Larissa Koidl, Salvatore Alessio Gentile, Eva Untersmayr
PURPOSE OF REVIEW: The globally rising food allergy prevalence is associated with the urgent need for new disease prevention methods, efficient treatment, and reliable risk assessment methods for characterization of food allergens. Due to inter-individual variations in the digestive system, food allergens are degraded to a different extent in each person. Food processing also influences allergen digestion. RECENT FINDINGS: In this review, we provide an overview of the digestive system with focus on relevance for food allergy...
September 4, 2023: Current Allergy and Asthma Reports
Eva Yarsky, Tina M Banzon, Wanda Phipatanakul
PURPOSE OF REVIEW: This review aims to assess the prevalence of common allergen exposures and environmental risk factors for asthma in schools, examine the underlying mechanisms of these environmental risk factors, and explore possible prevention strategies. RECENT FINDINGS: Cockroach, mouse, dust mites, fungi, viral infections, ozone pollution, and cleaning products are common allergen exposures and environmental risk factors in schools which may affect asthma morbidity...
August 31, 2023: Current Allergy and Asthma Reports
Juan Maza-Solano, Amparo Callejon-Leblic, Daniel Martin-Jimenez, Ramon Moreno-Luna, Jaime Gonzalez-Garcia, Alfonso Cuvillo, Serafin Sanchez-Gomez
PURPOSE OF REVIEW: Despite molecular underlying advances, limited and divergent data on monoclonal antibodies (mAb) therapy in chronic rhinosinusitis with nasal polyps (CRSwNP) make further analysis necessary. The objective of this study is to evaluate the effect of omalizumab as an adjunct to endoscopic sinus surgery (ESS) on the treatment of CRSwNP under real-life conditions. RECENT FINDINGS: Since the introduction of omalizumab, as the first biologic agent for the treatment of diseases such as severe allergic asthma, different studies have demonstrated an effect of omalizumab on CRSwNP, with significant improvements in sinonasal symptoms and endoscopic scores...
August 30, 2023: Current Allergy and Asthma Reports
Stephan Scheurer, Ann-Christine Junker, Chaoqi He, Stefan Sch├╝lke, Masako Toda
PURPOSE OF REVIEW: Immunoglobulin A (IgA) mediates immune exclusion of antigens in the gut. Notably, IgA plays also a role in the prevention of IgE-mediated allergies and induction of immune tolerance. The present review addresses the role of IgA in the manifestation of IgE-mediated allergies, including allergen-specific immunotherapy (AIT), the regulation of IgA production, and the mechanism of IgA in immune cell activation. RECENT FINDINGS: The majority of studies report an association of IgA with the induction of immune tolerance in IgE-mediated allergies...
August 23, 2023: Current Allergy and Asthma Reports
Carla Merma-Linares, M Dolores Martinez, Miriam Gonzalez, Isam Alobid, Enric Figuerola, Joaquim Mullol
PURPOSE OF REVIEW: Mechanical nasal obstruction (MNO) is a prevalent condition with a high impact on patient's quality-of-life (QoL) and socio-economic burden. The aim of this study was to determine the usefulness of both subjective and objective criteria in the appropriate management of MNO, either alone or associated to upper airway inflammatory diseases such as allergic rhinitis (AR) or chronic rhinosinusitis with nasal polyps (CRSwNP). RECENT FINDINGS: A long debate persists about the usefulness of subjective and objective methods for making decisions on the management of patients with nasal obstruction...
August 10, 2023: Current Allergy and Asthma Reports
Jose Zamora-Sifuentes, Jill A Poole
PURPOSE OF REVIEW: Occupational rhinitis is an underdiagnosed disease with significant morbidity and implications in the workplace. Multiple factors associated with this disease continue to pose a challenge to investigators. This review aims to summarize recent literature in occupational rhinitis, including classifications, pathogenesis, diagnosis, and treatment, as well as the impact of occupational rhinitis on individuals. Additionally, it identifies areas in need of further research and investigation...
July 15, 2023: Current Allergy and Asthma Reports
Emily Brigham, Alisa Hashimoto, Neil E Alexis
PURPOSE OF REVIEW: To provide a review of emerging literature describing the impact of diet on the respiratory response to air pollution in asthma. RECENT FINDINGS: Asthma phenotyping (observable characteristics) and endotyping (mechanistic pathways) have increased the specificity of diagnostic and treatment pathways and opened the doors to the identification of subphenotypes with enhanced susceptibility to exposures and interventions. Mechanisms underlying the airway immune response to air pollution are still being defined but include oxidative stress, inflammation, and activation of adaptive and innate immune responses, with genetic susceptibility highlighted...
July 13, 2023: Current Allergy and Asthma Reports
Emily Robbins, Kirti Johal, Anjeni Keswani
PURPOSE OF REVIEW: The use of telemedicine has greatly increased since the onset of the coronavirus disease 2019 (COVID-19) pandemic. This review discusses the types of telemedicine, current telehealth curricula in medical education, and benefits and disadvantages of incorporation of telemedicine into Allergy/Immunology training programs. RECENT FINDINGS: The majority of Allergists/Immunologists use telemedicine in their clinical practice with leaders in graduate medical education recommending inclusion of telemedicine in training...
July 7, 2023: Current Allergy and Asthma Reports
Ryan Allenbrand, Anita DiDonna, Jenny Marshall, Kevin Kennedy
PURPOSE OF REVIEW: Environmental home assessments have traditionally been performed in-person at the homes of Children's Mercy Kansas City patients. The COVID-19 pandemic brought many challenges to the way patients interact with their healthcare providers, including home visiting programs. Reaching out to patients with high-risk asthma and immunocompromised health was still needed, despite the pandemic. This project's purpose was to develop a virtual (telemedicine) healthy home assessment protocol that would continue to meet patients' needs during the isolation resulting from the pandemic...
July 5, 2023: Current Allergy and Asthma Reports
Eleni S Vasileiou, Kathryn C Fitzgerald
PURPOSE OF REVIEW: In this review, we provide a comprehensive update on current scientific advances and emerging therapeutic approaches in the field of multiple sclerosis. RECENT FINDINGS: Multiple sclerosis (MS) is a common disorder characterized by inflammation and degeneration within the central nervous system (CNS). MS is the leading cause of non-traumatic disability in the young adult population. Through ongoing research, an improved understanding of the disease underlying mechanisms and contributing factors has been achieved...
July 4, 2023: Current Allergy and Asthma Reports
Payel Gupta, Wajiha Kazmi, Gregory Della Penna, Kortney Kwong Hing
PURPOSE OF REVIEW: This review aims to improve our understanding of podcasts in the field of Allergy and Immunology and to share our experience in creating and hosting The Itch Podcast. To our knowledge, this is the first review providing an overview of podcasting in the field. RECENT FINDINGS: We found forty-seven podcasts in our search. Ten of these podcasts were specifically focused on Immunology and the other thirty seven covered allergy topics in general...
July 4, 2023: Current Allergy and Asthma Reports
Christian Calvo-Henriquez, Eugenio Di Corso, Isam Alobid, Elena Cantone, Tiziana Di Cesare, Joaquim Mullol
PURPOSE OF REVIEW: In the clinical practice, patients affected by chronic rhinosinusitis (CRS) commonly complain of otologic symptoms. This review aims to describe the available literature evidence assessing the relationship between CRS and ear illnesses published in the last 5 years. RECENT FINDINGS: Available evidence suggests a higher prevalence of otologic symptoms in patients suffering from CRS, affecting up to 87% of patients. These symptoms may be related to Eustachian tube dysfunction, which improves after treatment for CRS...
July 3, 2023: Current Allergy and Asthma Reports
Richmond Woodward, Sri Meghana Konda, Dilraj S Grewal
PURPOSE OF REVIEW: Provide a framework for recognizing key symptoms and clinical findings in patients with autoimmune inflammatory eye disease. RECENT FINDINGS: The most common manifestations of autoimmune inflammatory eye disease are episcleritis, scleritis, uveitis (anterior, intermediate, posterior, and panuveitis), and keratoconjunctivitis sicca. Etiologies can be idiopathic or in association with a systemic autoimmune condition. Referral of patients who may have scleritis is critical for patients presenting with red eyes...
August 2023: Current Allergy and Asthma Reports
Kriti Khatri, Andrea O'Malley, Christina Linn, Krzysztof Kowal, Maksymilian Chruszcz
PURPOSE OF REVIEW: A significant fraction of allergens bind small molecular ligands, and many of these compounds are classified as lipids. However, in most cases, we do not know the role that is played by the ligands in the allergic sensitization or allergic effector phases. RECENT FINDINGS: More effort is dedicated toward identification of allergens' ligands. This resulted in identification of some lipidic compounds that can play active immunomodulatory roles or impact allergens' molecular and allergic properties...
June 23, 2023: Current Allergy and Asthma Reports
Nadia Hamid, Jay M Portnoy, Aarti Pandya
PURPOSE OF REVIEW: Computer-assisted diagnosis and treatment (CAD/CAT) is a rapidly growing field of medicine that uses computer technology and telehealth to aid in the diagnosis and treatment of various diseases. The purpose of this paper is to provide a review on computer-assisted diagnosis and treatment. This technology gives providers access to diagnostic tools and treatment options so that they can make more informed decisions leading to improved patient outcomes. RECENT FINDINGS: CAD/CAT has expanded in allergy and immunology in the form of digital tools that enable remote patient monitoring such as digital inhalers, pulmonary function tests, and E-diaries...
June 23, 2023: Current Allergy and Asthma Reports
Grace Kelly, Osatohamwen I Idubor, Sophie Binney, Paul J Schramm, Maria C Mirabelli, Joy Hsu
PURPOSE OF REVIEW: This review discusses climate change-related impacts on asthma and allergic-immunologic disease, relevant US public health efforts, and healthcare professional resources. RECENT FINDINGS: Climate change can impact people with asthma and allergic-immunologic disease through various pathways, including increased exposure to asthma triggers (e.g., aeroallergens, ground-level ozone). Climate change-related disasters (e.g., wildfires, floods) disrupting healthcare access can complicate management of any allergic-immunologic disease...
June 7, 2023: Current Allergy and Asthma Reports
Luis Caraballo, Kevin Llinás-Caballero
PURPOSE OF REVIEW: Helminth infections modify the natural history of allergic diseases, by either decreasing or increasing their symptoms. Several helminth components are involved in the increasing of the allergic response and symptoms, overcoming the concomitant immunosuppression of helminthiases. However, the role of individual IgE-binding molecules in this process remains to be defined. RECENT FINDINGS: We updated the list of helminth allergens and IgE-binding molecules, their effects on asthma presentation, and their impact on allergy diagnosis...
June 3, 2023: Current Allergy and Asthma Reports
Jeffrey Shen, Elijah Lackey, Suma Shah
PURPOSE OF REVIEW: Neurosarcoidosis is a rare manifestation of sarcoidosis that is challenging to diagnose. Biopsy confirmation of granulomas is not sufficient, as other granulomatous diseases can present similarly. This review is intended to guide the clinician in identifying key conditions to exclude prior to concluding a diagnosis of neurosarcoidosis. RECENT FINDINGS: Although new biomarkers are being studied, there are no reliable tests for neurosarcoidosis...
May 31, 2023: Current Allergy and Asthma Reports
Benjamin L Wright, Mia Y Masuda, Danna R Ortiz, Adelyn Dao, Blake Civello, Grace C Pyon, Aliviya R Schulze, James A Yiannas, Matthew A Rank, Hirohito Kita, Alfred D Doyle
PURPOSE OF REVIEW: The prevalence and incidence of allergic disease have been rising in Westernized countries since the twentieth century. Increasingly, evidence suggests that damage to the epithelium initiates and shapes innate and adaptive immune responses to external antigens. The objective of this review is to examine the role of detergents as a potential risk factor for developing allergic disease. RECENT FINDINGS: Herein, we identify key sources of human detergent exposure...
May 26, 2023: Current Allergy and Asthma Reports
Austin Lai, Kelly Owens, Surya Patel, Matilda Nicholas
PURPOSE OF REVIEW: Atopic dermatitis (AD) remains a dermatological disease that imposes a significant burden on society. Air pollution has previously been linked to both the onset and severity of atopic dermatitis. As air pollution remains a critical environmental factor impacting human health, this review seeks to provide an overview of the relationship between different air pollutants and AD. RECENT FINDINGS: AD can develop from multiple causes that can be broadly grouped into epidermal barrier dysfunction and immune dysregulation...
May 26, 2023: Current Allergy and Asthma Reports
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