Lídia Matos, Irene Morgado, Luís Santos, Rui Camisa, Paulo Benvindo, Paulo Pereira
Promoting blood donation requires understanding and identifying the factors that motivate donations so that strategies for retaining and increasing loyalty can be developed. Transfusion literacy can be improved through school-based teaching and information about giving and solidarity to promote the development of future donors. For the purpose of aligning any strategies and motivational dynamics that promote adherence to informed donation and loyalty among students in the municipality of Coimbra. This study was undertaken to assess the perception of secondary school teachers regarding the students' knowledge of blood donation...
January 11, 2024: Transfusion and Apheresis Science
Paulo Pereira
Establishing the virological cutoff point, during epidemics, such as the COVID-19 Pandemic, is crucially important as inadequate standardization and the false qualitative results, have enormous clinical and economic consequences when screening for SARS-CoV-2. Moreover, a cutoff point is a crucial step in ensuring a minimal risk of clinical misclassification. Therefore complying with such statutory requirements is an essential part of obligatory good laboratory and clinical practices. In this concise report, we propose a novel methodology for establishing cutoff points for all samples exhibiting detectable levels of the measured parameter, even those from the disease-free group...
January 11, 2024: Transfusion and Apheresis Science
Helga Gonçalves, Carla Rodrigues, Hugo F Silva, Paulo Pereira
In the field of blood and transfusion medicine, European Directorate for the Quality of Medicines & HealthCare recommends practices for metrological devices. Monitoring and measurement resources, as well as their permitted metrological limits, must be considered in this regard. We must understand variables such as metrological domains, the International System of Units, metrological traceability, and metrological requirements and controls in the field of transfusions in order to understand these metrological devices...
January 11, 2024: Transfusion and Apheresis Science
O Pignalosa, E Vigorita, M Capuano, S Caruso, A Mastroianni, S De Martino, G Vaccaro, D Meomartini, C Nocera
The histo-blood group antigens P, P1 and Pk are a closely related set of glycosphingolipid structures expressed by red blood cells and other tissues. None of these three characters is expressed on p cells, a null phenotype that arises in the context of homozygous mutation of the A4GALT gene. Subjects with p phenotype spontaneously develop a natural alloantibody named anti-PP1Pk, which is a mixture of IgG and IgM against P1, P and Pk. While anti-P1 is a weak cold antibody with poor clinical significance, anti-P and anti-Pk antibodies are potent haemolysins responsible for severe hemolytic transfusion reactions...
January 10, 2024: Transfusion and Apheresis Science
Marie Patris, Anne Holoye, Deborah Goldman, Caroline De Coninck, Martin Colard
Hemolytic Disease of the Fetus and Newborn (HDFN) is a condition that affects 1 to 2 out of 1000 patients during pregnancy (1). When an alloantibody is present, it is essential to identify its nature in order to organize appropriate follow-up. Kell-mediated HDFN is rare; it occurs in about 5% of Kell alloimmunized pregnant women. It is important to note that in case of anti-Kell immunization, the severity of HDFN is not correlated with maternal antibody titers, and anemia tends to occur earlier and more severely...
January 5, 2024: Transfusion and Apheresis Science
Nichole LePage, Esther Soundar
Therapeutic plasma exchange is known to be an extracorporeal treatment procedure with few adverse effects. Anemia in chronically exchanged patients is not a well-recognized adverse effect. Our aim is to find if adult patients develop anemia while undergoing prolonged TPE treatments and to determine the time of onset of anemia. We retrospectively reviewed all outpatients that have undergone TPE at least once a week from July 2017 to March 2020. Kaplan-Meier time-to-event analysis was employed to calculate the time taken for development of anemia and time to reduction of hemoglobin by 1 g/dL from baseline in uncensored patients...
December 28, 2023: Transfusion and Apheresis Science
Paweł Kosowski
BACKGROUND AND OBJECTIVES: Given the decline in the number of voluntary blood donors in Poland and the lack of psychological research on blood donors and the donation system in the country, there is a need to develop a tool to measure barriers to recruiting new donors and retaining active donors. One significant barrier is the presence of specific fears associated with the blood donation process. Therefore, the main objective of this study was to perform the Polish adaptation of the Blood Donation Fears Inventory (the BDFI)...
December 28, 2023: Transfusion and Apheresis Science
Prashant Pandey, Aseem Tiwari, Sudipta Shekhar Das, Shamee Shastry, Vivek Kute, Mohit Chowdhry, Arghyadeep Marik, Geet Aggarwal, Supriya Kumari, Divya Setya, Saikat Mandal, Shweta Ranjan
BACKGROUND AND OBJECTIVES: ABO-incompatible transplantations allow patients to receive timely transplants. Isoagglutinin titration to ascertain levels of incompatible antibodies in the recipient is important in determining patient selection and transplant survivability. To find out the prevalent trends in India, the largest, first of its kind survey was carried out among the transplant centers regarding their practices in isoagglutinin titration. METHODS: The survey was drafted by a working group of Transfusion and Transplant Immunology specialists from six different centers...
December 22, 2023: Transfusion and Apheresis Science
Zhongfeng Liu, Weihua Liu, Zhiguo Chen, Hua Kang
Hematopoietic stem cells (HSCs) represent crucial target cells in the management of hematopoietic and immune system disorders. Unfortunately, the primary source of hematopoietic stem cells is limited. Hematopoietic stem cells derived from induced pluripotent stem cells (iPSCs) hold great promise for applications in cell therapy, disease modeling, and drug screening. To achieve a consistent induction method, one specific induction scheme capable of reliably generating CD34 and CD45 double-positive cells from iPSCs was optimized, employing a comparative analysis and screening of various induction methods...
December 20, 2023: Transfusion and Apheresis Science
Joyisa Deb, Ashish Jain, Daljit Kaur, Anupama Bahadur, Sriparna Basu, Gita Negi
Hemolytic disease of the newborn (HDN) results in the decreased lifespan of the red cells. HDN related to ABO incompatibility is mostly unnoticed because routine screening is not being done. This study was done to assess the prevalence of ABO-HDN and to compare different immunohematological tests. Methods-In this study 213 O group mothers and the 122 ABO-incompatible newborns born to them were included. Quantifying the maternal IgG anti-A/anti-B antibody titer was done by Conventional Tube Technique (CTT) using Dithiothreitol (DTT) pretreated maternal serum...
December 13, 2023: Transfusion and Apheresis Science
Giustina De Silvestro, Liviana Catalano, Giuseppe Marano, Vanessa Piccinini, Simonetta Pupella, Angelo Ostuni, Vincenzo De Angelis
Therapeutic apheresis refers to a group of extracorporeal blood processing procedures used in the treatment of a variety of systemic diseases. These complex procedures are burdened by adverse reactions related to both procedures and underlying medical conditions. Given the importance of centralizing the collection and the analysis of information on therapeutic apheresis, the Italian National Blood Center (NBC), at the request of the Italian Scientific Society of Hemapheresis and Cell Manipulation (SIdEM), implemented the Italian Registry of Therapeutic Apheresis (IRTA) including it in the Information System of Transfusion Services (SISTRA), coordinated by the NBC...
December 4, 2023: Transfusion and Apheresis Science
Kexuan Qu, Jianxiang Liu, Hao Chen, Lilan Gao, Shuxia Wang, Mengxing Lv
Osteomyelitis is a refractory disease caused by microbial invasion of the bone, leading to destruction of the bone tissue. It is more common in children. Osteomyelitis requires long treatment at high cost and is associated with high rates of recurrence and disability. It can also be complicated by sepsis that, if not treated in time, can result in death. Here, we report the first case of a 10-year-old patient who presented with chronic tibial osteomyelitis complicated with fracture. The patient had received traditional treatment for osteomyelitis for over 14 months without success...
December 2023: Transfusion and Apheresis Science
Aviv Sever, Jerry Stein, Alon Kalo, Michal Pearl-Yafe, Gili Kadmon, Avichai Weissbach, Elhanan Nahum, Eytan Kaplan
We report a case of therapeutic plasma exchange in a neonate with fulminant liver failure. A six-day old, 2800-gram baby was referred to our medical center for evaluation and treatment of fulminant hepatic failure. The working diagnosis at admission was gestational alloimmune liver disease, and therapeutic plasma exchange was proposed. A double volume plasma exchange was successfully performed, using the Spectra Optia apheresis system, primed with packed red blood cells. Access was obtained via a radial artery catheter and a peripheral intravenous line...
December 2023: Transfusion and Apheresis Science
María de Jesús Sánchez-Guzmán, Miguel Ángel Loyola-Cruz, Adolfo López-Ornelas, Clemente Cruz-Cruz, Emilio Mariano Durán-Manuel, Juan Manuel Bello-López
BACKGROUND: Poor disinfection is the main cause of blood contamination, so its elimination is key to limiting the entry of bacteria into the collection system. With the advancement of antiseptic technology, antiseptics with sterile, disposable applicators are now available. AIM: To evaluate in situ two antiseptics (with and without applicators) for blood banks and to demonstrate in vitro antiseptic activity on bacterial biofilms of importance in transfusion medicine...
November 25, 2023: Transfusion and Apheresis Science
Ioannis Griveas, Evaggelos Pratilas, Paraskevi Tseke
The therapeutic apheresis consists of a continuously improving therapeutic method for diseases with high mortality and morbidity, especially in cases with poor outcome by using current medications. Neurology is one the most famous and at the same most interesting era of apheresis intervention in clinical practice.
November 24, 2023: Transfusion and Apheresis Science
Ioannis Griveas
No abstract text is available yet for this article.
November 22, 2023: Transfusion and Apheresis Science
Xanthi Zikou, Derveni Vaia, Polychronidou Vasiliki, Chlorokostas Panagiotis, Aloizos Stavros
Apheresis is a modern medical approach in which plasma or cellular components are separated from the whole blood. Apheresis can be either diagnostic or therapeutic. Diagnostic apheresis is typically applied in hematology and cancer research. Therapeutic Apheresis (TA) includes a broad spectrum of extracorporeal treatments applied in various medical specialties, including Intensive Care Unit (ICU). Considering the complexity of the pathophysiologic characteristics of various clinical entities and in particular sepsis, apheresis methods are becoming increasingly applicable...
November 21, 2023: Transfusion and Apheresis Science
Jerard Seghatchian
No abstract text is available yet for this article.
November 21, 2023: Transfusion and Apheresis Science
Ioannis Griveas
The clinical efficacy of therapeutic apheresis is still controversial. We undertook a retrospective review of apheresis treatment to ascertain its safety and efficacy. The therapeutic apheresis consists of a continuously improving therapeutic method for diseases with high mortality and morbidity, especially in cases with poor outcome by using current medications.
November 20, 2023: Transfusion and Apheresis Science
Christina Melexopoulou, Vassilis Filiopoulos, Smaragdi Marinaki
Therapeutic apheresis (TA) plays a significant role in various aspects of renal transplantation. It has been a necessary preconditioning component in ABO incompatible kidney transplants and an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both in the context of desensitization protocols that have been developed to allow highly sensitized kidney transplant candidates to be successfully transplanted and as treatment of antibody mediated rejection episodes post transplantation...
November 17, 2023: Transfusion and Apheresis Science
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