journal
Journals American Journal of Alzheimer'...

American Journal of Alzheimer's Disease and Other Dementias

https://read.qxmd.com/read/38896870/an-integrative-review-of-the-feasibility-and-effects-of-the-use-of-location-tracking-devices-by-persons-living-with-cognitive-impairment
#1
REVIEW
Jayeong Kim, Mina Hwang, Yeji Hwang
OBJECTIVES: This study aimed to examine the effects of location-tracking devices on persons living with cognitive impairment, investigate facilitators of and barriers to using the devices, and provide future directions for the use of the devices. METHODS: An integrative review was conducted using 5 databases: PubMed, Embase, Web of Science, CINAHL, and Scopus. From the 1429 initially identified studies, 10 were included in the review. RESULTS: Location-tracking devices benefited persons living with cognitive impairment and their informal caregivers...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38877608/adapted-home-based-exercises-in-dementia-an-exploratory-pre-post-pilot-and-feasibility-study
#2
JOURNAL ARTICLE
Sophie Carrard, Stephan Eyer, Roger Hilfiker, Anne-Gabrielle Mittaz Hager
The goals of this exploratory pre-post pilot and feasibility study (NCT04916964) were to assess the feasibility and effectiveness of an adapted Test-and-Exercise home-based exercise program on basic functional mobility and executive functions in persons with prodromal or mild Alzheimer's disease. Participants followed an 8 week exercise program at home, once per week with a physiotherapist and twice per week with their usual caregiver or independently. Functional mobility and executive functions were assessed before and after the intervention...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38828622/mediating-factors-associated-with-physical-activity-in-older-adults-at-increased-dementia-risk
#3
JOURNAL ARTICLE
Maria Isabel Cardona, Melanie Luppa, Andrea Zülke, Eric S Kroeber, Alexander Bauer, Juliane Döhring, Catharina Escales, Christian Brettschneider, Thomas Frese, Robert P Kosilek, Jochen Gensichen, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut König, Birgitt Wiese, Steffi G Riedel-Heller, Jochen René Thyrian
While regular physical-activity (PA) is beneficial, multimorbid individuals at increased dementia risk may exhibit reduced PA levels. Thus, a more comprehensive understanding of mediating factors responsible for inactivity in this population is needed. This study investigated the impact of a multimodal intervention on PA changes at 24-month follow-up and associated mediating factors among community-dwelling patients aged 60-77, with increased dementia risk determined by the CAIDE Dementia Risk Score. Of 1030 participants recruited, 819 completed the assessment...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38798013/effectiveness-of-early-multimodal-non-pharmacological-interventions-in-cognitive-preservation-in-the-elderly
#4
JOURNAL ARTICLE
Sun-Wung Hsieh, Shih-Fen Hsiao, Lih-Jiun Liaw, Ling-Chun Huang, Yuan-Han Yang
INTRODUCTION: Multimodal non-pharmacological interventions (MNPI) have been determined as effective in delaying cognitive deterioration. The effectiveness of timing of such interventions in elderly is less discussed. We compared the different effectiveness of MNPI in cognitive preservation in elderly subjects with and without dementia. METHODS: We enrolled volunteer the elderly subjects. Subjects were classified as dementia group and non-dementia group by instrument of ascertainment of dementia 8...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38764310/-chanwuyi-lifestyle-medicine-program-improves-memory-and-executive-functions-of-older-adults-with-mild-cognitive-impairment
#5
RANDOMIZED CONTROLLED TRIAL
Mei-Chun Cheung, Sophia L Sze, Agnes S Chan
The Chanwuyi Lifestyle Medicine Program (CLMP) was found to enhance the memory and executive functions of older adults with or without subjective memory complaints. The present study investigated whether similar beneficial effects can be extended to mild cognitive impairment (MCI). Twenty-four older adults with MCI were randomly assigned to receive the CLMP (the experimental group) or strategic memory training (SMT; the active control group) for 10 weeks. They were assessed by neuropsychological tests at baseline and post-intervention...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38721926/interrelationship-of-sleep-disturbances-and-cognitive-status-on-mortality
#6
JOURNAL ARTICLE
Meghan K Mattos, Ifrah Zawar, Carol Manning, James Patrie, Mark S Quigg
Sleep disturbances may promote the development and advancement of Alzheimer's disease. Our purpose was to determine if sleep disturbances were associated with earlier mortality while accounting for cognition. The National Alzheimer's Coordinating Center database was used to evaluate mortality risk conferred by sleep, and the Montreal Cognitive Assessment score determined cognitive status. Demographics, sleep disturbances, cognitive status, and comorbid/other neuropsychiatric conditions were examined as predictors of survival time via Cox regression...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38621659/the-psychological-symptoms-and-their-relationship-to-the-quality-of-life-among-dementia-patients-caregivers
#7
JOURNAL ARTICLE
Mamduh Baniah Lafee Alzaben, Baha' Suhail Mousa Shawaqfeh
The study aims to identify psychological symptoms (depression and anxiety) and their relationship to the quality of life among dementia patients' caregivers, and whether there are differences in the level of each of them due to the gender variable. The study follows the correlational approach, with a sample of 174 dementia patients' caregivers. To pursue the analysis, the study uses 3 measurement tools: anxiety, depression, and quality of life. The results show that the level of depression, anxiety, and quality of life among dementia patients' caregivers is moderate...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38592304/different-splice-isoforms-of-peripheral-triggering-receptor-expressed-on-myeloid-cells-2-mrna-expressions-are-associated-with-cognitive-decline-in-mild-dementia-due-to-alzheimer-s-disease-and-reflect-central-neuroinflammation
#8
JOURNAL ARTICLE
Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fuh
Triggering receptor expressed on myeloid cells 2 (TREM2) is upregulated in activated microglia and may be related to cognitive decline in patients with Alzheimer's disease (AD). There is conflicting evidence regarding the association of peripheral TREM2 mRNA expression/soluble TREM2 (the extracellular domain of TREM2) with cognitive function/neuroinflammation in patients with AD. Herein, we studied the TREM2 and TREM2alt mRNA expression and their association with the cognitive performance in subjects with mild dementia due to AD and healthy controls...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38549562/a-longitudinal-dose-response-curve-between-leisure-time-physical-activity-and-the-prevalence-of-diabetes-based-on-the-different-levels-of-cognitive-function-among-older-adults
#9
JOURNAL ARTICLE
Jungjoo Lee, Junhyoung Kim, Hyo Jin Ju, Sang Joon An, Bomi Woo
This study investigated a dose-response relationship between Leisure-Time Physical Activity participation (LTPA) and the risk of diabetes and a comparison of the risk across different cognitive function groups among older adults. The Health and Retirement Study data were used from 2012 to 2020 (n = 18 746). This study conducted a Cox Proportional Hazard Regression to investigate the Dose-Response Curve between the prevalence of diabetes and the covariates following a level of LTPA participation. The result presented that the Odds Ratio continuously decreased as the level of LTPA participation increased...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38536663/-it-s-opened-my-eyes-to-a-whole-new-world-positive-behaviour-support-training-for-staff-and-family-members-supporting-residents-with-dementia-in-aged-care-settings
#10
JOURNAL ARTICLE
Alinka C Fisher, Katrina Reschke, Nijashree Shah, Sau Cheung, Claire O'Connor, Olivier Piguet
OBJECTIVES: This study examined the acceptability and usefulness of Positive Behaviour Support (PBS) training in enhancing the capabilities of support staff and family members providing behaviour support to residents with dementia in residential aged care (RAC). METHODS: A mixed-methods pilot study was conducted across 3 RAC organisations, involving pre- and post-training questionnaire assessments for clinical leaders (n = 8), support staff (n = 37) and family members (n = 18)...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38491918/migration-inhibition-factor-secreted-by-peripheral-blood-memory-b-cells-binding-to-cd74-cd44-receptor-complex-drives-macrophage-behavior-in-alzheimer-s-disease
#11
JOURNAL ARTICLE
Bo Liu, Wei Luo, Ling Huang, Chunying Wei, Xiaorui Huang, Jun Liu, Ran Tao, Yingmin Mo, Xuebin Li
Dysregulation of the peripheral immune system is be involved in the neuroinflammation in Alzheimer disease (AD) and accelerate the disease progression. The contribution of immune cells, particularly B cells, to AD pathogenesis has gained attention in recent research. In this study, we investigated the role of Peripheral Blood Memory B cells (PBMBs) and their secreted Migration Inhibition Factor (MIF) in driving macrophage behavior in AD based on the scRNA-seq technique, immunofluorescence and flow cytometry...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38436280/awareness-of-dementia-care-amongst-the-staff-working-at-day-care-centers-and-nursing-homes-in-macao
#12
JOURNAL ARTICLE
Sio Mui Wong, Wen Zeng, Iek Long Lo, Iek Hou Leong, Hong Lei Lou
BACKGROUND: The staff working at day-care centers and nursing homes are in a key frontline for early detection of older people living with dementia, however, whether the staff were well prepared and if they were appropriately trained were still little known. METHOD: A cross-sectional survey was conducted and the validated questionnaires exploring the awareness of dementia care, in terms of knowledge, attitude and preventive practice domain, were given to the staff working at day-care centers and nursing homes in Macao...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38262932/can-residents-with-late-stage-dementia-still-engage
#13
JOURNAL ARTICLE
Scott A Trudeau, Scott D Slotnick, Megan E Gately
Institutionalized persons with dementia often lack access to meaningful activity, which can lead to agitation, loneliness, and depression. Engagement in activity may improve negative symptoms but is difficult in most settings. In this study, we investigated the degree to which the Reading Buddies Program, in which occupational therapy graduate students read books with residents with dementia, engaged residents. We further assessed whether the level of engagement was affected by various parameters, including those related to interaction, environment, attention, attitude, and activity...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38198589/hearing-impairment-and-cognitive-function-mediating-role-of-social-isolation-and-depression
#14
JOURNAL ARTICLE
Fan Wu, Chenxi Zhou
ObjectivesTo examine the relationship between hearing impairment and cognitive function and the mediating role of social isolation and depression. Methods: Data came from the 2018 China Health and Retirement Longitudinal Study wave. A self-reported item, a composite index, the 10-item Center for Epidemiological Studies Depression Scale, and the Mini-Mental State Exam were used to measure hearing impairment, social isolation, depression, and cognitive function, respectively. Mediation analysis was performed...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38183177/neuropsychiatric-behavioral-assessments-in-mice-after-acute-and-long-term-treatments-of-low-intensity-pulsed-ultrasound
#15
JOURNAL ARTICLE
Ye Li, Yiqing Wu, Qi Luo, Xuanjie Ye, Jie Chen, Yuanlin Su, Ke Zhao, Xinmin Li, Jing Lin, Zhiqian Tong, Qi Wang, Dongwu Xu
Introduction: To evaluate whether both acute and chronic low-intensity pulsed ultrasound (LIPUS) affect brain functions of healthy male and female mice. Methods: Ultrasound (frequency: 1.5 MHz; pulse: 1.0 kHz; spatial average temporal average (SATA) intensity: 25 mW/cm2 ; and pulse duty cycle: 20%) was applied at mouse head in acute test for 20 minutes, and in chronic experiment for consecutive 10 days, respectively. Behaviors were then evaluated. Results: Both acute and chronic LIPUS at 25 mW/cm2 exposure did not affect the abilities of movements, mating, social interaction, and anxiety-like behaviors in the male and female mice...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38041525/serum-protein-based-profiles-for-the-diagnostic-model-of-alzheimer-s-disease
#16
JOURNAL ARTICLE
Li Yang, Liang He, Zhibin Bu, Cheng Xuan, Caiyan Yu, Jiong Wu
BACKGROUND: Determining a non-invasive, serum-based diagnostic panel for early diagnosis of AD will play a significant role in the prevention and treatment of the disease. METHODS: We performed standardized clinical assessments and neuroimaging measurements in 45 patients with AD and an equal number of sex - and age-matched controls. 48 target peptides of 14 identified target proteins were quantitatively analyzed by PRM. RESULTS: 8 protein markers were screened, including SAA4, PPBP, PF4, APOA4, F10, CPB2, C1S and IGHM...
2023: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38016118/a-12-year-comparison-of-alzheimer-s-dementia-patients-with-their-informants-in-taiwan
#17
JOURNAL ARTICLE
Kai-Ming Jhang, Wen-Fu Wang, Kuang-Nan Hsu, Shang-Chien Huang, Sheng-Hsiang Yang, Ling-Chun Huang, Yuan-Han Yang
BACKGROUND: To update the characteristics of patients with Alzheimer's disease (AD) and their informants in Taiwan and compare them from 12 years ago. METHODS: 1218 patients with AD and their informants were recruited from six hospitals in Taiwan. The uniform data set version 3.0 (UDS3, form A1-A3) were administered. RESULTS: Compared with the first registration from 2010-2012 (n = 691), the mean clinical dementia rating sum of boxes score was significantly lower, more patients living independently, and more informants not living together with the patients...
2023: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/37993973/music-engagement-as-a-source-of-cognitive-reserve
#18
REVIEW
Lee Wolff, Yixue Quan, Gemma Perry, William Forde Thompson
Music engagement is a ubiquitous activity that is thought to have cognitive benefits for the rapidly aging population. In the absence of robust treatment approaches for many age-related and neuropathological health issues, interest has emerged surrounding lifestyle-enriching activities, like exercise and music engagement, to build cognitive reserve across the lifespan and preserve neurocognitive function in older adults. The present review evaluates evidence of neurocognitive preservation arising from lifelong music engagement with respect to the cognitive reserve hypothesis...
2023: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/37977137/aerobic-treadmill-exercise-upregulates-epidermal-growth-factor-levels-and-improves-learning-and-memory-in-d-galactose-induced-aging-in-a-mouse-model
#19
JOURNAL ARTICLE
Cheng Guo, Xiaoyang Kong, Yongzhao Fan, Rihui Zhang
Previous studies have demonstrated that exercise improves cognitive function in Alzheimer's disease mice but the exact mechanism needs further studies. This research aimed to study the effects of aerobic treadmill exercise on epidermal growth factor (EGF) levels and learning and memory in d-galactose-induced aging in a mouse model. Forty male Kunming mice were analyzed in this study and randomly divided into 4 groups: control (C group), aerobic exercise (AE group), d-galactose (D-gal group), and d-galactose + aerobic exercise (D-gal + AE group)...
2023: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/37972355/the-neuropathological-impacts-of-covid-19-challenges-and-alternative-treatment-options-for-alzheimer-s-like-brain-changes-on-severely-sars-cov-2-infected-patients
#20
REVIEW
Md Rashidur Rahman, Raushanara Akter, Sharmind Neelotpol, Iffat Islam Mayesha, Afrina Afrose
Recently, some researchers claimed neuropathological changes lead to Alzheimer's-like brains after severe infection of SARS-CoV-2. Several mechanisms have been postulated on how SARS-CoV-2 neurological damage leads to Alzheimer's disease (AD) development. Neurobiochemical changes during infection may significantly induce Alzheimer's disease in severely COVID-19 infected people. The immune system is also compromised while infected by this novel coronavirus. However, recent studies are insufficient to conclude the relationship between Alzheimer's disease and COVID-19...
2023: American Journal of Alzheimer's Disease and Other Dementias
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