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Transfusion and Apheresis Science

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https://read.qxmd.com/read/30709590/human-pegivirus-1-hpgv-1-gbv-c-rna-prevalence-and-genotype-diversity-among-volunteer-blood-donors-from-an-intra-hospital-hemotherapy-service-in-southern-brazil
#1
Svetoslav Nanev Slavov, Roberta Maraninchi Silveira, Evandra Strazza Rodrigues, Cristiane Fração Diefenbach, Ana Maria Zimmermann, Dimas Tadeu Covas, Simone Kashima
OBJECTIVE: Human pegivirus (HPgV-1, GBV-C) is classified within the Pegivirus genus of the Flaviviriade family. The natural history of HPgV-1 infection is still unclear, however, the main route of viral transmission seems to be the parenteral one. The detection of HPgV-1 viremia in blood donors without parenteral exposure demonstrates that other routes of HPgV-1 transmission might also exist. The objective of the present study was to evaluate the prevalence of HPgV-1 RNA and circulating genotypes among blood donors from a intra-hospital Hemotherapy Service localized in the Santa Maria city, central part of the Rio Grande do Sul State in the extreme South of Brazil...
January 25, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30670326/reduction-in-adverse-transfusion-reactions-with-increased-use-of-washed-platelet-concentrates-in-japan-a-retrospective-multicenter-study
#2
Emi Ikebe, Sahoko Matsuoka, Asashi Tanaka, Yuji Yonemura, Yasuhiko Fujii, Akimichi Ohsaka, Hitoshi Okazaki, Junichi Kitazawa, Shinichi Ohtani, Takayuki Nakayama, Shun-Ya Momose, Izumi Miwa, Rikizo Taira, Kuro Toyota, Shuichi Kino, Hidefumi Kato, Isao Hamaguchi
Plasma removal by washing platelet concentrates (PCs) is effective in preventing adverse reactions to PC transfusions. The Japanese Red Cross Society (JRCS) started releasing washed PCs (WPCs) as a commercially approved blood product in September 2016. This retrospective multicenter study investigated the change in the number of transfused WPCs and the impact on the incidence of adverse reactions to PCs before and after the release. The numbers and types of transfused PCs and the adverse reactions to the PCs for a year before the start of the WPC release and for a year after the release were reported by 27 medical institutes in Japan...
January 6, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30655184/editor-s-notes-exploring-innovative-therapeutic-utilities-for-manufactured-erythrocyte-and-the-unresolved-issue-of-donor-health-assessment-and-the-discourse-about-the-clinical-use-of-thromboelastography-in-massively-bleeding-patients
#3
EDITORIAL
https://read.qxmd.com/read/30639177/validation-and-cost-effectiveness-of-an-in-house-dithiothreitol-dtt-treatment-protocol-for-daratumumab-patients-in-a-large-tertiary-care-hospital-provides-gateway-for-implementation-in-smaller-community-hospitals
#4
Mariam Youssef, Christine Arnesen, Cindy Arledge, Connie Langley, Danielle Sylvester, James Sikora, Marisa B Marques, X Long Zheng, Lance A Williams
BACKGROUND: Treatment of multiple myeloma with daratumumab (DARA) is increasing fast. Unfortunately, this antibody also attaches to red blood cells (RBCs) and mimics an autoantibody's panreactivity during pre-transfusion testing, necessitating specialized techniques, (e.g. dithiothreitol (DTT)) for alloantibody detection. Many hospitals use a reference lab for such testing, increasing both cost and turn-around time (TAT). Herein, we compare the cost and TAT, pre and post-implementation of an in-house DTT protocol...
January 6, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30639084/duffy-blood-group-system-the-frequency-of-duffy-antigen-polymorphisms-and-novel-mutations-in-the-polish-population
#5
Ewa Łukasik, Izabela Nowak, Marcin Czerwinski, Kazimiera Waśniowska
Duffy blood group genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The aim of this study was to genotype Duffy blood group antigens and to establish FY alleles frequency in the Polish population and screen for novel FY gene mutations. Duffy phenotype and genotype frequencies analysis was based on studies of 596 persons. All these subjects were genotyped by high-resolution melting (HRM) method. It was shown that phenotype Fy(a+b+), defined by genotypes FY*A/FY*B (33%), FY*A/FY*B298A (13%), and FY*A/FY*02W...
January 6, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30639083/motivations-and-attitudes-towards-the-act-of-blood-donation-among-undergraduate-health-science-students
#6
Maria José Gomes, António J Nogueira, Celeste Antão, Cristina Teixeira
BACKGROUND: Undergraduate students are a target for blood donation, as they constitute a young healthy and well-informed group. AIM: To understand motivations and attitudes underpinning the act of blood donation among undergraduate health science students. MATERIALS AND METHODS: Cross-sectional study enrolling undergraduate students of a College of Health Sciences in the Northeast of Portugal (January/February, 2017). Data collection tool was a self-administered questionnaire covering questions about motivations (n = 8) and attitudes (n = 5) towards the act of blood donation...
January 6, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30616960/in-memory-of-paolo-perseghin
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 2, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30616959/more-efficient-exchange-of-sickle-red-blood-cells-can-be-achieved-by-exchanging-the-densest-red-blood-cells-an-ex-vivo-proof-of-concept-study
#8
Suzanne R Thibodeaux, Yvette C Tanhehco, Leah Irwin, Lita Jamensky, Kevin Schell, Una O'Doherty
BACKGROUND: In sickle cell disease (SCD), red blood cells (RBCs) containing hemoglobin S can be denser than RBCs containing wild-type hemoglobin, especially when dehydrated. We hypothesize that targeting denser RBCs during red blood cell (RBC) exchange for SCD could result in more efficient removal of dehydrated, sickled RBCs and preservation of non-sickled RBCs. STUDY DESIGN AND METHODS: Waste products from RBC exchanges for SCD were used as "simulated patients"...
January 2, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30616957/the-use-of-thromboelastography-teg-in-massively-bleeding-patients-at-haukeland-university-hospital-2008-15
#9
REVIEW
Snorre Brundtland Saeveraas, Joar Sivertsen, Tor Hervig
Thromboelastography (TEG) has been part of the assessment of patients receiving massive transfusion (MT) at Haukeland university hospital (HUH) since 2007. However, the test has been used inconsistently, and in general, the value of the test in evaluation of patients with critical bleeding is still debated, although it has been suggested that the TEG-guided treatment decreases blood usage. This single-centre retrospective study examines the use of TEG and discusses its place as part of assessing MT patients...
January 2, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30630765/donor-health-assessment-when-is-blood-donation-safe
#10
REVIEW
Lise Sofie H Nissen-Meyer
Blood donation is a highly regulated practice in the world, ensuring the safety and efficacy of collected blood and its components whether used as irreplaceable parts of modern transfusion medicine, as a therapeutic modality or additional support to other clinical therapies. In Norway blood donation is regulated by governmental regulations ("Blodforskriften") and further instructed by national guidelines, "Veileder for transfusjonstjenesten" [1], providing an aid for assessment of donor health...
December 31, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30616958/ex-vivo-generation-of-transfusable-red-blood-cells-from-various-stem-cell-sources-a-concise-revisit-of-where-we-are-now
#11
REVIEW
Evangelia-Eleni Christaki, Marianna Politou, Marianna Antonelou, Angelos Athanasopoulos, Emmanouil Simantirakis, George Vassilopoulos
Blood transfusion is an essential and irreplaceable part of modern medicine, as a therapeutic modality or additional support to other clinical therapies. Nevertheless, the entire procedure from blood collection to administration, absorbs a significant amount of resources and has a number of problems that need to be addressed. The paucity of donors, the transmission of pathogenic microorganisms and the overall costs of the process have switched the scientific interest to the quest of alternative transfusion methods...
December 31, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30718153/novel-platelet-products-under-development-for-the-treatment-of-thrombocytopenia-or-acute-hemorrhage
#12
REVIEW
G Michael Fitzpatrick
Controlling hemorrhage has been a focus of survival since man recognized that the loss of blood led to death. Papyri from 1600 BCE describe methods for hemorrhage control including; direct pressure, ligature and the use of sutures. Multiple studies have demonstrated the survival advantage of early transfusion of whole blood or red cells and plasma. The added survival impact of early transfusion of platelets was recently reported in a substudy of the prospective Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial...
December 30, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30704925/cold-stored-platelets-a-product-with-function-optimized-for-hemorrhage-control
#13
REVIEW
K M Reddoch-Cardenas, J A Bynum, M A Meledeo, P M Nair, X Wu, D N Darlington, A K Ramasubramanian, A P Cap
Early administration of blood products following severe trauma is pivotal for establishing hemostasis and achieving successful outcomes. Platelet transfusions, in particular, provide rapid control of hemostasis and help to restore platelet dysfunction induced by trauma. In the U.S. platelets used for therapeutic purposes are stored at room temperature with a limited shelf life of 5-7 days. Issues with room temperature storage of platelets, including an increased risk of bacterial growth and a decline in platelet hemostatic function, have led to a resurgence in interest in cold-stored platelets for therapeutic transfusion...
December 30, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30639087/biography-stephen-j-wagner-ph-d
#14
EDITORIAL
Stephen J Wagner
No abstract text is available yet for this article.
December 30, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30639086/physiology-of-cold-stored-platelets
#15
REVIEW
Todd M Getz
Platelet transfusions are a life-saving medical intervention used for the treatment of thrombocytopenia or hemorrhage. Extensive research has gone into trying to understand how to store platelets prior to the transfusion event. Much has been learned about storage bag materials, synthetic solutions, and how temperature impacts platelet viability and function. While room temperature storage of platelets preserves 24-hour in vivo platelet recovery and survival there is a greater risk for bacterial growth. Therefore, cold storage of platelets has become attractive due to the reduction in potential bacterial proliferation and the maintenance of platelet function beyond 5 days of storage...
December 30, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30612945/frozen-platelets
#16
Kathleen Kelly, Larry J Dumont
The technical limitations on platelet shelf life and storage have driven research for alternatives, including cryopreservation of platelets. Over the past 60 years, product development has adopted freezing platelets in 6% dimethyl sulfoxide (DMSO) and storage in mechanical freezers at -80 °C for up to 2 years. Frozen platelets show a primed, hypercoagulable in vitro phenotype post-thaw when assayed using morphology, flow cytometry for marker expression, and thrombin capacity. In vivo studies show a role for frozen platelets in the maintenance of hemostasis and data from limited clinical trials show frozen platelets are safe and appear beneficial...
December 30, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30611653/guest-editorial-the-resurgence-of-cold-stored-platelets
#17
REVIEW
Stephen J Wagner
No abstract text is available yet for this article.
December 30, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30642808/italian-society-of-haemapheresis-and-cellular-manipulation
#18
REVIEW
Jean O'Brien-Louis
No abstract text is available yet for this article.
December 27, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30579750/in-vitro-evaluation-of-pathogen-inactivated-platelet-quality-an-8-year-experience-of-routine-use-in-galicia-spain
#19
Azucena Castrillo Fernández, Marion C Lanteri, Carina Arcas Otero, Almudena Díaz Pereira, Maria Adelantado Pérez
BACKGROUND: Platelet concentrates (PCs) treated by the pathogen inactivation technology (PI) using amotosalen and UVA illumination (PI-PCs) can be manufactured in additive solutions (PAS-III and PAS-IIIM) or in 100% Plasma. Quality control (QC) is an integral part of the production. We capitalized on our ongoing QC program to capture 8 years-worth of data on parameters related to the quality of 116,214 PI-PCs produced under different manufacturing methods. MATERIALS AND METHODS: Selected in vitro parameters of metabolism, activation, and storage were analyzed for the different manufacturing periods to compare PI-PCs versus conventional PCs (C-PCs) resuspended in different PAS...
December 10, 2018: Transfusion and Apheresis Science
https://read.qxmd.com/read/30639085/rh-d-alloimmunization-treated-by-double-filtration-plasmapheresis
#20
Sibel Gokcay Bek, Necmi Eren, Ant Uzay, Serkan Bakirdogen
Here in this report a 31 year old pregnant woman with positive serum antiglobulin test against anti-D antierythrocyte antibodies who was treated succesfully with double filtration plasmapheresis (DFPP) is presented. The DFPP was started in the early stage of pregnancy together with intravenous immunoglobulin therapy and the antierythrocyte antibody titer of the patient was successfully maintained in a stable level below 1:64 dilution. She delivered successfully on the 30th week of gestation. The favorable outcome of this patient implies that DFPP is an effective and safe treatment modality in pregnant women with red cell alloimmunization...
December 8, 2018: Transfusion and Apheresis Science
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