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Current Allergy and Asthma Reports

Enrico Heffler, Francesca Puggioni, Desideria Descalzi, Francesca Racca, Giorgio Walter Canonica, Giovanni Melioli
PURPOSE OF REVIEW: The impact of new technologies, especially multiplexed molecular allergy diagnostics based on allergen arrays, on the management of complex patients with respiratory allergies has been important. RECENT FINDINGS: Currently, the detailed characteristics of the IgE profile of the patient, such as sensitization to genuine or cross-reacting components or the sensitization to potentially harmful allergens, allow an allergist to tailor treatment in the context of precision medicine rules...
February 15, 2019: Current Allergy and Asthma Reports
Torie Grant, Ana M Rule, Kirsten Koehler, Robert A Wood, Elizabeth C Matsui
PURPOSE OF REVIEW: To review current indoor allergen sampling devices, including devices to measure allergen in reservoir and airborne dust, and personal sampling devices, with attention to sampling rationale and major indoor allergen size and characteristics. RECENT FINDINGS: While reservoir dust vacuuming samples and airborne dust volumetric air sampling remain popular techniques, recent literature describes sampling using furnace filters and ion-charging devices, both which help to eliminate the need for trained staff; however, variable correlation with reservoir dust and volumetric air sampling has been described...
February 12, 2019: Current Allergy and Asthma Reports
Steve Kagen, Amy Garland
PURPOSE OF REVIEW: This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps. RECENT FINDINGS: Primary care and specialty clinicians interested in introducing digital health apps into their practices will soon have more choices, for Apple® and major electronic medical record software companies are investing heavily in the mobile medical marketplace, guaranteeing personal health information and access to care will always be immediately available in one's digital hand...
February 2, 2019: Current Allergy and Asthma Reports
Saad Alsaleh, Jamil Manji, Amin Javer
PURPOSE OF REVIEW: The advent of endoscopic sinus surgery (ESS) has enabled the development of minimally invasive surgical procedures in Rhinology. However, proficiency with ESS techniques can still be hampered by poorly controlled bleeding limiting visibility of the surgical field (VSF). This can lead to increased operating time and, more importantly, increased risk of major and minor complications. To optimize the VSF and mitigate the risk of complications, many strategies have been explored...
February 2, 2019: Current Allergy and Asthma Reports
Ann Marie Kumfer, Scott P Commins
PURPOSE OF REVIEW: The goal of this review is to present an updated summary of the various approaches to prevent childhood food allergies and report recent advances in potential prevention trials for food allergy. RECENT FINDINGS: Several approaches related to maternal dietary supplementation as well as infant GI-based supplementation have been tried and are the subject of ongoing clinical investigation. The prevalence of food allergy appears to be increasing but several, varied approaches to prevention are being actively pursued such that an effective strategy may not be too far in the future...
February 2, 2019: Current Allergy and Asthma Reports
Jennifer A Dantzer, Robert A Wood
PURPOSE OF REVIEW: IgE-mediated food allergies are an increasing health concern, and current management includes food avoidance and use of emergency medications. Effective treatment of food allergy is highly desirable. Next generation approaches for the treatment of food allergy aim to improve both safety and efficacy, potentially including long-term tolerance. RECENT FINDINGS: Oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) will likely be integrated into clinical practice as part of food allergy management in the near future...
January 28, 2019: Current Allergy and Asthma Reports
Masako Toda, Michael Hellwig, Thomas Henle, Stefan Vieths
PURPOSE OF REVIEW: The Maillard reaction (MR) is a non-enzymatic reaction between reducing sugars and compounds with free amino groups such as proteins and takes place during thermal processing and storage of foods. This review aims to discuss potential effects of dietary MR products on the pathological mechanisms of allergic diseases. RECENT FINDINGS: Since the MR leads to modification of proteins with various types of glycation structures, the impact of the MR on the immunogenicity and potential allergenicity of food proteins in many allergenic foods has been assessed...
January 28, 2019: Current Allergy and Asthma Reports
Christiane Hilger, Jörg Fischer, Florian Wölbing, Tilo Biedermann
PURPOSE OF REVIEW: The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates. RECENT FINDINGS: IgE antibodies have been associated with delayed allergy to red meat...
January 23, 2019: Current Allergy and Asthma Reports
Alexander Vargas-Hernández, Lisa R Forbes
PURPOSE OF REVIEW: Natural killer cells are innate lymphoid cells (ILCs) that play critical roles in human host defense and are especially useful in combating viral pathogens and malignancy. RECENT FINDINGS: The NK cell deficiency (NKD) is particularly underscored in patients with a congenital immunodeficiency in which NK cell development or function is affected. The classical NK cell deficiency (cNKD) is a result of absent or a profound decrease in the number of circulating NK cells...
January 19, 2019: Current Allergy and Asthma Reports
Tania Elliott, Jennifer Shih
PURPOSE OF REVIEW: Telemedicine uses technology to connect patients and data with providers at a distance. Direct to consumer telemedicine is a rapidly growing segment of the industry. RECENT FINDINGS: The telehealth market has skyrocketed in recent years, making it a multi-billion dollar industry. Direct to consumer telehealth, dominated by the for-profit private sector, is the most popular form. Direct to consumer telemedicine is a subset of telehealth that shows promise in increasing access to and engagement in medical care...
January 19, 2019: Current Allergy and Asthma Reports
Oliver Hemmings, Matthew Kwok, Richard McKendry, Alexandra F Santos
PURPOSE OF REVIEW: The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT. RECENT FINDINGS: Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments...
November 15, 2018: Current Allergy and Asthma Reports
Ves Dimov, Alexei Gonzalez-Estrada, Frank Eidelman
PURPOSE OF REVIEW: Social media services dominate online consumption of information and play an ever expanding role in our lives. They are not only used to connect with friends and family but also to educate and recruit colleagues and patients, and to stay up-to-date with the new developments in the field of allergy and immunology. RECENT FINDINGS: There are known risks to social media user by health care professionals mostly related to breaches of patient confidentiality, professionalism, and privacy...
November 14, 2018: Current Allergy and Asthma Reports
Caroline Y Kuo, Rebecca Signer, Sulagna C Saitta
PURPOSE OF REVIEW: This review provides an update on the progress in identifying the range of immunological dysfunction seen in DiGeorge syndrome and on more recent diagnostic and treatment approaches. RECENT FINDINGS: Clinically, the associated thymic hypoplasia/aplasia is well known and can have profound effects on T cell function. Further, the humoral arm of the immune system can be affected, with hypogammaglobulinemia and poor vaccine-specific antibody response...
October 30, 2018: Current Allergy and Asthma Reports
Amanda L Cox, Anna Nowak-Wegrzyn
PURPOSE OF REVIEW: This review incorporates findings from studies of oral food challenges (OFC) over the last decade and highlights the latest innovations and understanding of the procedure. RECENT FINDINGS: PRACTALL guidelines are widely used in OFC research, but there is still no international consensus on the OFC protocol in clinical practice. Guidelines for performing OFC in clinical practice have been updated to include oral food challenges for infants. There have been advances in predictive models for outcomes and severity of reaction during OFC that take into account multiple clinical data as well as newer laboratory modalities...
October 30, 2018: Current Allergy and Asthma Reports
Katharina Bastl, Maximilian Kmenta, Uwe E Berger
PURPOSE OF REVIEW: The definition of a pollen season determines the start and the end of the time period with a certain amount of pollen in the ambient air. Different pollen season definitions were used for a long time including the use of different terms for data and methods used to define a pollen season. Recently suggested pollen season definitions for clinical trials were tested and applied for the first time to more aeroallergens. RECENT FINDINGS: This is a review on pollen season definitions and the latest recommendations...
October 29, 2018: Current Allergy and Asthma Reports
Matthew P Giannetti
PURPOSE OF REVIEW: This paper will review the pathophysiology, diagnosis, and treatment of exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis with an emphasis on novel studies published in the past several years. RECENT FINDINGS: Exercise-induced anaphylaxis (EIAn) is a clinical syndrome characterized by anaphylaxis during or shortly after physical exertion. The syndrome is broadly grouped into two categories: exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis (FDEIAn)...
October 26, 2018: Current Allergy and Asthma Reports
Martina Anzaghe, Stefan Schülke, Stephan Scheurer
PURPOSE OF REVIEW: Utilization of virus-like particles (VLPs) is considered to improve allergen-specific immunotherapy (AIT). AIT aims at the efficient uptake of the target allergen by antigen-presenting cells (APCs) subsequently inducing adaptive allergen-specific immune responses to induce tolerance. The purpose of this review is to describe the immune-modulating properties of VLPs per se and to summarize the application of VLPs as antigen carriers, preferably for Th2 cytokines or allergens, with and without simultaneous administration of adjuvants in order to modulate allergic immune responses...
October 25, 2018: Current Allergy and Asthma Reports
Margaretha A Faber, Ine I Decuyper, Athina L Van Gasse, Vito Sabato, Margo M Hagendorens, Didier G Ebo
No abstract text is available yet for this article.
October 25, 2018: Current Allergy and Asthma Reports
Ana Margarida Pereira, Cristina Jácome, Rute Almeida, João Almeida Fonseca
PURPOSE OF REVIEW: Evidence-based clinical diagnosis of allergic disorders is increasingly challenging. Clinical decision support systems implemented in mobile applications (apps) are being developed to assist clinicians in diagnostic decisions at the point of care. We reviewed apps for allergic diseases general diagnosis, diagnostic refinement and diagnostic personalisation. Apps designed for specific medical devices are not addressed. RECENT FINDINGS: Apps with potential usefulness in the initial diagnosis and diagnostic refinement of respiratory, food, skin and drug allergies are described...
October 25, 2018: Current Allergy and Asthma Reports
Rachel E Roditi, Jennifer J Shin
PURPOSE OF REVIEW: To examine the relationship between otitis media, allergic rhinitis, and age. RECENT FINDINGS: Otitis media and allergic rhinitis are prevalent conditions with a controversial relationship. Some data suggest that these entities are significantly associated, either through allergic rhinitis inducing Eustachian tube dysfunction or through allergic pathophysiology simultaneously occurring intranasally and in the ear. Other studies, however, have refuted this relationship...
October 20, 2018: Current Allergy and Asthma Reports
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