian rhythms of innate 24 h cycles comprise well-conserved biological phenomena from cyanobacteria to mammalian. They are driven by light and regulated by clock genes that work as transcription factors and control the expression of many other genes and physiological functions in the cells. The expression of ~ 40% of protein-coding genes shows 24 h oscillation patterns in mice, implying their importance in normal body functions. Indeed, the physiological and behavioural rhythmicity generated through clock genes-mediated multiple mechanisms affects the quality of life at large...
May 30, 2024: Current Topics in Medicinal Chemistry
Ram Kumar, M Arockia Babu, Shilpi Pathak
Benzimidazole is a privileged drug design and discovery scaffold with various phar-macological activities, including antimicrobial, anticancer, antitubercular, anti-inflammatory, an-tidiabetic, antihypertensive, antimalarial, and many more. This scaffold can be observed in the structure of numerous FDA-approved drugs and employed in medicinal chemistry to develop novel bioactive compounds through rational drug design. Its broad pharmacological significance is due to physicochemical attributes, including H-bond donor-acceptor efficiency, π-π stacking interactions, and hydrophobic interactions; these characteristics enable benzimidazole derivatives to bind with macromolecules efficiently...
May 30, 2024: Current Topics in Medicinal Chemistry
M D Abubakar, Lokesh Nama, Md Arif Ansari, Mohd Mazharuddin Ansari, Shivani Bhardwaj, Rajni Daksh, Katta Leela Venkata Syamala, Mohini Santosh Jamadade, Vishal Chhabra, Dileep Kumar, Nitesh Kumar
BACKGROUND: Alzheimer's disease (AD) is a widespread neurological illness in the elderly, which impacted about 50 million people globally in 2020. Type 2 diabetes has been identified as a risk factor. Insulin and incretins are substances that have various impacts on neurodegenerative processes. Preclinical research has shown that GLP-1 receptor agonists decrease neuroinflammation, tau phosphorylation, amyloid deposition, synaptic function, and memory formation. Phase 2 and 3 studies are now occurring in Alzheimer's disease populations...
May 27, 2024: Current Topics in Medicinal Chemistry
Yuli Wang, Qiaoling Chen, Jiaqi Zhang, Yun Deng, Changyu Liu, Shuangcui Wang, Maojuan Guo, Lili Song
Cardio-cerebrovascular disease has seen a rapid rise in recent years, with Heart Failure (HF) -- a terminal stage of various cardiovascular diseases -- also on the rise. HF has a complex pathogenesis involving multiple factors, such as inflammation, fibrosis, and oxidative stress. Due to its unique reverse shear mechanism, HF exhibits distinct expression patterns across different diseases. CircRNA has been linked to conditions like cancer, diabetes, and osteoarthritis. This article briefly introduces the mechanisms of circRNA biogenesis and its associated biological functions, focusing on CircSLC8A1-1, CircRNA_000203, and others at the early stage of HF, CircRNA PAN3, CircRNA (ACR), and others during the progression of HF, and CircHIPK3, CircNfix, and others at the end stage of HF...
May 24, 2024: Current Topics in Medicinal Chemistry
Shahram Taeb, Davoud Rostamzadeh, Seyed Mohammad Amini, Mohamad Rahmati, Mostafa Golshekan, Mahmoud Abedinzadeh, Elham Ahmadi, Singh Neha, Masoud Najafi
In recent years, mesenchymal stem cells (MSCs) have emerged as promising anti-- cancer mediators with the potential to treat several cancers. MSCs have been modified to produce anti-proliferative, pro-apoptotic, and anti-angiogenic molecules that could be effective against a variety of malignancies. Additionally, customizing MSCs with cytokines that stimulate pro-tumorigenic immunity or using them as vehicles for traditional chemical molecules with anti-cancer characteristics. Even though the specific function of MSCs in tumors is still challenged, promising outcomes from preclinical investigations of MSC-based gene therapy for a variety of cancers inspire the beginning of clinical trials...
May 23, 2024: Current Topics in Medicinal Chemistry
Caroline de S Barros, Claudio C Cirne-Santos, Priscilla O Esteves, Max W L Gomes, Vítor W Rabelo, Thamyres M Santos, Valéria L Teixeira, Izabel C N de P Paixão
INTRODUCTION: Zika virus (ZIKV) is a flavivirus transmitted through the bites of infected Aedes mosquitoes. These viruses can also be transmitted through sexual contact, vertical transmission, and possibly transfusion. Most cases are asymptomatic, but symptoms can include rash, conjunctivitis, fever, and arthralgia, which are characteristic of other arboviruses. Zika infection can lead to complications such as microcephaly, miscarriage, brain abnormalities, and Guillain-Barré syndrome (GBS)...
May 23, 2024: Current Topics in Medicinal Chemistry
Pompy Patowary, Manash Pratim Pathak, Pervej Alom Barbhuiya, Sanjeev Karmakar, Pronobesh Chattopadhyay, Kamaruz Zaman
Introduced into law enforcement in 1976, the oleoresin capsicum (OC) spray has been labeled as one of the most significant and radical developments in law enforcement. However, epidemiological research on OC health effects is deficient, receiving little public support. The major responses to acute exposure to OC spray can be found in the pulmonary system. The molecular mechanism(s) involved in the action of capsaicinoids, the active constituents in OC, are complex cascades of reactions which end up in necrosis or apoptosis...
May 22, 2024: Current Topics in Medicinal Chemistry
Patrícia Ribeiro Orlando, Hugo Giordano Tavares, Ramona Ramalho de Souza Pereira, Gabriela Silva, Jaqueline do Carmo Lima Carvalho, Alan Rodrigues Teixeira Machado, Leonardo Barros Dobbs, Marco Fabrício Dias-Peixoto, Luciano José Pereira, Eric Francelino Andrade
BACKGROUND: Humic acid (HA) is a bioproduct that can be extracted from different sources and has anti-inflammatory properties that have been little explored in the treatment and prevention of Periodontal Disease (PD). Thus, we aimed to investigate the effects of oral administration of HA on the progression of PD in rats. METHODS: Twenty-four male Wistar rats were distributed into three experimental groups (Control/ Sham, PD, and PD + HA). HA was administered by gavage (80 mg/kg/day) for 28 days, and PD was induced 14 days after the beginning of treatment...
May 20, 2024: Current Topics in Medicinal Chemistry
Leandro Bueno Bergantin
May 20, 2024: Current Topics in Medicinal Chemistry
Suman Rohilla, Garima Goyal, Paras Berwal, Nancy Mathur
Molecular hybridization is a rational design strategy used to create new ligands or pro-totypes by identifying and combining specific pharmacophoric subunits from the molecular struc-tures of two or more known bioactive derivatives. Molecular hybridization is a valuable technique in drug discovery, enabling the modulation of unwanted side effects and the creation of potential dual-acting drugs that combine the effects of multiple therapeutic agents. Indole-triazole conju-gates have emerged as promising candidates for new drug development...
May 17, 2024: Current Topics in Medicinal Chemistry
Seyed Morteza Naghib, Bahar Ahmadi, M R Mozafari
Chitosan-based nanoparticles have emerged as a promising tool in the realm of cancer therapy, particularly for gene delivery. With cancer being a prevalent and devastating disease, finding effective treatment options is of utmost importance. These nanoparticles provide a unique solution by encapsulating specific genes and delivering them directly to cancer cells, offering immense potential for targeted therapy. The biocompatibility and biodegradability of chitosan, a naturally derived polymer, make it an ideal candidate for this purpose...
May 14, 2024: Current Topics in Medicinal Chemistry
Sangita Saini, Sumit Tahlan, Neha Minocha
Benzodiazepines are commonly prescribed drugs for numerous indications such as epilepsy, anti-anxiety, sleep aids, sedatives, and hypnotics. Although the well-tolerated effects of benzodiazepine are seen in many clinical instances, the severity of side effects reduces its quantifiable use. Benzodiazepines, which are medically useful but theoretically unsafe, are frequently recommended by medical practitioners for psychotic patients but have misuse and dependence liabilities. It is impelled as a debateable topic globally about which no one talks...
May 10, 2024: Current Topics in Medicinal Chemistry
Nefeli Theodora Tsilimingkra, Christos Papaneophytou
BACKGROUND: Human rhinovirus 3C protease (HRV-3Cpro) plays a crucial role in viral proliferation, establishing it as a prime target for antiviral therapy. However, research on identifying HRV-3Cpro inhibitors is still limited. OBJECTIVE: This study had two primary objectives: first, to validate the efficacy of an end-point colorimetric assay, previously developed by our team, for identifying potential inhibitors of HRV-3Cpro; and second, to discover phytochemicals in medicinal plants that inhibit the enzyme's activity...
May 2, 2024: Current Topics in Medicinal Chemistry
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