journal
https://read.qxmd.com/read/38644062/platelet-function-testing-update-on-determinant-variables-and-permissive-windows-using-a-platelet-count-based-device
#1
REVIEW
Patricia Villar, Sofía Carreño, Sara Moro, Inés Díez Galindo, Ángel Bernardo, Laura Gutiérrez
While there are various aspects of platelet biology that can be studied in the lab (i.e. adhesion, degranulation, integrin activation), the master test for platelet function is that which gives a measure of the platelet aggregation capacity upon stimulation with an agonist. Platelet function testing is necessary for the diagnosis of platelet disorders and the monitoring of patients receiving anti-platelet treatments. Furthermore, it becomes relevant in the quality control of platelet concentrates for transfusion purposes, especially considering the global concern about long term storage, other forms of storage (i...
April 18, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38637253/impact-of-cell-salvage-on-hematocrit-and-post-partum-anemia-in-low-hemorrhage-risk-elective-cesarean-delivery
#2
JOURNAL ARTICLE
Daniel Katz, Annalin Griffel, Sarah Granozio, Gary Koenig, Hung-Mo Lin
BACKGROUND: Postpartum anemia is a significant contributor to peripartum morbidity. The utilization of cell salvage in low risk cases and its impact on postpartum anemia has not been investigated. We therefore aimed to examine the impact of autologous blood transfusion/cell salvage in routine cesarean delivery on postoperative hematocrit and anemia. STUDY DESIGN AND METHODS: Retrospective cohort study from a perfusion database from a large academic center where cell salvage is performed at the discretion of the obstetrical team...
April 16, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38614915/molecular-and-clinical-profile-of-rare-bleeding-disorders-a-single-center-retrospective-study
#3
JOURNAL ARTICLE
Arash Ahmadfard Moghadam, Amir Reza Manafzadeh, Mohammad Reza Nikoonia, Khadijeh Dajliry, Farahnaz Ramezan, Shadi Tabibian
INTRODUCTION: Due to their low frequency, there is little information on the molecular pathologies of rare bleeding disorders (RBD). Therefore, this study aimed to analyze the molecular and clinical profiles of patients with RBD. METHODS: A retrospective single-center study was conducted among patients with factor (F) II, FVII, FX, and FXIII deficiencies between March 20, 2000, and June 31, 2023. Data on patient demographics, genetic analysis, and laboratory results were documented for all patients...
April 1, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38570214/prevention-of-potential-delayed-hemolytic-transfusion-reaction-in-two-sickle-cell-patients-using-intravenous-immunoglobulins-and-steroids-before-and-after-red-blood-cell-exchange-with-antigen-positive-units-and-review-literature
#4
JOURNAL ARTICLE
Janna Shold, Amitava Dasgupta, Zhan Ye
Emergent Red Blood Cell (RBC) exchange is indicated in sickle cell disease (SCD) patients with severe acute chest syndrome. However, fully matched RBC units may not be available for patients with multiple RBC antibodies. Intravenous immunoglobulin (IVIG) and steroids were reported for preventing potential delayed hemolytic transfusion reaction (HTR) in simple transfusion of antigen-positive RBCs. We investigated the efficacy and safety of IVIG and steroids in two SCD patients presented with acute chest syndrome receiving RBC exchange with multiple incompatible units...
April 1, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38582651/utility-of-hemoglobin-electrophoresis-to-distinguish-between-severe-delayed-hemolytic-transfusion-reaction-versus-hyperhemolysis-syndrome
#5
JOURNAL ARTICLE
Robert Lukin, Jennie Y Law, Parvez M Lokhandwala
Delayed hemolytic transfusion reaction (DHTR) and hyperhemolysis syndrome (HHS) are both complications of red blood cell transfusions in patients with sickle cell disease.Clinically, both present with hemolysis and can be difficult to differentiate. Hemoglobin electrophoresis may aid in the diagnosis. Herein we describe a case in which a patient with hemoglobin SC disease presented with features of severe hemolysis several days after initiation of red blood cell exchange. Increase in reticulocyte count and complete absence of hemoglobin A on electrophoresis during this event supported the diagnosis of severe DHTR, indicating a rapid and selective destruction of the transfused red blood cells...
March 27, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38555232/impact-of-therapeutic-plasma-exchange-on-intact-protein-s-apolipoproteins-and-thrombin-generation
#6
JOURNAL ARTICLE
Hanna H Pitkänen, Mikko Haapio, Mika Saarela, Marja-Riitta Taskinen, Herm-Jan Brinkman, Riitta Lassila
INTRODUCTION: Therapeutic plasma exchange (TPE), with solvent/detergent (S/D)-treated plasma as replacement fluid, is an extracorporeal blood purification technique with major impact on both coagulation and lipids. Our previous in vitro study showed that S/D-plasma enhances thrombin generation by lowering intact protein S (PS) levels. AIMS: To evaluate the impact of altered lipid balance on coagulation phenotype during heparin-anticoagulated TPE with S/D-plasma, and to investigate whether the lowered intact PS levels with concomitant procoagulant phenotype, are recapitulated in vivo...
March 27, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38553365/transfusion-safety-is-there-a-difference-between-reported-reactions-in-low-to-middle-income-and-high-income-countries
#7
JOURNAL ARTICLE
Mohamed Amine Hmida, Sonia Mahjoub, Leila Ben Hamed, Najet Mojaat, Abdessalem Bahloul, Slama Hmida
BACKGROUND AND OBJECTIVES: Transfusion safety may be becoming dependent on the financial resources made available for transfusion structures and may vary between high-income countries (HIC) and low-to-middle-income countries (LMIC). To assess whether there is a difference in the reported TR between these two groups of countries, we examined TR reported in Tunis the capital of Tunisia, a LMIC, and compared their frequency with reported TR in HIC. MATERIALS AND METHODS: Data of TR were collected from transfusion incident report (TIR) forms declared by healthcare facilities in Tunis between 2015 and 2019...
March 19, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38519381/pain-is-what-hurts-an-exploration-of-perception-and-management-of-pain-in-peripheral-blood-stem-cell-donors
#8
JOURNAL ARTICLE
Suzanna M van Walraven, Leon C Witte, Femmeke Prinsze, Johanna C Wiersum-Osselton, Ivan Bank
BACKGROUND: Pain is a side effect of Granulocyte-Colony Stimulating Factor (G-CSF) administration. This prospective study investigates various aspects including pain perception occurring in Peripheral Blood Stem Cell (PBSC) donors. MATERIALS AND METHODS: Related and unrelated PBSC donors were prospectively studied. Donors recorded pain symptoms during the four-day period of G-CSF administration using the McGill Pain Questionnaire, a Visual Analog Scale and a pain diary...
March 19, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38538404/can-sars-cov-2-infection-cause-prolonged-pseudothrombocytopenia-a-case-presentation-and-literature-summary
#9
LETTER
Unal Atas, Mustafa Sinanoglu, Volkan Karakus
No abstract text is available yet for this article.
March 14, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38522978/correlation-between-serum-cytokine-levels-and-the-effect-of-allogeneic-serum-based-eye-drops
#10
JOURNAL ARTICLE
Katarzyna Chmielewska, Joanna Janus, Agata Mikołowska, Karolina Wrzodak, Marta Stącel, Jolanta Antoniewicz-Papis
INTRODUCTION: The Institute of Hematology and Transfusion Medicine (IHTM) in Warsaw has produced autologous serum eye drops (ASEDs) for the treatment of Dry Eye Syndrome (DES) since 1991. In 2019, IHTM introduced allogeneic tears (alloSEDs) for patients on long-term treatment. MATERIALS AND METHODS: 114 patients who applied alloSEDs were included in the study.They were asked to complete the OSDI questionnaire before and after using ASEDs and 100 units of alloSEDs drops from each donation...
March 14, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38467529/clinical-features-and-risk-factors-of-hepatic-sinusoidal-obstruction-syndrome-in-children-after-hematopoietic-stem-cell-transplantation-a-single-center-experience
#11
JOURNAL ARTICLE
İbrahim Kartal, Canan Albayrak, Ayhan Dağdemir, Oğuz Salih Dinçer, Hülya Kangal Şimşek, Ünsal Özgen, Davut Albayrak
Hepatic sinusoidal obstruction syndrome (SOS) is an illness with serious life effects that develops after hematopoietic stem cell transplantation (HSCT). We investigated the risk factors and clinical features of hepatic SOS in children following HSCT in 210 children who underwent allogeneic or autologous HSCT between 2009 and 2021 were analyzed in the context of SOS. The syndrome developed in 22 (10.4%) patients:frequently in neuroblastoma [24% (5/21)], hemophagocytic lymphohistiocytosis [57% (4/7)], and thalassemia major [22% (7/31)]...
March 8, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38480084/is-minimizing-iatrogenic-blood-loss-the-next-frontier-in-transfusion-medicine
#12
LETTER
Anubhav Gupta, Romesh Jain
No abstract text is available yet for this article.
March 2, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38431440/a-randomized-control-trial-for-evaluation-of-transfusion-related-immuno-modulation-in-patients-with-meningioma
#13
JOURNAL ARTICLE
Gopal Kumar Patidar, Girija Prasad Rath, Anjali Hazarika, Yashaswi Dhiman, Bhagya Ranjan Jena, Deep Sengupta
BACKGROUND: Blood transfusion necessity in neurosurgery varies based on surgical type, blood loss, and patient anemia. Leukocytes in red blood cells (RBCs) component release pro-inflammatory cytokines during storage, contributing to transfusion-related immunomodulation (TRIM). Our aim was to examine the impact of the leukocyte content in transfused PRBCs on patients undergoing neurosurgery for meningioma tumours. STUDY DESIGN AND METHODS: This prospective randomized controlled trial conducted from 2018 to 2020 by dividing patients randomly into non-leukoreduced (NLR) (n = 65) and leuko-reduced (LR) (n = 65) groups based on PRBCs received during surgery and hospital stay...
February 21, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38402066/editorial-comments-spotlights-on-knowledge-economy-in-transfusion-medicine-where-are-we-now
#14
EDITORIAL
Dr Jerard Seghatchian
No abstract text is available yet for this article.
February 21, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38395673/granulocyte-transfusions-in-life-threatening-infections-of-children-with-hemato-oncological-diseases
#15
JOURNAL ARTICLE
Esra Arslantaş, Kamuran Şanlı, Sultan Okur Acar, Sibel Akpınar Tekgündüz, Ali Ayçiçek
Granulocytes are the most important cells for host defense during infections. Granulocyte suspension transfusions (GTx) may be given as additional treatment in severely neutropenic patients with life-threatening infections when antimicrobial therapy is inadequate. The aim of this study was to evaluate the effectiveness and safety of GTx for the treatment of children with hemato-oncological disease, febrile neutropenia and serious life-threatening infections. Patients who underwent GTx between July 2020 and September 2022 were evaluated retrospectively...
February 20, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38402067/second-line-extracorporeal-photopheresis-for-cortico-resistant-acute-and-chronic-gvhd-after-allogeneic-hematopoietic-cell-transplantation-for-hematological-malignancies-long-term-results-from-a-real-life-study
#16
JOURNAL ARTICLE
Mauricette Michallet, Mohamad Sobh, Alexandre Deloire, Daniela Revesz, Youcef Chelgoum, Mohamed El-Hamri, Fiorenza Barraco, Helene Labussiere, Franck E Nicolini, Olivier Hequet
BACKGROUND & OBJECTIVES: The primary objective of this observational study was to perform an exhaustive description concerning patients receiving extracorporeal photopheresis (ECP) as second line treatment after steroid resistance for either acute or chronic GVHD following allo-HCT, secondary objectives were to evaluate the efficacy and long-term outcomes. STUDY DESIGN: A total of 106 patients were included, 65 (61%) males and 41 (39%) females with a median age at transplantation of 52 years (range: 20-67)...
February 16, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38388335/the-waa-registry
#17
EDITORIAL
Volker Witt, Bernd Stegmayr
No abstract text is available yet for this article.
February 15, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38341316/severe-jaundice-with-life-threatening-liver-failure-after-kratom-use-reversed-by-plasma-exchange
#18
JOURNAL ARTICLE
Amitava Dasgupta, Zhan Ye
Kratom is an herbal supplement which is used for its stimulating properties and pain reduction due to interaction with opioid receptors. Kratom overdose may cause fatality. A 56-year-old man was admitted to the emergency department with severe jaundice and liver failure. His total bilirubin reached at 70.6 mg/dL, but extensive workup did not show any liver mass. Family informed that the patient was taking Kratom. Plasma exchange was suggested as an unconventional therapy and consent from the patient was obtained because this procedure has never been performed to treat Kratom toxicity before...
February 8, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38485612/guest-editor-s-bios
#19
EDITORIAL
Viktoria Weber, Tanja Eichhorn
No abstract text is available yet for this article.
February 7, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38365525/impact-of-peri-operative-red-blood-cell-transfusions-for-treatment-of-anemia-on-acute-rejection-in-renal-transplant-recipients
#20
JOURNAL ARTICLE
Demetra Tsapepas, Adarsh Ramakrishnan, David M Salerno, Syed Ali Husain, Kristen King, Sumit Mohan
INTRODUCTION: Anemia occurs before and after kidney transplantation. Determining the impact of perioperative transfusion on post-transplant outcomes can help determine best management of anemia. PROJECT AIM: The current study aims to describe clinical outcomes associated with packed red blood cell transfusions in the peri-operative management of anemia after transplantation. DESIGN: This was a single-center, retrospective study of adult kidney recipients with anemia at the time of transplantation...
February 7, 2024: Transfusion and Apheresis Science
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