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American Journal of Alzheimer's Disease and Other Dementias

Angelica Boeve, Tanis J Ferman, Jeremiah Aakre, Erik St Louis, Michael Silber, Mary Machulda, Julie Fields, Neill Graff-Radford, Michelle Mielke, Yonas Geda, David Jones, Jonathon Graff-Radford, David Knopman, Ronald Petersen, Brad Boeve
There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13...
February 10, 2019: American Journal of Alzheimer's Disease and Other Dementias
B W Jervis, C Bigan, M W Jervis, M Besleaga
Previous work has suggested that evoked potential analysis might allow the detection of subjects with new-onset Alzheimer's disease, which would be useful clinically and personally. Here, it is described how subjects with new-onset Alzheimer's disease have been differentiated from healthy, normal subjects to 100% accuracy, based on the back-projected independent components (BICs) of the P300 peak at the electroencephalogram electrodes in the response to an oddball, auditory-evoked potential paradigm. After artifact removal, clustering, selection, and normalization processes, the BICs were classified using a neural network, a Bayes classifier, and a voting strategy...
February 7, 2019: American Journal of Alzheimer's Disease and Other Dementias
Cory K Chen, Nicole Nehrig, Karen S Abraham, Binhuan Wang, Amy P Palfrey, Alyssa L Baer
Resources for Enhancing All Caregivers Health (REACH VA) is a behavioral intervention for caregivers of individuals with dementia disseminated in the VA. Although shown to improve caregiver and care recipient outcomes, some caregivers continue to experience depression or caregiver burden following the intervention. Factors that predict symptom remission following REACH VA are unknown. The present study investigated attachment, social support, and psychopathology as predictors of symptom remission for family caregivers who completed REACH VA...
February 5, 2019: American Journal of Alzheimer's Disease and Other Dementias
Liron Sinvani, Andrew Strunk, Vidhi Patel, Shalin Shah, Colm Mulvany, Andrzej Kozikowski, Marie Boltz, Renee Pekmezaris, Gisele Wolf-Klein
Despite substantial staffing and cost implications, the use of constant observation (CO) has been poorly described in the acute care setting. The purpose of this cross-sectional, multicenter, survey study was to assess hospital provider practices regarding the use of CO. Of the 543 surveys distributed, 231 were completed across 5 sites. Most respondents worked on medical units (67.5%), as nurses (49.1%); 44.8% were white; and 75.6% were female. The majority (84.2%) reported at least 1 patient/wk requiring CO...
January 31, 2019: American Journal of Alzheimer's Disease and Other Dementias
JaeHoon Jung, Chang Hyun Lee, Kitack Shin, Daeyoung Roh, Sang-Kyu Lee, Yoo Sun Moon, Duk-In Jon, Do Hoon Kim
OBJECTIVES: This study aimed to identify the specific relationship between subdomains of religious variables and cognitive functions in outpatients with Alzheimer's disease (AD). METHODS: We recruited 325 patients with AD from a psychiatry outpatient clinic. The Korean version of the Consortium to Establish a Registry for Alzheimer's Disease and the Duke University Religion Index were used to assess cognitive functions and religiosity. We performed structural equation modeling and partial correlation analysis after controlling for demographic data...
January 31, 2019: American Journal of Alzheimer's Disease and Other Dementias
Noelle L Fields, Ling Xu, Vivian J Miller
Based on stress coping theory, this study investigated whether and how positive aspects of caregiving (PAC) and religiosity buffered the association between caregiving burden and desire to institutionalize (DTI). Secondary data (N = 637) were drawn from the baseline assessment of the Resources for Enhancing Alzheimer's Caregiver Health II project. Descriptive analysis, bivariate correlation, and multiple linear regressions were conducted. The results indicated that higher levels of caregiver burden, daily care bother, and Revised Memory and Behavioral Problem Checklist bother were all significantly associated with higher level of DTI...
January 30, 2019: American Journal of Alzheimer's Disease and Other Dementias
Gabriele Cipriani, Luca Cipriani, Sabrina Danti, Lucia Picchi, Mario Di Fiorino
Art is a system of human communication arising from symbolic cognition, conveying ideas, experiences, and feelings. The goal of this review is to describe the link between painting and dementia. Individuals with neurodegenerative diseases inevitably experience cognitive dysfunction that has the potential to limit and impair the artist's ability to realize their creative and expressive intentions through painting. The strategy to advance our understanding of the neural bases for art is to map locations and nature of neural damage to changes onto artistic production...
January 30, 2019: American Journal of Alzheimer's Disease and Other Dementias
Franziska Meichsner, Nils F Töpfer, Maren Reder, Renate Soellner, Gabriele Wilz
The present study examined the effects of a telephone-based cognitive behavioral intervention on dementia caregivers' quality of life (QoL). A total of 273 caregivers were randomly assigned to an intervention or control group. The intervention comprised 12 telephone sessions of individual cognitive behavioral therapy (CBT) over 6 months. At baseline, postintervention, and 6-month follow-up, QoL was assessed with the World Health Organization QoL-BREF, which measures perceived QoL for the domains physical health, psychological health, social relationships, and environment as well as overall QoL and satisfaction with general health...
January 13, 2019: American Journal of Alzheimer's Disease and Other Dementias
Esra Ates Bulut, Pinar Soysal, Idil Yavuz, Suleyman Emre Kocyigit, Ahmet Turan Isik
The purpose of this study is to assess the effect of vitamin D replacement on cognitive function in older adults. A total of 560 patients who underwent comprehensive geriatric assessment including Global cognitive assessment, Basic Activities of Daily Living (BADL), and Instrumental Activities of Daily Living (IADL) twice in 6-month period were retrospectively reviewed. Oral cholecalciferol was replaced to patients with vitamin D deficiency routinely. In baseline cognitive scores, BADL-IADL scores were lower in the severe deficiency group than in the deficiency and adequate groups ( P < ...
January 1, 2019: American Journal of Alzheimer's Disease and Other Dementias
Marjan Asadollahi, Musa Atazadeh, Maryam Noroozian
Alzheimer's disease (AD) is considered as a potential risk factor for the development of seizure due to neurodegeneration and imbalance between stimulatory and inhibitory circuits in the brain. Seizure could occur in any point during the course of AD, and its presentation varies from fluctuation in cognitive domains to more typical seizures. The clinical diagnosis of seizure in patients with dementia may be challenging due to difficulty in history taking and clinical assessment. No paraclinic methods other than electroencephalogram (EEG) could provide arguments for the diagnosis of AD-related seizures (neither imaging modalities nor cerebrospinal fluid biomarkers)...
December 30, 2018: American Journal of Alzheimer's Disease and Other Dementias
Uwe Konerding, Tom Bowen, Paul Forte, Eleftheria Karampli, Tomi Malmström, Elpida Pavi, Paulus Torkki, Elmar Graessel
The relationships between caregiver burden as measured with the Burden Scale for Family Caregivers-short form and 6 characteristics of caregivers caring for patients with dementia were investigated for caregivers from England (n = 36), Finland (n = 42), and Greece (n = 46) using survey data. In all 3 countries, caregiver burden increases with physical problems of the caregiver, emotional problems of the caregiver, and weekly hours of care. Hence, in all 3 countries, special support for informal care is required when these characteristics are at high levels...
December 30, 2018: American Journal of Alzheimer's Disease and Other Dementias
Michaël Rochoy, Sophie Gautier, Johana Béné, Régis Bordet, Emmanuel Chazard
BACKGROUND: The French nationwide exhaustive hospital discharge database (PMSI) is used for activity-based payment of hospital services. We hypothesized that the release of articles about alcohol and dementia could influence the identification of these diagnoses in PMSI. METHODS: We analyzed temporal evolution of coding for dementia and other persistent or late-onset cognitive impairment (OPLOCI) due to alcohol and other psychoactive substances in the PMSI database from 2007 to 2017 (285 748 938 inpatient stays)...
December 30, 2018: American Journal of Alzheimer's Disease and Other Dementias
Milena Zucca, Elisa Rubino, Alessandro Vacca, Flora Govone, Annalisa Gai, Paola De Martino, Silvia Boschi, Salvatore Gentile, Maria Teresa Giordana, Innocenzo Rainero
AIM: The purpose of the study was to determine the prevalence of suicidal ideation and attempts in patients with behavioral variant frontotemporal dementia (bvFTD), evaluating possible risk factors for suicidality. METHODS: Risk of suicide was assessed using the Scale for Suicide Ideation (SSI) in 35 patients with bvFTD and 25 controls. RESULTS: According to SSI, 40% of patients with bvFTD had suicidal ideation in comparison to 8% of controls ( P = ...
December 17, 2018: American Journal of Alzheimer's Disease and Other Dementias
Wayne Shelton, Evelyn Tenenbaum, Kevin Costello, David Hoffman
Patients with Alzheimer's disease and other types of dementia with acute medical problems, who have lost capacity and are without advance directives, are at risk of being over treated inhospitals. To deal with this growing demographic and ethical crisis, patients with dementia need to plan for their future medical care while they have capacity to do so. This article will examine the role of each member of the dementia care triad and how to empower the patient to participate in planning future medical care. A case will be made that physicians have the same professional disclosure obligations to dementia patients as they do to all other capable patients with terminal illnesses...
December 13, 2018: American Journal of Alzheimer's Disease and Other Dementias
Eleni Poptsi, Loulietta Lazarou, Nefeli Markou, Maria Vassiloglou, Evdokia Nikolaidou, Alexandra Diamantidou, Vassiliki Siatra, Elina Karathanassi, Anastasios Karakostas, Fotini Kounti Zafeiropoulou, Thrasyvoulos Tsiatsos, Magda Tsolaki
BACKGROUND: Although cognitive training is effective for people with mild cognitive impairment (MCI), it is not clear which format is more effective. OBJECTIVE: To compare the effectiveness of the same language programs when carried out via computer, paper/pencil and orally in people with MCI. METHODS: Seventy-one participants with MCI were randomly classified in 3 experimental and 2 control groups. The experimental groups attended 48 sessions of language training for 6 months...
December 5, 2018: American Journal of Alzheimer's Disease and Other Dementias
Hsin-Yun Liu, Wen-Che Tsai, Ming-Jang Chiu, Li-Yu Tang, Huey-Jane Lee, Yea-Ing L Shyu, Woan-Shyuan Wang
BACKGROUND: To examine the relationships between cognitive dysfunction status and quality of life. METHODS: Secondary analysis of a nationwide population-based survey (≥65 years) in Taiwan. The 5-dimension EuroQoL questionnaire (EQ-5D) was completed by 10 013 participants. RESULTS: Participants with mild cognitive impairment (MCI; odds ratio = 4.88), very mild dementia (VMD; 7.96), or dementia (32.85) were more likely than those with normal cognition to report self-care problems...
December 5, 2018: American Journal of Alzheimer's Disease and Other Dementias
Luis Ruano, Natália Araújo, Mariana Branco, Rui Barreto, Sandra Moreira, Ricardo Pais, Vítor Tedim Cruz, Nuno Lunet, Henrique Barros
BACKGROUND: Vascular disease may play an important role in the epidemiology of dementia in countries with high stroke incidence, such as Portugal. OBJECTIVE: To assess the prevalence and etiology of cognitive impairment in a population-based cohort from Portugal. METHODS: Individuals ≥55 years (n = 730) from the EPIPorto cohort were assessed using the Mini-Mental State Examination and the Montreal Cognitive Assessment. Those scoring below the age-/education-adjusted cutoff points were further evaluated to identify dementia or mild cognitive impairment (MCI) and to define its most common causes...
December 4, 2018: American Journal of Alzheimer's Disease and Other Dementias
Ji Eun Kim, Sung-Woo Kim, Minsuk Choi, Joon-Kyung Seong, Jae-Hong Lee
BACKGROUND: The aim of this study was to identify white matter structural networks of amnestic mild cognitive impairment (aMCI) dichotomized by β amyloid (Aβ) status and compare them using network-based statistics (NBS). METHODS: Patients underwent whole-brain diffusion-weighted magnetic resonance imaging, detailed neuropsychological test and [18 F]-Florbetaben amyloid positron emission tomography. We performed the NBS analysis to compare the whole-brain white matter structural networks extracted from diffusion tensor images...
November 29, 2018: American Journal of Alzheimer's Disease and Other Dementias
Flávia Borges-Machado, Óscar Ribeiro, Arnaldina Sampaio, Inês Marques-Aleixo, Joana Meireles, Joana Carvalho
This quasi-experimental, nonrandomized study examined the feasibility and impact of a multicomponent (MT) intervention on 7 community-dwelling individuals diagnosed with probable Alzheimer's disease (AD) at mild to moderate stage. During 6 months, patients with AD and their caregivers were submitted to a biweekly exercise program, including muscle strengthening, aerobics, balance, and postural exercises. The following tests were used: Senior Fitness Test and Incremental Treadmill Test, Disability Assessment for Dementia Scale, Alzheimer Disease Assessment Scale-Cognitive, and Quality of Life-Alzheimer's...
March 2019: American Journal of Alzheimer's Disease and Other Dementias
Babak Fathabadi, Mohammad Dehghanifiroozabadi, Jan Aaseth, Gholamreza Sharifzadeh, Samaneh Nakhaee, Ali Rajabpour-Sanati, Alireza Amirabadizadeh, Omid Mehrpour
BACKGROUND: It is argued that breakdown of β-amyloid in the brain causes deposition of senescent plaques and therefore Alzheimer's disease (AD). One of the influential factors for increasing level of this protein is exposure to lead. Our aim was to compare blood lead levels (BLLs) between patients with AD and healthy controls. METHODS: This case-control study was performed on all patients with cognitive impairment who were referred to the Neurological Clinic of Birjand in 2016 to 2017...
December 2018: American Journal of Alzheimer's Disease and Other Dementias
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