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Nano Letters

Nicolò Maccaferri, Yingqi Zhao, Tommi Isoniemi, Marzia Iarossi, Antonietta Parracino, Giuseppe Strangi, Francesco De Angelis
We introduce a novel concept of hybrid metal-dielectric meta-antenna supporting type II hyperbolic dispersion, which enables a full control of absorption and scattering of light in the visible/near-infrared spectral range. This ability lies on the different nature of the hyperbolic Bloch-like modes excited within the meta-antenna. The experimental evidence is corroborated by a comprehensive theoretical study. In particular, we demonstrate that two main modes, one radiative and one non-radiative, can be excited by direct coupling with the free-space radiation...
February 18, 2019: Nano Letters
Yong Lin Kong, Ian A Tamargo, Hyoungsoo Kim, Blake N Johnson, Maneesh K Gupta, Tae-Wook Koh, Huai-An Chin, Daniel A Steingart, Barry P Rand, Michael C McAlpine
No abstract text is available yet for this article.
February 18, 2019: Nano Letters
Andrew Holle, Neethu Govindan Kutty Devi, Kim Clar, Anthony Fan, M Taher Saif, Ralf Kemkemer, Joachim P Spatz
Cancer cell invasion through physical barriers in the extracellular matrix (ECM) requires a complex synergy of traction force against the ECM, mechanosensitive feedback, and subsequent cytoskeletal rearrangement. PDMS microchannels were used to investigate the transition from mesenchymal to amoeboid invasion in cancer cells. Migration was faster in narrow 3 μm-wide channels than in wider 10 μm channels, even in the absence of cell-binding ECM proteins. Cells permeating narrow channels exhibited blebbing and had smooth leading edge profiles, suggesting an ECM-induced transition from mesenchymal invasion to amoeboid invasion...
February 18, 2019: Nano Letters
Deliang Shen, Zhenhua Li, Shiqi Hu, Ke Huang, Teng Su, Hongxia Liang, Feiran Liu, Ke Cheng
Stem cell therapies have shown promise in treating acute and chronic ischemic heart disease. However, current therapies are limited by the low retention and poor integration of injected cells in the injured tissue. Taking advantage of the natural infarct-homing ability of platelets, we engineered CD34 antibody-linked platelets (P-CD34) to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart. In vitro, P-CD34 could bind to damaged aortas and capture endogenous stem cells in whole blood...
February 18, 2019: Nano Letters
Smruthi Suryaprakash, Yeh-Hsing Lao, Hyeon-Yeol Cho, Mingqiang Li, Ha Yeun Ji, Dan Shao, Hanze Hu, Chai Hoon Quek, Dantong Huang, Rachel Mintz, Juli R Bagó, Shawn Hingtgen, Ki Bum Lee, Kam W Leong
Mesenchymal stem cell (MSC) has been increasingly applied to cancer therapy because of its tumor-tropic capability. However, short retention at target tissue and limited payload option hinder the progress of MSC-based cancer therapy. Herein, we proposed a hybrid spheroid/nanomedicine system, comprising MSC spheroid entrapping drug-loaded nanocomposite to address these limitations. Spheroid formulation enhanced MSC's tumor tropism and facilitated loading of different types of therapeutic payloads. This system acted as an active drug delivery platform seeking and specifically targeting glioblastoma cells...
February 18, 2019: Nano Letters
Ken Yong, Daniel Yuen, Moore Zhe Chen, Christopher J H Porter, Angus P R Johnston
Protein-conjugated nanoparticles have the potential to precisely deliver therapeutics to target sites in the body by specifically binding to cell surface receptors. To maximize targeting efficiency, the three-dimensional presentation of ligands towards these receptors is crucial. Herein, we demonstrate significantly enhanced targeting of nanoparticles to cancer cells by controlling the protein orientation on the nanoparticle surface. To engineer the point of attachment, we used amber codon reassignment to incorporate a synthetic amino acid, p-azidophenylalanine (azPhe), at specific locations within a single domain antibody (sdAb or nanobody) that recognizes the human epidermal growth factor receptor (EGFR)...
February 18, 2019: Nano Letters
Chenyang Zhang, Liang Yan, Xin Wang, Xinghua Dong, Ruyi Zhou, Zhanjun Gu, Yuliang Zhao
Traditional radiotherapy can induce injury to the normal tissue around the tumor, so the development of novel radiosensitizer with high selectivity and controllability that can lead to more effective and reliable radiotherapy is highly desirable. Herein, a new smart radiosensitizer based on Cu2(OH)PO4 nanocrystals that can simultaneously respond to endogenous stimulus (H2O2) and exogenous stimulus (X-ray) is reported. First, Cu2(OH)PO4 nanocrystals can generate CuI sites under X-ray irradiation through X-ray-induced photoelectron transfer process...
February 18, 2019: Nano Letters
Yi Cui, Eric S Melby, Arielle C Mensch, Elizabeth D Laudadio, Mimi N Hung, Alice Dohnalkova, Dehong Hu, Robert J Hamers, Galya Orr
Engineered nanoparticles (NPs) can negatively impact biological systems through induced generation of reactive oxygen species (ROS). Over-produced ROS cause biochemical damage and hence need to be effectively buffered by a sophisticated cellular oxidative stress response system. How this complex cellular system, which consists of multiple enzymes, responds to NP-induced ROS is largely unknown. Here we apply a single cell analysis to quantitatively evaluate 10 key ROS responsive genes simultaneously to understand how the cell prioritizes tasks and reallocates resources in response to NP-induced oxidative stress...
February 18, 2019: Nano Letters
Joshua Ziegler, Rachael Klaiss, Andrew Blaikie, David Joseph Miller, Viva Horowitz, Benjamin J Aleman
Quantum emitters (QEs) in 2D hexagonal boron nitride (hBN) are extremely bright and are stable at high temperature and under harsh chemical conditions. Because of they reside within an atomically thin 2D material, these QEs have a unique potential to couple strongly to hybrid optoelectromechanical and quantum devices. However, this potential for coupling has been underexplored because of challenges in nanofabrication and patterning of hBN QEs. Motivated by recent studies showing that QEs in hBN tend to form at edges, we use a focused ion beam (FIB) to mill an array of patterned holes into hBN...
February 15, 2019: Nano Letters
Yang Yang, Lei Wang, Hongqian Cao, Qi Li, Ying Li, Mingjuan Han, Hao Wang, Junbai Li
As a non-invasive treatment, photodynamic therapy (PDT) is a promising strategy against tumors. It is based on photosensitizers (PS) induced photo-toxicity after irradiation. However, most clinically-approved PSs will be widely distributed in normal tissues, especially in the skin, where they will induce photo-toxicity on exposure to light. Herein, we proposed a strategy of aggregation-induced emission PSs (AIE-PS) entrapped in liposomes with controlled photosensitization. The AIE-PS become lose their photosensitivity when entrapped in liposomes...
February 15, 2019: Nano Letters
Gyeongwon Kang, Muwen Yang, Michael Mattei, George C Schatz, Richard P Van Duyne
Electrochemical atomic force microscopy tip-enhanced Raman spectroscopy (EC-AFM-TERS) was used for the first time to spatially resolve local heterogeneity in redox behavior on an electrode surface in-situ and at the nanoscale. A structurally well-defined Au(111) nanoplate located on a polycrystalline ITO substrate was studied to examine nanoscale redox contrast across the two electrode materials. By monitoring the TERS intensity of adsorbed Nile Blue (NB) molecules on the electrode surface, TERS maps were acquired with different applied potentials...
February 14, 2019: Nano Letters
Nisim Perets, Oshra Betzer, Ronit Shapira, Shmuel Brenstein, Ariel Angel, Tamar Sadan, Uri Ashery, Rachela Popovtzer, Daniel Offen
Exosomes, nano-vesicles that are secreted by different cell types, enable intercellular communication at local or distant sites. Though they have been found to cross the blood brain barrier, their migration and homing abilities within the brain remain unstudied. We have recently developed a method for longitudinal and quantitative in vivo neuroimaging of exosomes, based on the superior visualization abilities of classical X-ray computed tomography (CT), combined with gold nanoparticles as labeling agents. Here, we used this technique to track the migration and homing patterns of intranasally administrated exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) in different brain pathologies, including stroke, autism, Parkinson's disease and Alzheimer's disease...
February 14, 2019: Nano Letters
Sou Yasuhara, Shintaro Yasui, Takashi Teranishi, Keisuke Chajima, Yumi Yoshikawa, Yutaka Majima, Tomoyasu Taniyama, Mitsuru Itoh
Nanodot BaTiO3 supported LiCoO2 cathode thin films can dramatically improve high-rate chargeability and cyclability. The prepared BaTiO3 nanodot is less than 3 nm in height and 35 nm in diameter, and its coverage is less than 5%. Supported by high dielectric constant materials on the surface of cathode materials, Li ion can intercalate through robust Li paths around the triple phase interface consisting of the dielectric, cathode, and electrolyte. The current concentration around the triple phase interface is observed by the finite element method, and is in good agreement with the experimental data...
February 13, 2019: Nano Letters
Alberto Brambilla, Andrea Picone, Dario Giannotti, Alberto Calloni, Giulia Berti, Gianlorenzo Bussetti, Simona Achilli, Guido Fratesi, Mario I Trioni, Giovanni Vinai, Piero Torelli, Giancarlo Panaccione, Lamberto Duò, Marco Finazzi, Franco Ciccacci
No abstract text is available yet for this article.
February 13, 2019: Nano Letters
Jingxia Liu, Xihua Chen, Qinqin Wang, Mengmeng Xiao, Donglai Zhong, Wei Sun, Guangyu Zhang, Zhiyong Zhang
Field-effect transistor (FET) biosensors based on low-dimensional materials present the advantages of low cost, high speed, small size, and excellent compatibility with integrated circuits (ICs). In this work, we fabricated highly sensitive FET-based DNA biosensors based on chemical vapor deposition (CVD)-grown monolayer MoS2 films in batches and explored their application in noninvasive prenatal testing (NIPT) for trisomy 21 syndrome. Specifically, MoS2 was functionalized with gold nanoparticles (Au NPs) of an optimized size and at an ideal density, and then, probe DNAs for the specific capture of target DNAs were immobilized on the nanoparticles...
February 13, 2019: Nano Letters
Shaodong Zhai, Xianglong Hu, Zhong Ji, Huan Qin, Zhixiong Wang, Yongjun Hu, Da Xing
Serious side effects are plaguing traditional chemotherapy, and the development of drug-free treatment is expected to ease the dilemma. Herein, drug-free polyarginine probes are fabricated from the co-polymerization of arginine monomer and slight amount of rhodamine B monomer, which are efficient for thermoacoustic imaging and therapy with high biocompatibility and safe metabolism. Polyarginine can be strongly pumped upon pulsed microwave irradiation, generating significant thermoacoustic shockwaves, namely thermocavitation, which can in situ destroy mitochondria to initiate programmed cancer cell apoptosis...
February 13, 2019: Nano Letters
Gang Qiu, Shouyuan Huang, Mauricio Segovia, Prabhu K Venuthurumilli, Yi-Xiu Wang, Wen Zhuo Wu, Xianfan Xu, Peide D Ye
Tellurium (Te) is an intrinsically p-type doped narrow bandgap semiconductor with excellent electrical conductivity and low thermal conductivity. Bulk trigonal Te has been theoretically predicted and experimentally demonstrated to be an outstanding thermoelectric material with high value of thermoelectric figure-of-merit ZT. In view of the recent progress in developing synthesis route of two-dimensional (2D) tellurium thin films as well as the growing trend of exploiting nanostructures as thermoelectric devices, here for the first time we report excellent thermoelectric performance of tellurium nanofilms, with room temperature power factor of 31...
February 12, 2019: Nano Letters
Wei Wu, Mayra Daniela Morales-Acosta, Yongqiang Wang, Michael Thompson Pettes
Isotopes of an element have the same electron number but differ in neutron number and atomic mass. However, due to the thickness-dependent properties in MX2 (M=Mo, W; X=S, Se, Te) transition metal dichalcogenides (TMDs), the isotopic effect in atomically-thin TMDs still remains unclear especially for phonon-assisted indirect excitonic transitions. Here, we report the first observation of the isotope effect on the electronic and vibrational properties of a TMD material, using naturally abundant NA WNA Se2 and isotopically pure bilayer 186 W80 Se2 single crystals over a temperature range of 4...
February 12, 2019: Nano Letters
Peggy Schoenherr, Konstantin Shapovalov, Jakob Schaab, Zewu Yan, Edith D Bourret, Mario Hentschel, Massimiliano Stengel, Manfred Fiebig, Andrés Cano, Dennis Meier
Low-temperature electrostatic force microscopy (EFM) is used to probe unconventional domain walls in the improper ferroelectric semiconductor Er$_{0.99}$Ca$_{0.01}$MnO$_3$ down to cryogenic temperatures. The low-temperature EFM maps reveal pronounced electric far fields generated by partially uncompensated domain-wall bound charges. Positively and negatively charged walls display qualitatively different fields as a function of temperature, which we explain based on different screening mechanisms and the corresponding relaxation time of the mobile carriers...
February 12, 2019: Nano Letters
Nguyen Ngan Nguyen, Hyo Chan Lee, Boseok Kang, Mankyu Jo, Kilwon Cho
Growth of organic semiconductor thin films on a two-dimensional template is affected by its properties, and is not well understood. This growth process dictates a thin film's final morphology and crystal structure, and is controlled by the interactions between ad-molecules and the template. Here, we report that the template's charge density determines the tuning of such interactions. We observe the dependence of pentacene nucleation on charge carrier density ng in graphene under an applied electric field and contact-doping, then deduce that the interaction energy EA between the ad-molecule and the graphene is related linearly to ng ...
February 12, 2019: Nano Letters
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