Yoshiaki Zaizen, Masaki Okamoto, Koichi Azuma, Junya Fukuoka, Hironao Hozumi, Noriho Sakamoto, Takafumi Suda, Hiroshi Mukae, Tomoaki Hoshino
BACKGROUND: Interstitial lung disease is frequently comorbid with dermatomyositis and has a poor prognosis, especially in patients with the anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody. However, the pathogenesis of dermatomyositis-related interstitial lung disease remains unclear. METHODS: We examined 18 and 19 patients with dermatomyositis-related interstitial lung disease and idiopathic pulmonary fibrosis (control), respectively. Lung tissues obtained from these patients were semi-quantitatively evaluated by immunohistochemical staining with in-house anti-human MDA5 monoclonal antibodies, as well as anti-human immunoglobulin (Ig) G, IgM, IgA, and complement component 3(C3) antibodies...
March 19, 2023: Respiratory Research
Le-Le Wang, Hai-Wen Lu, Ling-Ling Li, Yong-Hua Gao, Yu-Hua Xu, Hong-Xiao Li, Yun-Zhu Xi, Fu-Sheng Jiang, Xue-Feng Ling, Wei Wei, Fa-Jiu Li, Bei Mao, Sen Jiang, Jin-Fu Xu
BACKGROUND: Nearly half of bronchiectasis patients receiving bronchial artery embolization (BAE) still have recurrent hemoptysis, which may be life-threatening. Worse still, the underlying risk factors of recurrence remain unknown. METHODS: A retrospective cohort was conducted of patients with idiopathic bronchiectasis who received BAE from 2015 to 2019 at eight centers. Patients were followed up for at least 24 months post BAE. Based on the outcomes of recurrent hemoptysis and recurrent severe hemoptysis, a Cox regression model was used to identify risk factors for recurrence...
March 18, 2023: Respiratory Research
Yong Jun Choi, Heejae Han, Jae-Hyun Lee, Jaeuk Lee, Chi Young Kim, Min Kwang Byun, Jae Hwa Cho, Hye Jung Park
BACKGROUND: Particulate matter10 (PM10 ) can induce airway inflammation and fibrosis. Recently, chitinase-1 has been shown to play key roles in inflammation and fibrosis. We aimed to investigate the effects of chitinase-1 inhibitor in PM10 -treated murine mice models. METHODS: In female BALB/c mice, PM10 was intranasally administered six times over 3 weeks, and ovalbumin (OVA) was intraperitoneally injected and then intranasally administered. Chitinase-1 inhibitor (CPX) 6 times over 3 weeks or dexamethasone 3 times in the last week were intraperitoneally administered...
March 18, 2023: Respiratory Research
Mohammad Talaei, Pauline M Emmett, Raquel Granell, Hossein Tabatabaeian, Kate Northstone, Anna Bergström, Seif O Shaheen
BACKGROUND: Longitudinal epidemiological data are scarce examining the relationship between dietary patterns and respiratory outcomes in childhood. We investigated whether three distinct dietary patterns in mid-childhood were associated with lung function and incident asthma in adolescence. METHODS: In the Avon Longitudinal Study of Parents and Children, 'processed', 'traditional', and 'health-conscious' dietary patterns were identified using principal components analysis from food frequency questionnaires at 7 years of age...
March 16, 2023: Respiratory Research
Ana M Rodriguez-Piñeiro, Florian Jaudas, Nikolai Klymiuk, Andrea Bähr, Gunnar C Hansson, Anna Ermund
BACKGROUND: The respiratory tract is protected from inhaled particles and microbes by mucociliary clearance, mediated by the mucus and the cilia creating a flow to move the mucus cephalad. Submucosal glands secrete linear MUC5B mucin polymers and because they pass through the gland duct before reaching the airway surface, bundled strands of 1000-5000 parallel molecules exit the glands. In contrast, the surface goblet cells secrete both MUC5AC and MUC5B. METHODS: We used mass-spectrometry based proteomic analysis of unstimulated and carbachol stimulated newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglet airways to study proteins in the airway surface liquid and mucus, to investigate if levels of MUC5AC and MUC5B were affected by carbachol stimulation and whether the proteins clustered according to function...
March 16, 2023: Respiratory Research
Zhuhua Wu, Li Zhu, Xinran Nie, Yingli Liu, Xiaoju Zhang, Yong Qi
BACKGROUND: Obesity has been identified as a risk factor for acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, the underlying mechanisms remain elusive. This study aimed to investigate the role of fatty acid synthase (FASN) in lipopolysaccharide (LPS)-induced ALI under obesity. METHODS: A high-fat diet-induced obese (DIO) mouse model was established and lean mice fed with regular chow diet were served as controls. LPS was intratracheally instilled to reproduce ALI in mice...
March 15, 2023: Respiratory Research
Matteo Storti, Maria Laura Faietti, Xabier Murgia, Chiara Catozzi, Ilaria Minato, Danilo Tatoni, Simona Cantarella, Francesca Ravanetti, Luisa Ragionieri, Roberta Ciccimarra, Matteo Zoboli, Mar Vilanova, Ester Sánchez-Jiménez, Marina Gay, Marta Vilaseca, Gino Villetti, Barbara Pioselli, Fabrizio Salomone, Simone Ottonello, Barbara Montanini, Francesca Ricci
BACKGROUND: Premature birth, perinatal inflammation, and life-saving therapies such as postnatal oxygen and mechanical ventilation are strongly associated with the development of bronchopulmonary dysplasia (BPD); these risk factors, alone or combined, cause lung inflammation and alter programmed molecular patterns of normal lung development. The current knowledge on the molecular regulation of lung development mainly derives from mechanistic studies conducted in newborn rodents exposed to postnatal hyperoxia, which have been proven useful but have some limitations...
March 15, 2023: Respiratory Research
Lihuang Su, Xiuchun Li, Xulong Mao, Tingting Xu, Yiying Zhang, Shini Li, Xiayan Zhu, Liangxing Wang, Dan Yao, Jian Wang, Xiaoying Huang
BACKGROUND: Circular RNAs (circRNAs), a novel class of non-coding RNAs, play an important regulatory role in pulmonary arterial hypertension (PAH); however, the specific mechanism is rarely studied. In this study, we aimed to discover functional circRNAs and investigate their effects and mechanisms in hypoxia-induced pulmonary vascular remodelling, a core pathological change in PAH. METHODS: RNA sequencing was used to illustrate the expression profile of circRNAs in hypoxic PAH...
March 13, 2023: Respiratory Research
Yizhu Yao, Yaozhe Li, Xiayan Zhu, Chengguang Zhao, Lehe Yang, Xiaoying Huang, Liangxing Wang
PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18-33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a subfamily of Argonaute (AGO) proteins that also contain the AGO family which bind to microRNA (miRNA). Recently studies indicate that piRNAs are not specific to in the mammalian germline, they are also expressed in a tissue-specific manner in a variety of human tissues and participated in various of diseases, such as cardiovascular, neurological, and urinary tract diseases, and are especially prevalent in malignant tumors in these systems...
March 13, 2023: Respiratory Research
Stephen Wai Hang Kwok, Guanjin Wang, Ferdous Sohel, Kianoush B Kashani, Ye Zhu, Zhen Wang, Eduardo Antpack, Kanika Khandelwal, Sandeep R Pagali, Sanjeev Nanda, Ahmed D Abdalrhim, Umesh M Sharma, Sumit Bhagra, Sagar Dugani, Paul Y Takahashi, Mohammad H Murad, Mohammed Yousufuddin
BACKGROUND: We applied machine learning (ML) algorithms to generate a risk prediction tool [Collaboration for Risk Evaluation in COVID-19 (CORE-COVID-19)] for predicting the composite of 30-day endotracheal intubation, intravenous administration of vasopressors, or death after COVID-19 hospitalization and compared it with the existing risk scores. METHODS: This is a retrospective study of adults hospitalized with COVID-19 from March 2020 to February 2021. Patients, each with 92 variables, and one composite outcome underwent feature selection process to identify the most predictive variables...
March 13, 2023: Respiratory Research
Alette A Koopman, Jefta van Dijk, Eline Oppersma, Robert G T Blokpoel, Martin C J Kneyber
BACKGROUND: The patient's neuro-respiratory drive, measured as electrical activity of the diaphragm (EAdi), quantifies the mechanical load on the respiratory muscles. It correlates with respiratory effort but requires a dedicated esophageal catheter. Transcutaneous (surface) monitoring of respiratory muscle electromyographic (sEMG) signals may be considered a suitable alternative to EAdi because of its non-invasive character, with the additional benefit that it allows for simultaneously monitoring of other respiratory muscles...
March 13, 2023: Respiratory Research
Mahsa Heidari-Foroozan, Alisam Aryan, Zahra Esfahani, Mohammad Amin Shahrbaf, Sahar Saeedi Moghaddam, Mohammad Keykhaei, Erfan Ghasemi, Mohammad-Mahdi Rashidi, Nazila Rezaei, Seyyed-Hadi Ghamari, Mohsen Abbasi-Kangevari, Sahar Mohammadi Fateh, Yousef Farzi, Negar Rezaei, Bagher Larijani
INTRODUCTION: Data on the distribution of the burden of diseases is vital for policymakers for the appropriate allocation of resources. In this study, we report the geographical and time trends of chronic respiratory diseases (CRDs) in Iran from 1990 to 2019 based on the Global burden of the Disease (GBD) study 2019. METHODS: Data were extracted from the GBD 2019 study to report the burden of CRDs through disability-adjusted life years (DALYs), mortality, incidence, prevalence, Years of Life lost (YLL), and Years Lost to Disability (YLD)...
March 11, 2023: Respiratory Research
Jieun Kang, Rugyeom Lee, Sei Won Lee
BACKGROUND: Gastroesophageal reflux disease (GERD) has been suggested as a risk factor for acute exacerbation of chronic obstructive pulmonary disease (COPD). However, it remains undetermined whether proton pump inhibitor (PPI) treatment reduces the risk of exacerbation or affects the risk of pneumonia. This study aimed to evaluate the risks of both exacerbation and pneumonia following PPI treatment for GERD in patients with COPD. METHODS: This study used a reimbursement database of the Republic of Korea...
March 11, 2023: Respiratory Research
Zili Zhang, Jian Wang, Yuanyuan Li, Fei Liu, Lingdan Chen, Shunping He, Fanjie Lin, Xinguang Wei, Yaowei Fang, Qiongqiong Li, Juntuo Zhou, Wenju Lu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease with high morbidity and mortality, especially in advanced patients. We aimed to develop multi-omics panels of biomarkers for the diagnosis and explore its molecular subtypes. METHODS: A total of 40 stable patients with advanced COPD and 40 controls were enrolled in the study. Proteomics and metabolomics techniques were applied to identify potential biomarkers. An additional 29 COPD and 31 controls were enrolled for validation of the obtained proteomic signatures...
March 11, 2023: Respiratory Research
Daniel B Horton, Amanda L Neikirk, Yiling Yang, Cecilia Huang, Reynold A Panettieri, Stephen Crystal, Brian L Strom, Lauren E Parlett
BACKGROUND: Prior studies have documented declines in pediatric asthma exacerbations and asthma-related health care utilization during the COVID-19 pandemic, but less is known about the incidence of asthma during the pandemic. METHODS: We conducted a retrospective cohort study of children under age 18 without a prior diagnosis of asthma within a large US commercial claims database. Incident asthma was defined using a combination of diagnosis codes, location of services, and medication dispensing...
March 10, 2023: Respiratory Research
Michael Kreuter, Elisabeth Bendstrup, Stéphane Jouneau, Toby M Maher, Yoshikazu Inoue, Corinna Miede, Dirk Lievens, Bruno Crestani
BACKGROUND: Lower body mass index (BMI) and weight loss have been associated with worse outcomes in some studies in patients with pulmonary fibrosis. We analyzed outcomes in subgroups by BMI at baseline and associations between weight change and outcomes in subjects with progressive pulmonary fibrosis (PPF) in the INBUILD trial. METHODS: Subjects with PPF other than idiopathic pulmonary fibrosis were randomized to receive nintedanib or placebo. In subgroups by BMI at baseline (< 25, ≥ 25 to < 30, ≥ 30 kg/m2 ), we analyzed the rate of decline in FVC (mL/year) over 52 weeks and time-to-event endpoints indicating disease progression over the whole trial...
March 9, 2023: Respiratory Research
Paola Faverio, Raffaella Ronco, Matteo Monzio Compagnoni, Matteo Franchi, Giovanni Franco, Giulia Bonaiti, Martina Bonifazi, Federico Mei, Fabrizio Luppi, Alberto Pesci, Giovanni Corrao
RATIONALE: Severe asthma is burdened by relevant socio-economic and clinical impact. Randomized controlled trials on Dupilumab showed efficacy and a good safety profile, but post-market studies are needed. OBJECTIVES: To evaluate the impact of Dupilumab on (i) the use of anti-asthmatic drugs, including oral corticosteroids (OCS), (ii) the rates of asthma exacerbation-related hospital admissions, and (iii) the healthcare costs in patients with asthma. METHODS: Data were retrieved from Healthcare Utilization database of Lombardy region (Italy)...
March 7, 2023: Respiratory Research
Yun Song, Wenhuan Fu, Youzhi Zhang, Doudou Huang, Jian Wu, Shuangmei Tong, Mingkang Zhong, Huifang Cao, Bin Wang
BACKGROUND: Airway epithelium is the first barrier against environmental insults, and epithelial barrier dysfunction caused by cigarette smoke (CS) is particularly relevant to chronic obstructive pulmonary disease (COPD) progression. Our study was to determine whether Azithromycin (AZI) ameliorates CS-induced airway epithelial barrier dysfunction and the underlying mechanisms. METHODS: Primary bronchial epithelial cells (PBECs), human bronchial epithelial cells (HBECs), Sprague Dawley rats and nuclear factor erythroid 2-related factor 2 (Nrf2)-/- mice were pretreated with AZI and subsequently exposed to CS...
March 6, 2023: Respiratory Research
Sun Mi Choi, Yosep Mo, Ji-Young Bang, Young Gyun Ko, Yoon Hae Ahn, Hye Young Kim, Jaemoon Koh, Jae-Joon Yim, Hye-Ryun Kang
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that has no cure. Although mesenchymal stem cells (MSCs) have been reported to ameliorate lung inflammation and fibrosis in mouse models, their mechanisms of action remain unknown. Therefore, we aimed to determine the changes in various immune cells, especially macrophages and monocytes, involved in the effects of MSC treatment on pulmonary fibrosis. METHODS: We collected and analyzed explanted lung tissues and blood from patients with IPF who underwent lung transplantation...
March 5, 2023: Respiratory Research
Li Ting, Yingying Feng, Ying Zhou, Zhongkai Tong, Zhaoxing Dong
PURPOSE: Previous studies have shown that interleukin-27 (IL-27) can reduce bleomycin (BLM)-induced pulmonary fibrosis (PF). However, the underlying mechanism by which IL-27 attenuates PF is not fully clear. METHODS: In this research, we used BLM to construct a PF mouse model, and MRC-5 cells stimulated by transforming growth factor-β1 (TGF-β1) were used to construct a PF model in vitro. The lung tissue status was observed by Masson and hematoxylin and eosin (HE) staining...
March 3, 2023: Respiratory Research
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