journal
https://read.qxmd.com/read/38311873/creative-and-generative-artificial-intelligence-for-personalized-medicine-and-healthcare-hype-reality-or-hyperreality
#1
EDITORIAL
Arash Shaban-Nejad, Martin Michalowski, Simone Bianco
No abstract text is available yet for this article.
February 4, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38282535/the-discovery-of-subunit-selective-glun1-glun2b-nmdar-antagonist-via-pharmacophere-based-virtual-screening
#2
JOURNAL ARTICLE
Jialing Tang, Ju Jin, Zhihong Huang, Faliang An, Caiguo Huang, Wenli Jiang
The incidence and mortality rates of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are gradually increasing worldwide. Numerous studies have demonstrated that N-methyl-D-aspartic acid receptor (NMDAR)-mediated excitotoxicity contributes to neurodegenerative diseases. Ifenprodil, a subtype-selective NMDAR antagonist, showed strong therapeutic potential. However, it suffers from low oral bioavailability and off-target side effects. In this study, natural compounds were identified for selective inhibition of GluN1/GluN2B NMDAR of human...
January 29, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38281087/a-quantum-based-oversampling-method-for-classification-of-highly-imbalanced-and-overlapped-data
#3
JOURNAL ARTICLE
Bei Yang, Guilan Tian, Joseph Luttrell, Ping Gong, Chaoyang Zhang
Data imbalance is a challenging problem in classification tasks, and when combined with class overlapping, it further deteriorates classification performance. However, existing studies have rarely addressed both issues simultaneously. In this article, we propose a novel quantum-based oversampling method (QOSM) to effectively tackle data imbalance and class overlapping, thereby improving classification performance. QOSM utilizes the quantum potential theory to calculate the potential energy of each sample and selects the sample with the lowest potential as the center of each cover generated by a constructive covering algorithm...
January 28, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38281083/data-driven-approach-to-quantify-trust-in-medical-devices-using-bayesian-networks
#4
REVIEW
Mini Thomas, Omar Boursalie, Reza Samavi, Thomas E Doyle
Bayesian networks are increasingly used to quantify the uncertainty of subjective and stochastic concepts such as trust. In this article, we propose a data-driven approach to estimate Bayesian parameters in the domain of wearable medical devices. Our approach extracts the probability of a trust factor being in a specific state directly from the devices (e.g. sensor quality). The strength of the relationship between related factors is defined by expert knowledge and incorporated into the model. We use propagation rules from requirements engineering to estimate how much each trust factor contributes to the related intermediate nodes in the network and ultimately compute the trust score...
January 27, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38281069/decision-rules-for-personalized-statin-treatment-prescriptions-over-multi-objectives
#5
JOURNAL ARTICLE
Pui Ying Yew, Yue Liang, Terrence J Adam, Julian Wolfson, Peter J Tonellato, Chih-Lin Chi
In our previous study, we demonstrated the feasibility of producing a proactive statin prescription strategy - a personalized statin treatment plan (PSTP) - using neural networks with big data. However, its non-transparency limited result interpretations and clinical usability. To improve the transparency of our previous approach with minimal compromise to the maximal statin treatment benefit-to-risk ratio, this study proposed a five-step pipeline approach called the decision rules for statin treatment (DRST)...
January 27, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38279511/deep-learning-diagnostic-performance-and-visual-insights-in-differentiating-benign-and-malignant-thyroid-nodules-on-ultrasound-images
#6
JOURNAL ARTICLE
Yujiang Liu, Ying Feng, Linxue Qian, Zhixiang Wang, Xiangdong Hu
This study aims to construct and evaluate a deep learning model, utilizing ultrasound images, to accurately differentiate benign and malignant thyroid nodules. The objective includes visualizing the model's process for interpretability and comparing its diagnostic precision with a cohort of 80 radiologists. We employed ResNet as the classification backbone for thyroid nodule prediction. The model was trained using 2096 ultrasound images of 655 distinct thyroid nodules. For performance evaluation, an independent test set comprising 100 cases of thyroid nodules was curated...
January 26, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38240248/single-nucleotide-polymorphisms-of-tlr4-and-gas7-linked-to-primary-open-angle-glaucoma-among-patients-of-shenyang-china
#7
JOURNAL ARTICLE
Jiao Jie, Tengfei Wu
The potential for adverse outcomes and classifications of glaucoma differ among race, country, gender, and family medical history. Nearly, 50 represent candidate genes are considered as potential contributors to the happening for the primary open-angle glaucoma (POAG) since the advent of GWASs. Our investigation is the first to report the Toll-like receptor 4 ( TLR4 ) and growth arrest-specific 7 ( GAS7 ) among people in Shenyang, China; to investigate whether single-nucleotide polymorphisms (SNPs) in ( TLR4 ) or GAS7 gene are risk factors for POAG among people in Shenyang, China; and also to explore their potential pathogenic mechanisms...
January 19, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38240216/research-of-restricted-migration-evaluation-of-mda-mb-231-cells-in-2d-and-3d-co-culture-models
#8
JOURNAL ARTICLE
Zhichang Du, Shaohui Yang, Qingzhong Gong, Zhonghua Lin, Guohong Xiao, Shengli Mi
The restricted migration evaluation is conducive to more complex tumor migration research because of the conformity with in vivo tumors. However, the differences between restricted and unrestricted cell migration and the distinction between different evaluation methods have not been systematically studied, hindering related research. In this study, by constructing the restricted environments on chips, the influence of co-culture conditions on the cancer cell migration capacity was studied. The results showed that the restricted channels can discriminate the influence of weak tumor environmental factors on complex tumor migration behaviors by limiting the free growth instinct of tumor cells...
January 19, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38240215/quercetin-suppresses-ovariectomy-induced-osteoporosis-in-rat-mandibles-by-regulating-autophagy-and-the-nlrp3-pathway
#9
JOURNAL ARTICLE
Yue Xiong, Cheng-Wei Huang, Chao Shi, Liang Peng, Yu-Ting Cheng, Wei Hong, Jian Liao
With the aging population and the popularity of implant prostheses, an increasing number of postmenopausal osteoporosis (PMOP) patients require implant restorations; however, poor bone condition affects the long-term stability of implant prostheses. This study aimed to investigate the therapeutic effect of quercetin (QR) compared with alendronate (ALN), the primary treatment for PMOP, on mandibular osteoporosis (OP) induced by ovariectomy (OVX) in female rats. Adult female rats were treated with QR (50 mg/kg/day), ALN (6...
January 19, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38230523/x-linked-hypophosphatemia-fibroblast-growth-factor-23-signaling-and-craniosynostosis
#10
REVIEW
Chelsey Grimbly, Daniel Graf, Leanne M Ward, R Todd Alexander
This review summarizes the current knowledge of fibroblast growth factor 23 signaling in bone and its role in the disease pathology of X-linked hypophosphatemia. Craniosynostosis is an under-recognized complication of X-linked hypophosphatemia. The clinical implications and potential cellular mechanisms invoked by increased fibroblast growth factor 23 signaling causing craniosynostosis are reviewed. Knowledge gaps are identified and provide direction for future clinical and basic science studies.
January 17, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38230520/-aedes-borne-orthoflavivirus-infections-in-neotropical-primates-ecology-susceptibility-and-pathogenesis
#11
REVIEW
Paula Rodrigues de Almeida, Matheus Nunes Weber, Luciana Sonne, Fernando Rosado Spilki
Arboviral diseases comprise a group of important infectious diseases imposing a heavy burden to public health in many locations of the world. Orthoflaviviruses are viruses belonging to the genus Orthoflavivirus ; this genus includes some of the most relevant arboviruses to human health. Orthoflaviviruses can infect several different hosts, with some species being transmitted in cycles involving birds and anthropophilic mosquitoes and others transmitted between mammals and mostly Aedes sp. mosquitoes. Some of the most important sylvatic reservoirs of orthoflaviviruses are non-human primates (NHPs)...
January 17, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38205769/green-synthesized-silver-nanoparticles-for-the-treatment-of-diabetes-and-the-related-complications-of-hyperlipidemia-and-oxidative-stress-in-diabetic-rats
#12
JOURNAL ARTICLE
Yousra G El-Baz, Amr Moustafa, Mohamed A Ali, Gaber E El-Desoky, Saikh M Wabaidur, Amjad Iqbal
This study was conducted to compare the impact of cinnamon silver nanoparticles (C-Ag-NPs) and cinnamon aqueous extract (CAE) on the total body weight (TBW), body weight gain (BWG), blood count (BC), fasting blood glucose (FBG), triglycerides (TGs), total cholesterol (TC), low-density (LDL-C) and high-density (HDL-C) lipoprotein cholesterol, liver function enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) of normal and streptozotocin (STZ) diabetic rats. The CAE was administered to rats at different doses (50...
January 11, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38205625/corrigendum-to-ctrp3-protects-against-uric-acid-induced-endothelial-injury-by-inhibiting-inflammation-and-oxidase-stress-in-rats
#13
(no author information available yet)
No abstract text is available yet for this article.
January 11, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38196081/whole-genome-analysis-and-evolutionary-characterization-of-cervical-and-oral-human-papillomavirus-16
#14
JOURNAL ARTICLE
Sadia Minhas, Muhammad Kashif, Haseeb Nisar, Muhammad Idrees, Farheen Ansari
High-throughput genome-wide sequencing has revealed high genomic variability of HPV16 in different geographic regions which is the most predominant genotype in human papillomavirus (HPV)-associated malignancies. Analysis of the HPV16 by whole-genome sequence (WGS) is an advanced method for the identification of mutations in the genome. There is limited information about HPV16 diversity in Pakistan, especially at the genomic level. Till now, WGS for HPV16 has not been previously reported in Pakistan. The current study has sequenced three HPV16 viral genomes, from two cervical and one oral cavity positive sample of women presented with general gynecological problems without any evidence of precancerous or cancerous lesions using an ion ampliseq customized panel...
January 9, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38183286/arbovirus-surveillance-in-mosquitoes-historical-methods-emerging-technologies-and-challenges-ahead
#15
REVIEW
Luis Janssen Maia, Cirilo Henrique de Oliveira, Arthur Batista Silva, Pedro Augusto Almeida Souza, Nicolas Felipe Drumm Müller, Jader da Cruz Cardoso, Bergmann Morais Ribeiro, Filipe Vieira Santos de Abreu, Fabrício Souza Campos
Arboviruses cause millions of infections each year; however, only limited options are available for treatment and pharmacological prevention. Mosquitoes are among the most important vectors for the transmission of several pathogens to humans. Despite advances, the sampling, viral detection, and control methods for these insects remain ineffective. Challenges arise with the increase in mosquito populations due to climate change, insecticide resistance, and human interference affecting natural habitats, which contribute to the increasing difficulty in controlling the spread of arboviruses...
January 6, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38166420/rxbert-enhancing-drug-labeling-text-mining-and-analysis-with-ai-language-modeling
#16
JOURNAL ARTICLE
Leihong Wu, Magnus Gray, Oanh Dang, Joshua Xu, Hong Fang, Weida Tong
The US drug labeling document contains essential information on drug efficacy and safety, making it a crucial regulatory resource for Food and Drug Administration (FDA) drug reviewers. Due to its extensive volume and the presence of free-text, conventional text mining analysis have encountered challenges in processing these data. Recent advances in artificial intelligence (AI) for natural language processing (NLP) have provided an unprecedented opportunity to identify key information from drug labeling, thereby enhancing safety reviews and support for regulatory decisions...
January 2, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38166412/link-between-m6a-modification-and-infiltration-characterization-of-tumor-microenvironment-in-lung-adenocarcinoma
#17
JOURNAL ARTICLE
Sha Yang, Ke Li, Jiqin Zhang, Jian Liu, Lin Liu, Ying Tan, Chuan Xu
N6-methyladenosine (m6A) RNA methylation plays a pivotal role in immune responses and the onset and advancement of cancer. Nonetheless, the precise impact of m6A modification in lung adenocarcinoma (LUAD) and its associated tumor microenvironment (TME) remains to be fully elucidated. Here, we distinguished distinct m6A modification patterns within two separate LUAD cohorts using a set of 21 m6A regulators. The TME characteristics associated with these two patterns align with the immune-inflamed and immune-excluded phenotypes, respectively...
January 2, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38166397/modeling-immunity-in-microphysiological-systems
#18
REVIEW
Brian J Kwee, Xiaoqing Li, Xinh-Xinh Nguyen, Courtney Campagna, Johnny Lam, Kyung E Sung
There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully recapitulate the function and physiology of the human immune system. Microphysiological systems (MPSs) that can model key microenvironment cues of the human immune system, as well as of specific organs and tissues, may be able to recapitulate specific features of the in vivo inflammatory response...
January 2, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38165134/retraction-notice
#19
(no author information available yet)
No abstract text is available yet for this article.
January 2, 2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38655370/establishment-and-validation-of-a-5-factor-diagnostic-model-for-obstructive-and-non-obstructive-azoospermia-based-on-routine-clinical-parameters
#20
JOURNAL ARTICLE
Xiaoyu Zhu, Yin Liu, Ying Huang, Hongxia Tan, Meifang He, Dong Wang
Azoospermia is a serious leading male-factor cause of infertility in couples of childbearing age. The two main azoospermia types, obstructive (OA) and non-obstructive (NOA) azoospermia, differ in their treatment approaches. Therefore, their clinical diagnosis is extremely important, requiring an accurate, efficient, and easy-to-use diagnostic model. This retrospective observational study included 707 patients with azoospermia treated between 2017 and 2021, 498 with OA, and 209 with NOA. Hematological and seminal plasma parameters, hormone levels, and testicular volume were used in logistic regression analysis to evaluate and compare their diagnostic performance, results showed that the optimal diagnostic model is constructed by five variables including semen volume, semen pH, seminal plasma neutral α-glucosidase activity, follicle-stimulating hormone in the serum, and testicular volume, compared with follicle-stimulating hormone-based and testicular volume-based models...
2024: Experimental Biology and Medicine
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