Dominik Soll, Philip Bischoff, Anne Frisch, Marie Jensen, Zehra Karadeniz, Martina T Mogl, David Horst, Tobias Penzkofer, Joachim Spranger, Ulrich Keilholz, Knut Mai
BACKGROUND: Anaplastic thyroid cancer (ATC) is a rare and aggressive neoplasm. We still lack effective treatment options, so survival rates remain very low. Here, we aimed to evaluate the activity of the combination of lenvatinib and pembrolizumab as systemic first-line therapy in ATC. METHODS: In a retrospective analysis, we investigated the activity and tolerability of combined lenvatinib (starting dose 14 to 24 mg daily) and pembrolizumab (200 mg every three weeks) as first-line therapy in an institutional cohort of ATC patients...
February 22, 2024: BMC Endocrine Disorders
Abdollahi Fariba, Mohammad Amerzadeh, Marjan Banazadeh, Saba Rashidi, Zahra Tayebi Myaneh
BACKGROUND: Hypoglycemia, a prevalent acute complication among individuals with type 2 diabetes (T2D), manifests with varied symptoms. Those with diabetes who have previously encountered hypoglycemic episodes commonly develop a Fear of Hyperglycemia (FOH). Illness perception (IP) significantly affects self-care behaviors and health outcomes in individuals diagnosed with T2D. OBJECTIVE: This study examined the correlation between IP and FOH among T2D patients and predictors of FOH...
February 20, 2024: BMC Endocrine Disorders
Lei Sui, Qiang Xie, Hong-Tao Jiang, Xiao-Dong Li
BACKGROUND: Diabetic foot ulcers (DFUs) have become a global health concern, which can lead to diabetic foot infection (DFI), lower leg amputation, and even mortality. Though the standard of care (SOC) practices have been recognized as the "gold standard" for DFU care, SOC alone may not be adequate to heal all DFUs and prevent their recurrence. The use of dermal matrix has emerged as an adjuvant treatment to enhance DFU healing. The current study aimed to evaluate the effectiveness and safety of dermal matrix application as an adjuvant treatment to the SOC...
February 20, 2024: BMC Endocrine Disorders
Changhui Yu, Shiming He, Maobin Kuang, Chao Wang, Xin Huang, Guotai Sheng, Yang Zou
BACKGROUND: Obesity is the most important driver of non-alcoholic fatty liver disease (NAFLD); nevertheless, the relationship of weight-adjusted waist index (WWI), a new obesity index, with NAFLD is unclear. METHODS: This retrospective study used data from the NAGALA project from 1994 to 2016. WWI values were calculated using waist circumference (WC) and weight measurements of the participants. Three stepwise adjusted logistic regression models were developed to assess the relationship of WWI with NAFLD in the whole population and in both sexes...
February 18, 2024: BMC Endocrine Disorders
Fatemeh Abdi, Milad Mohammadzadeh, Mahdieh Abbasalizad-Farhangi
BACKGROUND: The prevalence of obesity is a growing global public health concern. Certain dietary amino acids have been shown to have a potential therapeutic role in improving metabolic syndrome parameters and body composition in individuals with obesity. However, some amino acids have been linked to an increased risk of cardiometabolic disorders. This cross-sectional study aims to investigate the association between dietary amino acid patterns and cardiometabolic risk factors in individuals with obesity...
February 14, 2024: BMC Endocrine Disorders
Kyle Shen, Catherine Cadang, Daniel Phillips, Varsha Babu
BACKGROUND: Lymphocytic hypophysitis is a rare autoimmune condition that usually presents during pregnancy and causes inflammation of the pituitary gland. Although the pathophysiology is not well understood, it often presents with headaches, visual disturbances, and symptoms of hypopituitarism. However, not all cases may present with hypopituitarism which can make this rare disease with an incidence of ~ 1 in 9 million much more difficult to diagnose. CASE PRESENTATION: We present a 35-year-old G4P4 woman with progressive vision loss and intermittent frontal headaches during her first trimester through 2 months postpartum...
February 8, 2024: BMC Endocrine Disorders
Zongming Wang, Zize Feng, Dimin Zhu, Xin Wang, Jinping Chen, Yonghong Zhu, Haijun Wang
BACKGROUND: We assessed the value of positron emission tomography/computed tomography (PET/CT) with [13 N]N-ammonia ([13 N]N-NH3) and [11 C]C-methionine ([11 C]C-MET) for the evaluation and management of recurrent secreting pituitary adenoma, which could not be detected by magnetic resonance imaging (MRI) or fluorine-18 fluorodeoxyglucose ([18 F]F-FDG) PET. METHODS: Nine consecutive patients with biochemical and clinical evidence of active recurrent tumor not detected by MRI and [18 F]F-FDG PET were enrolled in this study...
February 5, 2024: BMC Endocrine Disorders
Qi Wang, Zhijuan Gan, Qing Gao, Meng Wang, Bingdong Zhan
BACKGROUND: Risk analysis is an important area of research in diabetes and cardiovascular disease (CVD), both of which have significant global health burdens. Although there is evidence that patients with prediabetes and diabetes mellitus may have an increased risk of CVD, few studies have been conducted in mainland China. METHODS: This retrospective cohort study utilized data from the Quzhou City Resident Health Information System and the Zhejiang Province Chronic Disease Surveillance System in China...
February 2, 2024: BMC Endocrine Disorders
Sethapong Lertsakulbunlue, Tanatip Sangkool, Varathpavee Bhuriveth, Mathirut Mungthin, Ram Rangsin, Anupong Kantiwong, Boonsub Sakboonyarat
BACKGROUND: Hyperuricemia has placed an immense burden on the global healthcare system. Studies have discovered a close correlation between serum uric acid (SUA) and insulin resistance (IR). The objective of this investigation is to examine the association between the triglyceride-glucose (TyG) index, a simple surrogate for IR, and the presence of hyperuricemia. METHODS: Between 2017 and 2021, an epidemiologic study was conducted on Royal Thai Army (RTA) personnel aged 35-60 years, involving a total of 231,286 participants...
February 1, 2024: BMC Endocrine Disorders
Kiyomi Kuba, Tomonori Kawasaki, Yuichiro Enoki, Hitoshi Inoue, Satoko Matsumura, Tomoko Yamazaki, Yasuhiro Ebihara, Mitsuhiko Nakahira, Masashi Sugasawa
BACKGROUND: Follicular adenomas with papillary architecture are rare tumors of thyroid origin and are composed of completely encapsulated follicular cells with a papillary architecture lacking the nuclear characteristics of papillary carcinoma. Herein, we present a case of follicular adenoma with papillary architecture originating from an ectopic thyroid gland, diagnosed from a mass in the submandibular region. CASE PRESENTATION: A 70-year-old woman was referred to our hospital with the chief complaint of a painless left submandibular mass that had been present for one year...
January 30, 2024: BMC Endocrine Disorders
Jing Zeng, Lan Li, Dong Wei
BACKGROUND: Graves' disease increases bone resorption in hyperthyroidism, leading to elevated serum calcium levels and a negative bone balance. Thymic hyperplasia is observed in some Graves' disease patients. What's more, there have been a few reports of increased serum calcium and severe osteoporosis induced by Graves' disease with thymic hyperplasia. It remains unclear whether Graves' disease with thymic hyperplasia is associated with higher serum calcium levels. Our study aimed to investigate the possibility of elevated serum calcium levels and aggravated bone mobilization in Graves' disease patients with thymic hyperplasia...
January 29, 2024: BMC Endocrine Disorders
Si Wang, Ping Chen, Yayi He, Jing Wei, Li Tian, Yajun Wu, Hongjun Lv, Xiaogang Peng, Xingru Zhang, Bingyin Shi, Qian Wu
BACKGROUND: Hypothyroidism is a major manifestation of autoimmune thyroid diseases (AITD). We previously reported that a low selenium (Se) status was linked to an elevated prevalence of thyroid diseases. We hypothesized that Se status may also influence the restoration of thyroid function. Thus, this study aimed to investigate the factors affecting the recovery of thyroid function in patients with (sub-)clinical hypothyroidism, with a specific focus on Se status. METHODS: We conducted a 6-year prospective cohort study comparing two counties with different Se concentrations...
January 29, 2024: BMC Endocrine Disorders
Seyed Farzad Maroufi, Mohammadmahdi Sabahi, Seyed Sahab Aarabi, Mohammad Samadian, Rocco Dabecco, Badih Adada, Karla M Arce, Hamid Borghei-Razavi
BACKGROUND AND OBJECTIVE: Management of recurrent acromegaly is challenging for both neurosurgeons and endocrinologists. Several treatment options including repeat surgery, medical therapy, and radiation are offered for such patients. The efficacy of these modalities for the treatment of recurrence has not been studied previously in the literature. In this study, we aim to systematically review the existing cases of recurrence and come to a conclusion regarding the appropriate treatment in such cases...
January 26, 2024: BMC Endocrine Disorders
Qilang Xiang, Mengling Yang, Wenxuan Luo, Yuzi Cao, Shiquan Shuai, Xin Wei, Anji Xiong
PURPOSE: To evaluate the efficacy and safety of combined glucocorticoids (GCs) and cyclophosphamide (CYC) treatment in Graves' ophthalmopathy (GO). METHODS: We searched PubMed, Embase, Cochrane Library, and four Chinese databases (Chinese National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), WanFang, and SinoMed) for any published randomized controlled trials (RCTs) produced from inception to December 1, 2023. Articles obtained using appropriate keywords were selected independently by two reviewers according to the established inclusion and exclusion criteria...
January 26, 2024: BMC Endocrine Disorders
Vishal Chandra Sharma, Sudha Vidyasagar, Cynthia Amrutha Sukumar, Nanda Krishna B, Sharanya Shree
No abstract text is available yet for this article.
January 19, 2024: BMC Endocrine Disorders
Morteza Haramshahi, Thoraya Mohamed Elhassan A-Elgadir, Hamid Mahmood Abdullah Daabo, Yahya Altinkaynak, Ahmed Hjazi, Archana Saxena, Mazin A A Najm, Abbas F Almulla, Ali Alsaalamy, Mohammad Amin Kashani
BACKGROUNDS: Although the significance of diet in preventing or managing diabetes complications is highlighted in current literature, there is insufficient evidence regarding the correlation between nutrient patterns and these complications. The objective of this case-control study is to investigate this relationship by analyzing the dietary intake of nutrients in participants with and without type 2 diabetes (T2D). METHODS: A case-control study was conducted at the Tabriz Center of Metabolism and Endocrinology to investigate the relationship between nutrient patterns and type 2 diabetes (T2D)...
January 17, 2024: BMC Endocrine Disorders
Guoying Chang, Lingwen Ying, Qianwen Zhang, Biyun Feng, Ruen Yao, Yu Ding, Juan Li, Xiaodong Huang, Yongnian Shen, Tingting Yu, Jian Wang, Xiumin Wang
BACKGROUND: ABCC8 variants can cause hyperinsulinemia by activating or deactivating gene expression. This study used targeted exon sequencing to investigate genetic variants of ABCC8 and the associated phenotypic features in Chinese patients with hyperinsulinemic hypoglycemia (HH). METHODS: We enrolled eight Chinese children with HH and analyzed their clinical characteristics, laboratory results, and genetic variations. RESULTS: The age at presentation among the patients ranged from neonates to 0...
January 12, 2024: BMC Endocrine Disorders
Yong Zhuang, Qingyan Cai, Xin Hu, Huibin Huang
AIMS: Carbohydrate antigen 199 (CA199) is a standard tumor marker, and recent studies have found elevated in CA199 levels in patients with diabetes. However, there is no systematic measurement and comparison of serum CA199 levels in patients with diabetes and cancer. Here, a detailed description of the changes in serum CA199 levels in patients with type 2 diabetes and various cancers was explored. METHODS: A total of 5,641 participants were screened for clinical laboratory test results of serum CA199 levels over the past three years (2020-2023)...
January 12, 2024: BMC Endocrine Disorders
Marta Borges-Canha, João Sérgio Neves, Maria Manuel Silva, Fernando Mendonça, Telma Moreno, Sara Ribeiro, Catarina Vale, Juliana Gonçalves, Helena Urbano Ferreira, Sara Gil-Santos, Raquel Calheiros, Inês Meira, João Menino, Vanessa Guerreiro, Jorge Pedro, Ana Sande, Selma B Souto, Eduardo Lima da Costa, Davide Carvalho, Paula Freitas
BACKGROUND: Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce. We aimed to assess prediabetes remission rate and clinical predictors of remission in a 4 year follow up period. METHODS: Observational longitudinal study including patients with obesity and prediabetes who had undergone bariatric surgery in our centre. Prediabetes was defined as having a baseline glycated haemoglobin (A1c) between 5...
January 11, 2024: BMC Endocrine Disorders
Zeinab Karimi, Gholamreza Daryabor, Fatemeh Masjedi
BACKGROUND: Diabetic nephropathy and hepatopathy are health problems described by specific renal and hepatic structure and function disturbances. The protective effects of the stem cell secretome have been shown in several kidney and liver diseases. The current study aims to evaluate the capability of conditioned media derived from human Wharton's jelly mesenchymal stem cells (hWJ-MSCs-CM) to alleviate diabetic complications. METHODS: Twenty Sprague Dawley rats were made diabetic through injection of STZ (60 mg/kg, i...
January 5, 2024: BMC Endocrine Disorders
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