journal
MENU ▼
Read by QxMD icon Read
search

Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG

journal
https://read.qxmd.com/read/30697139/pediatric-pharmacists-participation-in-cardiopulmonary-resuscitation-events
#1
Peter N Johnson, Amy Mitchell-Van Steele, Amy L Nguyen, Sylvia Stoffella, J Maria Whitmore
The Pediatric Pharmacy Advocacy Group (PPAG) understands the dilemma and varying factors that many institutions face concerning the routine participation of pharmacists in emergency resuscitation events. Acknowledging these obstacles, the PPAG encourages all institutions to strongly consider creating, adopting, and upholding policies to address pharmacists' participation in cardiopulmonary resuscitation (CPR) as evidenced by the impact pharmacist participation has shown on the reduction of hospital medication error and mortality rates in children...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697138/the-role-of-the-pediatric-pharmacist-in-precision-medicine-and-clinical-pharmacogenomics-for-children
#2
Jacob T Brown, David Gregornik, Mary Jayne Kennedy
With the initiatives by the National Institutes of Health and the US Food and Drug Administration, pharmacogenomics is transitioning from the laboratory to patient care. Nearly 200 drug products now contain pharmacogenomic information as part of their labeling; many of these products are commonly used in the pediatric population. Because pharmacogenomic testing can provide patient-specific predictors for drug response, pharmacists are positioned to assume a leadership role in pharmacogenomic testing, clinical interpretation of results, and recommendations for individualization of drug therapy...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697137/tolvaptan-use-to-treat-siadh-in-a-child
#3
Adem Yasin Koksoy, Meltem Kurtul, Aslı Kantar Ozsahin, Fatma Semsa Cayci, Meltem Tayfun, Umut Selda Bayrakci
Hyponatremia is one of the most common electrolyte abnormalities encountered in the clinical setting in hospitalized patients. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the leading cause of hyponatremia in most of these cases. While fluid restriction, hypertonic saline infusion, diuretics, and the treatment of underlying conditions constitute the first line of treatment of SIADH, in refractory cases, and especially for pediatric patients, there seems not to be any other choice for treatment...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697136/ceftaroline-plus-daptomycin-for-refractory-methicillin-resistant-staphylococcus-aureus-bacteremia-in-a-child
#4
Alan M Hall, Sean M McTigue
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can be difficult to treat, with growing adult literature supporting the combination of ceftaroline and daptomycin for these patients. Here, we report a pediatric patient with persistent MRSA bacteremia with associated cellulitis, fasciitis, myositis, and a deep venous thrombosis causing septic pulmonary emboli. After being unable to clear the bacteremia on vancomycin and then daptomycin monotherapy, the bacteremia cleared quickly with rapid clinical improvement after the addition of ceftaroline to daptomycin...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697135/dexmedetomidine-associated-fever-in-a-critically-ill-obese-child
#5
R Zachary Thompson, Lori McDonald, Keegan Ziemba, Joseph D Tobias, Claire A Stewart
Dexmedetomidine use in the pediatric intensive care unit has increased in recent years. Reports of dexmedetomidine-associated drug fever have been described in adult patients; however, this has not been reported in the pediatric population. We report a case of persistent fever that resolved with the discontinuation of dexmedetomidine and successful transition to clonidine. This is the first report of dexmedetomidine drug fever in a pediatric patient.
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697134/identification-of-factors-associated-with-the-desire-to-participate-in-a-pediatric-pharmacy-practice-based-research-network
#6
Jeremy S Stultz, Chad A Knoderer, Kalen B Manasco, Jill A Morgan, Hanna Phan
OBJECTIVES: To evaluate the practice-based research network (PBRN) potential within the Pediatric Pharmacy Advocacy Group (PPAG) membership and to identify characteristics associated with member willingness to join a PPAG PBRN. METHODS: In October 2016, a 21-question survey was sent by email to approximately 900 PPAG pharmacist members (excluding students) using contact information contained in the PPAG membership database. The survey elucidated information regarding training, clinical and research experience, practice site information, and willingness to participate in a PPAG PBRN...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697133/evaluation-of-the-cardiovascular-effects-of-clonidine-in-neonates-treated-for-neonatal-abstinence-syndrome
#7
Raymond P Meddock, Deirdre Bloemer
OBJECTIVES: Neonatal abstinence syndrome (NAS) is characterized by withdrawal symptoms in neonates exposed to legal or illegal substances in utero , and it is often managed with medications such as opiates, phenobarbital, and clonidine. Clonidine use is increasing, but further safety data regarding its use in neonates are warranted. This study evaluated the effects of clonidine on heart rate and blood pressure in neonates treated for NAS at doses up to 24 mcg/kg/day. METHODS: A retrospective review via the electronic medical record of infants at least 35 weeks' gestation treated adjunctively with clonidine for NAS in the neonatal intensive care unit at St Elizabeth was conducted...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697132/association-of-procalcitonin-value-and-bacterial-coinfections-in-pediatric-patients-with-viral-lower-respiratory-tract-infections-admitted-to-the-pediatric-intensive-care-unit
#8
John J Kotula, Wayne S Moore, Arun Chopra, Jeffrey J Cies
OBJECTIVE: Our primary objective was to determine the utility of procalcitonin (PCT) in detection of bacterial coinfection in children < 5 years admitted to the pediatric intensive care unit with viral lower respiratory tract infection (LRTI). METHODS: Electronic medical record review of children < 5 years admitted to the pediatric intensive care unit with a viral LRTI who also had at least 1 PCT concentration measurement. RESULTS: Seventy-five patients were admitted to the intensive care unit and met the inclusion criteria for this investigation...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697131/is-orally-administered-pentobarbital-a-safe-and-effective-alternative-to-chloral-hydrate-for-pediatric-procedural-sedation
#9
Jordan Anderson, Sevilay Dalabih, Esma Birisi, Abdallah Dalabih
OBJECTIVES: Chloral hydrate had been extensively used for children undergoing sedation for imaging studies, but after the manufacturer discontinued production, pediatric sedation providers explored alternative sedation medications. Those medications needed to be at least as safe and as effective as chloral hydrate. In this study, we examined if pentobarbital is a suitable replacement for chloral hydrate. METHODS: Subjects who received pentobarbital were recruited from a prospectively collected database, whereas we used a retrospective chart review to study subjects who received chloral hydrate...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697130/pharmacologic-management-of-agitation-and-aggression-in-a-pediatric-emergency-department-a-retrospective-cohort-study
#10
Jennifer G Kendrick, Ran D Goldman, Roxane R Carr
BACKGROUND: Benzodiazepine and antipsychotic use for acute management of agitation and aggression in the pediatric emergency department (ED) setting has not been well described. OBJECTIVES: To describe medication utilization in the management of agitation and aggression in a pediatric ED and to assess the safety of their use. METHODS: This was a retrospective observational study. Patients less than 20 years of age who presented to our pediatric ED and had agitation or aggression as part of their chief complaint were included if they received at least 1 dose of benzodiazepine or antipsychotic...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697129/safety-and-utility-of-continuous-ketamine-infusion-for-sedation-in-mechanically-ventilated-pediatric-patients
#11
Amy L Heiberger, Surachat Ngorsuraches, Gokhan Olgun, Lisa Luze, Caitlin Leimbach, Holly Madison, Saquib A Lakhani
OBJECTIVES: The selection of sedative medications for mechanically ventilated pediatric patients remains an ongoing clinical challenge. Although continuous ketamine infusion has been used in this population, support for its use remains largely anecdotal. This study describes a single institution's use of ketamine infusions as part of a sedation protocol in the pediatric intensive care unit (PICU). METHODS: This was a retrospective study of children who received ketamine infusions as part of a multidrug sedation protocol in a 12-bed PICU at a tertiary children's hospital...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697128/an-introduction-to-pharmacotherapy-for-inborn-errors-of-metabolism
#12
REVIEW
Aaron A Harthan
Inborn errors of metabolism comprise a wide array of diseases and complications in the pediatric patient. The rarity of these disorders limits the ability to conduct and review robust literature regarding the disease states, mechanisms of dysfunction, treatments, and outcomes. Often, treatment plans will be based on the pathophysiology associated with the disorder and theoretical agents that may be involved in the metabolic process. Medication therapies usually consist of natural or herbal products. Established efficacious pediatric doses for these products are difficult to find in tertiary resources, and adverse effects are routinely limited to single case reports...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30697127/glomerular-filtration-rate-estimation-formulas-for-pediatric-and-neonatal-use
#13
REVIEW
Edit Muhari-Stark, Gilbert J Burckart
Renal function assessment is of the utmost importance in predicting drug clearance and in ensuring safe and effective drug therapy in neonates. The challenges to making this prediction relate not only to the extreme vulnerability and rapid maturation of this pediatric subgroup but also to the choice of renal biomarker, covariates, and glomerular filtration rate (GFR) estimating formula. In order to avoid burdensome administration of exogenous markers and/or urine collection in vulnerable pediatric patients, estimation of GFR utilizing endogenous markers has become a useful tool in clinical practice...
November 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30429697/severe-neuropathic-pain-with-concomitant-administration-of-vincristine-and-posaconazole
#14
Mark John-Yung Lin, Megan Rose Paul, Dennis John Kuo
Vincristine is a chemotherapeutic agent with a potential toxicity of sensorimotor peripheral neuropathy. Patients receiving chemotherapy are in an immunocompromised state and may require antifungal agents. Triazole antifungals are known inhibitors of cytochrome P450 (CYP) enzymes. Vincristine is a known CYP3A4 and CYP3A5 substrate, and concomitant administration with fluconazole or voriconazole has been reported to increase vincristine toxicity and peripheral neuropathy, but there is limited literature on posaconazole in this regard...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30429696/assessment-of-outcomes-with-a-sedation-protocol-during-laser-photocoagulation-in-preterm-infants-with-retinopathy-of-prematurity
#15
Jennifer F Dannelley, Peter N Johnson, Michael P Anderson, Kari Oestreich, R Michael Siatkowski, Jamie L Miller
OBJECTIVES: To evaluate the success of a sedation protocol of fentanyl and midazolam infusions for infants undergoing laser photocoagulation for retinopathy of prematurity. METHODS: This retrospective study included infants receiving a sedation protocol for laser photocoagulation during a 4-year period. The primary objective was protocol success, defined as completion without interruption, absence of protocol dose deviations, and absence of interventions. Secondary objectives compared outcomes between those with and without opioid/benzodiazepine exposure...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30429695/effectiveness-of-antimicrobial-preservation-of-extemporaneous-diluted-simple-syrup-vehicles-for-pediatrics
#16
Ana Santoveña-Estévez, Javier Suárez-González, Martín Vera, Cristina González-Martín, Mabel Soriano, José B Fariña
OBJECTIVES: Extemporaneous or magistral formulation of active pharmaceutical ingredients using traditional compounding techniques is a common practice when no commercial form is available for pediatrics. For this vulnerable group of patients, the formulation must be prepared with the minimum quantity and lowest proportion of excipients approved for pediatrics, avoiding the use of preservatives. Often the vehicles used for these preparations are dilutions of simple syrup with water. The objective of this study is to assess the effectiveness of antimicrobial preservation in simple syrup diluted with aqua conservans (conserved water), without propylene glycol or with a reduced proportion of parabens...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30429694/use-of-intravenous-acetaminophen-in-children-for-analgesia-after-spinal-fusion-surgery-a-randomized-clinical-trial
#17
Nicole Rizkalla, Nicole R Zane, Janice L Prodell, Okan U Elci, Lynne G Maxwell, Mary Ann DiLiberto, Athena F Zuppa
OBJECTIVES: Opioid pharmacotherapy is the cornerstone of postoperative analgesia. Despite its effectiveness, it has a variety of potential adverse effects. Therefore, a multimodal approach with non-opioid analgesics would be optimal. The aim of this study was to determine if intravenous (IV) acetaminophen would reduce opioid requirements and improve clinical outcomes in children after surgery. METHODS: A single-center, randomized, double-blind study was conducted in 57 children (10-18 years old) undergoing posterior spine fusion surgery between July 2011 to May 2014...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30429693/azithromycin-induces-migrating-motor-complexes-in-pediatric-patients-undergoing-antroduodenal-motility-studies
#18
Asiya K Shakir, Muhammad Adnan Altaf
OBJECTIVE: Erythromycin (ERY) is used in the treatment of gastroparesis; however, this medication is associated with serious side effects, such as cardiac arrhythmias and consequent cardiorespiratory arrest. Azithromycin (AZM) has been suggested as an alternative to ERY as a result of its improved safety profile. Intravenous ERY (1 mg/kg) is administered during antroduodenal motility studies to induce migrating motor complexes (MMCs), the presence or absence of which helps diagnose motility disorders like gastroparesis and gastrointestinal dysmotility...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30429692/relationship-of-pulmonary-outcomes-microbiology-and-serum-antibiotic-concentrations-in-cystic-fibrosis-patients
#19
Andrea Hahn, Caroline Jensen, Hani Fanous, Hollis Chaney, Iman Sami, Geovanny F Perez, Stan Louie, Anastassios C Koumbourlis, James E Bost, John N van den Anker
OBJECTIVES: To determine the frequency of subtherapeutic exposure to intravenously administered β-lactam antibiotics in a cohort of cystic fibrosis (CF) patients who were treated for a pulmonary exacerbation, and its impact on pulmonary function. METHODS: Nineteen CF patients between the ages of 5 and 21 years treated at Children's National Health System for a pulmonary exacerbation were followed between March 2015 and August 2016 in a prospective, longitudinal study...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/30429691/pediatric-antiviral-stewardship-defining-the-potential-role-of-ribavirin-in-respiratory-syncytial-virus-associated-lower-respiratory-illness
#20
Jessica Hoover, Shannan Eades, Weng Man Lam
OBJECTIVES: Although no longer included in the American Academy of Pediatrics guideline, ribavirin was shown to be beneficial in a subset of adult patients with severe respiratory syncytial virus (RSV)-associated bronchiolitis. This study aimed to investigate risk factors for progression to severe acute respiratory tract infections in hospitalized pediatric patients with RSV-associated bronchiolitis to identify which patients may benefit from inhaled ribavirin therapy, despite its substantial cost, diffcult administration, and potential complications...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
journal
journal
39244
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"