journal
https://read.qxmd.com/read/38528483/correlation-between-insulin-resistance-and-the-rate-of-neutrophils-lymphocytes-monocytes-lymphocytes-platelets-lymphocytes-in-type-2-diabetic-patients
#1
JOURNAL ARTICLE
Yuanyuan Zhang, Huaizhen Liu
BACKGROUND: Insulin resistance (IR) was a prominent feature commonly observed in individuals with type 2 diabetes mellitus (T2DM). T2DM Individuals often exhibited a concomitant presence of low-grade chronic inflammation. In this study conducted retrospectively, the aim was to investigate the connection between neutrophils-lymphocytes rate (NLR), monocytes-lymphocytes rate (MLR), platelets-lymphocytes rate (PLR) and IR, specifically among individuals with T2DM. METHOD: This study encompassed a cohort of 405 individuals diagnosed with T2DM, comprising cases from January 2021 to November 2022...
March 25, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38509509/grade-adolopment-of-hyperthyroidism-treatment-guidelines-for-a-pakistani-context
#2
JOURNAL ARTICLE
Russell Seth Martins, Sarah Nadeem, Abeer Aziz, Sajjan Raja, Alina Pervez, Najmul Islam, Asma Ahmed, Aisha Sheikh, Saira Furqan, Nanik Ram, Azra Rizwan, Nashia Ali Rizvi, Mohsin Ali Mustafa, Salima Saleem Aamdani, Bushra Ayub, Muhammad Qamar Masood
INTRODUCTION: The prevalence of hyperthyroidism in Pakistan is 2.9%, which is two times higher than in the United States. Most high-quality hyperthyroidism clinical practice guidelines (CPGs) used internationally originate from high-income countries in the West. Local CPGs in Pakistan are not backed by transparent methodologies. We aimed to produce comprehensive, high-quality CPGs for the management of hyperthyroidism in Pakistan. METHODS: We employed the GRADE-ADOLOPMENT approach utilizing the 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis as the source CPG...
March 21, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38504196/non-alcoholic-fatty-liver-disease-and-gestational-diabetes-mellitus-a-bidirectional-two-sample-mendelian-randomization-study
#3
JOURNAL ARTICLE
Ben-Gang Zhou, Jian-Lei Xia, Xin Jiang, Yan-Bing Ding, Qiang She
PURPOSE: Previous observational studies have revealed a potential link between non-alcoholic fatty liver disease (NAFLD) and gestational diabetes mellitus (GDM), but their causal relationship remains unclear. Thus, this study aimed to examine whether a causal link exists between genetically determined NAFLD and GDM. METHODS: Utilizing publicly accessible genome-wide association studies (GWAS), a two-sample bidirectional Mendelian randomization (MR) analysis was conducted...
March 20, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38481208/secretion-of-glucagon-glp-1-and-gip-may-be-affected-by-circadian-rhythm-in-healthy-males
#4
JOURNAL ARTICLE
Dorte B Zilstorff, Michael M Richter, Jens Hannibal, Henrik L Jørgensen, Henriette P Sennels, Nicolai J Wewer Albrechtsen
BACKGROUND: Glucagon is secreted from pancreatic alpha cells in response to low blood glucose and increases hepatic glucose production. Furthermore, glucagon enhances hepatic protein and lipid metabolism during a mixed meal. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from gut endocrine cells during meals and control glucose homeostasis by potentiating insulin secretion and inhibiting food intake. Both glucose homeostasis and food intake have been reported to be affected by circadian rhythms and vice versa...
March 14, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38481206/plasma-adiponectin-leptin-ratio-associates-with-subcutaneous-abdominal-and-omental-adipose-tissue-characteristics-in-women
#5
JOURNAL ARTICLE
Eve-Julie Tremblay, André Tchernof, Mélissa Pelletier, Denis R Joanisse, Pascale Mauriège
BACKGROUND: A better understanding of adipose tissue (AT) dysfunction, which includes morphological and functional changes such as adipocyte hypertrophy as well as impaired adipogenesis, lipid storage/mobilization, endocrine and inflammatory responses, is needed in the context of obesity. One dimension of AT dysfunction, secretory adiposopathy, often assessed as a low plasma adiponectin (A)/leptin (L) ratio, is commonly observed in obesity. The aim of this study was to examine markers of AT development and metabolism in 67 women of varying age and adiposity (age: 40-62 years; body mass index, BMI: 17-41 kg/m2 ) according to levels of adiponectinemia, leptinemia or the plasma A/L ratio...
March 14, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38481234/plasma-aldosterone-response-to-acth-stimulation-test-for-diagnosis-of-primary-aldosteronism-a-cross-sectional-study
#6
JOURNAL ARTICLE
Worapaka Manosroi, Pichitchai Atthakomol, Piti Inthaphan, Supornthip Hintong
BACKGROUND: The diagnosis of primary aldosteronism (PA) requires screening and confirmation testing. The present study examined whether the 1 µg ACTH stimulation test for plasma aldosterone concentration (PAC) can accurately diagnose PA by bypassing the regular confirmatory steps of PA diagnosis. METHODS: A cross-sectional study with a total of 36 patients with an aldosterone-renin ratio (ARR) > 20 ng/dL per ng/m/hr were included. The confirmation test for PA was performed by saline infusion and the patients were categorized into PA and non-PA...
March 13, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38475734/circulating-levels-of-asprosin-in-children-with-obesity-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Yuwei Zhang, Yifei Zhang, Bao Yang, Simin Li, Ru Jia
BACKGROUND: Prior studies reported that elevated asprosin level was associated with obesity in adults and animal models. However, the relationship between asprosin level and children with obeisty remains controversial. The aim of our analysis was to systematically review available literatures linking asprosin and children with obesity for a comprehensive understanding of the relationship between circulating asprosin level and obesity in children. METHODS: Eight databases were gleaned for studies published up to January 2024...
March 13, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38468250/incidence-and-determinants-of-diabetic-ketoacidosis-among-people-with-diabetes-in-woldiya-comprehensive-specialized-hospital-ethiopia-a-retrospective-cohort-study
#8
JOURNAL ARTICLE
Beyene Zewdu, Tefera Belachew, Kemal Ahmed, Lehulu Tilahun, Kirubel Dagnaw
INTRODUCTION: Diabetic ketoacidosis is an acute complication of diabetes mellitus that is characterised by hyperglycemia, acidosis, and ketonuria. Diabetes is the most challenging public health problem in the twenty-first century for both developed and developing countries. OBJECTIVE: To assess the incidence of Diabetic ketoacidosis and its determinants among adult people with diabetes at an Ethiopian Hospital. METHOD: An institution-based retrospective cohort study was conducted among 390 adult people with diabetes attending services at Wolida Comprehensive Specialized Hospital...
March 11, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38468235/l-shaped-association-between-the-ga-hba1c-ratio-and-all-cause-mortality-in-u-s-adults-with-nafld-a-cross-sectional-study-from-the-nhanes-1999-2004
#9
JOURNAL ARTICLE
Zhaofu Zhang, Hao Wang, Mingyu Chen, Youpeng Chen
OBJECTIVE: It is currently unclear whether there is a relationship between the ratio of glycated albumin to hemoglobin A1c (GA/HbA1c) and mortality in individuals diagnosed with nonalcoholic fatty liver disease (NAFLD). The primary objective of the study was to investigate the relationship between the GA/HbA1c ratio and all-cause mortality in adults with NAFLD in the U.S. METHODS: The investigation included a total of 5,295 individuals aged ≥ 18 years who were diagnosed with NAFLD, these individuals were selected from the National Health and Nutrition Examination Survey conducted between 1999 and 2004...
March 11, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38462602/prevalence-and-prognosis-of-fulminant-type-1-diabetes-mellitus-in-the-middle-east-a-comparative-analysis-in-a-5-year-nationwide-cohort
#10
JOURNAL ARTICLE
Fateen Ata, Adeel Ahmad Khan, Ibrahim Khamees, Sham AlKodmani, Anas Al-Sadi, Khaled Bani Yaseen, Bassam Muthanna, Angela Godwin, Stephen Frederick Beer, Mohammed Bashir
PURPOSE: To analyze the prevalence and progression of fulminant type 1 diabetes (FT1D) in Qatar. METHODS: This retrospective study analyzed consecutive index- diabetic ketoacidosis (DKA) admissions (2015-2020) among patients with new-onset T1D (NT1D) in Qatar. RESULTS: Of the 242 patients, 2.5% fulfilled the FT1D diagnostic criteria. FT1D patients were younger (median-age 4-years vs.15-years in classic-T1D). Gender distribution in FT1D was equal, whereas the classic-T1D group showed a female predominance at 57...
March 11, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38443883/therapeutic-plasma-exchange-decreases-serum-triglyceride-level-rapidly-and-reduces-early-recurrence-rate-but-no-advantages-in-improving-outcomes-for-patients-with-hyperlipidemic-acute-pancreatitis-a-retrospective-propensity-score-matching-analysis-based-on
#11
JOURNAL ARTICLE
Canbin Zheng, Yongping Zheng, Zihui Zheng
BACKGROUND: Hyperlipidaemic acute pancreatitis (HLAP) has become the most common cause of acute pancreatitis (AP) not due to gallstones or alcohol (Mosztbacher et al, Pancreatology 20:608-616, 2020; Yin et al, Pancreas 46:504-509, 2017). Therapeutic plasma exchange (TPE) has been reported to be effective in reducing serum TG levels which is important in management of HLAP (World J Clin Cases 9:5794-803, 2021). However, studies on TPE are mostly focusing on cases reports, TPE remains poorly evaluated till date and need to be compared with conservative therapy with a well-designed study...
March 6, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38443972/evaluation-of-the-prevalence-of-cardiometabolic-disorders-diabetes-hypertension-and-hyperlipidemia-diagnosed-undiagnosed-treated-and-treatment-goal-in-the-elderly-bushehr-elderly-health-program-beh
#12
JOURNAL ARTICLE
Mahbube Ebrahimpur, Erfan Mohammadi-Vajari, Yasaman Sharifi, Leila Ghotbi, Masoumeh Sarvari, Aryan Ayati, Baran Hashemi, Zhaleh Shadman, Pouria Khashayar, Afshin Ostovar, Noushin Fahimfar, Gita Shafiee, Elnaz Shahmohamadi, Tahereh Yavari, Iraj Nabipour, Bagher Larijani, Moloud Payab, Farshad Sharifi
As the population ages, the global burden of cardiometabolic disorders will increase. This study aimed to investigate the prevalence of cardiometabolic disorders (diabetes, hypertension, and hyperlipidemia) in elderly and to evaluate the effects of various variables including age, sex, education, marital status, smoking, income, physical activity, dementia and depressed mood on untreated cardiometabolic disorders. This was a cross sectional study conducted in Bushehr Elderly Health Program. A total 2381 participants were included...
March 5, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38443895/correlation-between-the-triglyceride-glucose-index-and-arterial-stiffness-in-japanese-individuals-with-normoglycaemia-a-cross-sectional-study
#13
JOURNAL ARTICLE
Yuying Cai, Wenyue Sha, Hailian Deng, Tuming Zhang, Linlin Yang, Yueying Wu, Jinhua Luo, Guangyan Liu, Yu Yang, Dehui Feng
BACKGROUND: The association between the triglyceride-glucose (TyG) index and arterial stiffness in individuals with normoglycaemia remains unclear. We aimed to evaluate the relationship between the TyG index and arterial stiffness in Japanese individuals with normoglycaemia, providing additional evidence for predicting early arterial stiffness. METHODS: This study included 15,453 adults who participated in the NAGALA Physical Examination Project of the Murakami Memorial Hospital in Gifu, Japan, from 2004 to 2015...
March 5, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38443880/skin-advanced-glycation-end-products-as-indicators-of-the-metabolic-profile-in-diabetes-mellitus-correlations-with-glycemic-control-liver-phenotypes-and-metabolic-biomarkers
#14
JOURNAL ARTICLE
Grigorios Christidis, Frederic Küppers, Senem Ceren Karatayli, Ersin Karatayli, Susanne N Weber, Frank Lammert, Marcin Krawczyk
INTRODUCTION: The production of advanced glycation end-products (AGEs) is a key pathomechanism related to the complications of diabetes mellitus. The measurement of HbA1c as one of the AGEs is widely used in the clinic, but also other proteins undergo glycation in the course of diabetes. Here, we measure skin AGEs (SAGEs) in patients with diabetes type 1 (DM1) and type 2 (DM2) and correlate them with metabolic markers as well as non-invasively measured liver fibrosis and steatosis. PATIENTS AND METHODS: In this cross-sectional study, a total of 64 patients with either DM1 or DM2 and 28 healthy controls were recruited...
March 5, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38439031/expression-and-diagnostic-value-of-lncrna-malat1-and-nlrp3-in-lower-limb-atherosclerosis-in-diabetes
#15
JOURNAL ARTICLE
Juan Li, Chun Wang, Chen Shao, Jiaxin Xu
OBJECTIVE: This study aimed to examine the diagnostic predictive value of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1(MALAT1) and NOD-like receptor protein 3(NLRP3) expression in patients with type 2 diabetes mellitus(T2DM) and lower extremity atherosclerosis disease (LEAD). METHODS: A total of 162 T2DM patients were divided into T2DM with LEAD group (T2DM + LEAD group) and T2DM alone group (T2DM group). The lncRNA MALAT1 and NLRP3 expression levels were measured in peripheral blood, and their correlation was examined...
March 4, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38438865/association-of-serum-asprosin-with-metabolic-dysfunction-associated-fatty-liver-disease-in-older-adult-type-2-diabetic-patients-a-cross-sectional-study
#16
JOURNAL ARTICLE
Junfang Cui, Yunfeng Liu, Mina Li, Jianhong Yin, Jing Yang, Linxin Xu
BACKGROUND: To explore the association of serum asprosin levels with metabolic dysfunction-associated fatty liver disease (MAFLD) in older adults with type 2 diabetes mellitus (T2DM). METHODS: The cross-sectional study enrolled patients ≥ 65 years old diagnosed with T2DM at two community health service centers between November 2019 and July 2021. Logistic regression was applied to analyze the influencing factors of MAFLD. RESULTS: Totally 219 cases were included...
March 4, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38429765/dietary-polyphenols-and-the-risk-of-metabolic-syndrome-a-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Pushpamala Ramaiah, Kamilya Jamel Baljon, Ahmed Hjazi, Maytham T Qasim, Omar Abdulwahid Salih Al-Ani, Shad Imad, Beneen M Hussien, Ali Alsalamy, Nazila Garousi
BACKGROUND: Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary intake of polyphenols and the odds of MetS. METHODS: The PubMed and Scopus databases were systematically searched to obtain eligible studies. The risk of MetS for the highest versus the lowest intakes of total, subclasses and individual polyphenols were examined by pooling odds ratios (OR) and 95% confidence intervals (95%CI) using the random effects model...
March 1, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38383419/first-effectiveness-data-of-lenvatinib-and-pembrolizumab-as-first-line-therapy-in-advanced-anaplastic-thyroid-cancer-a-retrospective-cohort-study
#18
JOURNAL ARTICLE
Dominik Soll, Philip Bischoff, Anne Frisch, Marie Jensen, Zehra Karadeniz, Martina T Mogl, David Horst, Tobias Penzkofer, Joachim Spranger, Ulrich Keilholz, Knut Mai
BACKGROUND: Anaplastic thyroid cancer (ATC) is a rare and aggressive neoplasm. We still lack effective treatment options, so survival rates remain very low. Here, we aimed to evaluate the activity of the combination of lenvatinib and pembrolizumab as systemic first-line therapy in ATC. METHODS: In a retrospective analysis, we investigated the activity and tolerability of combined lenvatinib (starting dose 14 to 24 mg daily) and pembrolizumab (200 mg every three weeks) as first-line therapy in an institutional cohort of ATC patients...
February 22, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38378559/fear-of-hypoglycemia-and-illness-perception-in-type-ii-diabetes-patients
#19
JOURNAL ARTICLE
Abdollahi Fariba, Mohammad Amerzadeh, Marjan Banazadeh, Saba Rashidi, Zahra Tayebi Myaneh
BACKGROUND: Hypoglycemia, a prevalent acute complication among individuals with type 2 diabetes (T2D), manifests with varied symptoms. Those with diabetes who have previously encountered hypoglycemic episodes commonly develop a Fear of Hyperglycemia (FOH). Illness perception (IP) significantly affects self-care behaviors and health outcomes in individuals diagnosed with T2D. OBJECTIVE: This study examined the correlation between IP and FOH among T2D patients and predictors of FOH...
February 20, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38374102/effectiveness-and-safety-of-dermal-matrix-used-for-diabetic-foot-ulcer-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
JOURNAL ARTICLE
Lei Sui, Qiang Xie, Hong-Tao Jiang, Xiao-Dong Li
BACKGROUND: Diabetic foot ulcers (DFUs) have become a global health concern, which can lead to diabetic foot infection (DFI), lower leg amputation, and even mortality. Though the standard of care (SOC) practices have been recognized as the "gold standard" for DFU care, SOC alone may not be adequate to heal all DFUs and prevent their recurrence. The use of dermal matrix has emerged as an adjuvant treatment to enhance DFU healing. The current study aimed to evaluate the effectiveness and safety of dermal matrix application as an adjuvant treatment to the SOC...
February 20, 2024: BMC Endocrine Disorders
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