Kirill A Korvinson, Hari K Akula, Casina T Malinchak, Dellamol Sebastian, Wei Wei, Tashrique A Khandaker, Magdalena R Andrzejewska, Barbara Zajc, Mahesh K Lakshman
Facile reduction of aryl halides with a combination of 5% Pd/C, B2 (OH)4 , and 4-methylmorpholine is reported. Aryl bromides, iodides, and chlorides were efficiently reduced. Aryl dihalides containing two different halogen atoms underwent selective reduction: I over Br and Cl, and Br over Cl. Beyond these, aryl triflates were efficiently reduced. This combination was broadly general, effectuating reductions of benzylic halides and ethers, alkenes, alkynes, aldehydes, and azides, as well as for N -Cbz deprotection...
January 7, 2020: Advanced Synthesis & Catalysis