journal
https://read.qxmd.com/read/38468274/variables-associated-with-antibiotic-treatment-tolerance-in-patients-with-mycobacterium-avium-complex-pulmonary-disease
#21
REVIEW
Meghan Marmor, Husham Sharifi, Susan Jacobs, Kiana Fazeli, Stephen Ruoss
BACKGROUND: Treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) involves prolonged courses of multiple antibiotics that are variably tolerated and commonly cause adverse drug reactions (ADR). The purpose of this retrospective, single-center study was to identify demographic and disease-related variables associated with significant ADRs among patients treated with antibiotics against MAC-PD. METHODS: We reviewed all patients treated with antibiotic therapy for MAC-PD at a single center from 2000 to 2021...
March 11, 2024: Respiratory Research
https://read.qxmd.com/read/38468264/cardiopulmonary-exercise-test-to-detect-cardiac-dysfunction-from-pulmonary-vascular-disease
#22
REVIEW
Mona Alotaibi, Jenny Z Yang, Demosthenes G Papamatheakis, W Cameron McGuire, Timothy M Fernandes, Timothy A Morris
BACKGROUND: Cardiac dysfunction from pulmonary vascular disease causes characteristic findings on cardiopulmonary exercise testing (CPET). We tested the accuracy of CPET for detecting inadequate stroke volume (SV) augmentation during exercise, a pivotal manifestation of cardiac limitation in patients with pulmonary vascular disease. METHODS: We reviewed patients with suspected pulmonary vascular disease in whom CPET and right heart catheterization (RHC) measurements were taken at rest and at anaerobic threshold (AT)...
March 11, 2024: Respiratory Research
https://read.qxmd.com/read/38468259/quercetin-improves-epithelial-regeneration-from-airway-basal-cells-of-copd-patients
#23
JOURNAL ARTICLE
Elizabeth S McCluskey, Nathan Liu, Abhimaneu Pandey, Nathaniel Marchetti, Steven G Kelsen, Umadevi S Sajjan
BACKGROUND: Airway basal cells (BC) from patients with chronic obstructive pulmonary disease (COPD) regenerate abnormal airway epithelium and this was associated with reduced expression of several genes involved in epithelial repair. Quercetin reduces airway epithelial remodeling and inflammation in COPD models, therefore we examined whether quercetin promotes normal epithelial regeneration from COPD BC by altering gene expression. METHODS: COPD BC treated with DMSO or 1 µM quercetin for three days were cultured at air/liquid interface (ALI) for up to 4 weeks...
March 11, 2024: Respiratory Research
https://read.qxmd.com/read/38459594/circulating-mirnas-associate-with-historical-childhood-asthma-hospitalization-in-different-serum-vitamin-d-groups
#24
JOURNAL ARTICLE
Xiaoning Hong, Mingye Jiang, Alvin T Kho, Anshul Tiwari, Haiyan Guo, Alberta L Wang, Michael J McGeachie, Scott T Weiss, Kelan G Tantisira, Jiang Li
BACKGROUND: Vitamin D may help to alleviate asthma exacerbation because of its anti-inflammation effect, but the evidence is inconsistent in childhood asthma. MiRNAs are important mediators in asthma pathogenesis and also excellent non-invasive biomarkers. We hypothesized that circulating miRNAs are associated with asthma exacerbation and modified by vitamin D levels. METHODS: We sequenced baseline serum miRNAs from 461 participants in the Childhood Asthma Management Program (CAMP)...
March 8, 2024: Respiratory Research
https://read.qxmd.com/read/38459541/dectin-1-aggravates-neutrophil-inflammation-through-caspase-11-4-mediated-macrophage-pyroptosis-in-asthma
#25
JOURNAL ARTICLE
Runjin Cai, Xiaoxiao Gong, Xiaozhao Li, Yuanyuan Jiang, Shuanglinzi Deng, Jiale Tang, Huan Ge, Chendong Wu, Huan Tang, Guo Wang, Lei Xie, Xuemei Chen, Xinyue Hu, Juntao Feng
BACKGROUND: The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation. Recent studies have revealed that Dectin-1 is overexpressed in asthma, but the specific mechanism remains elusive. Additionally, Dectin-1 has been implicated in promoting pyroptosis, a hallmark of severe asthma airway inflammation. Nevertheless, the involvement of the non-classical pyroptosis signal caspase-11/4 and its upstream regulatory mechanisms in asthma has not been completely explored...
March 8, 2024: Respiratory Research
https://read.qxmd.com/read/38454475/muc5ac-concentrations-in-lung-lavage-fluids-are-associated-with-acute-lung-injury-after-cardiac-surgery
#26
LETTER
Judith van Paassen, Pieter S Hiemstra, Abraham C van der Linden, Evert de Jonge, Jaap Jan Zwaginga, Robert J M Klautz, M Sesmu Arbous
Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pre- and post-surgery non-fiberscopic miniBAL fluids were analysed for MUC5AC, MUC5B, IL-8, human neutrophil elastase, and neutrophils...
March 7, 2024: Respiratory Research
https://read.qxmd.com/read/38448933/differences-of-respiratory-mechanics-in-mechanical-ventilation-of-acute-respiratory-distress-syndrome-between-patients-with-covid-19-and-influenza-a
#27
JOURNAL ARTICLE
Eunki Chung, Ah Young Leem, Kyung Soo Chung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Hye Jin Jang, Su Hwan Lee
BACKGROUND: Whether COVID-19-induced acute respiratory distress syndrome (ARDS) should be approached differently in terms of mechanical ventilation therapy compared to other virus-induced ARDS is debatable. Therefore, we aimed to ascertain whether the respiratory mechanical characteristics of COVID-19-induced ARDS differ from those of influenza A induced ARDS, in order to establish a rationale for mechanical ventilation therapy in COVID-19-induced ARDS. METHODS: This was a retrospective cohort study comparing patients with COVID-19-induced ARDS and influenza A induced ARDS...
March 7, 2024: Respiratory Research
https://read.qxmd.com/read/38448986/response-to-are-there-over-200-distinct-types-of-interstitial-lung-diseases
#28
LETTER
Francesco Amati, Anna Stainer, Stefano Aliberti
No abstract text is available yet for this article.
March 6, 2024: Respiratory Research
https://read.qxmd.com/read/38448970/association-and-mediation-between-educational-attainment-and-respiratory-diseases-a-mendelian-randomization-study
#29
JOURNAL ARTICLE
Guohui Lan, Mengying Xie, Jieli Lan, Zelin Huang, Xiaowei Xie, Mengdan Liang, Zhehui Chen, Xiannuan Jiang, Xiaoli Lu, Xiaoying Ye, Tingting Xu, Yiming Zeng, Xiaoxu Xie
BACKGROUND: Respiratory diseases are a major health burden, and educational inequalities may influence disease prevalence. We aim to evaluate the causal link between educational attainment and respiratory disease, and to determine the mediating influence of several known modifiable risk factors. METHODS: We conducted a two-step, two-sample Mendelian randomization (MR) analysis using summary statistics from genome-wide association studies (GWAS) and single nucleotide polymorphisms (SNPs) as instrumental variables for educational attainment and respiratory diseases...
March 6, 2024: Respiratory Research
https://read.qxmd.com/read/38448953/disease-trajectories-in-interstitial-lung-diseases-data-from-the-exciting-ild-registry
#30
JOURNAL ARTICLE
Katharina Buschulte, Hans-Joachim Kabitz, Lars Hagmeyer, Peter Hammerl, Albert Esselmann, Conrad Wiederhold, Dirk Skowasch, Christoph Stolpe, Marcus Joest, Stefan Veitshans, Marc Höffgen, Phillen Maqhuzu, Larissa Schwarzkopf, Andreas Hellmann, Michael Pfeifer, Jürgen Behr, Rainer Karpavicius, Andreas Günther, Markus Polke, Philipp Höger, Vivien Somogyi, Christoph Lederer, Philipp Markart, Michael Kreuter
BACKGROUND: Interstitial lung diseases (ILD) comprise a heterogeneous group of mainly chronic lung diseases with different disease trajectories. Progression (PF-ILD) occurs in up to 50% of patients and is associated with increased mortality. METHODS: The EXCITING-ILD (Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases) registry was analysed for disease trajectories in different ILD. The course of disease was classified as significant (absolute forced vital capacity FVC decline > 10%) or moderate progression (FVC decline 5-10%), stable disease (FVC decline or increase < 5%) or improvement (FVC increase ≥ 5%) during time in registry...
March 6, 2024: Respiratory Research
https://read.qxmd.com/read/38448858/deciphering-the-molecular-regulatory-of-rab32-gprc5a-axis-in-chronic-obstructive-pulmonary-disease
#31
JOURNAL ARTICLE
Yixing Wu, Binfeng He, Jianlan Hua, Weiping Hu, Yaopin Han, Jing Zhang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a significant public health problem characterized by persistent airflow limitation. Despite previous research into the pathogenesis of COPD, a comprehensive understanding of the cell-type-specific mechanisms in COPD remains lacking. Recent studies have implicated Rab GTPases in regulating chronic immune response and inflammation via multiple pathways. In this study, the molecular regulating mechanism of RAB32 in COPD was investigated by multiple bioinformatics mining and experimental verification...
March 6, 2024: Respiratory Research
https://read.qxmd.com/read/38443957/self-administered-at-home-lung-ultrasound-with-remote-guidance-in-patients-without-clinical-training
#32
JOURNAL ARTICLE
Nika Elmi, Yasmin Sadri, Frank Myslik, Jordan Chenkin, William Cherniak
BACKGROUND: Access to timely and accurate diagnostic imaging is essential for high-quality healthcare. Point-of-care ultrasound has been shown to be accessible and effective in many aspects of healthcare, including assessing changes in lung pathology. However, few studies have examined self-administered at-home lung ultrasound (SAAH-LUS), in particular performed by non-clinical patients (NCPs). RESEARCH QUESTION: Are NCPs able to perform SAAH-LUS using remote teleguidance and produce interpretable images? STUDY DESIGN: Patients were enrolled to the study in a mix of in-person and virtual recruitment, and shipped a smartphone as well as a point of care ultrasound device...
March 5, 2024: Respiratory Research
https://read.qxmd.com/read/38431661/peroxiredoxin-3-has-a-crucial-role-in-the-macrophage-polarization-by-regulating-mitochondrial-homeostasis
#33
JOURNAL ARTICLE
Wenhui Huang, Lianfang Wang, Zhipeng Huang, Zhichao Sun, Bojun Zheng
Acute lung injury (ALI) is one of the life-threatening complications of sepsis, and macrophage polarization plays a crucial role in the sepsis-associated ALI. However, the regulatory mechanisms of macrophage polarization in ALI and in the development of inflammation are largely unknown. In this study, we demonstrated that macrophage polarization occurs in sepsis-associated ALI and is accompanied by mitochondrial dysfunction and inflammation, and a decrease of PRDX3 promotes the initiation of macrophage polarization and mitochondrial dysfunction...
March 2, 2024: Respiratory Research
https://read.qxmd.com/read/38429645/prognosis-of-mechanically-ventilated-patients-with-covid-19-after-failure-of-high-flow-nasal-cannula-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Dong-Gon Hyun, Su Yeon Lee, Jee Hwan Ahn, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
BACKGROUND: There is an argument whether the delayed intubation aggravate the respiratory failure in Acute respiratory distress syndrome (ARDS) patients with coronavirus disease 2019 (COVID-19). We aimed to investigate the effect of high-flow nasal cannula (HFNC) failure before mechanical ventilation on clinical outcomes in mechanically ventilated patients with COVID-19. METHODS: This retrospective cohort study included mechanically ventilated patients who were diagnosed with COVID-19 and admitted to the intensive care unit (ICU) between February 2020 and December 2021 at Asan Medical Center...
March 1, 2024: Respiratory Research
https://read.qxmd.com/read/38419061/p80-natural-essence-spray-and-lozenges-provide-respiratory-protection-against-influenza-a-b-and-sars-cov-2
#35
JOURNAL ARTICLE
Viktoria Zaderer, Gabriel Diem, Wilfried Posch, Thomas Jakschitz, Günther K Bonn, Rosa Bellmann-Weiler, Lukas A Huber, Doris Wilflingseder
Seasonally circulating viruses, such as Influenza, as well as newly emerging viruses and variants thereof, and waning immunity urge the need for safe, easy-to-use and inexpensive drugs to protect from these challenges. To prevent transmission of these viruses and subsequent excessive inflammatory reactions on mucous membranes, we tested the efficacy of the natural essence P80 as spray and in form of lozenges against respiratory infections caused by SARS-CoV-2 variants of concern (VoCs), influenza A (H3N2) and influenza B (Victoria)...
February 28, 2024: Respiratory Research
https://read.qxmd.com/read/38419044/fgf18-alleviates-sepsis-induced-acute-lung-injury-by-inhibiting-the-nf-%C3%AE%C2%BAb-pathway
#36
JOURNAL ARTICLE
Zhenyu Hu, Jindan Dai, Tianpeng Xu, Hui Chen, Guoxiu Shen, Jie Zhou, Hongfang Ma, Yang Wang, Litai Jin
BACKGROUND: Acute lung injury (ALI) is a devastating clinical disorder with a high mortality rate, and there is an urgent need for more effective therapies. Fibroblast growth factor 18 (FGF18) has potent anti-inflammatory properties and therefore has become a focus of research for the treatment of lung injury. However, the precise role of FGF18 in the pathological process of ALI and the underlying mechanisms have not been fully elucidated. METHODS: A mouse model of ALI and human umbilical vein endothelial cells (HUVEC) stimulated with lipopolysaccharide (LPS) was established in vivo and in vitro...
February 28, 2024: Respiratory Research
https://read.qxmd.com/read/38419035/immunomodulatory-and-clinical-effects-of-receptor-interacting-protein-kinase-1-ripk1-inhibitor-eclitasertib-sar443122-in-patients-with-severe-covid-19-a-phase-1b-randomized-double-blinded-placebo-controlled-study
#37
RANDOMIZED CONTROLLED TRIAL
Pierre-Francois Clot, Christine Farenc, Benjamin T Suratt, Tillmann Krahnke, Agnes Tardat, Peter Florian, Robert Pomponio, Naimish Patel, Maria Wiekowski, Yong Lin, Benjamin Terrier, Heribert Staudinger
BACKGROUND: Targeting receptor-interacting serine/threonine protein kinase 1 could mitigate the devastating sequelae of the hyperinflammatory state observed in severe cases of COVID-19. This study explored the immunomodulatory and clinical effects of the receptor-interacting serine/threonine protein kinase 1 inhibitor SAR443122 (eclitasertib) in patients with severe COVID-19. METHODS: In this Phase 1b, double-blinded, placebo-controlled study (NCT04469621) a total of 82 patients were screened, of whom 68 patients were eligible and randomized (2:1) to receive eclitasertib 600 mg (300 mg twice daily) or placebo up to 14 days...
February 28, 2024: Respiratory Research
https://read.qxmd.com/read/38419021/the-effect-of-combining-an-inhaled-corticosteroid-and-a-long-acting-muscarinic-antagonist-on-human-airway-epithelial-cells-in-vitro
#38
JOURNAL ARTICLE
Maria Gabriella Matera, Barbara Rinaldi, Cecilia Calabrese, Carmela Belardo, Luigino Calzetta, Mario Cazzola, Clive Page
BACKGROUND: Airway epithelial cells (AECs) are a major component of local airway immune responses. Direct effects of type 2 cytokines on AECs are implicated in type 2 asthma, which is driven by epithelial-derived cytokines and leads to airway obstruction. However, evidence suggests that restoring epithelial health may attenuate asthmatic features. METHODS: We investigated the effects of passive sensitisation on IL-5, NF-κB, HDAC-2, ACh, and ChAT in human bronchial epithelial cells (HBEpCs) and the effects of fluticasone furoate (FF) and umeclidinium (UME) alone and in combination on these responses...
February 28, 2024: Respiratory Research
https://read.qxmd.com/read/38419020/associations-between-long-term-ozone-exposure-and-small-airways-function-in-chinese-young-adults-a-longitudinal-cohort-study
#39
JOURNAL ARTICLE
Shurong Feng, Liu Yang, Siqi Dou, Xinyuan Li, Shuo Wen, Lailai Yan, Wenzhong Huang, Yiwen Zhang, Bin Ma, Linghong Yuan, Shanshan Li, Peng Lu, Yuming Guo
BACKGROUND: Increasing evidence is appearing that ozone has adverse effects on health. However, the association between long-term ozone exposure and lung function is still inconclusive. OBJECTIVES: To investigate the associations between long-term exposure to ozone and lung function in Chinese young adults. METHODS: We conducted a prospective cohort study among 1594 college students with a mean age of 19.2 years at baseline in Shandong, China from September 2020 to September 2021...
February 28, 2024: Respiratory Research
https://read.qxmd.com/read/38419014/local-heterogeneity-of-normal-lung-parenchyma-and-small-airways-disease-are-associated-with-copd-severity-and-progression
#40
JOURNAL ARTICLE
Alexander J Bell, Ravi Pal, Wassim W Labaki, Benjamin A Hoff, Jennifer M Wang, Susan Murray, Ella A Kazerooni, Stefanie Galban, David A Lynch, Stephen M Humphries, Fernando J Martinez, Charles R Hatt, MeiLan K Han, Sundaresh Ram, Craig J Galban
BACKGROUND: Small airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema. Although the amount of SAD in the lungs can be quantified using our Parametric Response Mapping (PRM) approach, the full breadth of this readout as a measure of emphysema and COPD progression has yet to be explored. We evaluated topological features of PRM-derived normal parenchyma and SAD as surrogates of emphysema and predictors of spirometric decline...
February 28, 2024: Respiratory Research
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